Regulation of steady-state β-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme

Journal of Biological Chemistry

Volumn 281, Issue 41, 2006, Pages 30471-30478

  Eckman, Elizabeth A ^a   Adams, Stephanie K ^a   Troendle, Frederick J ^a   Stodola, Becky A ^a   Kahn, Murad A ^a   Fauq, Abdul H ^a   Xiao, Hong D ^b   Bernstein, Kenneth E ^b   Eckman, Christopher B ^a  

^a MAYO CLINIC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE (AD); AMYLOID; CARDIOVASCULAR DISORDERS; NEPRILYSIN;

BRAIN; DEGRADATION; DRUG PRODUCTS; ENZYME KINETICS; GENES; MEDICAL PROBLEMS;

STARCH;

2 (4 BIPHENYLYL) 1 (1H TETRAZOL 5 YL)ETHYLAMINOMETHYLPHOSPHONIC ACID; AMYLOID BETA PROTEIN; CAPTOPRIL; CGS 26393; CGS 35066; CGS 35339; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL MALEATE; ENALAPRILAT; ENDOTHELIN CONVERTING ENZYME; MEMBRANE METALLOENDOPEPTIDASE; METALLOPROTEINASE INHIBITOR; PERINDOPRIL; PHOSPHORAMIDON; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; EXPERIMENTAL MODEL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; STEADY STATE;

ADMINISTRATION, ORAL; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ASPARTIC ENDOPEPTIDASES; BRAIN; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; METALLOENDOPEPTIDASES; MICE; MICE, KNOCKOUT; NEPRILYSIN; PEPTIDYL-DIPEPTIDASE A;

EID: 33750047859     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605827200     Document Type: Article

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