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Volumn 86, Issue 1, 2012, Pages 36-48

Down-modulation of CD8αβ is a fundamental activity of primate: Lentiviral nef proteins

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD8ALPHA BETA ANTIGEN; ENHANCED GREEN FLUORESCENT PROTEIN; LYMPHOCYTE ANTIGEN; NEF PROTEIN; UNCLASSIFIED DRUG;

EID: 84855918309     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00717-11     Document Type: Article
Times cited : (17)

References (74)
  • 1
    • 0030835321 scopus 로고    scopus 로고
    • Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A
    • Aiken C. 1997. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A. J. Virol. 71:5871-5877.
    • (1997) J. Virol. , vol.71 , pp. 5871-5877
    • Aiken, C.1
  • 2
    • 0034001233 scopus 로고    scopus 로고
    • Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    • Akari H, et al. 2000. Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation. J. Virol. 74:2907-2912.
    • (2000) J. Virol. , vol.74 , pp. 2907-2912
    • Akari, H.1
  • 3
    • 70349705617 scopus 로고    scopus 로고
    • The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses
    • Arhel N, et al. 2009. The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. J. Clin. Invest. 119:2965-2975.
    • (2009) J. Clin. Invest. , vol.119 , pp. 2965-2975
    • Arhel, N.1
  • 4
    • 47749133802 scopus 로고    scopus 로고
    • HIV Nef: role in pathogenesis and viral fitness
    • Ariën KK, Verhasselt B. 2008. HIV Nef: role in pathogenesis and viral fitness. Curr. HIV Res. 6:200-208.
    • (2008) Curr. HIV Res. , vol.6 , pp. 200-208
    • Ariën, K.K.1    Verhasselt, B.2
  • 5
    • 44649173294 scopus 로고    scopus 로고
    • HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice
    • Atkins KM, et al. 2008. HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice. J. Biol. Chem. 283:11772-11784.
    • (2008) J. Biol. Chem. , vol.283 , pp. 11772-11784
    • Atkins, K.M.1
  • 6
    • 0038047665 scopus 로고    scopus 로고
    • Hybrid origin of SIV in chimpanzees
    • Bailes E, et al. 2003. Hybrid origin of SIV in chimpanzees. Science 300: 1713.
    • (2003) Science , vol.300 , pp. 1713
    • Bailes, E.1
  • 7
    • 0033568211 scopus 로고    scopus 로고
    • Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4
    • Bresnahan PA, Yonemoto W, Greene WC. 1999. Cutting edge: SIV Nef protein utilizes both leucine- and tyrosine-based protein sorting pathways for down-regulation of CD4. J. Immunol. 163:2977-2981.
    • (1999) J. Immunol. , vol.163 , pp. 2977-2981
    • Bresnahan, P.A.1    Yonemoto, W.2    Greene, W.C.3
  • 8
    • 43849084874 scopus 로고    scopus 로고
    • HIV evolution in response to HLArestricted CTL selection pressures: a population-based perspective
    • Carlson JM, Brumme ZL. 2008. HIV evolution in response to HLArestricted CTL selection pressures: a population-based perspective. Microbes Infect. 10:455-461.
    • (2008) Microbes Infect , vol.10 , pp. 455-461
    • Carlson, J.M.1    Brumme, Z.L.2
  • 9
    • 42949092720 scopus 로고    scopus 로고
    • Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage
    • Chopera DR, et al. 2008. Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage. PLoS Pathog. 4:e1000033.
    • (2008) PLoS Pathog , vol.4
    • Chopera, D.R.1
  • 10
    • 4444351647 scopus 로고    scopus 로고
    • High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo
    • Cochrane A, et al. 2004. High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo. J. Virol. 78: 9862-9871.
    • (2004) J. Virol. , vol.78 , pp. 9862-9871
    • Cochrane, A.1
  • 11
    • 0033151621 scopus 로고    scopus 로고
    • The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    • Cohen GB, et al. 1999. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10:661-671.
    • (1999) Immunity , vol.10 , pp. 661-671
    • Cohen, G.B.1
  • 12
    • 32444451769 scopus 로고    scopus 로고
    • Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif
    • Coleman SH, et al. 2006. Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif. J. Virol. 80:1837-1849.
    • (2006) J. Virol. , vol.80 , pp. 1837-1849
    • Coleman, S.H.1
  • 13
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D. 1998. HIV-1 nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391:397-400.
    • (1998) Nature , vol.391 , pp. 397-400
    • Collins, K.L.1    Chen, B.K.2    Kalams, S.A.3    Walker, B.D.4    Baltimore, D.5
  • 14
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV 1 Nef with the cellular dileucine based sorting pathway is required for CD4 down regulation and optimal viral infectivity
    • Craig HM, Pandori MW, Guatelli JC. 1998. Interaction of HIV 1 Nef with the cellular dileucine based sorting pathway is required for CD4 down regulation and optimal viral infectivity. Proc. Natl. Acad. Sci. U. S. A. 95:11229-11234.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 11229-11234
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 15
    • 40149096828 scopus 로고    scopus 로고
    • Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2
    • DeGottardi MQ, et al. 2008. Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2. J. Virol. 82:3139-3146.
    • (2008) J. Virol. , vol.82 , pp. 3139-3146
    • DeGottardi, M.Q.1
  • 17
    • 0024987981 scopus 로고
    • In vitro studies of HIV-1 infection in thymic lymphocytes: a putative role of the thymus in AIDS pathogenesis
    • De Rossi A, et al. 1990. In vitro studies of HIV-1 infection in thymic lymphocytes: a putative role of the thymus in AIDS pathogenesis. AIDS Res. Hum. Retroviruses 6:287-298.
    • (1990) AIDS Res. Hum. Retroviruses , vol.6 , pp. 287-298
    • De Rossi, A.1
  • 18
    • 0032539865 scopus 로고    scopus 로고
    • Activation of CD8+T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis
    • Flamand L, et al. 1998. Activation of CD8+T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. Proc. Natl. Acad. Sci. U. S. A. 95:3111-3116.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 3111-3116
    • Flamand, L.1
  • 19
    • 2342663130 scopus 로고    scopus 로고
    • The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR coreceptor CD8alphabeta
    • Gangadharan D, Cheroutre H. 2004. The CD8 isoform CD8alphaalpha is not a functional homologue of the TCR coreceptor CD8alphabeta. Curr. Opin. Immunol. 16:264-270.
    • (2004) Curr. Opin. Immunol. , vol.16 , pp. 264-270
    • Gangadharan, D.1    Cheroutre, H.2
  • 20
    • 0034894379 scopus 로고    scopus 로고
    • Structure-function relationships in HIV-1 Nef
    • Geyer M, Fackler OT, Peterlin BM. 2001. Structure-function relationships in HIV-1 Nef. EMBO Rep. 2:580-585.
    • (2001) EMBO Rep. , vol.2 , pp. 580-585
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3
  • 21
    • 0030990038 scopus 로고    scopus 로고
    • CD8 lineage commitment in the absence of CD8
    • Goldrath AW, Hogquist KA, Bevan MJ. 1997. CD8 lineage commitment in the absence of CD8. Immunity 6:633-642.
    • (1997) Immunity , vol.6 , pp. 633-642
    • Goldrath, A.W.1    Hogquist, K.A.2    Bevan, M.J.3
  • 22
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • Greenberg ME, Iafrate AJ, Skowronski J. 1998. The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes. EMBO J. 17:2777-2789.
    • (1998) EMBO J. , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1    Iafrate, A.J.2    Skowronski, J.3
  • 23
    • 0034723385 scopus 로고    scopus 로고
    • AIDS as a zoonosis: scientific and public health implications
    • Hahn BH, Shaw GM, De Cock KM, Sharp PM. 2000. AIDS as a zoonosis: scientific and public health implications. Science 287:607-614.
    • (2000) Science , vol.287 , pp. 607-614
    • Hahn, B.H.1    Shaw, G.M.2    De Cock, K.M.3    Sharp, P.M.4
  • 24
    • 26444567338 scopus 로고    scopus 로고
    • Distinct profile of T cell activation in HIV type 2 compared to HIV type 1 infection: differential mechanism for immunoprotection
    • Hanson A, et al. 2005. Distinct profile of T cell activation in HIV type 2 compared to HIV type 1 infection: differential mechanism for immunoprotection. AIDS Res. Hum. Retroviruses 21:791-798.
    • (2005) AIDS Res. Hum. Retroviruses , vol.21 , pp. 791-798
    • Hanson, A.1
  • 25
    • 0030861249 scopus 로고    scopus 로고
    • Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4
    • Hua J, Cullen BR. 1997. Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4. J. Virol. 71:6742-6748.
    • (1997) J. Virol. , vol.71 , pp. 6742-6748
    • Hua, J.1    Cullen, B.R.2
  • 26
    • 0031039979 scopus 로고    scopus 로고
    • Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling
    • Iafrate AJ, Bronson S, Skowronski J. 1997. Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling. EMBO J. 16:673-684.
    • (1997) EMBO J. , vol.16 , pp. 673-684
    • Iafrate, A.J.1    Bronson, S.2    Skowronski, J.3
  • 27
    • 0035080263 scopus 로고    scopus 로고
    • Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP
    • Janvier K, et al. 2001. Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP. J. Virol. 75: 3971-3976.
    • (2001) J. Virol. , vol.75 , pp. 3971-3976
    • Janvier, K.1
  • 28
    • 67249114758 scopus 로고    scopus 로고
    • Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2
    • Jia B, et al. 2009. Species-specific activity of SIV Nef and HIV-1 Vpu in overcoming restriction by tetherin/BST2. PLoS Pathog. 5:e1000429.
    • (2009) PLoS Pathog. , vol.5
    • Jia, B.1
  • 29
    • 77958182786 scopus 로고    scopus 로고
    • Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses
    • Kirchhoff F. 2010. Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses. Cell Host Microbe 8:55-67.
    • (2010) Cell Host Microbe , vol.8 , pp. 55-67
    • Kirchhoff, F.1
  • 31
    • 0031660975 scopus 로고    scopus 로고
    • Costimulation of naive CD8+ lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection
    • Kitchen SG, Korin YD, Roth MD, Landay A, Zack JA. 1998. Costimulation of naive CD8+ lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J. Virol. 72:9054-9060.
    • (1998) J. Virol. , vol.72 , pp. 9054-9060
    • Kitchen, S.G.1    Korin, Y.D.2    Roth, M.D.3    Landay, A.4    Zack, J.A.5
  • 32
    • 0033798906 scopus 로고    scopus 로고
    • Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I downregulation
    • Le Gall S, et al. 2000. Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I downregulation. J. Virol. 74:9256-9266.
    • (2000) J. Virol. , vol.74 , pp. 9256-9266
    • Le Gall, S.1
  • 33
    • 0032055774 scopus 로고    scopus 로고
    • Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC 1 molecules
    • Le Gall S, et al. 1998. Nef interacts with the μ subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC 1 molecules. Immunity 8:483-495.
    • (1998) Immunity , vol.8 , pp. 483-495
    • Le Gall, S.1
  • 34
    • 25144458435 scopus 로고    scopus 로고
    • LA-UR 04-7420. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM
    • Leitner T, et al. 2003. HIV sequence compendium. LA-UR 04-7420. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM.
    • (2003) HIV sequence compendium
    • Leitner, T.1
  • 35
    • 79960391235 scopus 로고    scopus 로고
    • HIV- 1 Nef disrupts intracellular trafficking of MHC-I, CD4, CD8, and CD28 by distinct pathways that share common elements
    • Leonard JA, Filzen T, Carter CC, Schaefer M, Collins KL. 2011. HIV-1 Nef disrupts intracellular trafficking of MHC-I, CD4, CD8, and CD28 by distinct pathways that share common elements. J. Virol. 85:6867-6881.
    • (2011) J. Virol. , vol.85 , pp. 6867-6881
    • Leonard, J.A.1    Filzen, T.2    Carter, C.C.3    Schaefer, M.4    Collins, K.L.5
  • 36
    • 38349109364 scopus 로고    scopus 로고
    • A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
    • Lindwasser OW, et al. 2008. A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2. J. Virol. 82:1166-1174.
    • (2008) J. Virol. , vol.82 , pp. 1166-1174
    • Lindwasser, O.W.1
  • 37
    • 0032076086 scopus 로고    scopus 로고
    • Interactions between HIV-1 Nef and vacuolar ATPase facilitate the internalization of CD4
    • Lu X, Yu H, Liu SH, Brodsky FM, Peterlin BM. 1998. Interactions between HIV-1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8:647-656.
    • (1998) Immunity , vol.8 , pp. 647-656
    • Lu, X.1    Yu, H.2    Liu, S.H.3    Brodsky, F.M.4    Peterlin, B.M.5
  • 38
    • 0023946292 scopus 로고
    • Clinical, hematological, and immunologic crosssectional evaluation of individuals exposed to human immunodeficiency virus type-2 (HIV-2)
    • Marlink RG, et al. 1988. Clinical, hematological, and immunologic crosssectional evaluation of individuals exposed to human immunodeficiency virus type-2 (HIV-2). AIDS Res. Hum. Retroviruses 4:137-148.
    • (1988) AIDS Res. Hum. Retroviruses , vol.4 , pp. 137-148
    • Marlink, R.G.1
  • 39
    • 62749177486 scopus 로고    scopus 로고
    • HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition
    • Miura T, et al. 2009. HLA-B57/B*5801 human immunodeficiency virus type 1 elite controllers select for rare gag variants associated with reduced viral replication capacity and strong cytotoxic T-lymphocyte recognition. J. Virol. 83:2743-2755.
    • (2009) J. Virol. , vol.83 , pp. 2743-2755
    • Miura, T.1
  • 40
    • 37049029214 scopus 로고    scopus 로고
    • Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses
    • Münch J, et al. 2007. Nef-mediated enhancement of virion infectivity and stimulation of viral replication are fundamental properties of primate lentiviruses. J. Virol. 81:13852-13864.
    • (2007) J. Virol. , vol.81 , pp. 13852-13864
    • Münch, J.1
  • 41
    • 23244465720 scopus 로고    scopus 로고
    • Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication
    • Münch J, et al. 2005. Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication. J. Virol. 79:10547-10560.
    • (2005) J. Virol. , vol.79 , pp. 10547-10560
    • Münch, J.1
  • 42
    • 0034796441 scopus 로고    scopus 로고
    • Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques
    • Münch J, Stolte N, Fuchs D, Stahl-Hennig C, Kirchhoff F. 2001. Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques. J. Virol. 75:10532-10536.
    • (2001) J. Virol. , vol.75 , pp. 10532-10536
    • Münch, J.1    Stolte, N.2    Fuchs, D.3    Stahl-Hennig, C.4    Kirchhoff, F.5
  • 43
    • 0025880978 scopus 로고
    • HIV-2-induced immunosuppression among asymptomatic West African prostitutes: evidence that HIV-2 is pathogenic, but less so than HIV-1
    • Pepin J, et al. 1991. HIV-2-induced immunosuppression among asymptomatic West African prostitutes: evidence that HIV-2 is pathogenic, but less so than HIV-1. AIDS 5:1165-1172.
    • (1991) AIDS , vol.5 , pp. 1165-1172
    • Pepin, J.1
  • 44
    • 0033515427 scopus 로고    scopus 로고
    • Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes
    • Piguet V, et al. 1999. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes. Cell 97:63-73.
    • (1999) Cell , vol.97 , pp. 63-73
    • Piguet, V.1
  • 45
    • 0033776709 scopus 로고    scopus 로고
    • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
    • Piguet V, et al. 2000. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. Nat. Cell Biol. 2:163-167.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 163-167
    • Piguet, V.1
  • 46
    • 8644224930 scopus 로고    scopus 로고
    • Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts
    • Pulkkinen K, Renkema GH, Kirchhoff F, Saksela K. 2004. Nef associates with p21-activated kinase 2 in a p21-GTPase-dependent dynamic activation complex within lipid rafts. J. Virol. 78:12773-12780.
    • (2004) J. Virol. , vol.78 , pp. 12773-12780
    • Pulkkinen, K.1    Renkema, G.H.2    Kirchhoff, F.3    Saksela, K.4
  • 47
    • 9444261890 scopus 로고    scopus 로고
    • HIV-1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion
    • Quaranta MG, Mattioli B, Giordani L, Viora M. 2004. HIV-1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion. FASEB J. 18:1459-1461.
    • (2004) FASEB J , vol.18 , pp. 1459-1461
    • Quaranta, M.G.1    Mattioli, B.2    Giordani, L.3    Viora, M.4
  • 48
    • 0033518291 scopus 로고    scopus 로고
    • Identification of the Nef-associated kinase as p21-activated kinase 2
    • Renkema GH, Manninen A, Mann DA, Harris M, Saksela K. 1999. Identification of the Nef-associated kinase as p21-activated kinase 2. Curr. Biol. 9:1407-1410.
    • (1999) Curr. Biol. , vol.9 , pp. 1407-1410
    • Renkema, G.H.1    Manninen, A.2    Mann, D.A.3    Harris, M.4    Saksela, K.5
  • 49
    • 0035134242 scopus 로고    scopus 로고
    • Isolation of primary HIV-1 that targets CD8+ T lymphocytes using CD8 as a receptor
    • Saha K, et al. 2001. Isolation of primary HIV-1 that targets CD8+ T lymphocytes using CD8 as a receptor. Nat. Med. 7:65-72.
    • (2001) Nat. Med. , vol.7 , pp. 65-72
    • Saha, K.1
  • 50
    • 0035280376 scopus 로고    scopus 로고
    • Evidence of productively infected CD8+T cells in patients with AIDS: implications for HIV-1 pathogenesis
    • Saha K, Zhang J, Zerhouni B. 2001. Evidence of productively infected CD8+T cells in patients with AIDS: implications for HIV-1 pathogenesis. J. Acquir. Immune Defic. Syndr. 26:199-207.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.26 , pp. 199-207
    • Saha, K.1    Zhang, J.2    Zerhouni, B.3
  • 51
    • 0028878783 scopus 로고
    • Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
    • Saksela K, Cheng G, Baltimore D. 1995. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J. 14:484-491.
    • (1995) EMBO J. , vol.14 , pp. 484-491
    • Saksela, K.1    Cheng, G.2    Baltimore, D.3
  • 52
    • 71749105713 scopus 로고    scopus 로고
    • Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains
    • Sauter D, et al. 2009. Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains. Cell Host Microbe 6:409-421.
    • (2009) Cell Host Microbe , vol.6 , pp. 409-421
    • Sauter, D.1
  • 53
    • 50849129910 scopus 로고    scopus 로고
    • HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    • Schaefer MR, Wonderlich ER, Roeth JF, Leonard JA, Collins KL. 2008. HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS Pathog. 4:e1000131.
    • (2008) PLoS Pathog , vol.4
    • Schaefer, M.R.1    Wonderlich, E.R.2    Roeth, J.F.3    Leonard, J.A.4    Collins, K.L.5
  • 54
    • 4544337312 scopus 로고    scopus 로고
    • Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques
    • Schindler M, et al. 2004. Comprehensive analysis of nef functions selected in simian immunodeficiency virus-infected macaques. J. Virol. 78: 10588-10597.
    • (2004) J. Virol. , vol.78 , pp. 10588-10597
    • Schindler, M.1
  • 55
    • 33745070227 scopus 로고    scopus 로고
    • Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1
    • Schindler M, et al. 2006. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 125:1055-1067.
    • (2006) Cell , vol.125 , pp. 1055-1067
    • Schindler, M.1
  • 56
    • 0141521574 scopus 로고    scopus 로고
    • Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles
    • Schindler M, et al. 2003. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. J. Virol. 77:10548-10556.
    • (2003) J. Virol. , vol.77 , pp. 10548-10556
    • Schindler, M.1
  • 57
    • 0032105515 scopus 로고    scopus 로고
    • Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals
    • Schmitz JE, et al. 1998. Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals. Blood 92:198-206.
    • (1998) Blood , vol.92 , pp. 198-206
    • Schmitz, J.E.1
  • 58
    • 78650646751 scopus 로고    scopus 로고
    • The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses
    • Schmökel J, et al. 2011. The presence of a vpu gene and the lack of Nef-mediated downmodulation of T cell receptor-CD3 are not always linked in primate lentiviruses. J. Virol. 85:742-752.
    • (2011) J. Virol. , vol.85 , pp. 742-752
    • Schmökel, J.1
  • 59
    • 0029875421 scopus 로고    scopus 로고
    • Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein
    • Schwartz O, Marechal V, Le Gall S, Lemonnier F, Heard JM. 1996. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nat. Med. 2:338-342.
    • (1996) Nat. Med. , vol.2 , pp. 338-342
    • Schwartz, O.1    Marechal, V.2    Le Gall, S.3    Lemonnier, F.4    Heard, J.M.5
  • 61
    • 68349157582 scopus 로고    scopus 로고
    • Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts
    • Sodora DL, et al. 2009. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat. Med. 15:861-865.
    • (2009) Nat. Med. , vol.15 , pp. 861-865
    • Sodora, D.L.1
  • 62
    • 40649109097 scopus 로고    scopus 로고
    • Selective down-modulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses
    • Specht A, et al. 2008. Selective down-modulation of HLA-A and -B by Nef alleles from different groups of primate lentiviruses. Virology 373: 229-237.
    • (2008) Virology , vol.373 , pp. 229-237
    • Specht, A.1
  • 63
    • 23844471509 scopus 로고    scopus 로고
    • Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8αβ
    • Stove V, et al. 2005. Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8αβ. J. Virol. 79:11422-11433.
    • (2005) J. Virol. , vol.79 , pp. 11422-11433
    • Stove, V.1
  • 64
    • 0035834141 scopus 로고    scopus 로고
    • HIV-1 Nef impairs MHC class II antigen presentation and surface expression
    • Stumptner-Cuvelette P, et al. 2001. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc. Natl. Acad. Sci. U. S. A. 98:12144-12149.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12144-12149
    • Stumptner-Cuvelette, P.1
  • 65
    • 0034034278 scopus 로고    scopus 로고
    • SIV and HIV Nef proteins use different surfaces to downregulate class I major histocompatibility antigen expression
    • Swigut T, Iafrate AJ, Münch J, Kirchhoff F, Skowronski J. 2000. SIV and HIV Nef proteins use different surfaces to downregulate class I major histocompatibility antigen expression. J. Virol. 74:5691-5701.
    • (2000) J. Virol. , vol.74 , pp. 5691-5701
    • Swigut, T.1    Iafrate, A.J.2    Münch, J.3    Kirchhoff, F.4    Skowronski, J.5
  • 66
    • 8644289282 scopus 로고    scopus 로고
    • Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus
    • Swigut T, et al. 2004. Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus. J. Virol. 78:13335-13344.
    • (2004) J. Virol. , vol.78 , pp. 13335-13344
    • Swigut, T.1
  • 67
    • 47249130306 scopus 로고    scopus 로고
    • Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination
    • Thakral D, Dobbins J, Devine L, Kavathas PB. 2008. Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination. J. Immunol. 180:7431-7442.
    • (2008) J. Immunol. , vol.180 , pp. 7431-7442
    • Thakral, D.1    Dobbins, J.2    Devine, L.3    Kavathas, P.B.4
  • 68
    • 0034469552 scopus 로고    scopus 로고
    • Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection
    • Veazey RS, et al. 2000. Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infection. J. Virol. 74:11001-11007.
    • (2000) J. Virol. , vol.74 , pp. 11001-11007
    • Veazey, R.S.1
  • 69
    • 58149390134 scopus 로고    scopus 로고
    • Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection
    • Wang X, Das A, Lackner AA, Veazey RS, Pahar B. 2008. Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection. Blood 112:4981-4990.
    • (2008) Blood , vol.112 , pp. 4981-4990
    • Wang, X.1    Das, A.2    Lackner, A.A.3    Veazey, R.S.4    Pahar, B.5
  • 70
    • 79960255087 scopus 로고    scopus 로고
    • HIV immune evasion disruption of antigen presentation by the HIV Nef protein
    • Wonderlich ER, Leonard JA, Collins KL. 2011. HIV immune evasion disruption of antigen presentation by the HIV Nef protein. Adv. Virus Res. 80:103-127.
    • (2011) Adv. Virus Res. , vol.80 , pp. 103-127
    • Wonderlich, E.R.1    Leonard, J.A.2    Collins, K.L.3
  • 71
    • 0030744349 scopus 로고    scopus 로고
    • Evasion of cytotoxic T lymphocyte (CTL) responses by Nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells
    • Xu XN, et al. 1997. Evasion of cytotoxic T lymphocyte (CTL) responses by Nef-dependent induction of Fas ligand (CD95L) expression on simian immunodeficiency virus-infected cells. J. Exp. Med. 186:7-16.
    • (1997) J. Exp. Med. , vol.186 , pp. 7-16
    • Xu, X.N.1
  • 72
    • 0347003600 scopus 로고    scopus 로고
    • Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytes
    • Zerhouni B, Nelson JA, Saha K. 2004. Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytes. J. Virol. 78: 1243-1255.
    • (2004) J. Virol. , vol.78 , pp. 1243-1255
    • Zerhouni, B.1    Nelson, J.A.2    Saha, K.3
  • 73
    • 79958024908 scopus 로고    scopus 로고
    • SIV Nef proteins recruit the AP-2 complex to antagonize tetherin and facilitate virion release
    • Zhang F, et al. 2011. SIV Nef proteins recruit the AP-2 complex to antagonize tetherin and facilitate virion release. PLoS Pathog. 7:e1002039.
    • (2011) PLoS Pathog , vol.7
    • Zhang, F.1
  • 74
    • 67651111833 scopus 로고    scopus 로고
    • Nef proteins from simian immunodeficiency viruses are tetherin antagonists
    • Zhang F, et al. 2009. Nef proteins from simian immunodeficiency viruses are tetherin antagonists. Cell Host Microbe 6:54-67.
    • (2009) Cell Host Microbe , vol.6 , pp. 54-67
    • Zhang, F.1


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