Analysis of the T-cell receptor repertoire of human T-cell leukemia virus type 1 (HTLV-1) tax-specific CD8+ cytotoxic t lymphocytes from patients with HTLV-1-associated disease: Evidence for oligoclonal expansion

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 843-851

  Utz, Ursula ^a   Banks, Darhlene ^b   Jacobson, Steven ^b   Biddison, William E ^b  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CYTOTOXIC T LYMPHOCYTE; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LYMPHOCYTE SUBPOPULATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RETROVIRUS; SEQUENCE ANALYSIS; SPINAL CORD ATROPHY; SPINAL CORD DISEASE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CELLS, CULTURED; CLONE CELLS; DNA PRIMERS; EPITOPES; GENE PRODUCTS, TAX; HLA-A2 ANTIGEN; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PARAPARESIS, TROPICAL SPASTIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0030033451     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.843-851.1996     Document Type: Article

References (53)

1. Argaet, V. P., C. W. Schmidt, S. R. Burrows, S. L. Silins, M. G. Kurilla, D. L. Doolan, A. Suhrbier, D. J. Moss, E. Kieff, T. B. Sculley, and I. S. Misko. 1994. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. J. Exp Med. 180:2335-2340.
2. Ben-Nun, A., R. S. Liblau, L. Cohen, D. Lehmann, E. Tournier-Lasserve, A. Rosenzweig, Z. Jingwu, J. C. M. Raus, and M. A. Bach. 1991. Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis predominant genes vary in individuals. Proc. Natl. Acad. Sci. USA 88:2466-2470.
3. Bentley, G. A., G. Boulot, K. Karjalainen, and R. A. Mariuzza. 1995. Crystal structure of the beta chain of a T cell antigen receptor Science 267:1984-1987.
4. Boitel, B., U. Blank, D. Mege, G. Corradin, J. Sidney, A. Sette, and O. Acuto. 1995. Strong similarities in antigen fine specificity among DRB1*1302-restricted tetanus toxin tt830-843-specific TCRs in spite of highly heterogeneous CDR3 J. Immunol. 154:3245-3255.
5. Chien, Y.-H., and M. M. Davis. 1993. How ab T-cell receptors 'see' peptide/MHC complexes Immunol Today 14:597-601.
6. Chirgwin, J. M., A. E. Przybala, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonucleases. Biochemistry 18:5294-5301.
7. Chothia, C., D. R. Boswell, and A. M. Lesk. 1988. The outline structure of the T-cell αβ receptor. EMBO J. 7:3745-3755.
8. Claverie, J. M., A. Prochnicka-Chalufour, and L. Bougueleret. 1989. Implications of a Fab-like structure for the T-cell receptor. Immunol. Today 10:10-14.
9. Davis, M. M., and P. J. Bjorkman. 1988. T-cell antigen receptor genes and T-cell recognition. Nature (London) 334:395-402
10. DiBrino, M., K. C. Parker, J. Shiloach, M. Knierman, J. Lukzo, R. V. Turner, W. E. Biddison, and J. E. Coligan. 1993 Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides. Proc Natl Acad. Sci. USA 90:1508-1512.
11. Elovaara, I., S. Koenig, A. Y. Brewah, R. M. Woods, T. Lehky, and S. Jacobson. 1993. High human T-cell lymphotropic virus type I (HTLV-I)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-I-associated neurological disease. J. Exp Med. 177:1567-1573.
12. Giegerich, G., M. Pette, E. Meinl, J. T. Epplen, H. Wekerle, and A. Hinkkanen. 1992 Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes. Eur. J Immunol. 22:753-758.
13. Hara, H., M. Morita, T. Iwaki, T. Hatae, Y. Itoyana, T. Kitamoto, S. Akizuki, I. Goto, and T. Watanabe. 1994. Detection of human T lymphotropic virus type I (HTLV-I) proviral DNA and analysis of T cell receptor Vb CDR3 sequences in spinal cord lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis. J. Exp. Med 180:831-839.
14. Heber-Katz, E., and H. Acha-Orbea. 1989. The V-region disease hypothesis: evidence from autoimmune encephalomyelitis. Immunol. Today 10:164-169.
15. Hogan, K., N. Shimojo, S. Walk, V. Engelhard, L. Maloy, J. E. Coligan, and W. E. Biddison. 1988. Mutations in the alpha two helix of HLA-A2 affect presentation but do not inhibit binding of influenza virus matrix peptide. J. Exp Med. 168:725-736.
16. Hollsberg, P., and D. A. Hafler. 1995 What is the pathogenesis of human T-cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis? Ann. Neurol. 37:143-145.
17. b class I molecule. Cell Immunol. 160:33-42.
18. Jacobson, S., A. Gupta, D. Mattson, E. Mingioli, and D. E. McFarlin. 1990. Immunological studies in tropical spastic paraparesis. Ann. Neurol. 27:149.
19. Jacobson, S., D. McFarlin, S. Robinson, R. Voskuhl, R. Martin, A. Brewah, A. J. Newell, and S. Koenig. 1992. Demonstration of HTLV-I specific cytotoxic T lymphocytes in the cerebrospinal fluid of patients with HTLV-I associated neurologic disease Ann. Neurol 32:651-657.
20. Jacobson, S., H. Shida, D. E. McFarlin, A. S. Fauci, and S. Koenig. 1990. Circulating CD8+ cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease. Nature (London) 348:245-248.
21. Jorgensen, J. L., U. Esser, B. Fazekas de St. Groth, P. A. Reay, and M. M. Davis. 1992. Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics. Nature (London) 355:224-230.
22. Koenig, S., R. Woods, A. Y. Brewah, A. Newell, G. Jones, E. Boone, J. Adelsberger, M. Baseler, S. M. Robinson, and S. Jacobson. 1993. Characterization of major histocompatibility complex (MHC) class I-restricted cytotoxic T cell (CTL) responses to Tax in HTLV-I infected patients with neurological disease. J Immunol 156:3874-3883.
23. Koike, T., M. Kagami, and K. Takabayashi. 1985. Antibodies to human T cell leukemia virus are absent in patients with systemic lupus erythematosus. Arthritis Rheum. 28:481.
24. Kotzin, B. L., S. Karuturi, Y. K. Chou, J. Lafferty, J. M. Forrester, M. Better, G. E. Nedwin, H. Offner, and A. A. Vandenbark. 1991. Preferential T-cell receptor b-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis Proc. Natl. Acad. Sci. USA 88:161-165.
25. Kubota, R., F. Umehara, S. J. Izumo, S. Ijichi, K. Matsumura, S. Yashiki, T. Fujijoshi, S. Sonoda, and M. Osame. 1994 HTLV-I proviral DNA correlates with infiltrating CD4+ lymphocytes in the spinal cord from patients with HTLV-I associated myelopathy. J. Neuroimmunol. 53:23-29.
26. Kuroda, Y., M. Matsui, M. Kikuchi, K. Kirohara, C. Endo, M. Yukitake, Y. Matsuda, O. Tokunaga, A. Komine-Sakaki, and R. Kawaguchi. 1994. In situ demonstration of the HTLV-I genome in the spinal cord of a patient with HTLV-I associated myelopathy Neurology 44:2295-2299.
27. Lehky, T. J., C. H. Fox, S. Koenig, M. C. Levin, N. Flerlage, S. Izumo, E. Sato, C. S. Raine, M. Osame, and S. Jacobson. 1995. Detection of human T lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I associated myelopathy/tropical spastic paraparesis patients by in situ hybridization. Ann. Neurol 37:246-254.
28. Lehner, P. J., E. C. Y. Wang, P. A. H. Moss, S. Williams, K. Platt, S. M. Friedman, J. I. Bell, and L. K. Borysiewicz. 1995. Human HLA-A0201-restricted cytotoxic t lymphocyte recognition of influenza A is dominant by T cells hearing the Vb17 gene segment J Exp. Med. 181:79-91.
29. Madden, D. R., D. N. Garboczi, and D. C. Wiley. 1993. The antigenic identity of peptide/MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell 75:693-708.
30. Man, S., J. P. Ridge, and V. H. Engelhard. 1994. Diversity and dominance among TCR recognizing HLA-A2 1+ influenza matrix peptide in human MHC class I transgenic mice. J. Immunol. 153:4458-4467.
31. Martin, R., U. Utz, J. E. Coligan, J. R. Richert, M. Flerlage, E. Robinson, R. Stone, W. E. Biddison, D. E. McFarlin, and H. F. McFarland. 1992. Diversity ins fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106. J. Immunol. 148:1359-1566.
32. Masuko, K., T. Kato, Y. Ikeda, M. Okubo, Y. Mizushima, K. Nishioka, and K. Yamamoto. 1994. Dynamic changes of accumulated T cell clonotypes during antigenic stimulation in vivo and in vitro. Int. Immunol. 6:1959-1966
33. Moore, G. R. W., U. Traugott, L. C. Schienberg, and C. S. Raine. 1989. Tropical spastic paraparesis: a model of virus-induced cytotoxic T cell mediated demyelination? Ann Neurol. 26:523-530.
34. Moss, P. A., R. J. Moots, W. M. Rosenberg, J. S. Rowland, H. C. Bodmer, A. J. McMichael, and J. I. Bell. 1991. Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide Proc. Natl. Acad. Sci. USA 88:8987.
35. Oksenberg, J. R., M. A. Panzara, A. B. Begovich, D. Mitchell, H. A. Erlich, R. S. Murray, R. Shimonkevitz, M. Sherritt, J. Rothbard, C. C. A. Bernard, and L. Steinman. 1993. Selection for T-cell receptor V beta-D beta-J beta gene rearrangements with specificity for a myclin basic protein peptide in brain lesions of multiple sclerosis. Nature (London) 362:68-70.
36. Oksenberg, J. R., S. Stuart, A. B. Begovich, R. B. Bell, H. A. Erlich, L. Steinman, and C. C. A. Bernard. 1990. Limited heterogeneity of rearranged T-cell receptor V alpha transcripts in brains of multiple sclerosis patients. Nature (London) 345:344-346. (Erratum. 353:94, 1991.)
37. Rock, E. P., P. R. Sibbald, M. M. Davis, and Y.-H. Chien. 1994. CDR3 length in antigen-specific immune receptors. J. Exp. Med. 179:323-328.
38. Roman, G. C., and M. Osame. 1988. Identity of HTLV-I-associated tropical spastic paraparesis and HTLV-I-associated myelopathy. Lancet i:651.
39. Rotteveel, F. T., I. Kokkelink, H. K. van Walbeek, C. H. Polman, J. J. van Dongen, and C. L. Lucas. 1987. Analysis of T cell receptor-gene rearrangement in T cells from the cerebrospinal fluid of patients with multiple sclerosis. J Neuroimmunol 5:243-249.
40. Salvetti, M., G. Ristori, M. D'Amato, C. Buttinelli, M. Falcone, C. Fieschi, H. Wekerle, and C. Pozzilli. 1993. Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Eur. J. Immunol. 23:1232-1239.
41. Shimojo, N., B. Anderson, D. Mattson, R. Turner, J. E. Coligan, and W. E. Biddison. 1990. The kinetics of peptide binding to HLA-A2 and the conformation of the peptide-A2 complex can be determined by amino acid side chains on the floor of the peptide binding groove Int. Immunol. 2:193.
42. Storkus, W. J., D. N. Howell, R. D. Salter, J. R. Dawson, and P. Cresswell. 1987. NK susceptibility varies inversely with target cell class I HLA antigen expression. J. Immunol. 138:1657-1559.
43. Umehara, F., S. Izumo, M. Nakaga, A. T. Ronquillo, K. Takahashi, K. Matsumuro, E. Sato, and M. Osame. 1993 Immunocytochemical analysis of the cellular infiltrates in the spinal cord lesions in HTLV-I associated myelopathy. J. Neuropathol. Exp. Neurol. 52:424-130.
44. Usuku K., S. Sonoda, M. Osame, S. Yashiki, K. Takahashi, M. Matsumoto, T. Sauada, T. Kimiyoshi, M. Tara, and A. Igata. 1988 Immune responsiveness against HTLV-I in HTLV-I-associated myelopathy, comparison with adult T-cell leukemu/lymphoma. Ann. Neurol. 23(Suppl.):143.
45. 44a. Utz, U. Unpublished data.
46. Utz, U., S. Koenig, J. E. Coligan, and W. E. Biddison. 1992. Presentation of three different viral peptides, HTLV-I Tax, HCMV gB, and influenza virus Ml is determined by common structural features of the HLA-A2.1 molecule. J. Immunol. 149:214-221.
47. Vernant, J. C., G. Buisson, J. Magdelaine, J. de Thore, A. Jovanelle, D. Neisson-Vernant, and N. Monplaisir. 1988 T lymphocyte alveolitis, tropical spastic paraparesis and Sjögren's-syndrome. Lancet i:177.
48. Waksman, B. H. 1989 Multiple sclerosis' relationship to a retrovirus? Nature (London) 337:599
49. Wilson, D. B., L. Steinman, and D. P. Gold. 1993 The V-region disease hypothesis: new evidence suggests it is probably wrong. Immunol. Today 14:376-380.
50. Wu, E., D. W. Dickson, S. Jacobson, and C. S. Raine. 1993. Neuroaxonal dystrophy in HTLV-I associated myelopathy/tropical spastic paraparesis: neuropathologic and neuroimmunologic correlations. Acta Neuropathol. 86:224-235.
51. Wucherpfennig, K. W., K. Ota, N. Endo, J. G. Seidman, A. Rosenzweig, H. L. Weiner, and D. A. Hafler. 1990 Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science 248:1016-1019.
52. Wucherpfennig, K. W., J. Zhang, C. Witek, M. Matsui, Y. Modabber, K. Ota, and D. A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide J. Immunol. 152:5581-5592
53. Zamvil, S. S., D. J. Mitchell, N. E. Lee, A. C. Moore, M. K. Walder, K. Sakai, J. B. Rothbard, H. O. McDevitt, L. Steinman, and H. Acha-Orbea. 1988. Predominant expression of a T cell receptor V beta gene subfamily in autoimmune encephalomyelitis J Exp. Med. 167:1586-1596. (Erratum, 168:455.)