In Vitro and In Vivo gene delivery mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes

Journal of Controlled Release

Volumn 146, Issue 1, 2010, Pages 106-117

  Arima, Hidetoshi ^a   Yamashita, Shogo ^a   Mori, Yoshimasa ^a   Hayashi, Yuya ^a   Motoyama, Keiichi ^a   Hattori, Kenjiro ^b   Takeuchi, Tomoko ^b   Jono, Hirofumi ^c   Ando, Yukio ^c   Hirayama, Fumitoshi ^d   Uekama, Kaneto ^d  

^a KUMAMOTO UNIVERSITY   (Japan)

^b TOKYO POLYTECHNIC UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

^d SOJO UNIVERSITY   (Japan)

Author keywords

Cyclodextrin; Dendrimer conjugate; Hepatocyte; Lactose; Non viral vector

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTORS; BLOOD CHEMISTRY; CELL SURFACES; CELLULAR ASSOCIATION; CHARGE RATIO; DEGREES OF SUBSTITUTION; GENE DELIVERY; GENE TRANSFER ACTIVITY; HEPATOCYTES; HEPG2 CELLS; IN-VITRO; INTRAVENOUS ADMINISTRATION; LACTOSE; NONVIRAL VECTORS; PHYSICOCHEMICAL PROPERTY; PLASMID DNA (PDNA); POLYAMIDOAMINES; STARBURST DENDRIMER;

DENDRIMERS; GENE EXPRESSION; SUGARS;

GENE TRANSFER;

ALPHA CYCLODEXTRIN; ASIALOGLYCOPROTEIN RECEPTOR; CELL SURFACE RECEPTOR; DENDRIMER; LACTOSE; PLASMID DNA; POLYAMIDOAMINE;

ARTICLE; BLOOD CHEMISTRY; COMPLEX FORMATION; CONJUGATE; CONTROLLED STUDY; DRUG CYTOTOXICITY; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MALE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALPHA-CYCLODEXTRINS; ANIMALS; CELL CULTURE TECHNIQUES; DENDRIMERS; DNA; DRUG CARRIERS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HEPATOCYTES; HUMANS; KB CELLS; LACTOSE; LIVER; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; ORGAN SPECIFICITY; PLASMIDS; POLYETHYLENEIMINE; SURFACE PLASMON RESONANCE;

EID: 77955278078     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.05.030     Document Type: Article

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