Directed evolution of human T-cell receptors with picomolar affinities by phage display

Nature Biotechnology

Volumn 23, Issue 3, 2005, Pages 349-354

  Li, Yi ^a   Moysey, Ruth ^a   Molloy, Peter E ^a   Vuidepot, Anne Lise ^a   Mahon, Tara ^a   Baston, Emma ^a   Dunn, Steven ^a   Liddy, Nathaniel ^a   Jacob, Jansen ^a   Jakobsen, Bent K ^a   Boulter, Jonathan M ^a,b  

^a Avidex Ltd   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; CELL CULTURE; CHEMICAL BONDS; POLYPEPTIDES; TUMORS;

HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE 1 (HLTV-1); NATURAL AFFINITIES; PEPTIDE-HUMAN LEUKOCYTE ANTIGEN (PHLA) COMPLEXES; T-CELL RECEPTORS (TCR);

PROTEINS;

HLA A ANTIGEN; HLA ANTIGEN; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE LIBRARY;

ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; DISULFIDE BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECEPTOR BINDING; T LYMPHOCYTE; ANTIBODY AFFINITY; ANTIBODY PRODUCTION; BIOSYNTHESIS; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; DIRECTED MOLECULAR EVOLUTION; GENETIC RECOMBINATION; GENETICS; IMMUNOLOGY; LETTER; METHODOLOGY; PROTEIN BINDING; PROTEIN ENGINEERING;

HUMAN T-LYMPHOTROPIC VIRUS 1;

ANTIBODY AFFINITY; ANTIBODY FORMATION; COMPLEMENTARITY DETERMINING REGIONS; DIRECTED MOLECULAR EVOLUTION; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICROCHEMISTRY; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN ENGINEERING; RECEPTORS, ANTIGEN, T-CELL; RECOMBINATION, GENETIC;

EID: 21444445173     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1070     Document Type: Article

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