메뉴 건너뛰기




Volumn 5, Issue 1, 2011, Pages 61-78

Potential use of polyamidoamine dendrimer conjugates with cyclodextrins as novel carriers for siRNA

Author keywords

Conjugate; Cyclodextrin; Multifunction; Polyamidoamine dendrimer; siRNA delivery

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CYCLODEXTRIN; DENDRIMER; DRUG CARRIER; LIPOFECTAMINE; LIPOFECTIN; MACROGOL; NANOPARTICLE; OLIGODEOXYNUCLEOTIDE; POLYAMIDOAMINE; POLYCATION; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 84855935111     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5010061     Document Type: Review
Times cited : (20)

References (93)
  • 1
    • 78649659237 scopus 로고    scopus 로고
    • Delivery of sirna therapeutics: Barriers and carriers
    • Wang, J.; Lu, Z.; Wientjes, M.G.; Au, J.L. Delivery of sirna therapeutics: Barriers and carriers. AAPS J. 2010, 12, 492-503.
    • (2010) AAPS J. , vol.12 , pp. 492-503
    • Wang, J.1    Lu, Z.2    Wientjes, M.G.3    Au, J.L.4
  • 2
    • 58749104364 scopus 로고    scopus 로고
    • The promises and pitfalls of RNA-interference-based therapeutics
    • Castanotto, D.; Rossi, J.J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 2009, 457, 426-433.
    • (2009) Nature , vol.457 , pp. 426-433
    • Castanotto, D.1    Rossi, J.J.2
  • 3
    • 33847036990 scopus 로고    scopus 로고
    • Strategies for silencing human disease using RNA interference
    • Kim, D.H.; Rossi, J.J. Strategies for silencing human disease using RNA interference. Nat. Rev. Genet. 2007, 8, 173-184.
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 173-184
    • Kim, D.H.1    Rossi, J.J.2
  • 4
    • 77954362096 scopus 로고    scopus 로고
    • Aptamer-targeted cell-specific RNA interference
    • Zhou, J.; Rossi, J.J. Aptamer-targeted cell-specific RNA interference. Silence 2010, 1, 4.
    • (2010) Silence , vol.1 , pp. 4
    • Zhou, J.1    Rossi, J.J.2
  • 6
    • 33645136607 scopus 로고    scopus 로고
    • Therapeutic short hairpin RNA expression in the liver: Viral targets and vectors
    • Grimm, D.; Kay, M.A. Therapeutic short hairpin RNA expression in the liver: Viral targets and vectors. Gene Ther. 2006, 13, 563-575.
    • (2006) Gene Ther. , vol.13 , pp. 563-575
    • Grimm, D.1    Kay, M.A.2
  • 7
    • 34248682403 scopus 로고    scopus 로고
    • RNAi therapeutics: Principles, prospects and challenges
    • Aagaard, L.; Rossi, J.J. RNAi therapeutics: Principles, prospects and challenges. Adv. Drug Deliv. Rev. 2007, 59, 75-86.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 75-86
    • Aagaard, L.1    Rossi, J.J.2
  • 10
    • 14044250982 scopus 로고    scopus 로고
    • Formation and intracellular trafficking of lipoplexes and polyplexes
    • Elouahabi, A.; Ruysschaert, J.M. Formation and intracellular trafficking of lipoplexes and polyplexes. Mol. Ther. 2005, 11, 336-347.
    • (2005) Mol. Ther. , vol.11 , pp. 336-347
    • Elouahabi, A.1    Ruysschaert, J.M.2
  • 11
    • 77956871233 scopus 로고    scopus 로고
    • Chitosan as a carrier for targeted delivery of small interfering RNA
    • Rudzinski, W.E.; Aminabhavi, T.M. Chitosan as a carrier for targeted delivery of small interfering RNA. Int. J. Pharm. 2010, 399, 1-11.
    • (2010) Int. J. Pharm. , vol.399 , pp. 1-11
    • Rudzinski, W.E.1    Aminabhavi, T.M.2
  • 13
    • 34047190259 scopus 로고    scopus 로고
    • Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting
    • de Paula, D.; Bentley, M.V.; Mahato, R.I. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA 2007, 13, 431-456.
    • (2007) RNA , vol.13 , pp. 431-456
    • de Paula, D.1    Bentley, M.V.2    Mahato, R.I.3
  • 14
    • 60749099046 scopus 로고    scopus 로고
    • Polymer nanocarriers for the delivery of small fragments of nucleic acids: Oligonucleotides and siRNA
    • de Martimprey, H.; Vauthier, C.; Malvy, C.; Couvreur, P. Polymer nanocarriers for the delivery of small fragments of nucleic acids: Oligonucleotides and siRNA. Eur. J. Pharm. Biopharm. 2009, 71, 490-504.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 490-504
    • de Martimprey, H.1    Vauthier, C.2    Malvy, C.3    Couvreur, P.4
  • 16
    • 0008267588 scopus 로고
    • Dendrimer research
    • Tomalia, D.A. Dendrimer research. Science 1991, 252, 1231.
    • (1991) Science , vol.252 , pp. 1231
    • Tomalia, D.A.1
  • 17
    • 1642414039 scopus 로고    scopus 로고
    • Dendrimers in drug research
    • Boas, U.; Heegaard, P.M. Dendrimers in drug research. Chem. Soc. Rev. 2004, 33, 43-63.
    • (2004) Chem. Soc. Rev. , vol.33 , pp. 43-63
    • Boas, U.1    Heegaard, P.M.2
  • 18
    • 0035342007 scopus 로고    scopus 로고
    • Poly(amidoamine) (pamam) dendrimers: From biomimicry to drug delivery and biomedical applications
    • Esfand, R.; Tomalia, D.A. Poly(amidoamine) (pamam) dendrimers: From biomimicry to drug delivery and biomedical applications. Drug Discov. Today 2001, 6, 427-436.
    • (2001) Drug Discov. Today , vol.6 , pp. 427-436
    • Esfand, R.1    Tomalia, D.A.2
  • 19
    • 14344262752 scopus 로고    scopus 로고
    • Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles
    • Braun, C.S.; Vetro, J.A.; Tomalia, D.A.; Koe, G.S.; Koe, J.G.; Middaugh, C.R. Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles. J. Pharm. Sci. 2005, 94, 423-436.
    • (2005) J. Pharm. Sci. , vol.94 , pp. 423-436
    • Braun, C.S.1    Vetro, J.A.2    Tomalia, D.A.3    Koe, G.S.4    Koe, J.G.5    Middaugh, C.R.6
  • 20
    • 38949118666 scopus 로고    scopus 로고
    • DNA condensation by pamam dendrimers: Self-assembly characteristics and effect on transcription
    • Fant, K.; Esbjorner, E.K.; Lincoln, P.; Norden, B. DNA condensation by pamam dendrimers: Self-assembly characteristics and effect on transcription. Biochemistry 2008, 47, 1732-1740.
    • (2008) Biochemistry , vol.47 , pp. 1732-1740
    • Fant, K.1    Esbjorner, E.K.2    Lincoln, P.3    Norden, B.4
  • 21
    • 75149167354 scopus 로고    scopus 로고
    • Dendrimer nanocarriers as versatile vectors in gene delivery
    • Dutta, T.; Jain, N.K.; McMillan, N.A.; Parekh, H.S. Dendrimer nanocarriers as versatile vectors in gene delivery. Nanomedicine 2010, 6, 25-34.
    • (2010) Nanomedicine , vol.6 , pp. 25-34
    • Dutta, T.1    Jain, N.K.2    McMillan, N.A.3    Parekh, H.S.4
  • 22
    • 42649104017 scopus 로고    scopus 로고
    • Studies on polyamidoamine dendrimers as efficient gene delivery vector
    • Hui, Z.; He, Z.G.; Zheng, L.; Li, G.Y.; Shen, S.R.; Li, X.L. Studies on polyamidoamine dendrimers as efficient gene delivery vector. J. Biomater. Appl. 2008, 22, 527-544.
    • (2008) J. Biomater. Appl. , vol.22 , pp. 527-544
    • Hui, Z.1    He, Z.G.2    Zheng, L.3    Li, G.Y.4    Shen, S.R.5    Li, X.L.6
  • 23
    • 0035229874 scopus 로고    scopus 로고
    • Dendrimers: Properties and applications
    • Klajnert, B.; Bryszewska, M. Dendrimers: Properties and applications. Acta Biochim. Pol. 2001, 48, 199-208.
    • (2001) Acta Biochim. Pol. , vol.48 , pp. 199-208
    • Klajnert, B.1    Bryszewska, M.2
  • 24
    • 22244491275 scopus 로고    scopus 로고
    • A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes
    • Braun, C.S.; Fisher, M.T.; Tomalia, D.A.; Koe, G.S.; Koe, J.G.; Middaugh, C.R. A stopped-flow kinetic study of the assembly of nonviral gene delivery complexes. Biophys. J. 2005, 88, 4146-4158.
    • (2005) Biophys. J. , vol.88 , pp. 4146-4158
    • Braun, C.S.1    Fisher, M.T.2    Tomalia, D.A.3    Koe, G.S.4    Koe, J.G.5    Middaugh, C.R.6
  • 26
    • 79955919831 scopus 로고    scopus 로고
    • Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA
    • Shah, N.; Steptoe, R.J.; Parekh, H.S. Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA. J. Pept. Sci. 2011, 17, 470-478.
    • (2011) J. Pept. Sci. , vol.17 , pp. 470-478
    • Shah, N.1    Steptoe, R.J.2    Parekh, H.S.3
  • 28
    • 69549086354 scopus 로고    scopus 로고
    • Ethylendiamine core pamam dendrimers/siRNA complexes as in vitro silencing agents
    • Perez, A.P.; Romero, E.L.; Morilla, M.J. Ethylendiamine core pamam dendrimers/siRNA complexes as in vitro silencing agents. Int. J. Pharm. 2009, 380, 189-200.
    • (2009) Int. J. Pharm. , vol.380 , pp. 189-200
    • Perez, A.P.1    Romero, E.L.2    Morilla, M.J.3
  • 29
    • 0024355622 scopus 로고
    • Biochemical characterisation of polycation-induced cytotoxicity to human vascular endothelial cells
    • Morgan, D.M.; Larvin, V.L.; Pearson, J.D. Biochemical characterisation of polycation-induced cytotoxicity to human vascular endothelial cells. J. Cell Sci. 1989, 94, 553-559.
    • (1989) J. Cell Sci. , vol.94 , pp. 553-559
    • Morgan, D.M.1    Larvin, V.L.2    Pearson, J.D.3
  • 32
    • 77955240438 scopus 로고    scopus 로고
    • Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity
    • Merkel, O.M.; Mintzer, M.A.; Librizzi, D.; Samsonova, O.; Dicke, T.; Sproat, B.; Garn, H.; Barth, P.J.; Simanek, E.E.; Kissel, T. Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity. Mol. Pharm. 2010, 7, 969-983.
    • (2010) Mol. Pharm. , vol.7 , pp. 969-983
    • Merkel, O.M.1    Mintzer, M.A.2    Librizzi, D.3    Samsonova, O.4    Dicke, T.5    Sproat, B.6    Garn, H.7    Barth, P.J.8    Simanek, E.E.9    Kissel, T.10
  • 33
    • 77949275122 scopus 로고    scopus 로고
    • Dendrimer-based drug and imaging conjugates: Design considerations for nanomedical applications
    • Menjoge, A.R.; Kannan, R.M.; Tomalia, D.A. Dendrimer-based drug and imaging conjugates: Design considerations for nanomedical applications. Drug Discov. Today 2010, 15, 171-185.
    • (2010) Drug Discov. Today , vol.15 , pp. 171-185
    • Menjoge, A.R.1    Kannan, R.M.2    Tomalia, D.A.3
  • 34
    • 80052140404 scopus 로고    scopus 로고
    • Polymers in small-interfering RNA delivery
    • Singha, K.; Namgung, R.; Kim, W.J. Polymers in small-interfering RNA delivery. Nucleic Acid Ther. 2011, 21, 133-147.
    • (2011) Nucleic Acid Ther. , vol.21 , pp. 133-147
    • Singha, K.1    Namgung, R.2    Kim, W.J.3
  • 35
    • 79952939225 scopus 로고    scopus 로고
    • Recent advances of siRNA delivery by nanoparticles
    • Yuan, X.; Naguib, S.; Wu, Z. Recent advances of siRNA delivery by nanoparticles. Expert Opin. Drug Deliv. 2011, 8, 521-536.
    • (2011) Expert Opin. Drug Deliv. , vol.8 , pp. 521-536
    • Yuan, X.1    Naguib, S.2    Wu, Z.3
  • 39
    • 0028265295 scopus 로고
    • Medicinal applications of cyclodextrins
    • Szejtli, J. Medicinal applications of cyclodextrins. Med. Res. Rev. 1994, 14, 353-386.
    • (1994) Med. Res. Rev. , vol.14 , pp. 353-386
    • Szejtli, J.1
  • 40
    • 10444279209 scopus 로고    scopus 로고
    • Cyclodextrin-based pharmaceutics: Past, present and future
    • Davis, M.E.; Brewster, M.E. Cyclodextrin-based pharmaceutics: Past, present and future. Nat. Rev. Drug Discov. 2004, 3, 1023-1035.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 1023-1035
    • Davis, M.E.1    Brewster, M.E.2
  • 41
    • 0032119526 scopus 로고    scopus 로고
    • Cyclodextrin drug carrier systems
    • Uekama, K.; Hirayama, F.; Irie, T. Cyclodextrin drug carrier systems. Chem Rev. 1998, 98, 2045-2076.
    • (1998) Chem Rev. , vol.98 , pp. 2045-2076
    • Uekama, K.1    Hirayama, F.2    Irie, T.3
  • 42
    • 16344364096 scopus 로고    scopus 로고
    • Design and evaluation of cyclodextrin-based drug formulation
    • (Tokyo)
    • Uekama, K. Design and evaluation of cyclodextrin-based drug formulation. Chem. Pharm. Bull. (Tokyo) 2004, 52, 900-915.
    • (2004) Chem. Pharm. Bull. , vol.52 , pp. 900-915
    • Uekama, K.1
  • 43
    • 0033106020 scopus 로고    scopus 로고
    • Highly soluble cyclodextrin derivatives: Chemistry, properties, and trends in development
    • Szente, L.; Szejtli, J. Highly soluble cyclodextrin derivatives: Chemistry, properties, and trends in development. Adv. Drug Deliv. Rev. 1999, 36, 17-28.
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , pp. 17-28
    • Szente, L.1    Szejtli, J.2
  • 45
    • 0024806367 scopus 로고
    • Differential effects of alpha-, beta-and gamma-cyclodextrins on human erythrocytes
    • Ohtani, Y.; Irie, T.; Uekama, K.; Fukunaga, K.; Pitha, J. Differential effects of alpha-, beta-and gamma-cyclodextrins on human erythrocytes. Eur. J. Biochem. 1989, 186, 17-22.
    • (1989) Eur. J. Biochem. , vol.186 , pp. 17-22
    • Ohtani, Y.1    Irie, T.2    Uekama, K.3    Fukunaga, K.4    Pitha, J.5
  • 46
    • 0030843265 scopus 로고    scopus 로고
    • Mechanism of alpha-cyclodextrin-induced hemolysis. 1. The two-step extraction of phosphatidylinositol from the membrane
    • Fauvelle, F.; Debouzy, J.C.; Crouzy, S.; Goschl, M.; Chapron, Y. Mechanism of alpha-cyclodextrin-induced hemolysis. 1. The two-step extraction of phosphatidylinositol from the membrane. J. Pharm. Sci. 1997, 86, 935-943.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 935-943
    • Fauvelle, F.1    Debouzy, J.C.2    Crouzy, S.3    Goschl, M.4    Chapron, Y.5
  • 47
    • 70349642521 scopus 로고    scopus 로고
    • Recent findings concerning pamam dendrimer conjugates with cyclodextrins as carriers of DNA and RNA
    • 6364-6361
    • Arima, H.; Motoyama, K. Recent findings concerning pamam dendrimer conjugates with cyclodextrins as carriers of DNA and RNA. Sensors 2009, 9, 6364-6361.
    • (2009) Sensors , vol.9
    • Arima, H.1    Motoyama, K.2
  • 48
    • 0033231242 scopus 로고    scopus 로고
    • New class of polymers for the delivery of macromolecular therapeutics
    • Gonzalez, H.; Hwang, S.J.; Davis, M.E. New class of polymers for the delivery of macromolecular therapeutics. Bioconjug. Chem. 1999, 10, 1068-1074.
    • (1999) Bioconjug. Chem. , vol.10 , pp. 1068-1074
    • Gonzalez, H.1    Hwang, S.J.2    Davis, M.E.3
  • 49
    • 0035079050 scopus 로고    scopus 로고
    • Effects of structure of beta-cyclodextrin-containing polymers on gene delivery
    • Hwang, S.J.; Bellocq, N.C.; Davis, M.E. Effects of structure of beta-cyclodextrin-containing polymers on gene delivery. Bioconjug. Chem. 2001, 12, 280-290.
    • (2001) Bioconjug. Chem. , vol.12 , pp. 280-290
    • Hwang, S.J.1    Bellocq, N.C.2    Davis, M.E.3
  • 51
    • 39549120024 scopus 로고    scopus 로고
    • Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
    • Bartlett, D.W.; Davis, M.E. Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles. Biotechnol. Bioeng. 2008, 99, 975-985.
    • (2008) Biotechnol. Bioeng. , vol.99 , pp. 975-985
    • Bartlett, D.W.1    Davis, M.E.2
  • 53
    • 33947696667 scopus 로고    scopus 로고
    • Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles
    • Bartlett, D.W.; Davis, M.E. Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug. Chem. 2007, 18, 456-468.
    • (2007) Bioconjug. Chem. , vol.18 , pp. 456-468
    • Bartlett, D.W.1    Davis, M.E.2
  • 54
    • 67249128859 scopus 로고    scopus 로고
    • The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic
    • Davis, M.E. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic. Mol. Pharm. 2009, 6, 659-668.
    • (2009) Mol. Pharm. , vol.6 , pp. 659-668
    • Davis, M.E.1
  • 56
    • 34347272315 scopus 로고    scopus 로고
    • Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
    • Heidel, J.D.; Yu, Z.; Liu, J.Y.; Rele, S.M.; Liang, Y.; Zeidan, R.K.; Kornbrust, D.J.; Davis, M.E. Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. Proc. Natl. Acad. Sci. USA 2007, 104, 5715-5721.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5715-5721
    • Heidel, J.D.1    Yu, Z.2    Liu, J.Y.3    Rele, S.M.4    Liang, Y.5    Zeidan, R.K.6    Kornbrust, D.J.7    Davis, M.E.8
  • 57
    • 77955666824 scopus 로고    scopus 로고
    • Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing
    • Boe, S.L.; Longva, A.S.; Hovig, E. Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing. Oligonucleotides 2010, 20, 175-182.
    • (2010) Oligonucleotides , vol.20 , pp. 175-182
    • Boe, S.L.1    Longva, A.S.2    Hovig, E.3
  • 60
    • 0034915353 scopus 로고    scopus 로고
    • Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-,-, and γ-cyclodextrins
    • Arima, H.; Kihara, F.; Hirayama, F.; Uekama, K. Enhancement of gene expression by polyamidoamine dendrimer conjugates with α-,-, and γ-cyclodextrins. Bioconjug. Chem. 2001, 12, 476-484.
    • (2001) Bioconjug. Chem. , vol.12 , pp. 476-484
    • Arima, H.1    Kihara, F.2    Hirayama, F.3    Uekama, K.4
  • 61
    • 0036861008 scopus 로고    scopus 로고
    • Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with α-cyclodextrin
    • Kihara, F.; Arima, H.; Tsutsumi, T.; Hirayama, F.; Uekama, K. Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with α-cyclodextrin. Bioconjug. Chem. 2002, 13, 1211-1219.
    • (2002) Bioconjug. Chem. , vol.13 , pp. 1211-1219
    • Kihara, F.1    Arima, H.2    Tsutsumi, T.3    Hirayama, F.4    Uekama, K.5
  • 62
    • 0037347198 scopus 로고    scopus 로고
    • In vitro and in vivo gene transfer by an optimized α-cyclodextrin conjugate with polyamidoamine dendrimer
    • Kihara, F.; Arima, H.; Tsutsumi, T.; Hirayama, F.; Uekama, K. In vitro and in vivo gene transfer by an optimized α-cyclodextrin conjugate with polyamidoamine dendrimer. Bioconjug. Chem. 2003, 14, 342-350.
    • (2003) Bioconjug. Chem. , vol.14 , pp. 342-350
    • Kihara, F.1    Arima, H.2    Tsutsumi, T.3    Hirayama, F.4    Uekama, K.5
  • 63
    • 80051788617 scopus 로고    scopus 로고
    • Preparation and evaluation of polyamidoamine dendrimer (g2)/branched-β-cyclodextrin conjugate as a novel gene transfer carrier
    • Anno, T.; Motoyama, K.; Higashi, T.; Hirayama, F.; Uekama, K.; Arima, H. Preparation and evaluation of polyamidoamine dendrimer (g2)/branched-β-cyclodextrin conjugate as a novel gene transfer carrier. J. Incl. Phenom. Macro. Chem. 2011, 70, 339-344.
    • (2011) J. Incl. Phenom. Macro. Chem. , vol.70 , pp. 339-344
    • Anno, T.1    Motoyama, K.2    Higashi, T.3    Hirayama, F.4    Uekama, K.5    Arima, H.6
  • 64
    • 84858803236 scopus 로고    scopus 로고
    • Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a DNA carrier in vitro and in vivo
    • in press
    • Anno, T.; Higashi, T.; Motoyama, K.; Hirayama, F.; Uekama, K.; Arima, H. Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a DNA carrier in vitro and in vivo. J. Drug. Target. 2011, in press.
    • (2011) J. Drug. Target.
    • Anno, T.1    Higashi, T.2    Motoyama, K.3    Hirayama, F.4    Uekama, K.5    Arima, H.6
  • 65
    • 34248643411 scopus 로고    scopus 로고
    • Evaluation of polyamidoamine dendrimer/ α-cyclodextrin conjugate (generation 3, g3) as a novel carrier for small interfering RNA (siRNA)
    • Tsutsumi, T.; Hirayama, F.; Uekama, K.; Arima, H. Evaluation of polyamidoamine dendrimer/ α-cyclodextrin conjugate (generation 3, g3) as a novel carrier for small interfering RNA (siRNA). J. Control. Release 2007, 119, 349-359.
    • (2007) J. Control. Release , vol.119 , pp. 349-359
    • Tsutsumi, T.1    Hirayama, F.2    Uekama, K.3    Arima, H.4
  • 66
    • 52449097964 scopus 로고    scopus 로고
    • Potential use of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, g3) as a novel carrier for short hairpin RNA-expressing plasmid DNA
    • Tsutsumi, T.; Hirayama, F.; Uekama, K.; Arima, H. Potential use of polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, g3) as a novel carrier for short hairpin RNA-expressing plasmid DNA. J. Pharm. Sci. 2008, 97, 3022-3034.
    • (2008) J. Pharm. Sci. , vol.97 , pp. 3022-3034
    • Tsutsumi, T.1    Hirayama, F.2    Uekama, K.3    Arima, H.4
  • 67
    • 80053898092 scopus 로고    scopus 로고
    • Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/ α-cyclodextrin conjugate (generation 3, g3) on endogenous gene expression
    • Arima, H.; Tsutsumi, T.; Yoshimatsu, A.; Ikeda, H.; Motoyama, K.; Higashi, T.; Hirayama, F.; Uekama, K. Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/ α-cyclodextrin conjugate (generation 3, g3) on endogenous gene expression. Eur. J. Pharm. Sci. 2011, 44, 375-384.
    • (2011) Eur. J. Pharm. Sci. , vol.44 , pp. 375-384
    • Arima, H.1    Tsutsumi, T.2    Yoshimatsu, A.3    Ikeda, H.4    Motoyama, K.5    Higashi, T.6    Hirayama, F.7    Uekama, K.8
  • 70
    • 3042613471 scopus 로고    scopus 로고
    • Glyco-dependent nuclear import of glycoproteins, glycoplexes and glycosylated plasmids
    • Monsigny, M.; Rondanino, C.; Duverger, E.; Fajac, I.; Roche, A.C. Glyco-dependent nuclear import of glycoproteins, glycoplexes and glycosylated plasmids. Biochim. Biophys. Acta 2004, 1673, 94-103.
    • (2004) Biochim. Biophys. Acta , vol.1673 , pp. 94-103
    • Monsigny, M.1    Rondanino, C.2    Duverger, E.3    Fajac, I.4    Roche, A.C.5
  • 71
    • 0033516472 scopus 로고    scopus 로고
    • Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells
    • Diebold, S.S.; Kursa, M.; Wagner, E.; Cotten, M.; Zenke, M. Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells. J. Biol. Chem. 1999, 274, 19087-19094.
    • (1999) J. Biol. Chem. , vol.274 , pp. 19087-19094
    • Diebold, S.S.1    Kursa, M.2    Wagner, E.3    Cotten, M.4    Zenke, M.5
  • 72
    • 0031281282 scopus 로고    scopus 로고
    • In vitro gene delivery to hepatocytes with galactosylated polyethylenimine
    • Zanta, M.A.; Boussif, O.; Adib, A.; Behr, J.P. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine. Bioconjug. Chem. 1997, 8, 839-844.
    • (1997) Bioconjug. Chem. , vol.8 , pp. 839-844
    • Zanta, M.A.1    Boussif, O.2    Adib, A.3    Behr, J.P.4
  • 74
    • 33751236506 scopus 로고    scopus 로고
    • Enhancement of gene transfer activity mediated by mannosylated dendrimer/α-cyclodextrin conjugate (generation 3, g3)
    • Arima, H.; Chihara, Y.; Arizono, M.; Yamashita, S.; Wada, K.; Hirayama, F.; Uekama, K. Enhancement of gene transfer activity mediated by mannosylated dendrimer/α-cyclodextrin conjugate (generation 3, g3). J. Control. Release 2006, 116, 64-74.
    • (2006) J. Control. Release , vol.116 , pp. 64-74
    • Arima, H.1    Chihara, Y.2    Arizono, M.3    Yamashita, S.4    Wada, K.5    Hirayama, F.6    Uekama, K.7
  • 75
    • 19444374526 scopus 로고    scopus 로고
    • Enhancing effects of galactosylated dendrimer/α-cyclodextrin conjugates on gene transfer efficiency
    • Wada, K.; Arima, H.; Tsutsumi, T.; Hirayama, F.; Uekama, K. Enhancing effects of galactosylated dendrimer/α-cyclodextrin conjugates on gene transfer efficiency. Biol. Pharm. Bull. 2005, 28, 500-505.
    • (2005) Biol. Pharm. Bull. , vol.28 , pp. 500-505
    • Wada, K.1    Arima, H.2    Tsutsumi, T.3    Hirayama, F.4    Uekama, K.5
  • 78
    • 64549134676 scopus 로고    scopus 로고
    • Nonviral vectors for gene delivery
    • Mintzer, M.A.; Simanek, E.E. Nonviral vectors for gene delivery. Chem. Rev. 2009, 109, 259-302.
    • (2009) Chem. Rev. , vol.109 , pp. 259-302
    • Mintzer, M.A.1    Simanek, E.E.2
  • 79
    • 4444354794 scopus 로고    scopus 로고
    • Cd19-targeting liposomes containing imatinib efficiently kill philadelphia chromosome-positive acute lymphoblastic leukemia cells
    • Harata, M.; Soda, Y.; Tani, K.; Ooi, J.; Takizawa, T.; Chen, M.; Bai, Y.; Izawa, K.; Kobayashi, S.; Tomonari, A.; et al. Cd19-targeting liposomes containing imatinib efficiently kill philadelphia chromosome-positive acute lymphoblastic leukemia cells. Blood 2004, 104, 1442-1449.
    • (2004) Blood , vol.104 , pp. 1442-1449
    • Harata, M.1    Soda, Y.2    Tani, K.3    Ooi, J.4    Takizawa, T.5    Chen, M.6    Bai, Y.7    Izawa, K.8    Kobayashi, S.9    Tomonari, A.10
  • 80
    • 67651183769 scopus 로고    scopus 로고
    • Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide
    • Chen, H.; Ahn, R.; van den Bossche, J.; Thompson, D.H.; O'Halloran, T.V. Folate-mediated intracellular drug delivery increases the anticancer efficacy of nanoparticulate formulation of arsenic trioxide. Mol. Cancer Ther. 2009, 8, 1955-1963.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 1955-1963
    • Chen, H.1    Ahn, R.2    van den Bossche, J.3    Thompson, D.H.4    O'Halloran, T.V.5
  • 81
    • 67649849650 scopus 로고    scopus 로고
    • Folate-targeted therapeutic and imaging agents for cancer
    • Low, P.S.; Kularatne, S.A. Folate-targeted therapeutic and imaging agents for cancer. Curr. Opin. Chem. Biol. 2009, 13, 256-262.
    • (2009) Curr. Opin. Chem. Biol. , vol.13 , pp. 256-262
    • Low, P.S.1    Kularatne, S.A.2
  • 82
    • 80053626103 scopus 로고    scopus 로고
    • Targeting of nanoparticles in cancer: Drug delivery and diagnostics
    • Talekar, M.; Kendall, J.; Denny, W.; Garg, S. Targeting of nanoparticles in cancer: Drug delivery and diagnostics. Anticancer Drugs 2011, 22, 949-962.
    • (2011) Anticancer Drugs , vol.22 , pp. 949-962
    • Talekar, M.1    Kendall, J.2    Denny, W.3    Garg, S.4
  • 83
    • 80052004369 scopus 로고    scopus 로고
    • Active tumor targeting of nanomaterials using folic acid, transferrin and integrin receptors
    • Kolhatkar, R.; Lote, A.; Khambati, H. Active tumor targeting of nanomaterials using folic acid, transferrin and integrin receptors. Curr. Drug Discov. Technol. 2011, 8, 197-206.
    • (2011) Curr. Drug Discov. Technol. , vol.8 , pp. 197-206
    • Kolhatkar, R.1    Lote, A.2    Khambati, H.3
  • 84
    • 77956394256 scopus 로고    scopus 로고
    • Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery
    • Yuan, Q.; Lee, E.; Yeudall, W.A.; Yang, H. Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery. Oral Oncol. 2010, 46, 698-704.
    • (2010) Oral Oncol. , vol.46 , pp. 698-704
    • Yuan, Q.1    Lee, E.2    Yeudall, W.A.3    Yang, H.4
  • 85
    • 33644827912 scopus 로고    scopus 로고
    • RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
    • Temming, K.; Schiffelers, R.M.; Molema, G.; Kok, R.J. RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature. Drug Resist. Updat. 2005, 8, 381-402.
    • (2005) Drug Resist. Updat. , vol.8 , pp. 381-402
    • Temming, K.1    Schiffelers, R.M.2    Molema, G.3    Kok, R.J.4
  • 86
    • 1942439032 scopus 로고    scopus 로고
    • Antifolates targeted specifically to the folate receptor
    • Jackman, A.L.; Theti, D.S.; Gibbs, D.D. Antifolates targeted specifically to the folate receptor. Adv. Drug Deliv. Rev. 2004, 56, 1111-1125.
    • (2004) Adv. Drug Deliv. Rev. , vol.56 , pp. 1111-1125
    • Jackman, A.L.1    Theti, D.S.2    Gibbs, D.D.3
  • 87
    • 0034981659 scopus 로고    scopus 로고
    • Specific targeting of folatedendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts
    • Konda, S.D.; Aref, M.; Wang, S.; Brechbiel, M.; Wiener, E.C. Specific targeting of folatedendrimer MRI contrast agents to the high affinity folate receptor expressed in ovarian tumor xenografts. Magn. Reson. Mater. Phys. Bio. Med. 2001, 12, 104-113.
    • (2001) Magn. Reson. Mater. Phys. Bio. Med. , vol.12 , pp. 104-113
    • Konda, S.D.1    Aref, M.2    Wang, S.3    Brechbiel, M.4    Wiener, E.C.5
  • 89
    • 48249086053 scopus 로고    scopus 로고
    • Dendrimers and their pharmaceutical applications-a review
    • Singh, I.; Rehni, A.K.; Kalra, R.; Joshi, G.; Kumar, M. Dendrimers and their pharmaceutical applications-a review. Pharmazie 2008, 63, 491-496.
    • (2008) Pharmazie , vol.63 , pp. 491-496
    • Singh, I.1    Rehni, A.K.2    Kalra, R.3    Joshi, G.4    Kumar, M.5
  • 90
    • 77956937217 scopus 로고    scopus 로고
    • Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment
    • Wang, P.; Zhao, X.H.; Wang, Z.Y.; Meng, M.; Li, X.; Ning, Q. Generation 4 polyamidoamine dendrimers is a novel candidate of nano-carrier for gene delivery agents in breast cancer treatment. Cancer Lett. 2010, 298, 34-49.
    • (2010) Cancer Lett. , vol.298 , pp. 34-49
    • Wang, P.1    Zhao, X.H.2    Wang, Z.Y.3    Meng, M.4    Li, X.5    Ning, Q.6
  • 91
    • 0034840405 scopus 로고    scopus 로고
    • Cyclodextrin-based molecular machines
    • Harada, A. Cyclodextrin-based molecular machines. Acc. Chem. Res. 2001, 34, 456-464.
    • (2001) Acc. Chem. Res. , vol.34 , pp. 456-464
    • Harada, A.1
  • 92
    • 63049108067 scopus 로고    scopus 로고
    • Cyclodextrin-based supramolecular polymers
    • Harada, A.; Takashima, Y.; Yamaguchi, H. Cyclodextrin-based supramolecular polymers. Chem. Soc. Rev. 2009, 38, 875-882.
    • (2009) Chem. Soc. Rev. , vol.38 , pp. 875-882
    • Harada, A.1    Takashima, Y.2    Yamaguchi, H.3
  • 93
    • 79953665234 scopus 로고    scopus 로고
    • Potential use of polypseudorotaxanes of pegylated polyamidoamine dendrimer with cyclodextrins as novel sustained release systems for DNA
    • Motoyama, K.; Hayashida, K.; Arima, H. Potential use of polypseudorotaxanes of pegylated polyamidoamine dendrimer with cyclodextrins as novel sustained release systems for DNA. Chem. Pharm. Bull. 2011, 59, 476-479.
    • (2011) Chem. Pharm. Bull. , vol.59 , pp. 476-479
    • Motoyama, K.1    Hayashida, K.2    Arima, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.