Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

Hepatology

Volumn 51, Issue 1, 2010, Pages 227-236

  Fannin, Rick D ^a   Russo, Mark ^b   O'Connell, Thomas M ^c,d   Gerrish, Kevin ^a   Winnike, Jason H ^e   Macdonald, Jeffrey ^e   Newton, Jack ^f   Malik, Shahid ^f   Sieber, Stella O ^a   Parker, Joel ^g   Shah, Ruchir ^h   Zhou, Tong ^c   Watkins, Paul B ^c   Paules, Richard S ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

^c HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f Chenomx Inc   (Canada)

^g Expression Analysis   (United States)

^h SRA International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PLACEBO; TRANSCRIPTOME;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; DOWN REGULATION; DRUG EXPOSURE; DRUG METABOLISM; DRUG OVERDOSE; FEMALE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; LACTATE BLOOD LEVEL; LIVER TOXICITY; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLOME; METABOLOMICS; NONHUMAN; NORMAL HUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSCRIPTOMICS;

ACETAMINOPHEN; ADULT; ANIMALS; BIOLOGICAL MARKERS; DOWN-REGULATION; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; HUMANS; LIVER; METABOLOME; MIDDLE AGED; OXIDATIVE PHOSPHORYLATION; PLACEBOS; RATS;

EID: 73449144437     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.23330     Document Type: Article

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