Dendrimers: A novel polymer for drug delivery

International Journal of Pharmaceutical Sciences Review and Research

Volumn 9, Issue 1, 2011, Pages 88-99

  Challa, Threveen ^a   Agaiah Goud, B ^a   Baskar, S ^a   Chandra Mouli, G ^a   Jukuri, Rakesh ^b  

^a SRR College of Pharmaceutical Sciences   (India)

^b Talla Padmavathi College of Pharmacy   (India)

Author keywords

Characterization of dendritic polymer; Dendrimers; PAMAM dendrimer; Synthesis

Indexed keywords

DENDRIMER; FLUOROURACIL;

BIOCOMPATIBILITY; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; COVALENT BOND; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; GENE VECTOR; NANOENCAPSULATION; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHOTODYNAMIC THERAPY; PHYSICAL CHEMISTRY; REVIEW; STRUCTURE ANALYSIS;

EID: 79960601148     PISSN: None     EISSN: 0976044X     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. Buhleier E, Wehner W and Vogtle F, "Cascade and Nonskid-chainlike Synthesis of Molecular Cavity Topologies", Synthesis, 2, 1978, 155-158.
2. Tomalia D. A, Baker H, Dewald J, Hall M, Kallos G, Martin S, Roeck J, Ryder J and Smith P, "A New Class of Polymers: Starburst-Dendritic Macromolecules", Polym. J., 17(1), 1985, 117-132.
3. Newkome G. R, Yao Z. Q, Baker G. R and Gupta V. K, "Cascade molecules: A new approach to micelles, A", J. Org. Chem., 50(11), 1985, 2003-2006.
4. Pushkar S, Philip A, Pathak K and Pathak D, "Dendrimers: Nanotechnology Derived Novel Polymers in Drug Delivery", Indian J. Pharm. Educ. Res., 40 (3), 2006, 153-158.
5. Sakthivel T and Florence A. T, "Adsorption of Amphipathic Dendrons on Polystyrene Nanoparticles", Int. J. Pharm., 254, 2003, 23-26.
6. Yiyun C, Zhenhua X, Minglu M and Tonguen X, "Dendrimers as Drug Carriers: Applications in Different Routes of Drug", J. Pharma. Sci., 97(1), 2008, 123-143.
7. Hawker C and Fréchet J.M. J, "A new convergent approach to monodisperse dendritic molecule" J. Chem. Soc. Chem. Commun., 15, 1990, 1010-1012.
8. Hawker C, Wooley K. L and Fréchet J.M. J, J. Chem. Soc. Perkin. Trans., 1, 1993, 1287-1289.
9. Frechet J.M. J and Tomalia D. A, "Introduction to the Dendritic state", Dendrimers and other Dendritic Polymers, John Wiley & Sons Ltd, 2001, 24-23.
10. Sonke S and Tomalia D. A, "Dendrimers in biomedical applications reflections on the Field", Advanced Drug Delivery Reviews, 57, 2005, 2106-2129.
11. Christine D, Ijeoma F. U and Andreas G. S, "Dendrimers in gene delivery", Advanced Drug Delivery Reviews, 57, 2005, 2177-2202.
12. Freeman A. W and Frechet J.M. J, "Developments in the Accelerated Convergent Synthesis of Dendrimers", Dendrimers and other Dendritic Polymers Edited by Jean M. J. Fréchet and Donald A. Tomalia, 91-101.
13. Barbara K. and Maria B., "Review Dendrimers: properties and applications", Acta Biochimica Polonica, 48 (1), 2001, 199-208.
14. R.P. Patel et al. "Dendrimers: A new innovation in drug delivery", Pharma Bio World, 2007, 42-52.
15. Boris D, Rubinstein M, "A self-consistent mean field model of a starburst dendrimer: dense core vs. dense shell", Macromolecules, 29, 1996, 7251-7260.
16. Chai M, Niu Y., Youngs W. J and Rinaldi P. L, "Structure and conformation of DAB dendrimers in solution via multidimensional NMR techniques", J. Am. Chem. Soc., 123, 2001, 4670-4678.
17. Gupta U, Agashe H and Jain N. K, "Polypropylene imine dendrimer mediated solubility enhancement: effect of pH and functional groups of hydrophobes", J. Pharm. Sci., 10(3), 2007, 358-67.
18. Wang D. J and Imae T, "fluorescence emission from Dendrimer & its pH dependence", J. Am. Chem. Soc., 126(41), 2004, 13204-13205.
19. Zinselmeyer B. H, Mackay S. P, Schatzlein A. G and Uchegbu I. F, "The lower-generation polypropylenimine dendrimers are effective gene-transfer agents", Pharm. Res., 19, 2002, 960-967.
20. Jevprasesphant R, Penny J, Jalal R, Attwood D, McKeown N. B and D'Emanuele A., "The influence of surface modification on the cytotoxicity of PAMAM dendrimers", Int. J. Pharm., 252, 2003, 263-266.
21. Jevprasesphant R, Penny J, Jalal R, Attwood D, McKeown N. B and D'Emanuele A., "Engineering of dendrimer surfaces to enhance transepithelial transport and reduce cytotoxicity", Pharm. Res. 20, 2003, 1543-1550.
22. Satija J, Gupta U and Jain N. K "Pharmaceutical and biomedical potential of surface engineered dendrimers" Crit Rev Ther Drug Carrier Syst., 24 (3), 2007, 257-306.
23. Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener J. W, Meijer E. W, Paulus W and Duncan R, "Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled polyamidoamine dendrimers in vivo", J. Control. Release, 65, 2000, 133-148.
24. Uchegbu I. F, Sadiq L, Pardakhty A, El-Hammadi M, Gray A. I, Tetley L, Wang W, Zinselmeyer B. H and Schatzlein A. G, "Gene transfer with three amphiphilic glycol chitosans-the degree of polymerisation is the main controller of transfection efficiency", J. Drug Target., 12, 2004, 527-539.
25. Brownlie A, Uchegbu I. F and Schatzlein A. G, "PEI-based vesiclepolymer hybrid gene delivery system with improved biocompatibility", Int. J. Pharm., 274, 2004, 41-52.
26. Schatzlein A. G, Zinselmeyer B. H, Elouzi A, Dufes C, Chim Y. T, Roberts C. J, Davies M. C, Munro A, Gray A. I and Uchegbu I. F, "Preferential liver gene expression with polypropylenimine dendrimers", J. Control. Release, 101, 2005, 247-258.
27. Chen H. T, Neerman M. F, Parrish A. R and Simanek E. E, "Cytotoxicity, hemolysis, and acute in vivo toxicity of dendrimers based on melamine, candidate vehicles for drug delivery", J. Am. Chem. Soc., 126, 2004, 10044-10048.
28. Gillies E.R. and Fréchet J.M. J, "Dendrimers and dendritic polymers in drug delivery" Drug Discovery Today, 10, 2005, 35-43.
29. Esfand, R. and Tomalia, D.A. "Polyamidoamine (PAMAM) dendrimers: from biomimicry to drug delivery and biomedical applications". Drug Discov. Today, 6, 2001, 427-436.
30. Jevpraesesphant, R. et al., "The influence of surface modificastion on the cytotoxicity of PAMAM dendrimers", Int.J. Pharm., 252, 2003, 263-266.
31. Hawker, C.J. and Fréchet, J.M.J. "Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules". J. Am. Chem. Soc., 112, 1990, 7638-7647.
32. Liu, M. et al. "Water-soluble unimolecular micelles: their potential as drug delivery agents". J. Control. Release, 65, 2000, 121-131.
33. Liu, M. et al. "Water-soluble dendrimer-polyethylene glycol starlike conjugates as potential drug carriers". J. Polym. Sc i., A 37, 1999, 121-131.
34. Haag, R. et al. "An approach to glycerol dendrimers and pseudodendritic polyglycerols". J. Am. Chem. Soc., 122, 2000, 2954-2955.
35. Neerman M. F et al. "In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery". Int. J. Pharm., 281, 2004, 2954-2955.
36. Caminade A. M, Laurent R. and Majoral J. P, "Characterization of dendrimers", Advanced Drug Delivery Reviews, 57, 2005, 2130-2146.
37. Mohammad N and Antony D, "Crossing cellular barriers using dendrimer nanotechnologies", Current Opinion in Pharmacology, 6, 2006, 522-527.
38. Lee S. C "Dendrimers In Nanobiological Devices", Dendrimers and other Dendritic Polymers Edited by Fréchet J.M. J and Tomalia D.A., 547-554.
39. Kleij A. W, Ford A, JastrzebskI H and Vankoten G, "Dendritic Polymer Applications: Catalysts", Edited by Fréchet J.M. J and Tomalia D.A., 485-507.
40. Kofoed J and Reymond J, "Dendrimers as artificial enzymes", Current Opinion in Chemical Biology, 9, 2005, 656-664.