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Volumn 17, Issue 6, 2011, Pages 470-478

Low-generation asymmetric dendrimers exhibit minimal toxicity and effectively complex DNA

Author keywords

Asymmetric dendrimers; Cytotoxicity; Low generation peptides; PAMAM G1; Toroids

Indexed keywords

ARGININE; DENDRIMER; DNA; POLYAMIDOAMINE;

EID: 79955919831     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.1347     Document Type: Article
Times cited : (55)

References (53)
  • 1
    • 0027655718 scopus 로고
    • Polyamidoamine cascade polymers mediate efficient transfection of cells in culture
    • Haensler J, Szoka Jr FC. Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 1993; 4: 372-379.
    • (1993) Bioconjugate Chem. , vol.4 , pp. 372-379
    • Haensler, J.1    Szoka Jr, F.C.2
  • 4
    • 79251595220 scopus 로고    scopus 로고
    • Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro characterization
    • DOI:10.1016/j.physletb.2003.10.071.
    • Luo K, Li C, Wang G, Nie Y, He B, Wu Y, Gu Z. Peptide dendrimers as efficient and biocompatible gene delivery vectors: Synthesis and in vitro characterization. J. Controlled Release 2010; DOI:10.1016/j.physletb.2003.10.071.
    • (2010) J. Controlled Release
    • Luo, K.1    Li, C.2    Wang, G.3    Nie, Y.4    He, B.5    Wu, Y.6    Gu, Z.7
  • 6
    • 28744447299 scopus 로고    scopus 로고
    • Development of radioactive gold-dendrimer nanocomposite devices to treat tumor microvasculature: Synthesis and biodistribution
    • Balogh LP, Nigavekar SS, Sung LY, Balogh P, Shi XY, Cook AT, Minc LD, Khan MK. Development of radioactive gold-dendrimer nanocomposite devices to treat tumor microvasculature: Synthesis and biodistribution. J. Nucl. Med. 2003; 44: 1094.
    • (2003) J. Nucl. Med. , vol.44 , pp. 1094
    • Balogh, L.P.1    Nigavekar, S.S.2    Sung, L.Y.3    Balogh, P.4    Shi, X.Y.5    Cook, A.T.6    Minc, L.D.7    Khan, M.K.8
  • 9
    • 5844259443 scopus 로고    scopus 로고
    • Starburst(R) dendrimers-Nanoscopic supermolecules according dendritic rules and principles
    • Tomalia DA. Starburst(R) dendrimers-Nanoscopic supermolecules according dendritic rules and principles. Macromol. Symp. 1996; 101: 243-255.
    • (1996) Macromol. Symp. , vol.101 , pp. 243-255
    • Tomalia, D.A.1
  • 10
    • 0038817081 scopus 로고
    • Preparation of polymers with controlled molecular architecture-A new convergent approach to dendritic macromolecules
    • Hawker CJ, Frechet JMJ. Preparation of polymers with controlled molecular architecture-A new convergent approach to dendritic macromolecules. J. Am. Chem. Soc. 1990; 112: 7638-7647.
    • (1990) J. Am. Chem. Soc. , vol.112 , pp. 7638-7647
    • Hawker, C.J.1    Frechet, J.M.J.2
  • 12
    • 0030042315 scopus 로고    scopus 로고
    • Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst(TM) dendrimers
    • Roberts JC, Bhalgat MK, Zera RT. Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst(TM) dendrimers. J. Biomed. Mater. Res. 1996; 30: 53-65.
    • (1996) J. Biomed. Mater. Res. , vol.30 , pp. 53-65
    • Roberts, J.C.1    Bhalgat, M.K.2    Zera, R.T.3
  • 13
    • 0034005436 scopus 로고    scopus 로고
    • Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled polyamidoamine dendrimers in vivo
    • Malik N, Wiwattanapatapee R, Klopsch R, Lorenz K, Frey H, Weener JW, Meijer EW, Paulus W, Duncan R. Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled polyamidoamine dendrimers in vivo. J. Controlled Release 2000; 65: 133-148.
    • (2000) J. Controlled Release , vol.65 , pp. 133-148
    • Malik, N.1    Wiwattanapatapee, R.2    Klopsch, R.3    Lorenz, K.4    Frey, H.5    Weener, J.W.6    Meijer, E.W.7    Paulus, W.8    Duncan, R.9
  • 15
    • 14344262752 scopus 로고    scopus 로고
    • Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles
    • Braun CS, Vetro JA, Tomalia DA, Koe GS, Koe JG, Middaugh CR. Structure/function relationships of polyamidoamine/DNA dendrimers as gene delivery vehicles. J. Pharm. Sci. 2005; 94: 423-436.
    • (2005) J. Pharm. Sci. , vol.94 , pp. 423-436
    • Braun, C.S.1    Vetro, J.A.2    Tomalia, D.A.3    Koe, G.S.4    Koe, J.G.5    Middaugh, C.R.6
  • 16
    • 28744443398 scopus 로고    scopus 로고
    • Dendrimers in biomedical applications-Reflections on the field
    • Svenson S, Tomalia DA. Dendrimers in biomedical applications-Reflections on the field. Adv. Drug Delivery Rev. 2005; 57: 2106-2129.
    • (2005) Adv. Drug Delivery Rev. , vol.57 , pp. 2106-2129
    • Svenson, S.1    Tomalia, D.A.2
  • 17
    • 16244386865 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimers
    • Krishna TR, Jain S, Tatu US, Jayaraman N. Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimers. Tetrahedron 2005; 61: 4281-4288.
    • (2005) Tetrahedron , vol.61 , pp. 4281-4288
    • Krishna, T.R.1    Jain, S.2    Tatu, U.S.3    Jayaraman, N.4
  • 18
    • 39049119263 scopus 로고    scopus 로고
    • Past and future evolution in colloidal drug delivery systems
    • Boyd BJ. Past and future evolution in colloidal drug delivery systems. Expert Opinion on Drug Delivery 2008; 5: 69-85.
    • (2008) Expert Opinion on Drug Delivery , vol.5 , pp. 69-85
    • Boyd, B.J.1
  • 20
    • 20744456789 scopus 로고
    • Solid phase peptide synthesis. I. The synthesis of a tetrapeptide
    • Merrifield RB. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 1963; 85: 2149-2154.
    • (1963) J. Am. Chem. Soc. , vol.85 , pp. 2149-2154
    • Merrifield, R.B.1
  • 22
    • 0003423124 scopus 로고
    • Solid phase synthesis-The Merrifield technique and Fluorenylmethoxycarbonyl (Fmoc) amino acids
    • IRL Press at Oxford University Press: Oxford, England; New York, and 47-61.
    • Atherton E, Sheppard RC. Solid phase synthesis-The Merrifield technique and Fluorenylmethoxycarbonyl (Fmoc) amino acids. In Solid phase peptide synthesis A practical approach. IRL Press at Oxford University Press: Oxford, England; New York, 1989; 13-37 and 47-61.
    • (1989) In Solid phase peptide synthesis A practical approach , pp. 13-37
    • Atherton, E.1    Sheppard, R.C.2
  • 23
    • 0141838723 scopus 로고    scopus 로고
    • The fluorenymethoxycarbonyl group in solid phase synthesis
    • Sheppard R. The fluorenymethoxycarbonyl group in solid phase synthesis. J. Pept. Sci. 2003; 9: 545-552.
    • (2003) J. Pept. Sci. , vol.9 , pp. 545-552
    • Sheppard, R.1
  • 26
    • 0035470159 scopus 로고    scopus 로고
    • Gene therapy of cystic fibrosis: The glycofection approach
    • Fajac I, Briand P, Monsigny M. Gene therapy of cystic fibrosis: The glycofection approach. Glycoconjugate J. 2001; 18: 723-729.
    • (2001) Glycoconjugate J. , vol.18 , pp. 723-729
    • Fajac, I.1    Briand, P.2    Monsigny, M.3
  • 27
    • 35748935107 scopus 로고    scopus 로고
    • The advance of dendrimers-A versatile targeting platform for gene/drug delivery
    • Parekh HS. The advance of dendrimers-A versatile targeting platform for gene/drug delivery. Curr. Pharm. Des. 2007; 13: 2837-2850.
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 2837-2850
    • Parekh, H.S.1
  • 28
    • 72049087778 scopus 로고    scopus 로고
    • Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments
    • Mutalik S, Hewavitharana AK, Shaw PN, Anissimov YG, Roberts MS, Parekh HS. Development and validation of a reversed-phase high-performance liquid chromatographic method for quantification of peptide dendrimers in human skin permeation experiments. J. Chromatogr. B 2009; 877: 3556-3562.
    • (2009) J. Chromatogr. B , vol.877 , pp. 3556-3562
    • Mutalik, S.1    Hewavitharana, A.K.2    Shaw, P.N.3    Anissimov, Y.G.4    Roberts, M.S.5    Parekh, H.S.6
  • 29
    • 33646809712 scopus 로고    scopus 로고
    • Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition
    • Parekh HS, Marano RJ, Rakoczy EP, Blanchfield J, Toth I. Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition. Bioorg. Med. Chem. 2006; 14: 4775-4780.
    • (2006) Bioorg. Med. Chem. , vol.14 , pp. 4775-4780
    • Parekh, H.S.1    Marano, R.J.2    Rakoczy, E.P.3    Blanchfield, J.4    Toth, I.5
  • 30
    • 79955910961 scopus 로고    scopus 로고
    • URL: [last accessed November 2010].
    • URL: [last accessed November 2010].
  • 31
    • 0019627519 scopus 로고
    • Quantitative monitoring of solid-phase peptide-synthesis by the ninhydrin reaction
    • Sarin VK, Kent SBH, Tam JP, Merrifield RB. Quantitative monitoring of solid-phase peptide-synthesis by the ninhydrin reaction. Anal. Biochem. 1981; 117: 147-157.
    • (1981) Anal. Biochem. , vol.117 , pp. 147-157
    • Sarin, V.K.1    Kent, S.B.H.2    Tam, J.P.3    Merrifield, R.B.4
  • 32
    • 0037607609 scopus 로고    scopus 로고
    • A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles
    • Wiethoff CM, Gill ML, Koe GS, Koe JG, Middaugh CR. A fluorescence study of the structure and accessibility of plasmid DNA condensed with cationic gene delivery vehicles. J. Pharm. Sci. 2003; 92: 1272-1285.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1272-1285
    • Wiethoff, C.M.1    Gill, M.L.2    Koe, G.S.3    Koe, J.G.4    Middaugh, C.R.5
  • 33
    • 0032515426 scopus 로고    scopus 로고
    • High-yield preparation of oligomeric C-type DNA toroids and their characterization by cryoelectron microscopy
    • Bottcher C, Endisch C, Fuhrhop JH, Catterall C, Eaton M. High-yield preparation of oligomeric C-type DNA toroids and their characterization by cryoelectron microscopy. J. Am. Chem. Soc. 1998; 120: 12-17.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 12-17
    • Bottcher, C.1    Endisch, C.2    Fuhrhop, J.H.3    Catterall, C.4    Eaton, M.5
  • 34
    • 0026253815 scopus 로고
    • Condensation of DNA by multivalent cations-considerations on mechanism
    • Bloomfield VA. Condensation of DNA by multivalent cations-considerations on mechanism. Biopolymers 1991; 31: 1471-1481.
    • (1991) Biopolymers , vol.31 , pp. 1471-1481
    • Bloomfield, V.A.1
  • 35
    • 0029086091 scopus 로고
    • DNA condensation by cobalt hexaammine(III) in alcohol-water mixtures-dielectric-constant and other solvent effects
    • Arscott PG, Ma CL, Wenner JR, Bloomfield VA. DNA condensation by cobalt hexaammine(III) in alcohol-water mixtures-dielectric-constant and other solvent effects. Biopolymers 1995; 36: 345-364.
    • (1995) Biopolymers , vol.36 , pp. 345-364
    • Arscott, P.G.1    Ma, C.L.2    Wenner, J.R.3    Bloomfield, V.A.4
  • 37
  • 40
    • 0030743086 scopus 로고    scopus 로고
    • The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA
    • Bielinska AU, KukowskaLatallo JF, Baker JR. The interaction of plasmid DNA with polyamidoamine dendrimers: mechanism of complex formation and analysis of alterations induced in nuclease sensitivity and transcriptional activity of the complexed DNA. Biochim. Biophys. Acta, Gene Struct. Expression 1997; 1353: 180-190.
    • (1997) Biochim. Biophys. Acta, Gene Struct. Expression , vol.1353 , pp. 180-190
    • Bielinska, A.U.1    KukowskaLatallo, J.F.2    Baker, J.R.3
  • 41
    • 15944410339 scopus 로고    scopus 로고
    • Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers
    • Tang MX, Li WJ, Szoka FC. Toroid formation in charge neutralized flexible or semi-flexible biopolymers: potential pathway for assembly of DNA carriers. J. Gene. Med. 2005; 7: 334-342.
    • (2005) J. Gene. Med. , vol.7 , pp. 334-342
    • Tang, M.X.1    Li, W.J.2    Szoka, F.C.3
  • 42
    • 0038793496 scopus 로고    scopus 로고
    • Synthesis of Novel Cationic Lipids Having Polyamidoamine Dendrons and Their Transfection Activity
    • Takahashi T, Kono K, Itoh T, Emi N, Takagishi T. Synthesis of Novel Cationic Lipids Having Polyamidoamine Dendrons and Their Transfection Activity. Bioconjugate Chem. 2003; 14: 764-773.
    • (2003) Bioconjugate Chem. , vol.14 , pp. 764-773
    • Takahashi, T.1    Kono, K.2    Itoh, T.3    Emi, N.4    Takagishi, T.5
  • 43
    • 33846152890 scopus 로고    scopus 로고
    • Positive Dendritic Effect in DNA/Porphyrin Composite Photocurrent Generators Containing Dendrimers as the Stationary Phase
    • Ogasawara S, Ikeda A, Kikuchi J. Positive Dendritic Effect in DNA/Porphyrin Composite Photocurrent Generators Containing Dendrimers as the Stationary Phase. Chem. Mater. 2006; 18: 5982-5987.
    • (2006) Chem. Mater. , vol.18 , pp. 5982-5987
    • Ogasawara, S.1    Ikeda, A.2    Kikuchi, J.3
  • 44
    • 42949087378 scopus 로고    scopus 로고
    • Antibody-dendrimer conjugates: The number, not the size of the dendrimers, determines the immunoreactivity
    • Waengler C, Moldenhauer G, Eisenhut M, Haberkorn U, Mier W. Antibody-dendrimer conjugates: The number, not the size of the dendrimers, determines the immunoreactivity. Bioconjugate Chem. 2008; 19: 813-820.
    • (2008) Bioconjugate Chem. , vol.19 , pp. 813-820
    • Waengler, C.1    Moldenhauer, G.2    Eisenhut, M.3    Haberkorn, U.4    Mier, W.5
  • 45
    • 0033585470 scopus 로고    scopus 로고
    • Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes
    • Plank C, Tang MX, Wolfe AR, Szoka FC. Branched cationic peptides for gene delivery: Role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum. Gene Ther. 1999; 10: 319-332.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 319-332
    • Plank, C.1    Tang, M.X.2    Wolfe, A.R.3    Szoka, F.C.4
  • 46
    • 33846543838 scopus 로고    scopus 로고
    • Synthesis and characterization of guanidinylated poly(propylene imine) dendrimers as gene transfection agents
    • Tziveleka LA, Psarra AMG, Tsiourvas D, Paleos CM. Synthesis and characterization of guanidinylated poly(propylene imine) dendrimers as gene transfection agents. J. Controlled Release 2007; 117: 137-146.
    • (2007) J. Controlled Release , vol.117 , pp. 137-146
    • Tziveleka, L.A.1    Psarra, A.M.G.2    Tsiourvas, D.3    Paleos, C.M.4
  • 47
    • 0142227090 scopus 로고    scopus 로고
    • Characters of dendritic poly((L)-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro
    • Okuda T, Sugiyama A, Niidome T, Aoyagi H. Characters of dendritic poly((L)-lysine) analogues with the terminal lysines replaced with arginines and histidines as gene carriers in vitro. Biomaterials 2004; 25: 537-544.
    • (2004) Biomaterials , vol.25 , pp. 537-544
    • Okuda, T.1    Sugiyama, A.2    Niidome, T.3    Aoyagi, H.4
  • 50
    • 0037150304 scopus 로고    scopus 로고
    • Structural molecular dynamics studies on polyamidoamine dendrimers for a therapeutic application: Effects of pH and generation
    • Lee I, Athey BD, Wetzel AW, Meixner W, Baker JR. Structural molecular dynamics studies on polyamidoamine dendrimers for a therapeutic application: Effects of pH and generation. Macromolecules 2002; 35: 4510-4520.
    • (2002) Macromolecules , vol.35 , pp. 4510-4520
    • Lee, I.1    Athey, B.D.2    Wetzel, A.W.3    Meixner, W.4    Baker, J.R.5
  • 52
    • 0017895903 scopus 로고
    • Molecular theory of polyelectrolyte solutions with applications to electrostatic properties of polynucleotides
    • Manning GS. Molecular theory of polyelectrolyte solutions with applications to electrostatic properties of polynucleotides. Q. Rev. Biophys. 1978; 11: 179-246.
    • (1978) Q. Rev. Biophys. , vol.11 , pp. 179-246
    • Manning, G.S.1
  • 53
    • 0018803816 scopus 로고
    • Counter-ion-induced condensation of deoxyribonucleic-acid-light-scattering study
    • Wilson RW, Bloomfield VA. Counter-ion-induced condensation of deoxyribonucleic-acid-light-scattering study. Biochemistry 1979; 18: 2192-2196.
    • (1979) Biochemistry , vol.18 , pp. 2192-2196
    • Wilson, R.W.1    Bloomfield, V.A.2


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