Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke

Nature Medicine

Volumn 12, Issue 6, 2006, Pages 621-623

  Arumugam, Thiruma V ^a   Chan, Sic L ^a   Jo, Dong Gyu ^a   Yilmaz, Gokhan ^b   Tang, Sung Chun ^a,c   Cheng, Aiwu ^a   Gleichmann, Marc ^a   Okun, Eitan ^a   Dixit, Vishwa D ^a   Chigurupati, Srinivasulu ^a   Mughal, Mohamed R ^a   Ouyang, Xin ^a   Miele, Lucio ^d   Magnus, Tim ^a   Poosala, Suresh ^a   Granger, D Neil ^b   Mattson, Mark P ^a,e  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [2 (3,5 DIFLUOROPHENYL)ACETYLAMINO] N (5 METHYL 6 OXODIHYDRO 5H DIBENZO[B,D]AZEPIN 7 YL)PROPIONAMIDE; ENZYME INHIBITOR; GAMMA SECRETASE; NOTCH1 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ARTERY; BRAIN CELL; BRAIN CORTEX; BRAIN DAMAGE; BRAIN FUNCTION; CELL ACTIVATION; CELL DEATH; CELL HYPOXIA; CELL INFILTRATION; CELL STIMULATION; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFICACY; DRUG INFUSION; DRUG TARGETING; FUNCTIONAL ASSESSMENT; IN VIVO STUDY; INFLAMMATION; INTRACELLULAR SPACE; ISCHEMIA; LEUKOCYTE; MICROGLIA; MODULATION; MOUSE; NERVE CELL; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; NUCLEIC ACID PROBE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REPERFUSION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; BRAIN; BRAIN ISCHEMIA; CELLS, CULTURED; CEREBROVASCULAR ACCIDENT; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; LEUKOCYTES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROGLIA; NEURONS; PEPTIDES; RATS; RECEPTOR, NOTCH1; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 33744981148     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1403     Document Type: Article

References (15)

1. Costa, R.M., Drew, C. & Silva, A.J. Trends Neurosci. 28, 429-435 (2005).
2. Selkoe, D. & Kopan, R. Annu. Rev. Neurosci. 26, 565-597 (2003).
3. Yoon, K. & Gaiano, N. Nat. Neurosci. 8, 709-715 (2005).
4. Sugawara, T. et al. NeuroRx 1, 17-25 (2004).
5. Frijns, C.J. & Kappelle, L.J. Stroke 33, 2115-2122 (2002).
6. Wang, Y. et al. Proc. Natl. Acad. Sci. USA 101, 9458-9462 (2004).
7. Dovey, H.F. et al. J. Neurochem. 76, 173-181 (2001).
8. Milano, J. et al. Toxicol. Sci. 82, 341-358 (2004).
9. Ciofani, M. & Zuniga-Pflucker, J.C. Nat. Immunol. 6, 881-888 (2005).
10. Berezovska, O. et al. Neuroscience 93, 433-439 (1999).
11. Ishikura, N. et al. Proc. Natl. Acad. Sci. USA 102, 886-891 (2005).
12. Mattson, M.P. Nat. Rev. Mol. Cell Biol. 1, 120-129 (2000).
13. Prunell, G.F., Arboleda, V.A. & Troy, C.M. Curr. Drug Targets CNS Neurol. Disord. 4, 51-61 (2005).
14. Eagar, T.N. et al. Immunity 20, 407-415 (2004).
15. Pollack, S.J. & Lewis, H. Curr. Opin. Investig. Drugs 6, 35-47 (2005).