A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

Journal of Medicinal Chemistry

Volumn 48, Issue 5, 2005, Pages 1489-1495

  Rush III, Thomas S ^a   Grant, J Andrew ^b   Mosyak, Lidia ^a   Nicholls, Anthony ^c  

^a PFIZER INC   (United States)

^b ASTRAZENECA   (United Kingdom)

^c OpenEye Scientific Software Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; FTSZ PROTEIN; PROTEIN INHIBITOR; PROTEIN ZIPA; SMALL MOLECULE INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; ALGORITHM; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; COMPUTER PROGRAM; DRUG IDENTIFICATION; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; INFORMATION SYSTEM; NONHUMAN; PREDICTION; PROTEIN PROTEIN INTERACTION; RAPID OVERLAY OF CHEMICAL STRUCTURES; STRUCTURE ANALYSIS; VALIDATION PROCESS; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BINDING SITES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; CYTOSKELETAL PROTEINS; ESCHERICHIA COLI PROTEINS; MOLECULAR STRUCTURE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 14944348527     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040163o     Document Type: Article

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