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Volumn 7, Issue 1, 2012, Pages 20-33

Metabolic engineering for the production of clinically important molecules: Omega-3 fatty acids, artemisinin, and taxol

Author keywords

Artemisinin; Metabolic Engineering; Omega 3; Taxol

Indexed keywords

ANTI-CANCER AGENTS; ARTEMISINIC ACID; ARTEMISININ; CARDIO-VASCULAR DISEASE; CLINICAL APPLICATION; COMMERCIAL-SCALE PRODUCTION; EFFICIENT COUPLING; FATTY ACID METABOLISM; ISOPRENOIDS; LOW COSTS; METABOLIC ENGINEERING; NEW SOLUTIONS; OMEGA-3; OMEGA-3-FATTY ACIDS; SYNTHETIC BIOLOGY; TAXOL;

EID: 84855598579     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201100289     Document Type: Review
Times cited : (41)

References (94)
  • 1
    • 78649716727 scopus 로고    scopus 로고
    • Manufacturing molecules through metabolic engineering.
    • Keasling, J. D., Manufacturing molecules through metabolic engineering. Science 2010, 330, 1355-1358.
    • (2010) Science , vol.330 , pp. 1355-1358
    • Keasling, J.D.1
  • 2
    • 78650099747 scopus 로고    scopus 로고
    • Tissue engineering for clinical applications.
    • Bhatia, S. K., Tissue engineering for clinical applications. Biotechnol. J. 2010, 5, 1309-1323.
    • (2010) Biotechnol. J. , vol.5 , pp. 1309-1323
    • Bhatia, S.K.1
  • 3
    • 58149190072 scopus 로고    scopus 로고
    • Metabolic engineering of microorganisms: General strategies and drug production.
    • Lee, S. Y., Kim, H. U., Park, J. H., Park, J. M. et al., Metabolic engineering of microorganisms: General strategies and drug production. Drug Discov. Today 2009, 14, 78-88.
    • (2009) Drug Discov. Today , vol.14 , pp. 78-88
    • Lee, S.Y.1    Kim, H.U.2    Park, J.H.3    Park, J.M.4
  • 4
    • 55349135709 scopus 로고    scopus 로고
    • Differences between dietary supplement and prescription drug omega-3 fatty acid formulations: A legislative and regulatory perspective.
    • Collins, N., Tighe, A. P., Brunton, S. A., Kris-Etherton, P. M., Differences between dietary supplement and prescription drug omega-3 fatty acid formulations: A legislative and regulatory perspective. J. Am. Coll. Nutr. 2008, 27, 659-666.
    • (2008) J. Am. Coll. Nutr. , vol.27 , pp. 659-666
    • Collins, N.1    Tighe, A.P.2    Brunton, S.A.3    Kris-Etherton, P.M.4
  • 5
    • 33947583493 scopus 로고    scopus 로고
    • Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis.
    • Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y. et al., Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet 2007, 369, 1090-1098.
    • (2007) Lancet , vol.369 , pp. 1090-1098
    • Yokoyama, M.1    Origasa, H.2    Matsuzaki, M.3    Matsuzawa, Y.4
  • 6
    • 49749128376 scopus 로고    scopus 로고
    • multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS).
    • Saito, Y., Yokoyama, M., Origasa, H., Matsuzaki, M. et al., multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis 2008, 200, 135-140.
    • (2008) Atherosclerosis , vol.200 , pp. 135-140
    • Saito, Y.1    Yokoyama, M.2    Origasa, H.3    Matsuzaki, M.4
  • 7
    • 53049110571 scopus 로고    scopus 로고
    • GISSI-HF Investigators, Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet
    • GISSI-HF Investigators, Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet 2008, 372, 1223-1230.
    • (2008) , vol.372 , pp. 1223-1230
  • 9
    • 47649090693 scopus 로고    scopus 로고
    • Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: Subanalysis of the JELIS trial.
    • Tanaka, K., Ishikawa, Y., Yokoyama, M., Origasa, H. et al., Reduction in the recurrence of stroke by eicosapentaenoic acid for hypercholesterolemic patients: Subanalysis of the JELIS trial. Stroke 2008, 39, 2052-2058.
    • (2008) Stroke , vol.39 , pp. 2052-2058
    • Tanaka, K.1    Ishikawa, Y.2    Yokoyama, M.3    Origasa, H.4
  • 10
    • 34147107925 scopus 로고    scopus 로고
    • Plasma n-3 fatty acids and the risk of cognitive decline in older adults: The Atherosclerosis risk in communities study.
    • Beydoun, M. A., Kaufman, J. S., Satia, J. A., Rosamond, W. et al., Plasma n-3 fatty acids and the risk of cognitive decline in older adults: The Atherosclerosis risk in communities study. Am. J. Clin. Nutr. 2007, 85, 1103-1111.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 1103-1111
    • Beydoun, M.A.1    Kaufman, J.S.2    Satia, J.A.3    Rosamond, W.4
  • 11
    • 33746830525 scopus 로고    scopus 로고
    • N-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases.
    • Calder, P. C., N-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am. J. Clin. Nutr. 2006, 83, 1505S-1519S.
    • (2006) Am. J. Clin. Nutr. , vol.83
    • Calder, P.C.1
  • 12
    • 84855570253 scopus 로고    scopus 로고
    • Expanding the docosahexaenoic acid food web for sustainable production: Engineering lower plant pathways into higher plants.
    • DOI: 10.1093/aobpla/plr.011
    • Petrie, P. C., Singh, P. C., Expanding the docosahexaenoic acid food web for sustainable production: Engineering lower plant pathways into higher plants. AoB PLANTS 2011. DOI: 10.1093/aobpla/plr.011.
    • (2011) AoB PLANTS
    • Petrie, P.C.1    Singh, P.C.2
  • 13
    • 80053612718 scopus 로고    scopus 로고
    • Transgenic oilseed crops as an alternative to fish oils.
    • DOI:10.1016/j.pleta.2011.04.013.
    • Sayanova, O., Napier, J. A., Transgenic oilseed crops as an alternative to fish oils. Prostaglandins Leukot. Essent. Fatty Acids 2011, DOI:10.1016/j.pleta.2011.04.013.
    • (2011) Prostaglandins Leukot. Essent. Fatty Acids
    • Sayanova, O.1    Napier, J.A.2
  • 14
    • 84944386604 scopus 로고    scopus 로고
    • Metabolic engineering of an oleaginous yeast for the production of omega-3 fatty acids
    • Cohen Z., Ratledge C. (Eds.), Single Cell Oil, 2nd Edn., ACOS Press, Urbana, IL
    • Zhu, Q., Xue, Z., Yadav, N., Damude, H. et al., Metabolic engineering of an oleaginous yeast for the production of omega-3 fatty acids, in: Cohen Z., Ratledge C. (Eds.), Single Cell Oil, 2nd Edn., ACOS Press, Urbana, IL 2010, pp. 51-73.
    • (2010) , pp. 51-73
    • Zhu, Q.1    Xue, Z.2    Yadav, N.3    Damude, H.4
  • 15
    • 0037092587 scopus 로고    scopus 로고
    • The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis.
    • D'andrea, S., Guillou, H., Jan, S., Catheline, D. et al., The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis. Biochem. J. 2002, 364, 49-55.
    • (2002) Biochem. J. , vol.364 , pp. 49-55
    • D'andrea, S.1    Guillou, H.2    Jan, S.3    Catheline, D.4
  • 16
    • 0036693244 scopus 로고    scopus 로고
    • The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids.
    • Sprecher, H., The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids. Prostaglandins Leukot. Essent. Fatty Acids 2002, 67, 79-83.
    • (2002) Prostaglandins Leukot. Essent. Fatty Acids , vol.67 , pp. 79-83
    • Sprecher, H.1
  • 17
    • 4143147532 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids: Biochemical, nutritional and epigenetic properties.
    • Benatti, P., Peluso, G., Nicolai, R., Calvani, M., Polyunsaturated fatty acids: Biochemical, nutritional and epigenetic properties. J. Am. Coll. Nutr. 2004, 23, 281-302.
    • (2004) J. Am. Coll. Nutr. , vol.23 , pp. 281-302
    • Benatti, P.1    Peluso, G.2    Nicolai, R.3    Calvani, M.4
  • 18
    • 27244445146 scopus 로고    scopus 로고
    • Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults.
    • Burdge, G. C., Calder, P. C., Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. Reprod. Nutr. Dev. 2005, 45, 581-597.
    • (2005) Reprod. Nutr. Dev. , vol.45 , pp. 581-597
    • Burdge, G.C.1    Calder, P.C.2
  • 19
    • 33747120160 scopus 로고    scopus 로고
    • n-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: A systematic review.
    • Wang, C., Harris, W. S., Chung, M. et al., n-3 fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: A systematic review. Am J. Clin. Nutr. 2006, 84, 5-17.
    • (2006) Am J. Clin. Nutr. , vol.84 , pp. 5-17
    • Wang, C.1    Harris, W.S.2    Chung, M.3
  • 20
    • 60349095847 scopus 로고    scopus 로고
    • Contaminants in fish tissue from US lakes and reservoirs: A national probabilistic study.
    • Stahl, L. L., Snyder, B. D., Olsen, A. R., Pitt, J. L., Contaminants in fish tissue from US lakes and reservoirs: A national probabilistic study. Environ. Monit. Assess. 2009, 150, 3-19.
    • (2009) Environ. Monit. Assess. , vol.150 , pp. 3-19
    • Stahl, L.L.1    Snyder, B.D.2    Olsen, A.R.3    Pitt, J.L.4
  • 21
    • 33847264063 scopus 로고    scopus 로고
    • Levels of PCDD/PCDFs and PCBs in edible marine species and human intake: A literature review.
    • Domingo, J. L., Bocio, A., Levels of PCDD/PCDFs and PCBs in edible marine species and human intake: A literature review. Environ. Int. 2007, 33, 397-405.
    • (2007) Environ. Int. , vol.33 , pp. 397-405
    • Domingo, J.L.1    Bocio, A.2
  • 22
    • 0036138566 scopus 로고    scopus 로고
    • Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture.
    • Papanikolaou, S., Aggelis, G., Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture. Bioresour. Technol. 2002, 82, 43-49.
    • (2002) Bioresour. Technol. , vol.82 , pp. 43-49
    • Papanikolaou, S.1    Aggelis, G.2
  • 23
    • 0036192006 scopus 로고    scopus 로고
    • Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures.
    • Papanikolaou, S., Chevalot, I., Komaitis, M., Aggelis, G. et al., Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures. Appl. Microbiol. Biotechnol. 2002, 58, 308-312.
    • (2002) Appl. Microbiol. Biotechnol. , vol.58 , pp. 308-312
    • Papanikolaou, S.1    Chevalot, I.2    Komaitis, M.3    Aggelis, G.4
  • 24
    • 0034891767 scopus 로고    scopus 로고
    • Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: Generation of tagged mutations in genes involved in hydrophobic substrate utilization.
    • Mauersberger, S., Wang, H. J., Gaillardin, C., Barth, G., Nicaud, J. M., Insertional mutagenesis in the n-alkane-assimilating yeast Yarrowia lipolytica: Generation of tagged mutations in genes involved in hydrophobic substrate utilization. J. Bacteriol. 2001, 183, 5102-5109.
    • (2001) J. Bacteriol. , vol.183 , pp. 5102-5109
    • Mauersberger, S.1    Wang, H.J.2    Gaillardin, C.3    Barth, G.4    Nicaud, J.M.5
  • 25
    • 33745475386 scopus 로고    scopus 로고
    • Identification of bifunctional Delta 12/omega 3 fatty acid desaturases for improving the ratio of omega 3 to omega 6 fatty acids in microbes and plants.
    • Damude, H. G., Zhang, H. X., Farrall, L., Ripp, K. G., Identification of bifunctional Delta 12/omega 3 fatty acid desaturases for improving the ratio of omega 3 to omega 6 fatty acids in microbes and plants. Proc. Natl. Acad. Sci. USA 2006, 103, 9446-9451.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9446-9451
    • Damude, H.G.1    Zhang, H.X.2    Farrall, L.3    Ripp, K.G.4
  • 26
    • 84855599053 scopus 로고    scopus 로고
    • High eicosapentaenoic acid producing strains of Yarrowia lipolytica. US Patent 07932077
    • Damude, H. G., Gillies, P. J., Macool, D. J., Picataggio, S. K. et al., High eicosapentaenoic acid producing strains of Yarrowia lipolytica. US Patent 07932077, 2011.
    • (2011)
    • Damude, H.G.1    Gillies, P.J.2    Macool, D.J.3    Picataggio, S.K.4
  • 27
    • 78751578967 scopus 로고    scopus 로고
    • Safety assessment of EPA-rich triglyceride oil produced from yeast: Genotoxicity and 28-day oral toxicity in rats.
    • Belcher, L. A., MacKenzie, S. A., Donner, M., Sykes, G. P., Safety assessment of EPA-rich triglyceride oil produced from yeast: Genotoxicity and 28-day oral toxicity in rats. Regul. Toxicol. Pharmacol. 2010, 59, 53-63.
    • (2010) Regul. Toxicol. Pharmacol. , vol.59 , pp. 53-63
    • Belcher, L.A.1    MacKenzie, S.A.2    Donner, M.3    Sykes, G.P.4
  • 28
    • 79959517602 scopus 로고    scopus 로고
    • Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study.
    • MacKenzie, S. A., Belcher, L. A., Sykes, G. P., Frame, S. R. et al., Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study. Regul. Toxicol. Pharmacol. 2010, 58, 490-500.
    • (2010) Regul. Toxicol. Pharmacol. , vol.58 , pp. 490-500
    • MacKenzie, S.A.1    Belcher, L.A.2    Sykes, G.P.3    Frame, S.R.4
  • 29
    • 0038135045 scopus 로고    scopus 로고
    • Metabolism of stearidonic acid in human subjects: Comparison with the metabolism of other n-3 fatty acids.
    • James, M. J., Ursin, V. M., Cleland, L. G., Metabolism of stearidonic acid in human subjects: Comparison with the metabolism of other n-3 fatty acids. Am. J. Clin. Nutr. 2003, 77, 1140-1145.
    • (2003) Am. J. Clin. Nutr. , vol.77 , pp. 1140-1145
    • James, M.J.1    Ursin, V.M.2    Cleland, L.G.3
  • 30
    • 68849119034 scopus 로고    scopus 로고
    • The synthesis and accumulation of stearidonic acid in transgenic plants: A novel source of 'heart-healthy' omega-3 fatty acids.
    • Ruiz-López, N., Haslam, R. P., Venegas-Calerón, M., Larson, T. R. et al., The synthesis and accumulation of stearidonic acid in transgenic plants: A novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnol. J. 2009, 7, 704-716.
    • (2009) Plant Biotechnol. J. , vol.7 , pp. 704-716
    • Ruiz-López, N.1    Haslam, R.P.2    Venegas-Calerón, M.3    Larson, T.R.4
  • 31
    • 58649120075 scopus 로고    scopus 로고
    • Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits.
    • Whelan, J., Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits. J. Nutr. 2009, 139, 5-10.
    • (2009) J. Nutr. , vol.139 , pp. 5-10
    • Whelan, J.1
  • 32
    • 84855581480 scopus 로고    scopus 로고
    • Monsanto Company
    • Stearidonic (SDA) Omega-3 Soybean Oil GRAS Notice
    • Monsanto Company, Stearidonic (SDA) Omega-3 Soybean Oil GRAS Notice 2009. (http://www.accessdata.fda.gov/scripts/fcn/gras_notices/grn000283.pdf).
    • (2009)
  • 33
    • 78049444460 scopus 로고    scopus 로고
    • Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: Randomized, double-blind clinical study of efficacy and safety.
    • Lemke, S. L., Vicini, J. L., Su, H., Goldstein, D. A., Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: Randomized, double-blind clinical study of efficacy and safety. Am. J. Clin. Nutr. 2010, 92, 766-75.
    • (2010) Am. J. Clin. Nutr. , vol.92 , pp. 766-775
    • Lemke, S.L.1    Vicini, J.L.2    Su, H.3    Goldstein, D.A.4
  • 34
    • 51349141189 scopus 로고    scopus 로고
    • Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker.
    • Harris, W. S., Lemke, S. L., Hansen, S. N. et al., Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker. Lipids 2008, 43, 805-811.
    • (2008) Lipids , vol.43 , pp. 805-811
    • Harris, W.S.1    Lemke, S.L.2    Hansen, S.N.3
  • 35
    • 77954632352 scopus 로고    scopus 로고
    • US Food and Drug Administration
    • Agency Response Letter GRAS Notice No. GRN 000283
    • US Food and Drug Administration, Agency Response Letter GRAS Notice No. GRN 000283 2009. (http://www.fda.gov/Food/FoodIngredientsPackaging/GenerallyRecognizedasSafeGRAS/GRASListings/ucm185688.htm).
    • (2009)
  • 36
    • 51549104553 scopus 로고    scopus 로고
    • Enhancing plant seed oils for human nutrition.
    • Damude, H. G., Kinney, A. J., Enhancing plant seed oils for human nutrition. Plant Physiol. 2008, 147, 962-968.
    • (2008) Plant Physiol. , vol.147 , pp. 962-968
    • Damude, H.G.1    Kinney, A.J.2
  • 37
    • 2942654745 scopus 로고    scopus 로고
    • Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.
    • Posner, G. H., O'Neill, P. M., Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Acc. Chem. Res. 2004, 37, 397-404.
    • (2004) Acc. Chem. Res. , vol.37 , pp. 397-404
    • Posner, G.H.1    O'Neill, P.M.2
  • 38
    • 79960992639 scopus 로고    scopus 로고
    • Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.
    • Klonis, N., Crespo-Ortiz, M. P., Bottova, I., Abu-Bakar, N. et al., Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc. Natl. Acad. Sci. USA 2011, 108, 11405-11410.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 11405-11410
    • Klonis, N.1    Crespo-Ortiz, M.P.2    Bottova, I.3    Abu-Bakar, N.4
  • 39
    • 79951491623 scopus 로고    scopus 로고
    • Artemisinins act through at least two targets in a yeast model.
    • Moore, C. M., Hoey, E. M., Trudgett, A., Timson, D. J., Artemisinins act through at least two targets in a yeast model. FEMS Yeast Res. 2011, 11, 233-7.
    • (2011) FEMS Yeast Res. , vol.11 , pp. 233-237
    • Moore, C.M.1    Hoey, E.M.2    Trudgett, A.3    Timson, D.J.4
  • 40
    • 77949661216 scopus 로고    scopus 로고
    • Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation.
    • Wang, J., Huang, L., Li, J., Fan, Q. et al., Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS One 2010, 5, e9582.
    • (2010) PLoS One , vol.5
    • Wang, J.1    Huang, L.2    Li, J.3    Fan, Q.4
  • 41
    • 77952795743 scopus 로고    scopus 로고
    • Anticancer activities of artemisinin and its bioactive derivatives.
    • Firestone, G. L., Sundar, S. M., Anticancer activities of artemisinin and its bioactive derivatives. Expert. Rev. Mol. Med. 2009, 11, e32.
    • (2009) Expert. Rev. Mol. Med. , vol.11
    • Firestone, G.L.1    Sundar, S.M.2
  • 42
    • 77249123257 scopus 로고    scopus 로고
    • World Health Organization
    • Geneva: WHO Press
    • World Health Organization, World Malaria Report 2008, Geneva: WHO Press 2008.
    • (2008) World Malaria Report 2008
  • 43
    • 42349104331 scopus 로고    scopus 로고
    • Qinghaosu (Artemisinin): The Price of Success.
    • White, N. J., Qinghaosu (Artemisinin): The Price of Success. Science 2008, 18, 330-334.
    • (2008) Science , vol.18 , pp. 330-334
    • White, N.J.1
  • 44
    • 84855616076 scopus 로고    scopus 로고
    • Artemisinin Market: Quantities and pricing
    • Artemisinin Conference 2010, Antananarivo, Madagascar.
    • Artepal, J. P., Artemisinin Market: Quantities and pricing. Artemisinin Conference 2010, Antananarivo, Madagascar.
    • Artepal, J.P.1
  • 45
    • 34547609909 scopus 로고    scopus 로고
    • The non-mevalonate pathway of isoprenoid precursor biosynthesis.
    • Hunter, W. N., The non-mevalonate pathway of isoprenoid precursor biosynthesis. J. Biol. Chem. 2007, 282, 21573-21577.
    • (2007) J. Biol. Chem. , vol.282 , pp. 21573-21577
    • Hunter, W.N.1
  • 46
    • 0034700150 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes.
    • Lange, B. M., Rujan, T., Martin, W., Croteau, R., Isoprenoid biosynthesis: The evolution of two ancient and distinct pathways across genomes. Proc. Natl. Acad. Sci. USA 2000, 97, 13172-13177.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13172-13177
    • Lange, B.M.1    Rujan, T.2    Martin, W.3    Croteau, R.4
  • 47
    • 0033230281 scopus 로고    scopus 로고
    • Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis.
    • Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H., van Loo, B. et al., Amorpha-4, 11-diene synthase catalyses the first probable step in artemisinin biosynthesis. Phytochemistry 1999, 52, 843-854.
    • (1999) Phytochemistry , vol.52 , pp. 843-854
    • Bouwmeester, H.J.1    Wallaart, T.E.2    Janssen, M.H.3    van Loo, B.4
  • 48
    • 33645870422 scopus 로고    scopus 로고
    • Production of the antimalarial drug precursor artemisinic acid in engineered yeast.
    • Ro, D. K., Paradise, E. M., Ouellet, M., Fisher, K. J. et al., Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006, 440, 940-943.
    • (2006) Nature , vol.440 , pp. 940-943
    • Ro, D.K.1    Paradise, E.M.2    Ouellet, M.3    Fisher, K.J.4
  • 49
    • 32344437343 scopus 로고    scopus 로고
    • Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin.
    • Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G. et al., Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin. FEBS Lett. 2006, 580, 1411-1416.
    • (2006) FEBS Lett. , vol.580 , pp. 1411-1416
    • Teoh, K.H.1    Polichuk, D.R.2    Reed, D.W.3    Nowak, G.4
  • 50
    • 52049090608 scopus 로고    scopus 로고
    • The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.
    • Zhang, Y., Teoh, K. H., Reed, D. W., Maes, L. et al., The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J. Biol. Chem. 2008, 283, 21501-21508.
    • (2008) J. Biol. Chem. , vol.283 , pp. 21501-21508
    • Zhang, Y.1    Teoh, K.H.2    Reed, D.W.3    Maes, L.4
  • 51
    • 68149089486 scopus 로고    scopus 로고
    • Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua.
    • Teoh, K. H., Polichuk, D. R., Reed, D. W., Covello, P. S., Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annua. Botany 2009, 87, 635-642.
    • (2009) Botany , vol.87 , pp. 635-642
    • Teoh, K.H.1    Polichuk, D.R.2    Reed, D.W.3    Covello, P.S.4
  • 52
    • 0038391517 scopus 로고    scopus 로고
    • Engineering a mevalonate pathway in Escherichia coli for production of terpenoids.
    • Martin, V. J., Pitera, D. J., Withers, S. T., Newman, J. D., Keasling, J. D., Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat. Biotechnol. 2003, 21, 796-802.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 796-802
    • Martin, V.J.1    Pitera, D.J.2    Withers, S.T.3    Newman, J.D.4    Keasling, J.D.5
  • 53
    • 33847309176 scopus 로고    scopus 로고
    • Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.
    • Pitera, D. J., Paddon, C. J., Newman, J. D., Keasling, J. D., Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli. Metab. Eng. 2007, 9, 193-207.
    • (2007) Metab. Eng. , vol.9 , pp. 193-207
    • Pitera, D.J.1    Paddon, C.J.2    Newman, J.D.3    Keasling, J.D.4
  • 54
    • 84879142653 scopus 로고    scopus 로고
    • High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli.
    • Tsuruta, H., Paddon, C. J., Eng, D., Lenihan, J. R. et al., High-level production of amorpha-4, 11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PLoS One 2009, 4, e4489.
    • (2009) PLoS One , vol.4
    • Tsuruta, H.1    Paddon, C.J.2    Eng, D.3    Lenihan, J.R.4
  • 55
    • 0030772492 scopus 로고    scopus 로고
    • Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae.
    • Donald, K. A., Hampton, R. Y., Fritz, I. B., Effects of overproduction of the catalytic domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase on squalene synthesis in Saccharomyces cerevisiae. Appl. Environ. Microbiol. 1997, 63, 3341-3344.
    • (1997) Appl. Environ. Microbiol. , vol.63 , pp. 3341-3344
    • Donald, K.A.1    Hampton, R.Y.2    Fritz, I.B.3
  • 56
    • 0034810736 scopus 로고    scopus 로고
    • Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae.
    • Vik, A., Rine, J., Upc2p and Ecm22p, dual regulators of sterol biosynthesis in Saccharomyces cerevisiae. Mol. Cell. Biol. 2001, 21, 6395-6405.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6395-6405
    • Vik, A.1    Rine, J.2
  • 57
    • 13544263331 scopus 로고    scopus 로고
    • Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua.
    • Bertea, C. M., Freije, J. R., van der Woude, H., Verstappen, F. W. et al., Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua. Planta Med. 2005, 71, 40-47.
    • (2005) Planta Med. , vol.71 , pp. 40-47
    • Bertea, C.M.1    Freije, J.R.2    van der Woude, H.3    Verstappen, F.W.4
  • 58
    • 84855616073 scopus 로고    scopus 로고
    • Semi-Synthetic Artemisinin Project.
    • Artemisinin Conference 2010, Antananarivo, Madagascar.
    • Farret, H., Semi-Synthetic Artemisinin Project. Artemisinin Conference 2010, Antananarivo, Madagascar.
    • Farret, H.1
  • 59
    • 84855581482 scopus 로고    scopus 로고
    • Semi-Synthetic Project One World Health.
    • Artemisinin Conference 2010, Antananarivo, Madagascar.
    • Nguyen, T. H., Semi-Synthetic Project One World Health. Artemisinin Conference 2010, Antananarivo, Madagascar.
    • Nguyen, T.H.1
  • 60
    • 70449338387 scopus 로고    scopus 로고
    • Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants.
    • Aquil, S., Husaini, A. M., Abdin, M. Z., Rather, G. M., Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants. Planta Med. 2009, 75, 1453-1458.
    • (2009) Planta Med. , vol.75 , pp. 1453-1458
    • Aquil, S.1    Husaini, A.M.2    Abdin, M.Z.3    Rather, G.M.4
  • 61
    • 80052703808 scopus 로고    scopus 로고
    • Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content.
    • Alam, P., Abdin, M. Z., Over-expression of HMG-CoA reductase and amorpha-4, 11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content. Plant Cell Rep. 2011. 30, 1919-1928.
    • (2011) Plant Cell Rep. , vol.30 , pp. 1919-1928
    • Alam, P.1    Abdin, M.Z.2
  • 62
    • 84930486745 scopus 로고    scopus 로고
    • Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene.
    • DOI:10.1055/S-0030-1271038
    • Chen, J. L., Fang, H. M., Ji, Y. P., Pu, G. B., Artemisinin biosynthesis enhancement in transgenic Artemisia annua plants by downregulation of the β-caryophyllene synthase gene. Planta Med. 2011, DOI:10.1055/S-0030-1271038.
    • (2011) Planta Med.
    • Chen, J.L.1    Fang, H.M.2    Ji, Y.P.3    Pu, G.B.4
  • 63
    • 67349227971 scopus 로고    scopus 로고
    • Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing
    • Zhang, L., Jing, F., Li, F., Li, M. et al., Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing Biotechnol. Appl. Biochem. 2009, 52, 199-207.
    • (2009) Biotechnol. Appl. Biochem. , vol.52 , pp. 199-207
    • Zhang, L.1    Jing, F.2    Li, F.3    Li, M.4
  • 65
    • 78649953180 scopus 로고    scopus 로고
    • Nicotiana benthamiana as a production platform for artemisinin precursors.
    • van Herpen, T. W., Cankar, K., Nogueira, M., Bosch, D. et al., Nicotiana benthamiana as a production platform for artemisinin precursors. PLoS One 2010, 5, e14222.
    • (2010) PLoS One , vol.5
    • van Herpen, T.W.1    Cankar, K.2    Nogueira, M.3    Bosch, D.4
  • 66
    • 25444501303 scopus 로고    scopus 로고
    • Genetic engineering of terpenoid metabolism attracts, bodyguards to Arabidopsis.
    • Kappers, I. F., Aharoni, A., van Herpen, T. W., Luckerhoff, L. L. et al., Genetic engineering of terpenoid metabolism attracts, bodyguards to Arabidopsis. Science 2005, 309, 2070-2072.
    • (2005) Science , vol.309 , pp. 2070-2072
    • Kappers, I.F.1    Aharoni, A.2    van Herpen, T.W.3    Luckerhoff, L.L.4
  • 67
    • 0035015174 scopus 로고    scopus 로고
    • Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: A putative ribosomal 'skip'.
    • Donnelly, M. L., Luke, G., Mehrotra, A., Li, X. et al., Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: A putative ribosomal 'skip'. J. Gen. Virol. 2001, 82, 1013-1025.
    • (2001) J. Gen. Virol. , vol.82 , pp. 1013-1025
    • Donnelly, M.L.1    Luke, G.2    Mehrotra, A.3    Li, X.4
  • 68
    • 58649103971 scopus 로고    scopus 로고
    • Building a golden triangle for the production and use of artemisinin derivatives against falciparum malaria in Africa.
    • Brisibe, E. A., Uyoh, E. A., Brisibe, F., Magalhaes, P. M. et al., Building a golden triangle for the production and use of artemisinin derivatives against falciparum malaria in Africa. Afr. J. Biotechnol. 2008, 7, 4884-4896.
    • (2008) Afr. J. Biotechnol. , vol.7 , pp. 4884-4896
    • Brisibe, E.A.1    Uyoh, E.A.2    Brisibe, F.3    Magalhaes, P.M.4
  • 69
    • 84855581481 scopus 로고    scopus 로고
    • Dafra Pharma, Chicory Project
    • Dafra Pharma, Chicory Project (http://www.dafra.be/content/chicory-project).
  • 71
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol.
    • Schiff, P. B., Fant, J., Horwitz, S. B., Promotion of microtubule assembly in vitro by taxol. Nature 1979, 277, 665-667.
    • (1979) Nature , vol.277 , pp. 665-667
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 72
    • 70450284524 scopus 로고    scopus 로고
    • Medicinal chemistry of paclitaxel and its analogues.
    • Fu, Y., Li, S., Zu, Y., Yang, G. et al., Medicinal chemistry of paclitaxel and its analogues. Curr. Med. Chem. 2009, 16, 3966-3985.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 3966-3985
    • Fu, Y.1    Li, S.2    Zu, Y.3    Yang, G.4
  • 73
    • 0030840892 scopus 로고    scopus 로고
    • Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery.
    • Axel, D. I., Kunert, W., Göggelmann, C., Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery. Circulation 1997, 96, 636-645.
    • (1997) Circulation , vol.96 , pp. 636-645
    • Axel, D.I.1    Kunert, W.2    Göggelmann, C.3
  • 74
    • 67349155006 scopus 로고    scopus 로고
    • A critical appraisal of the safety and efficacy of drug-eluting stents.
    • Maluenda, G., Lemesle, G., Waksman, R., A critical appraisal of the safety and efficacy of drug-eluting stents. Clin. Pharmacol. Ther. 2009, 85, 474-480.
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 474-480
    • Maluenda, G.1    Lemesle, G.2    Waksman, R.3
  • 76
    • 77955262023 scopus 로고    scopus 로고
    • Paclitaxel-loaded polymeric micelles modified with MCF-7 cell-specific phage protein: Enhanced binding to target cancer cells and increased cytotoxicity.
    • Wang, T., Petrenko, V. A., Torchilin, V. P., Paclitaxel-loaded polymeric micelles modified with MCF-7 cell-specific phage protein: Enhanced binding to target cancer cells and increased cytotoxicity. Mol. Pharm. 2010, 7, 1007-1014.
    • (2010) Mol. Pharm. , vol.7 , pp. 1007-1014
    • Wang, T.1    Petrenko, V.A.2    Torchilin, V.P.3
  • 77
    • 77954534436 scopus 로고    scopus 로고
    • Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery.
    • Sawant, R. R., Vaze, O. S., Rockwell, K., Torchilin, V. P., Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery. Eur. J. Pharm. Biopharm. 2010, 75, 321-326.
    • (2010) Eur. J. Pharm. Biopharm. , vol.75 , pp. 321-326
    • Sawant, R.R.1    Vaze, O.S.2    Rockwell, K.3    Torchilin, V.P.4
  • 78
    • 0028896166 scopus 로고
    • Camptothecin and taxol: Discovery to clinic-thirteenth Bruce F. Cain Memorial Award Lecture.
    • Wall, M. E., Wani, M. C., Camptothecin and taxol: Discovery to clinic-thirteenth Bruce F. Cain Memorial Award Lecture. Cancer Res. 1995, 55, 753-760.
    • (1995) Cancer Res. , vol.55 , pp. 753-760
    • Wall, M.E.1    Wani, M.C.2
  • 79
    • 0015211527 scopus 로고
    • Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
    • Wani, M. C., Taylor, H. L., Wall, M. E., Coggon, P. et al., Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc. 1971, 93, 2325-2327.
    • (1971) J. Am. Chem. Soc. , vol.93 , pp. 2325-2327
    • Wani, M.C.1    Taylor, H.L.2    Wall, M.E.3    Coggon, P.4
  • 80
    • 0003735974 scopus 로고    scopus 로고
    • The story of taxol: Nature and politics in the pursuit of an anti-cancer drug. Cambridge University Press, Cambridge
    • Goodman, J., Walsh V., The story of taxol: Nature and politics in the pursuit of an anti-cancer drug. Cambridge University Press, Cambridge 2001, 193-249.
    • (2001) , pp. 193-249
    • Goodman, J.1    Walsh, V.2
  • 81
    • 0028353983 scopus 로고
    • First total synthesis of taxol. 2. completion of the C and D rings.
    • Holton, R. A., Kim, H. B., Somoza, C., Liang, F. et al., First total synthesis of taxol. 2. completion of the C and D rings. J. Am. Chem. Soc. 1994, 116, 1599-1600.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 1599-1600
    • Holton, R.A.1    Kim, H.B.2    Somoza, C.3    Liang, F.4
  • 82
    • 0028213668 scopus 로고
    • First total synthesis of taxol. 1. Functionalization of the B ring.
    • Holton, R. A., Somoza, C., Kim, H. B., Liang, F. et al., First total synthesis of taxol. 1. Functionalization of the B ring. J. Am. Chem. Soc. 1994, 116, 1597-1598.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 1597-1598
    • Holton, R.A.1    Somoza, C.2    Kim, H.B.3    Liang, F.4
  • 83
  • 84
    • 0003160677 scopus 로고
    • Semisynthesis of taxol and taxotere.
    • Suffness M. (Ed.), Taxol Science and Applications. CRC Press, Boca Raton
    • Holton, R. A., Biediger, R. J., Boatman, P. D., Semisynthesis of taxol and taxotere. in: Suffness M. (Ed.), Taxol Science and Applications. CRC Press, Boca Raton 1995, pp. 97-121.
    • (1995) , pp. 97-121
    • Holton, R.A.1    Biediger, R.J.2    Boatman, P.D.3
  • 85
    • 84855581486 scopus 로고    scopus 로고
    • Phyton Biotech.
    • Phyton Biotech. 2010. (http://www.phytonbiotech.com/index.htm).
    • (2010)
  • 86
    • 0035838940 scopus 로고    scopus 로고
    • Taxol biosynthetic genes.
    • Walker, K., Croteau, R., Taxol biosynthetic genes. Phytochemistry 2001, 58, 1-7.
    • (2001) Phytochemistry , vol.58 , pp. 1-7
    • Walker, K.1    Croteau, R.2
  • 88
    • 2642518854 scopus 로고    scopus 로고
    • Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis.
    • Jennewein, S., Long, R. M., Williams, R. M., Croteau, R., Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem Biol. 2004, 11, 379-87.
    • (2004) Chem Biol. , vol.11 , pp. 379-387
    • Jennewein, S.1    Long, R.M.2    Williams, R.M.3    Croteau, R.4
  • 89
    • 50149089756 scopus 로고    scopus 로고
    • Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis.
    • Long, R., Lagisetti, R., Coates, R., Croteau, R., Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis. Arch. Biochem. Biophys. 2008, 477, 384-389.
    • (2008) Arch. Biochem. Biophys. , vol.477 , pp. 384-389
    • Long, R.1    Lagisetti, R.2    Coates, R.3    Croteau, R.4
  • 90
    • 33645573250 scopus 로고    scopus 로고
    • Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae.
    • Dejong, J. M., Liu, Y., Bollon, A. P., Long, R. M. et al., Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae. Biotechnol. Bioeng. 2006, 93, 212-224.
    • (2006) Biotechnol. Bioeng. , vol.93 , pp. 212-224
    • Dejong, J.M.1    Liu, Y.2    Bollon, A.P.3    Long, R.M.4
  • 91
    • 44749083814 scopus 로고    scopus 로고
    • Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production.
    • Engels, B., Dahm, P., Jennewein, S., Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab. Eng. 2008, 10, 201-206.
    • (2008) Metab. Eng. , vol.10 , pp. 201-206
    • Engels, B.1    Dahm, P.2    Jennewein, S.3
  • 92
    • 77957329119 scopus 로고    scopus 로고
    • Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli.
    • Ajikumar, P. K., Xiao, W. H., Tyo, K. E., Wang, Y. et al., Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science 2010, 330, 70-74.
    • (2010) Science , vol.330 , pp. 70-74
    • Ajikumar, P.K.1    Xiao, W.H.2    Tyo, K.E.3    Wang, Y.4
  • 93
    • 33751120932 scopus 로고    scopus 로고
    • Production of isoprenoid pharmaceuticals by engineered microbes.
    • Chang, M. C., Keasling, J. D., Production of isoprenoid pharmaceuticals by engineered microbes. Nat. Chem. Biol. 2006, 2, 674-681.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 674-681
    • Chang, M.C.1    Keasling, J.D.2
  • 94
    • 36649037393 scopus 로고    scopus 로고
    • Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli.
    • Leonard, E., Koffas, M. A., Engineering of artificial plant cytochrome P450 enzymes for synthesis of isoflavones by Escherichia coli. Appl. Environ. Microbiol. 2007, 73, 7246-7251.
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 7246-7251
    • Leonard, E.1    Koffas, M.A.2


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