Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors

Protein Engineering, Design and Selection

Volumn 24, Issue 4, 2011, Pages 361-372

  Aggen, David H ^a   Chervin, Adam S ^a   Insaidoo, Francis K ^b   Piepenbrink, Kurt H ^b   Baker, Brian M ^b   Kranz, David M ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

directed evolution; peptide MHC; single chain; T cell receptors; yeast display

Indexed keywords

DIAGNOSTIC APPLICATIONS; DIRECTED EVOLUTION; SINGLE-CHAIN; SINGLE-CHAIN ANTIBODIES; T CELL RECEPTOR; T CELL RECEPTORS; TARGET CELLS; THERMAL STABILITY; WILD TYPES; YEAST DISPLAY; YEAST SYSTEMS;

CELL MEMBRANES; DISPLAY DEVICES; ESCHERICHIA COLI; PEPTIDES; YEAST;

ANTIBODIES;

HLA A2 ANTIGEN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE CHAIN T LYMPHOCYTE RECEPTOR VARIABLE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ANTIGEN PRESENTING CELL; ARTICLE; ESCHERICHIA COLI; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FOLDING; TARGET CELL; THERMOSTABILITY;

CLONING, MOLECULAR; ESCHERICHIA COLI; HLA-A2 ANTIGEN; HUMANS; PEPTIDES; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FOLDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SACCHAROMYCES CEREVISIAE; SINGLE-CHAIN ANTIBODIES;

ESCHERICHIA COLI;

EID: 79952654605     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq113     Document Type: Article

References (55)

1. Bargou, R., Leo, E., Zugmaier, G., et al. (2008) Science, 321, 974-977.
2. Boder, E.T. and Wittrup, K.D. (2000) Methods Enzymol., 328, 430-444.
3. Boulter, J.M., Glick, M., Todorov, P.T., Baston, E., Sami, M., Rizkallah, P. and Jakobsen, B.K. (2003) Protein Eng., 16, 707-711.
4. Buonpane, R.A., Moza, B., Sundberg, E.J. and Kranz, D.M. (2005) J. Mol. Biol., 353, 308-321.
5. Card, K.F., Price-Schiavi, S.A., Liu, B., et al. (2004) Cancer Immunol. Immunother., 53, 345-357.
6. Chlewicki, L.K., Holler, P.D., Monti, B.C., Clutter, M.A. and Kranz, D.M. (2005) J. Mol. Biol., 346, 223-239.
7. Chung, S., Wucherpfenning, KA., Friedman, S.M., Hafler, D.A. and Strominger, J.L. (1994) Proc. Natl Acad. Sci. USA, 91, 12654-12658.
8. Cole, D.K., Yuan, F., Rizkallah, P.J., Miles, J.J., Gostick, E., Price, D.A., Gao, G.F., Jakobsen, B.K. and Sewell, A.K. (2009) J. Biol. Chem., 284, 27281-27289.
9. Davis, M.M., Boniface, J.J., Reich, Z., Lyons, D., Hampl, J., Arden, B. and Chien, Y. (1998)Annu. Rev. Immunol., 16, 523-544.
10. Davis-Harrison, R.L., Armstrong, K.M. and Baker, B.M. (2005) J. Mol. Biol., 346, 533-550.
11. Dietrich, P.Y., Le Gal, F.A., Dutoit, V., et al. (2003) J. Immunol., 170, 5103-5109.
12. Dunn, S.M., Rizkallah, P.J., Baston, E., et al. (2006) Protein Sci., 15, 710-721.
13. Ewert, S., Huber, T., Honegger, A. and Pluckthun, A. (2003) J. Mol. Biol., 325, 531-553.
14. Feldhaus, M., Siegel, R., Opresko, L., et al. (2003) Nat. Biotechnol., 21, 163-170.
15. Garboczi, D.N., Ghosh, P., Utz, U., Fan, Q.R., Biddison, W.E. and Wiley, D.C. (1996a) Nature, 384, 134-141.
16. Garboczi, D.N., Utz, U., Ghosh, P., Seth, A., Kim, J., VanTienhoven, E.A., Biddison, W.E. and Wiley, D.C. (1996b) J. Immunol., 157, 5403-5410.
17. Garcia, K.C., Radu, C.G., Ho, J., Ober, R.J. and Ward, E.S. (2001) Proc. Natl Acad. Sci. USA, 98, 6818-6823.
18. Holler, P.D., Holman, P.O., Shusta, E.V., O'Herrin, S., Wittrup, K.D. and Kranz, D.M. (2000) Proc. Natl Acad. Sci. USA, 97, 5387-5392.
19. Holler, P.D., Chlewicki, L.K. and Kranz, D.M. (2003) Nat. Immunol., 4, 55-62.
20. Holliger, P. and Hudson, P.J. (2005) Nat. Biotechnol., 23, 1126-1136.
21. Honegger, A., Malebranche, A.D., Rothlisberger, D. and Pluckthun, A. (2009) Protein Eng. Des. Sel., 22, 121-134.
22. Hoogenboom, H.R. (2005) Nat. Biotechnol., 23, 1105-1116.
23. Jones, L.L., Brophy, S.E., Bankovich, A.J., Colf, LA., Hanick, N.A., Garcia, K.C. and Kranz, D.M. (2006) J. Biol. Chem., 281, 25734-25744.
24. Jones, L.L., Colf, L.A., Bankovich, A.J., Stone, J.D., Gao, Y.G., Chan, C.M., Huang, R.H., Garcia, K.C. and Kranz, D.M. (2008) Biochemistry, 47, 12398-12408.
25. Karlsson, R., Katsamba, P.S., Nordin, H., Pol, E. and Myszka, D.G. (2006) Anal. Biochem., 349, 136-147.
26. Kieke, M.C., Shusta, E.V., Boder, E.T., Teyton, L., Wittrup, K.D. and Kranz, D.M. (1999) Proc. Natl Acad. Sci. USA, 96, 5651-5656.
27. Li, Y., Moysey, R., Molloy, P.E., et al. (2005) Nat. Biotechnol., 23, 349-354.
28. Mantovani, S., Palermo, B., Garbelli, S., Campanelli, R., Robustelli Della Cuna, G., Gennari, R., Benvenuto, F., Lantelme, E. and Giachino, C. (2002) J. Immunol., 169, 6253-6260.
29. Miller, B.R., Demarest, S.J., Lugovskoy, A., et al. (2010) Protein Eng. Des. Sel., 23, 549-557.
30. Orr, BA., Carr, L.M., Wittrup, K.D., Roy, E.J. and Kranz, D.M. (2003) Biotechnol. Prog., 19, 631-638.
31. Piepenbrink, K.H., Borbulevych, O.Y., Sommese, R.F., Clemens, J., Armstrong, K.M., Desmond, C., Do, P. and Baker, B.M. (2009) Biochem. J., 423, 353-361.
32. Plaksin, D., Polakova, K., McPhie, P. and Margulies, D.H. (1997) J. Immunol., 158, 2218-2227.
33. Richman, S.A. and Kranz, D.M. (2007) Biomol. Eng., 24, 361-373.
34. Richman, S.A., Aggen, D.H., Dossett, M.L., Donermeyer, D.L., Allen, P.M., Greenberg, P.D. and Kranz, D.M. (2009) Mol. Immunol., 46, 902-916.
35. Rothe, C., Urlinger, S., Lohning, C., et al. (2008) J. Mol. Biol., 376, 1182-1200.
36. Rudolph, M.G., Stanfield, R.L. and Wilson, I.A. (2006) Annu. Rev. Immunol., 24, 419-466.
37. Sadelain, M., Brentjens, R. and Riviere, I. (2009) Curr. Opin. Immunol., 21, 215-223.
38. Sami, M., Rizkallah, P.J., Dunn, S., et al. (2007) Protein Eng. Des. Sel., 20, 397-403.
39. Shusta, E.V., Kieke, M.C., Parke, E., Kranz, D.M. and Wittrup, K.D. (1999) J. Mol. Biol., 292, 949-956.
40. Shusta, E.V., Holler, P.D., Kieke, M.C., Kranz, D.M. and Wittrup, K.D. (2000) Nat. Biotechnol., 18, 754-759.
41. Soo Hoo, W.F., Lacy, M.J., Denzin, L.K., Voss, E.W.J., Hardman, K.D. and Kranz, D.M. (1992) Proc. Natl Acad. Sci. USA, 89, 4759-4763.
42. Starr, T.K., Jameson, S.C. and Hogquist, K.A. (2003) Annu. Rev. Immunol., 21, 139-176.
43. Stone, J.D., Chervin, A.S. and Kranz, D.M. (2009) Immunology, 126, 165-176.
44. Thakur, A. and Lum, L.G. (2010) Curr. Opin. Mol. Ther., 12, 340-349.
45. Thomas, D.L., Kim, M., Bowerman, NA., Narayanan, S., Kranz, D.M., Schreiber, H. and Roy, E.J. (2009) J. Immunol., 183, 1828-1837.
46. Trautmann, L., Labarriere, N., Jotereau, F., Karanikas, V., Gervois, N., Connerotte, T., Coulie, P. and Bonneville, M. (2002) Eur. J. Immunol., 32, 3181-3190.
47. Utz, U., Banks, D., Jacobson, S. and Biddison, W.E. (1996) J. Virol., 70, 843-851.
48. Van der Merwe, PA. and Davis, S.J. (2003) Annu. Rev. Immunol., 21, 659-684.
49. Varela-Rohena, A., Molloy, P.E., Dunn, S.M., et al. (2008) Nat. Med., 14, 1390-1395.
50. Warrens, A.N., Jones, M.D. and Lechler, R.I. (1997) Gene, 186, 29-35.
51. Wayne, A.S., Kreitman, R.J., Findley, H.W., Lew, G., Delbrook, C., Steinberg, S.M., Stetler-Stevenson, M., Fitzgerald, D.J. and Pastan, I. (2010) Clin. Cancer Res., 16, 1894-1903.
52. Weber, K.S., Donermeyer, D.L., Allen, P.M. and Kranz, D.M. (2005) Proc. Natl Acad. Sci. USA, 102, 19033-19038.
53. Worn, A. and Pluckthun, A. (2001) J. Mol. Biol., 305, 989-1010.
54. Zhang, B., Bowerman, NA., Salama, J.K., et al. (2007) J. Exp. Med., 204, 49-55.
55. Zhang, B., Zhang, Y., Bowerman, NA., Schietinger, A., Fu, Y.X., Kranz, D.M., Rowley, D.A. and Schreiber, H. (2008) Cancer Res., 68, 1563-1571.