Studies on polyamidoamine dendrimers as efficient gene delivery vector

Journal of Biomaterials Applications

Volumn 22, Issue 6, 2008, Pages 527-544

  Zhong, Hui ^a   He Zhi Guo, Z G ^b   Li, Zheng ^a   Li, Gui Yuan ^a   Shen, Shou Rong ^b   Li, Xiao Ling ^a  

^a The First People s Hospital of Changde City)   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Cytotoxicity; Gene transfer; In vivo expression and distribution; Polyamidoamine dendrimers

Indexed keywords

AMINES; CYTOTOXICITY; DENDRIMERS; GENE EXPRESSION; GENE TRANSFER; PLASMA (HUMAN); PROTEINS;

GENE DELIVERY VECTOR; GENETIC THERAPY; POLYAMIDOAMINE DENDRIMERS;

BIOMATERIALS;

DENDRIMER; DNA; DRUG CARRIER; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; PAMAM STARBURST; POLYAMINE;

ANIMAL; ARTICLE; CELL LINE; CELL SURVIVAL; DRUG EFFECT; GENE TRANSFER; GENETICS; HUMAN; METABOLISM;

ANIMALS; CELL LINE; CELL SURVIVAL; DENDRIMERS; DNA; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMANS; POLYAMINES;

EID: 42649104017     PISSN: 08853282     EISSN: 15308022     Source Type: Journal    
DOI: 10.1177/0885328207080005     Document Type: Article

References (27)

1. Felgner, J.H., Kumar, R., Sridhar, C.N., Wheeler, C.J., Tsai, Y.J., Border, R., Ramsey, P., Martin, M. and Felgner, P.L. (1994). Enhanced Gene Delivery and Mechanism Studies with a Novel Series of Cationic Lipid Formulations, J. Biol. Chem., 269: 2550-2561.
2. Lau, C., Soriano, H.E., Ledley, F.D., Finegold, M.J., Wolfe, J.H., Birkenmeier, E.H. and Henning, S.J. (1995). Retroviral Gene Transfer into the Intestinal Epithelium, Hum. Gene Ther., 6: 1145-1151.
3. Van Craynest, N., Santaella, C., Boussif, O. and Vierling, P. (2002). Polycationic Telomers and Cotelomers for Gene Transfer: Synthesis and Evaluation of Their in vitro Transfection Efficiency, Bioconjug. Chem., 13: 59-75.
4. Mao, H.Q., Roy, K., Troung-Le, V.L., Janes, K.A., Lin, K.Y., Wang, Y., August, J.T. and Leong, K.W. (2001). Chitosan-DNA Nanoparticles as Gene Carriers: Synthesis, Characterization and Transfection Efficiency, J. Control Release, 70(3): 399-421.
5. Kneuer, C., Sameti, M., Haltner, E.G., Schiestel, T., Schirra, H., Schmidt, H. and Lehr, C.M. (2000). Silica Nanoparticles Modified with Aminosilanes as Carriers for Plasmid DNA, Intern. J. Pharma., 196: 257-261.
6. Vijayanathan, V., Thomas, T. and Thomas, T.J. (2002). DNA Nanoparticles and Development of DNA Delivery Vehicles for Gene Therapy, Biochemistry, 41(48): 14085-14094.
7. Tomalia, D.A., Naylor, A.M. and Goddard III, W.A. (1990). Starburst Dendrimers: Molecular-level Control of Size, Shape, Surface Chemistry, Topology and Flexibility in the Conversion of Atoms to Macroscopic Materials, Angew. Chem., Int. Ed. Engl., 29: 138-175.
8. Kukowska-Latallo, J.F., Bielinska, A.U., Johnson, J., Spindler, R., Tomalia, D.A. and Baker Jr, J.R. (1996). Efficient Transfer of Genetic Material into Mammalian Cells using Starburst Polyamidoamine Dendrimers, Proc. Natl. Acad. Sci. USA, 93(10): 4897-4902.
9. Olbrich, C., Bakowsky, U., Lehr, C.M., Muller, R.H. and Kneuer, C. (2001). Cationic Solid-lipid Nanoparticles can Efficiently Bind and Transfect Plasmid DNA, J. Control Release, 77: 345-355.
10. Roberts, J.C., Bhalgat, M.K. and Zera, R.T. (1996). Preliminary Biological Evaluation of Polyamidoamine (PAMAM) Starburst Dendrimers, J. Biomed. Mater. Res., 30: 53-65.
11. Fischer, D., Bieber, T., Li, Y., Elsasser, H.P. and Kissel, T. (1999). A Novel Nonviral Vector for DNA Delivery Based on Low Molecular Weight, Branched Polyethylenimine: Effect of Molecular Weight on Transfection Efficiency and Cytotoxicity, Pharm. Res., 16: L272-l278.
12. Kukowska-Latallo, J.F., Candido, K.A., Cao, Z., Nigavekar, S.S., Majoros, I.J., Thomas, T.P., Balogh, L.P., Khan, M.K. and Baker Jr, J.R. (2005). Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer, Cancer Res., 65(12): 1-8.
13. Nourse, A., Millar, D.B. and Minton, A.P. (2000). Physicochemical Characterization of Generation 5 Polyamidoamine Dendrimers, Biopolymers, 53(4): 316-328.
14. Devarakonda, B., Hill, R.A. and de Villiers, M.M. (2004). The Effect of PAMAM Dendrimer Generation Size and Surface Functional Group on the Aqueous Solubility of Nifedipine, Int. J. Pharm., 284(1-2): 133-140.
15. Jevprasesphant, R., Penny, J., Attwood, D., McKeown, N.B. and D'Emanuele, A. (2003). Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity, Pharm Res., 20(10): 1543-1550.
16. Braun, C.S., Vetro, J.A., Tomalia, D.A., Koe, G.S., Koe, J.G. and Middaugh, C.R. (2005). Structure/Function Relationships of Polyamidoamine/DNA Dendrimers as Gene Delivery Vehicles, J. Pharm. Sci., 94(2): 423-436.
17. Moghimi, S.M., Hunter, A.C. and Murray, J.C. (2001). Long-circulating and Target-specific Nanoparticles: Theory to Practice, Pharmacol. Rev., 53: 283-318.
18. Choi, Y., Thomas, T., Kotlyar, A., Islam, M.T. and Baker Jr, J.R. (2005). Synthesis and Functional Evaluation of DNA-assembled Polyamidoamine Dendrimer Clusters for Cancer Cell-specific Targeting, Chem. Biol., 12(1): 35-43.
19. Hong, S., Bielinska, A.U., Mecke, A., Keszler, B., Beals, J.L., Shi, X., Balogh, L., Orr, B.G., Baker Jr, J.R. and Banaszak Holl, M.M. (2004). Interaction of Poly(amidoamine) Dendrimers with Supported Lipid Bilayers and Cells: Hole Formation and the Relation to Transport, Bioconjug Chem., 15(4): 774-782.
20. Dennig, J. and Duncan, E. (2002). Gene Transfer into Eukaryotic Cells using Activated Polyamidoamine Dendrimers, J. Biotechnol., 90(3-4): 339-347, Review.
21. Helin, V., Gottikh, M., Mishal, Z., Subra, F., Malvy, C. and Lavignon, M. (1999). Uptake and Intracellular Distribution of Oligonucleotides Vectorized by a PAMAM Dendrimer, Nucleosides Nucleotides, 18(6-7): 1721-1722.
22. Duncan, R. and Izzo, L. (2005). Dendrimer Biocompatibility and Toxicity, Adv. Drug Deliv. Rev., 57(15): 2215-2237. Epub (2005) Nov. 16, Review.
23. Ding, J.J., Guo, C.Y., Cai, Q.L., Lin, Y.H. and Wang, H. (2005). In vivo Expression of Green Fluorescent Protein Gene and Immunogenicity of ES312 Vaccine both Mediated by Starburst Polyamidoamine Dendrimers, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 27(4): 499-503.
24. Nigavekar, S.S., Sung, L.Y., Llanes, M., El-Jawahri, A., Lawrence, T.S., Becker, C.W., Balogh, L. and Khan, M.K. (2004). 3H Dendrimer Nanoparticle Organ/tumor Distribution, Pharm. Res., 21(3): 476-483.
25. Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J.W., Meijer, E.W., Paulus, W. and Duncan, R. (2000). Dendrimers: Relationship between Structure and Biocompatibility in vitro, and Preliminary Studies on the Biodistribution of 125I-labelled Polyamidoamine Dendrimers in vivo. J. Control Release, 65(1-2): 133-148. Erratum in: J. Control Release (2000), 68(2): 299-302.
26. Khan, M.K., Nigavekar, S.S., Minc, L.D., Kariapper, M.S., Nair, B.M., Lesniak, W.G. and Balogh, L.P. (2005). In vivo Biodistribution of Dendrimers and Dendrimer Nanocomposites-Implications for Cancer Imaging and Therapy, Technol. Cancer. Res. Treat., 4(6): 603-613.
27. Maruyama-Tabata, H., Harada, Y., Matsumura, T., Satoh, E., Cui, F., Iwai, M., Kita, M., Hibi, S., Imanishi, J., Sawada, T. and Mazda, O. (2000). Effective Suicide Gene Therapy in vivo by EBV-based Plasmid Vector Coupled with Polyamidoamine Dendrimer, Gene Ther., 7(1): 53-60.