The Nonstructural Protein 3 Protease/Helicase Requires an Intact Protease Domain to Unwind Duplex RNA Efficiently

Journal of Biological Chemistry

Volumn 279, Issue 2, 2004, Pages 1269-1280

  Frick, David N ^a   Rypma, Ryan S ^a   Lam, Angela M I ^a   Gu, Baohua ^b  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b Jefferson Ctr for Biomed Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; DNA; ENZYME KINETICS; OLIGOMERS; PROTEINS; RNA; VIRUSES;

TRANSLOCATIONS; VIRAL REPLICATION;

BIOCHEMISTRY;

GLUTATHIONE TRANSFERASE; HELICASE; PROTEINASE; RNA HELICASE; SINGLE STRANDED DNA; STRUCTURAL PROTEIN; SYNAPSIN II;

AMINO TERMINAL SEQUENCE; ARTICLE; DNA DENATURATION; DNA RNA HYBRIDIZATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE DELETION; HEPATITIS C VIRUS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROCESSING; PROTEIN STRUCTURE; VIRUS REPLICATION;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; DNA, SINGLE-STRANDED; ENDOPEPTIDASES; GENE DELETION; GLUTATHIONE TRANSFERASE; HYDROLYSIS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID DENATURATION; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RIBONUCLEASES; RNA; RNA HELICASES; RNA, DOUBLE-STRANDED; SPECTROMETRY, FLUORESCENCE; TEMPERATURE; TIME FACTORS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 0346463036     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310630200     Document Type: Article

References (48)

1. Tan, S. L., Pause, A., Shi, Y., and Sonenberg, N. (2002) Nat. Rev. Drug. Discov. 1, 867-881
2. Kolykhalov, A. A., Mihalik, K., Feinstone, S. M., and Rice, C. M. (2000) J. Virol. 74, 2046-2051
3. Frick, D. N. (2003) Curr. Org. Chem. 7, in press
4. Yanagi, M., Purcell, R. H., Emerson, S. U., and Bukh, J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 8738-8743
5. Yao, N., Reichert, P., Taremi, S. S., Prosise, W. W., and Weber, P. C. (1999) Struct. Fold Des. 7, 1353-1363
6. Yao, N., Hesson, T., Cable, M., Hong, Z., Kwong, A. D., Le, H. V., and Weber, P. C. (1997) Nat. Struct. Biol. 4, 463-467
7. Kim, J. L., Morgenstern, K. A., Griffith, J. P., Dwyer, M. D., Thomson, J. A., Murcko, M. A., Lin, C., and Caron, P. R. (1998) Structure 6, 89-100
8. Cho, H. S., Ha, N. C., Kang, L. W., Chung, K. M., Back, S. H., Jang, S. K., and Oh, B. H. (1998) J. Biol. Chem. 273, 15045-15052
9. Sali, D. L., Ingram, R., Wendel, M., Gupta, D., McNemar, C., Tsarbopoulos, A., Chen, J. W., Hong, Z., Chase, R., Risano, C., Zhang, R., Yao, N., Kwong, A. D., Ramanathan, L., Le, H. V., and Weber, P. C. (1998) Biochemistry 37, 3392-3401
10. Preugschat, F., Danger, D. P., Carter, L. H., 3rd, Davis, R. G., and Porter, D. J. (2000) Biochemistry 39, 5174-5183
11. Heilek, G. M., and Peterson, M. G. (1997) J. Virol. 71, 6264-6266
12. Jin, L., and Peterson, D. L. (1995) Arch. Biochem. Biophys. 323, 47-53
13. Lin, C., and Kim, J. L. (1999) J. Virol. 73, 8798-8807
14. Du, M. X., Johnson, R. B., Sun, X. L., Staschke, K. A., Colacino, J., and Wang, Q. M. (2002) Biochem. J. 363, 147-155
15. Lam, A. M. I., Keeney, D., Eckert, P. Q., and Frick, D. N. (2003) J. Virol. 77, 3950-3961
16. Lam, A. M. I., Keeney, D., and Frick, D. N. (2003) J. Biol. Chem. 278, 44514-44524
17. Khu, Y. L., Koh, E., Lim, S. P., Tan, Y. H., Brenner, S., Lim, S. G., Hong, W. J., and Goh, P. Y. (2001) J. Virol. 75, 205-214
18. Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., and Gray, T. (1995) Protein Sci. 4, 2411-2423
19. Dubendorff, J. W., and Studier, F. W. (1991) J. Mol. Biol. 219, 45-59
20. Morris, P. D., and Raney, K. D. (1999) Biochemistry 38, 5164-5171
21. Morris, P. D., Byrd, A. K., Tackett, A. J., Cameron, C. E., Tanega, P., Ott, R., Fanning, E., and Raney, K. D. (2002) Biochemistry 41, 2372-2378
22. Levin, M. K., Gurjar, M. M., and Patel, S. S. (2003) J. Biol. Chem. 278, 23311-23316
23. Gallinari, P., Brennan, D., Nardi, C., Brunetti, M., Tomei, L., Steinkuhler, C., and De Francesco, R. (1998) J. Virol. 72, 6758-6769
24. Piccininni, S., Varaklioti, A., Nardelli, M., Dave, B., Raney, K. D., and McCarthy, J. E. (2002) J. Biol. Chem. 277, 45670-45679
25. Pang, P. S., Jankowsky, E., Planet, P. J., and Pyle, A. M. (2002) EMBO J. 21, 1168-1176
26. Lohmann, V., Korner, F., Dobierzewska, A., and Bartenschlager, R. (2001) J. Virol. 75, 1437-1449
27. Blight, K. J., McKeating, J. A., and Rice, C. M. (2002) J. Virol. 76, 13001-13014
28. Gu, B., Gates, A. T., Isken, O., Behrens, S.-E., and Sarisky, R. T. (2003) J. Virol. 77, 5352-5359
29. Grobler, J. A., Markel, E. J., Fay, J. F., Graham, D. J., Simcoe, A. L., Ludmerer, S. W., Murray, E. M., Migliaccio, G., and Flores, O. A. (2003) J. Biol. Chem. 278, 16741-16746
30. Bukh, J., Pietschmann, T., Lohmann, V., Krieger, N., Faulk, K., Engle, R. E., Govindarajan, S., Shapiro, M., St. Claire, M., and Bartenschlager, R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 14416-14421
31. Paolini, C., De Francesco, R., and Gallinari, P. (2000) J. Gen. Virol. 81, 1335-1345
32. Gwack, Y., Kim, D. W., Han, J. H., and Choe, J. (1997) Eur. J. Biochem. 250, 47-54
33. Ali, J. A., and Lohman, T. M. (1997) Science 275, 377-380
34. Porter, D. J., Short, S. A., Hanlon, M. H., Preugschat, F., Wilson, J. E., Willard, D. H., Jr., and Consler, T. G. (1998) J. Biol. Chem. 273, 18906-18914
35. Levin, M. K., and Patel, S. S. (2002) J. Biol. Chem. 277, 29377-29385
36. Levin, M. K., and Patel, S. S. (1999) J. Biol. Chem. 274, 31839-31846
37. Locatelli, G. A., Spadari, S., and Maga, G. (2002) Biochemistry 41, 10332-10342
38. Preugschat, F., Averett, D. R., Clarke, B. E., and Porter, D. J. T. (1996) J. Biol. Chem. 271, 24449-24457
39. Flajolet, M., Rotondo, G., Daviet, L., Bergametti, F., Inchauspe, G., Tiollais, P., Transy, C., and Legrain, P. (2000) Gene (Amst.) 242, 369-379
40. Suzich, J. A., Tamura, J. K., Palmer-Hill, F., Warrener, P., Grakoui, A., Rice, C. M., Feinstone, S. M., and Collett, M. S. (1993) J. Virol. 67, 6152-6158
41. Kim, D. W., Gwack, Y., Han, J. H., and Choe, J. (1997) Virus Res. 49, 17-25
42. Banerjee, R., and Dasgupta, A. (2001) J. Virol. 75, 1708-1721
43. Howe, A. Y., Chase, R., Taremi, S. S., Risano, C., Beyer, B., Malcolm, B., and Lau, J. Y. (1999) Protein Sci. 8, 1332-1341
44. Silverman, E., Edwalds-Gilbert, G., and Lin, R. J. (2003) Gene (Amst.) 312, 1-16
45. Gallinari, P., Paolini, C., Brennan, D., Nardi, C., Steinkuhler, C., and De Francesco, R. (1999) Biochemistry 38, 5620-5632
46. Wong, I., and Lohman, T. M. (1992) Science 256, 350-355
47. Maluf, N. K., Fischer, C. J., and Lohman, T. M. (2003) J. Mol. Biol. 325, 913-935
48. Gibrat, J. F., Madej, T., and Bryant, S. H. (1996) Curr. Opin. Struct. Biol. 6, 377-385