Safety assessment of EPA-rich triglyceride oil produced from yeast: Genotoxicity and 28-day oral toxicity in rats

Regulatory Toxicology and Pharmacology

Volumn 59, Issue 1, 2011, Pages 53-63

  Belcher, Leigh A ^a   MacKenzie, Susan A ^a   Donner, Maria ^a   Sykes, Greg P ^a   Frame, Steven R ^a   Gillies, Peter J ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Dietary supplement; Eicosapentaenoic acid; EPA oil; Genotoxicity; Omega 3 polyunsaturated fatty acid; Safety; Toxicity

Indexed keywords

ICOSAPENTAENOIC ACID; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOTECHNOLOGICAL PROCEDURES; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FATTY ACID ANALYSIS; FEMALE; FERMENTATION; FOOD INTAKE; GENOTOXICITY; IONIZATION; MALE; MICRONUCLEUS; MUTAGENESIS; NONHUMAN; ORGAN WEIGHT; OVARY FOLLICLE CELL; PRIORITY JOURNAL; RAT; SAFETY; URINALYSIS; YARROWIA LIPOLYTICA;

ADMINISTRATION, ORAL; ANIMALS; ARACHIDONIC ACIDS; BODY WEIGHT; CELL LINE, TUMOR; CHOLESTEROL; EATING; FEMALE; FISH OILS; HYPERPLASIA; LIVER; MALE; MICE; MICE, INBRED ICR; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; OILS; PLANT OILS; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; THYROID GLAND; TIME FACTORS; TOXICITY TESTS; TRIGLYCERIDES; YARROWIA;

RATTUS; YARROWIA LIPOLYTICA;

EID: 78751578967     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2010.09.007     Document Type: Article

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