Directed evolution of a stable scaffold for T-cell receptor engineering

Nature Biotechnology

Volumn 18, Issue 7, 2000, Pages 754-759

  Shusta, Eric V ^a   Holler, Phillp D ^a   Kieke, Michele C ^a   Kranz, David M ^a   Wittrup, K Dane ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Directed evolution; Stability maturation; T cell receptor; Yeast display

Indexed keywords

BACTERIAL ANTIGEN; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR;

ANTIGEN PRESENTING CELL; ARTICLE; CELL SELECTION; CELLULAR IMMUNITY; DIRECTED MOLECULAR EVOLUTION; GENE LIBRARY; GENETIC ENGINEERING; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMBRANE TRANSPORT; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN STABILITY; THERMODYNAMICS; THERMOSTABILITY; YEAST;

ANIMALS; ANTIGEN-PRESENTING CELLS; CELL MEMBRANE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE LIBRARY; GENES, FUNGAL; GENETIC ENGINEERING; KINETICS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PROTEIN BINDING; PROTEIN FOLDING; RECEPTORS, ANTIGEN, T-CELL; TEMPERATURE; THERMODYNAMICS;

BACTERIA (MICROORGANISMS);

EID: 0033926329     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/77325     Document Type: Article

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