Quantifying elasticity analysis: How external effectors cause changes to metabolic systems

BioSystems

Volumn 49, Issue 2, 1999, Pages 151-159

  Ainscow, Edward K ^a   Brand, Martin D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Control coefficient; Elasticity analysis; Metabolic control analysis; Regulation analysis; Response coefficient

Indexed keywords

HORMONE;

ARTICLE; ELASTICITY; MATHEMATICAL ANALYSIS; METABOLIC REGULATION; METABOLITE;

EID: 0032969639     PISSN: 03032647     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-2647(98)00040-9     Document Type: Article

References (17)

1. Brand M.D. Regulation analysis of energy metabolism. J. Exp. Biol. 200:1997;193-202.
2. Brand, M.D., 1998. Top-down elasticity analysis and its application to energy metabolism in isolated mitochondria and intact cells. Mol. Cell. Biochem.
3. Fell D.A. Understanding the Control of Metabolism. 1997;Portland Press, London.
4. Fell D.A., Thomas S. Physiological control of metabolic flux: the requirement for multisite modulation. Biochem. J. 311:1995;35-39.
5. Hofmeyr J.H.S., Cornish-Bowden A., Rohwer J.M. Taking enzyme kinetics out of control: putting control into regulation. Eur. J. Biochem. 212:1993;833-837.
6. Kacser H., Acerenza L. A universal method of achieving increases in metabolite production. Eur. J. Biochem. 216:1993;361-367.
7. Kacser H., Burns J.A. Molecular democracy: who shares the controls? Biochem. Soc. Trans. 7:1979;1149-1160.
8. Kahn D., Westerhoff H.V. The regulatory strength: how to be precise about regulation and homeostasis. Acta Biotheor. 41:1993;85-96.
9. Kesseler A., Brand M.D. Localisation of the sites of action of cadmium on oxidative phosphorylation in potato tuber mitochondria using top-down elasticity analysis. Eur. J. Biochem. 225:1994;897-906.
10. Kesseler A., Brand M.D. Effects of cadmium on the control and internal regulation of oxidative phosphorylation in potato tuber mitochondria. Eur. J. Biochem. 225:1994;907-922.
11. Kesseler A., Brand M.D. Quantitative determination of the regulation of oxidative phosphorylation by cadmium in potato tuber mitochondria. Eur. J. Biochem. 225:1994;923-935.
12. Kholodenko B.N. How do external parameters control fluxes and concentrations of metabolites? FEBS Lett. 232:1988;383-386.
13. Kholodenko B.N. Metabolic control theory. New relationships for determining control coefficients of enzymes and response coefficients of system variables. J. Nonlinear Biol. 1:1990;107-126.
14. Korzeniewski B., Harper M.E., Brand M.D. Proportional activation coefficients during stimulation of oxidative phosphorylation by lactate and pyruvate or by vasopressin. Biochim. Biophys. Acta. 1229:1995;315-322.
15. Reder C. Metabolic control theory: a structural approach. J. Theor. Biol. 135:1988;175-201.
16. Small J.R., Kacser H. Responses of metabolic systems to large changes in enzyme activities and effectors 1: the linear treatment of unbranched chains. Eur. J. Biochem. 213:1993;613-624.
17. Small J.R., Kacser H. Responses of metabolic systems to large changes in enzyme activities and effectors 2: the linear treatment of branched pathways and metabolite concentrations: assessment of the general non-linear case. Eur. J. Biochem. 213:1993;625-640.