Metabolism of [1,3-13C]glycerol-1,2,3-tris(methylsuccinate) and glycerol-1,2,3-tris(methyl[2,3-13C]succinate) in rat hepatocytes

Metabolism: Clinical and Experimental

Volumn 49, Issue 2, 2000, Pages 178-185

  Malaisse, Willy J ^a,b,c   Ladrière, Laurence ^a,b,c   Verbruggen, Ingrid ^a,b,c   Grue Sorenson, Gunnar ^a,b,c   Björkling, Fredrik ^a,b,c   Willem, Rudolph ^a,b,c  

^a FREE UNIVERSITY OF BRUSSELS   (Belgium)

^b VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^c LEO PHARMA A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CARBON 13; FUMARIC ACID; GLUCOSE; GLYCERALDEHYDE 3 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCEROL; GLYCEROL 1,2,3 TRIS(METHYLSUCCINATE); GLYCEROL DERIVATIVE; LACTIC ACID; MALIC ACID; PYRUVIC ACID; TRIOSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; LIVER CELL; LIVER METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033975109     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(00)91195-8     Document Type: Article

References (19)

1. Malaisse WJ The esters of carboxylic nutrients as insulinotropic tools in non—insulin-dependent diabetes mellitus Gen Pharmacol 26 1995 1133 1141
2. Conget I Zhang T-M Eizirik DL SAM prevents impairment of glucose-stimulated insulin secretion caused by hexose deprivation or starvation Am J Physiol 268 1995 E580 E587
3. Malaisse WJ Bakkali-Nadi A Ladrière L Protective effects of succinic acid dimethyl ester infusion in experimental endotoxemia Nutrition 13 1997 330 341
4. Ladrière L Mercan D Björkling F Improved viability and metabolic behaviour of hepatocytes after liver storage in the presence of a succinic acid ester Transplantation 66 1998 183 185
5. Malaisse WJ Ladrière L Laghmich A Insulinotropic action of 1,2,3-tri(methylsuccinyl)glycerol ester Biochem Mol Med 62 1997 76 84
6. Ladrière L Laghmich A Malaisse-Lagae F Comparison between the insulinotropic potential of ten new esters of succinic acid Eur J Pharmacol 344 1998 87 93
7. Laghmich A Ladrière L Malaisse-Lagae F Stimulation of biosynthetic activity by novel succinate esters in rat pancreatic islets Biochem Pharmacol 55 1998 909 913
8. Malaisse WJ Grue-Sørensen G Björkling F Metabolism of glycerol-1,2,3-trimethylsuccinate in rat pancreatic islets Biochem Biophys Res Commun 236 1997 26 28
9. Seglen PO Preparation of isolated rat liver cells Methods Cell Biol 13 1976 29 83
10. Malaisse WJ Maggetto C Leclercq-Meyer V Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats J Clin Invest 91 1993 432 436
11. 13C]succinic acid in rat hepatocytes Mol Cell Biochem 189 1998 137 144
12. Ladrière L Grue-Sørensen G Björkling F Metabolism of glycerol-1,2,3-trimethylsuccinate in rat hepatocytes Mol Cell Biochem 198 1999 135 139
13. Schambye P Wood HG Biological asymmetry of glucerol and formation of asymmetrically labeled glucose J Biol Chem 206 1954 875 882
14. 13C]pyruvate in rat hepatocytes: Implications in terms of enzyme-to-enzyme channelling Arch Biochem Biophys 332 1996 341 351
15. 13C]pyruvate in rat hepatocytes Biochem Biol Med 61 1997 229 235
16. Magnusson I Schumann WC Bartsch GE Noninvasive tracing of Krebs cycle metabolism in liver J Biol Chem 266 1991 6975 6984
17. 13C-labeling pattern of glucose by gas chromatography—mass spectrometry Anal Biochem 212 1993 526 531
18. Previs SF Hallowell PT Neimanis KD Limitations of the mass isotopomer distribution analysis of glucose to study gluconeogenesis Heterogeneity of glucose labeling in incubated hepatocytes J Biol Chem 273 1998 16853 16859
19. McGarry JP Kuwajima M Newgard CB From dietary glucose to liver glycogen: The full circle round Annu Rev Nutr 7 1987 51 73