Notch signaling proteins HES-1 and Hey-1 bind to insulin degrading enzyme (IDE) proximal promoter and repress its transcription and activity: Implications for cellular Aβ metabolism

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 2, 2012, Pages 227-235

  Leal, María C ^a   Surace, Ezequiel I ^a   Holgado, María P ^a   Ferrari, Carina C ^a   Tarelli, Rodolfo ^a   Pitossi, Fernando ^a   Wisniewski, Thomas ^b   Castaño, Eduardo M ^a   Morelli, Laura ^a  

^a FUNDACIÓN INSTITUTO LELOIR   (Argentina)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amyloid metabolism; HES; Hey; IDE gene promoter; Notch signaling; Transcriptional repressors

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; INSULINASE; JAGGED1; MESSENGER RNA; NOTCH RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 1; TRANSCRIPTION FACTOR HEY 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; BRAIN CELL; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC TRANSFECTION; GROWTH INHIBITION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MEDIATOR; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NOTCH INTRACELLULAR DOMAIN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SPORADIC ALZHEIMER DISEASE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; CELL LINE; HIPPOCAMPUS; HOMEODOMAIN PROTEINS; HUMANS; INSULYSIN; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

MUS;

EID: 84855774121     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2011.09.014     Document Type: Article

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