T cell receptor engineering

Methods in Enzymology

Volumn 503, Issue , 2012, Pages 189-222

  Stone, Jennifer D ^a   Chervin, Adam S ^a   Aggen, David H ^a   Kranz, David M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Complementarity determining regions; Fluorescence activated cell sorting; Keywords; Major histocompatibility complex; Protein engineering; Splicing by overlap extension; T cell display; T cell receptor; Yeast display

Indexed keywords

BGL2 PROTEIN; CD8 ANTIGEN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MYC PROTEIN; PLASMID DNA; RETROVIRUS VECTOR; SODIUM PROTON EXCHANGE PROTEIN 1; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG; XHO1 PROTEIN;

ANTIBIOTIC RESISTANCE; ANTIGEN EXPRESSION; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; CD4+ T LYMPHOCYTE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ENGINEERING; ENZYME ISOLATION; ENZYME PURIFICATION; ENZYME STABILITY; ESCHERICHIA COLI; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FUNGAL CELL CULTURE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HYBRIDOMA CELL CULTURE; IN VITRO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR CLONING; MUTAGENESIS; NONHUMAN; PEPTIDE LIBRARY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTRICTION MAPPING; RESTRICTION SITE;

ESCHERICHIA COLI;

EID: 84855584055     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-396962-0.00008-2     Document Type: Chapter

References (66)

1. D.H. Aggen, A.S. Chervin, F.K. Insaidoo, K.H. Piepenbrink, B.M. Baker, and D.M. Kranz Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors Protein Eng. Des. Sel. 24 2011 361 372
2. M. Aleksic, O. Dushek, H. Zhang, E. Shenderov, J.L. Chen, V. Cerundolo, D. Coombs, and P.A. van der Merwe Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time Immunity 32 2010 163 174
3. J.D. Altman, P.A.H. Moss, P.J.R. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMicheal, and M.M. Davis Phenotypic analysis of antigen-specific T lymphocytes Science 274 1996 94 96 (Pubitemid 26332731)
4. K.M. Armstrong, K.H. Piepenbrink, and B.M. Baker Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes Biochem. J. 415 2008 183 196
5. M.N. Artyomov, M. Lis, S. Devadas, M.M. Davis, and A.K. Chakraborty CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery Proc. Natl. Acad. Sci. USA 107 2010 16916 16921
6. R. Bargou, E. Leo, G. Zugmaier, M. Klinger, M. Goebeler, S. Knop, R. Noppeney, A. Viardot, G. Hess, and M. Schuler Tumor regression in cancer patients by very low doses of a T cell-engaging antibody Science 321 2008 974 977
7. E.T. Boder, and K.D. Wittrup Yeast surface display for screening combinatorial polypeptide libraries Nat. Biotechnol. 15 1997 553 557 (Pubitemid 27251573)
8. E.T. Boder, and K.D. Wittrup Yeast surface display for directed evolution of protein expression, affinity, and stability Methods Enzymol. 328 2000 430 444
9. J.M. Boulter, M. Glick, P.T. Todorov, E. Baston, M. Sami, P. Rizkallah, and B.K. Jakobsen Stable, soluble T-cell receptor molecules for crystallization and therapeutics Protein Eng. 16 2003 707 711 (Pubitemid 37314399)
10. N.A. Bowerman, T.S. Crofts, L. Chlewicki, P. Do, B.M. Baker, K. Christopher Garcia, and D.M. Kranz Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity Mol. Immunol. 46 2009 3000 3008
11. K.F. Card, S.A. Price-Schiavi, B. Liu, E. Thomson, E. Nieves, H. Belmont, J. Builes, J.A. Jiao, J. Hernandez, and J. Weidanz A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity Cancer Immunol. Immunother. 53 2004 345 357 (Pubitemid 38392312)
12. A.S. Chervin, D.H. Aggen, J.M. Raseman, and D.M. Kranz Engineering higher affinity T cell receptors using a T cell display system J. Immunol. Methods 339 2008 175 184
13. A.S. Chervin, J.D. Stone, P.D. Holler, A. Bai, J. Chen, H.N. Eisen, and D.M. Kranz The impact of TCR-binding properties and antigen presentation format on T cell responsiveness J. Immunol. 183 2009 1166 1178
14. S. Chung, K.A. Wucherpfenning, S.M. Friedman, D.A. Hafler, and J.L. Strominger Functional three-domain single chain T-cell receptors Proc. Natl. Acad. Sci. USA 91 1994 12654 12658
15. L.A. Colf, A.J. Bankovich, N.A. Hanick, N.A. Bowerman, L.L. Jones, D.M. Kranz, and K.C. Garcia How a single T cell receptor recognizes both self and foreign MHC Cell 129 2007 135 146 (Pubitemid 46507586)
16. M.M. Davis, J.J. Boniface, Z. Reich, D. Lyons, J. Hampl, B. Arden, and Y. Chien Ligand recognition by alpha beta T cell receptors Annu. Rev. Immunol. 16 1998 523 544 (Pubitemid 28183375)
17. M.M. Davis, M. Krogsgaard, M. Huse, J. Huppa, B.F. Lillemeier, and Q.J. Li T cells as a self-referential, sensory organ Annu. Rev. Immunol. 25 2007 681 695 (Pubitemid 46697921)
18. A. Deichmann, S. Hacein-Bey-Abina, M. Schmidt, A. Garrigue, M.H. Brugman, J. Hu, H. Glimm, G. Gyapay, B. Prum, and C.C. Fraser Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy J. Clin. Invest. 117 2007 2225 2232 (Pubitemid 47219567)
19. B. Engels, and W. Uckert Redirecting T lymphocyte specificity by T cell receptor gene transfer - A new era for immunotherapy Mol. Aspects Med. 28 2007 115 142
20. B. Engels, H. Cam, T. Schuler, S. Indraccolo, M. Gladow, C. Baum, T. Blankenstein, and W. Uckert Retroviral vectors for high-level transgene expression in T lymphocytes Hum. Gene Ther. 14 2003 1155 1168 (Pubitemid 36930405)
21. B. Fahnert, H. Lilie, and P. Neubauer Inclusion bodies: Formation and utilisation Adv. Biochem. Eng. Biotechnol. 89 2004 93 142
22. S.A. Gai, and K.D. Wittrup Yeast surface display for protein engineering and characterization Curr. Opin. Struct. Biol. 17 2007 467 473 (Pubitemid 47454774)
23. D.N. Garboczi, D.T. Hung, and D.C. Wiley HLA-A2-peptide complexes: Refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides Proc. Natl. Acad. Sci. USA 89 1992 3429 3433
24. D.N. Garboczi, U. Utz, P. Ghosh, A. Seth, J. Kim, E.A. VanTienhoven, W.E. Biddison, and D.C. Wiley Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2 J. Immunol. 157 1996 5403 5410 (Pubitemid 126448959)
25. K.C. Garcia, J.J. Adams, D. Feng, and L.K. Ely The molecular basis of TCR germline bias for MHC is surprisingly simple Nat. Immunol. 10 2009 143 147
26. R.D. Gietz, and R.A. Woods Transformation of yeast by lithium acetate/single-stranded carrier DNA/polyethylene glycol method Methods Enzymol. 350 2002 87 96 (Pubitemid 34619485)
27. A.C. Grabski Advances in preparation of biological extracts for protein purification Methods Enzymol. 463 2009 285 303
28. B.J. Hackel, and K.D. Wittrup The full amino acid repertoire is superior to serine/tyrosine for selection of high affinity immunoglobulin G binders from the fibronectin scaffold Protein Eng. Des. Sel. 23 2010 211 219
29. P.D. Holler, and D.M. Kranz Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation Immunity 18 2003 255 264 (Pubitemid 36263000)
30. P.D. Holler, P.O. Holman, E.V. Shusta, S. O'Herrin, K.D. Wittrup, and D.M. Kranz In vitro evolution of a T cell receptor with high affinity for peptide/MHC Proc. Natl. Acad. Sci. USA 97 2000 5387 5392 (Pubitemid 30313728)
31. P.D. Holler, L.K. Chlewicki, and D.M. Kranz TCRs with high affinity for foreign pMHC show self-reactivity Nat. Immunol. 4 2003 55 62 (Pubitemid 36104709)
32. J. Huang, V.I. Zarnitsyna, B. Liu, L.J. Edwards, N. Jiang, B.D. Evavold, and C. Zhu The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness Nature 464 2010 932 936
33. J.B. Huppa, M. Axmann, M.A. Mortelmaier, B.F. Lillemeier, E.W. Newell, M. Brameshuber, L.O. Klein, G.J. Schutz, and M.M. Davis TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity Nature 463 2010 963 967
34. L.L. Jones, S.E. Brophy, A.J. Bankovich, L.A. Colf, N.A. Hanick, K.C. Garcia, and D.M. Kranz Engineering and characterization of a stabilized alpha1/alpha2 module of the class I major histocompatibility complex product Ld J. Biol. Chem. 281 2006 25734 25744 (Pubitemid 44401962)
35. L.L. Jones, L.A. Colf, A.J. Bankovich, J.D. Stone, Y.G. Gao, C.M. Chan, R.H. Huang, K.C. Garcia, and D.M. Kranz Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors Biochemistry 47 2008 12398 12408
36. L.L. Jones, L.A. Colf, J.D. Stone, K.C. Garcia, and D.M. Kranz Distinct CDR3 conformations in T cell receptors determine the level of cross-reactivity for diverse antigens, but not the docking orientation J. Immunol. 181 2008 6255 6264
37. H.W. Kessels, M.D. van Den Boom, H. Spits, E. Hooijberg, and T.N. Schumacher Changing T cell specificity by retroviral T cell receptor display Proc. Natl. Acad. Sci. USA 97 2000 14578 14583 (Pubitemid 32016618)
38. M.C. Kieke, E.V. Shusta, E.T. Boder, L. Teyton, K.D. Wittrup, and D.M. Kranz Selection of functional T cell receptor mutants from a yeast surface- display library Proc. Natl. Acad. Sci. USA 96 1999 5651 5656 (Pubitemid 29234673)
39. F. Letourneur, and B. Malissen Derivation of a T cell hybridoma variant deprived of functional T cell receptor alpha and beta chain transcripts reveals a nonfunctional alpha-mRNA of BW5147 origin Eur. J. Immunol. 19 1989 2269 2274 (Pubitemid 20024752)
40. Q.J. Li, A.R. Dinner, S. Qi, D.J. Irvine, J.B. Huppa, M.M. Davis, and A.K. Chakraborty CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse Nat. Immunol. 5 2004 791 799 (Pubitemid 39172972)
41. Y. Li, R. Moysey, P.E. Molloy, A.L. Vuidepot, T. Mahon, E. Baston, S. Dunn, N. Liddy, J. Jacob, and B.K. Jakobsen Directed evolution of human T-cell receptors with picomolar affinities by phage display Nat. Biotechnol. 23 2005 349 354 (Pubitemid 41094424)
42. S. Morita, T. Kojima, and T. Kitamura Plat-E: An efficient and stable system for transient packaging of retroviruses Gene Ther. 7 2000 1063 1066 (Pubitemid 30398356)
43. K. Nagai, and H.C. Thogersen Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli Methods Enzymol. 153 1987 461 481
44. S.M. O'Herrin, M.S. Lebowitz, J.G. Bieler, B.K. al-Ramadi, U. Utz, A.L. Bothwell, and J.P. Schneck Analysis of the expression of peptide-major histocompatibility complexes using high affinity soluble divalent T cell receptors J. Exp. Med. 186 1997 1333 1345 (Pubitemid 27469029)
45. B.A. Orr, L.M. Carr, K.D. Wittrup, E.J. Roy, and D.M. Kranz Rapid method for measuring ScFv thermal stability by yeast surface display Biotechnol. Prog. 19 2003 631 638 (Pubitemid 36421017)
46. M.A. Purbhoo, D.J. Irvine, J.B. Huppa, and M.M. Davis T cell killing does not require the formation of a stable mature immunological synapse Nat. Immunol. 5 2004 524 530 (Pubitemid 38660465)
47. M.A. Purbhoo, D.H. Sutton, J.E. Brewer, R.E. Mullings, M.E. Hill, T.M. Mahon, J. Karbach, E. Jager, B.J. Cameron, and N. Lissin Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors J. Immunol. 176 2006 7308 7316 (Pubitemid 43849031)
48. S.A. Richman, and D.M. Kranz Display, engineering, and applications of antigen-specific T cell receptors Biomol. Eng. 24 2007 361 373 (Pubitemid 47391576)
49. S.A. Richman, D.H. Aggen, M.L. Dossett, D.L. Donermeyer, P.M. Allen, P.D. Greenberg, and D.M. Kranz Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments Mol. Immunol. 46 2009 902 916
50. S.A. Richman, D.M. Kranz, and J.D. Stone Biosensor detection systems: Engineering stable, high-affinity bioreceptors by yeast surface display Methods Mol. Biol. 504 2009 323 350
51. P.F. Robbins, Y.F. Li, M. El-Gamil, Y. Zhao, J.A. Wargo, Z. Zheng, H. Xu, R.A. Morgan, S.A. Feldman, and L.A. Johnson Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions J. Immunol. 180 2008 6116 6131
52. S.A. Rosenberg Of mice, not men: No evidence for graft-versus-host disease in humans receiving T-cell receptor-transduced autologous T cells Mol. Ther. 18 2010 1744 1745
53. M.G. Rudolph, R.L. Stanfield, and I.A. Wilson How TCRs bind MHCs, peptides, and coreceptors Annu. Rev. Immunol. 24 2006 419 466
54. T.M. Schmitt, G.B. Ragnarsson, and P.D. Greenberg T cell receptor gene therapy for cancer Hum. Gene Ther. 20 2009 1240 1248
55. E.V. Shusta, M.C. Kieke, E. Parke, D.M. Kranz, and K.D. Wittrup Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency J. Mol. Biol. 292 1999 949 956 (Pubitemid 29481708)
56. E.V. Shusta, P.D. Holler, M.C. Kieke, D.M. Kranz, and K.D. Wittrup Directed evolution of a stable scaffold for T-cell receptor engineering Nat. Biotechnol. 18 2000 754 759 (Pubitemid 30460692)
57. W.F. Soo Hoo, M.J. Lacy, L.K. Denzin, E.W.J. Voss, K.D. Hardman, and D.M. Kranz Characterization of a single-chain T cell receptor expressed in E. coli Proc. Natl. Acad. Sci. USA 89 1992 4759 4763
58. J.D. Stone, A.S. Chervin, and D.M. Kranz T-cell receptor binding affinities and kinetics: Impact on T-cell activity and specificity Immunology 126 2009 165 176
59. U. Utz, D. Banks, S. Jacobson, and W.E. Biddison Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) Tax-specific CD8 + cytotoxic T lymphocytes from patients with HTLV-1-associated disease: Evidence for oligoclonal expansion J. Virol. 70 1996 843 851
60. A. Varela-Rohena, P.E. Molloy, S.M. Dunn, Y. Li, M.M. Suhoski, R.G. Carroll, A. Milicic, T. Mahon, D.H. Sutton, and B. Laugel Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor Nat. Med. 14 2008 1390 1395
61. A.N. Warrens, M.D. Jones, and R.I. Lechler Splicing by overlap extension by PCR using asymmetric amplification: An improved technique for the generation of hybrid proteins of immunological interest Gene 186 1997 29 35 (Pubitemid 27084826)
62. K.S. Weber, D.L. Donermeyer, P.M. Allen, and D.M. Kranz Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function Proc. Natl. Acad. Sci. USA 102 2005 19033 19038 (Pubitemid 43049561)
63. B.E. Willcox, G.F. Gao, J.R. Wyer, J.E. Ladbury, J.I. Bell, B.K. Jakobsen, and P. Anton van der Merwe TCR binding to peptide-MHC stabilizes a flexible recognition interface Immunity 10 1999 357 365 (Pubitemid 29165290)
64. B. Zhang, N.A. Bowerman, J.K. Salama, H. Schmidt, M.T. Spiotto, A. Schietinger, P. Yu, Y.X. Fu, R.R. Weichselbaum, and D.A. Rowley Induced sensitization of tumor stroma leads to eradication of established cancer by T cells J. Exp. Med. 204 2007 49 55 (Pubitemid 46148755)
65. Y. Zhao, A.D. Bennett, Z. Zheng, Q.J. Wang, P.F. Robbins, L.Y. Yu, Y. Li, P.E. Molloy, S.M. Dunn, and B.K. Jakobsen High-affinity TCRs generated by phage display provide CD4 + T cells with the ability to recognize and kill tumor cell lines J. Immunol. 179 2007 5845 5854
66. R.M. Zinkernagel, and P.C. Doherty Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system Nature 248 1974 701 702