Solution conformations and dynamics of ABL kinase-inhibitor complexes determined by NMR substantiate the different binding modes of imatinib/nilotinib and dasatinib

Journal of Biological Chemistry

Volumn 283, Issue 26, 2008, Pages 18292-18302

  Vajpai, Navratna ^b   Strauss, André ^a   Fendrich, Gabriele ^a   Cowan Jacob, Sandra W ^a   Manley, Paul W ^a   Grzesiek, Stephan ^b   Jahnke, Wolfgang ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; DYNAMICS; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TENSORS; TROPOSPHERE;

ACTIVATION LOOPS; ACTIVE CONFORMATIONS; BINDING MODES; CHRONIC MYELOGENOUS LEUKEMIAS; CRYSTALLOGRAPHIC STUDIES; DRUG TARGETS; IMATINIB; INACTIVE CONFORMATIONS; INHIBITOR COMPLEXES; MICROSECOND DYNAMICS; NMR TECHNIQUES; RESIDUAL DIPOLAR COUPLINGS; RESONANCE ASSIGNMENTS; SOLUTION CONFORMATIONS; SOLUTION STATES;

CONFORMATIONS;

6 (2,6 DICHLOROPHENYL) 2 (4 FLUORO 3 METHYLANILINO) 8 METHYL 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; ABELSON KINASE; ABELSON KINASE INHIBITOR; AFN 941; DASATINIB; IMATINIB; NILOTINIB; NITROGEN 15; UNCLASSIFIED DRUG; 4 METHYL N (3 (4 METHYLIMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)PHENYL) 3 ((4 PYRIDIN 3 YLPYRIMIDIN 2 YL)AMINO)BENZAMIDE; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CANCER RESISTANCE; CHRONIC MYELOID LEUKEMIA; COMPUTER PREDICTION; DRUG BINDING; DRUG CONFORMATION; ENZYME CONFORMATION; ENZYME INHIBITOR COMPLEX; MOLECULAR MODEL; NANOANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POINT MUTATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG DESIGN; HUMAN; METHODOLOGY; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PIPERAZINES; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; THIAZOLES;

EID: 49649108911     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801337200     Document Type: Article

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