A comparative analysis of the substrate permissiveness of HCV and GBV-B NS3/4A proteases reveals genetic evidence for an interaction with NS4B protein during genome replication

Virology

Volumn 406, Issue 2, 2010, Pages 228-240

  Benureau, Yann ^a,b,c,e   Warter, Lucile ^a,b,c,f   Malcolm, Bruce A ^d   Martin, Annette ^a,b,c  

^a Sorbonne Paris Cité   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Tibotec   (Belgium)

^e INSTITUT PASTEUR   (France)

^f AGENCY FOR SCIENCE   (Singapore)

Author keywords

GB virus B; Hepacivirus; Hepatitis C virus; Mutagenesis; NS3; NS4B; Protease; Replication; Structural model; Substrate specificity

Indexed keywords

NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; NONSTRUCTURAL PROTEIN 4B; VIRUS RNA; NS3 PROTEIN, FLAVIVIRUS; NS3 PROTEIN, HEPATITIS C VIRUS; NS4B PROTEIN, FLAVIVIRUS; PROTEIN BINDING; RNA HELICASE; SERINE PROTEINASE; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME SPECIFICITY; HEPATITIS C VIRUS; HEPATITIS GB VIRUS B; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REPLICON; REVERTANT; VIRUS GENOME; VIRUS REPLICATION; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DNA REPLICATION; ENZYMOLOGY; FLAVIVIRIDAE INFECTION; GENETICS; HEPACIVIRUS; HEPATITIS C; METABOLISM; MOLECULAR GENETICS; PEGIVIRUS B; VIROLOGY; VIRUS HEPATITIS;

AMINO ACID SEQUENCE; CELL LINE; DNA REPLICATION; FLAVIVIRIDAE INFECTIONS; GB VIRUS B; HEPACIVIRUS; HEPATITIS C; HEPATITIS, VIRAL, HUMAN; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RNA HELICASES; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPACIVIRUS; HEPATITIS C VIRUS; HEPATITIS GB VIRUS B; PRIMATES;

EID: 84755161499     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2010.07.014     Document Type: Article

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