TMP21 transmembrane domain regulates γ-secretase cleavage

Journal of Biological Chemistry

Volumn 284, Issue 42, 2009, Pages 28634-28641

  Pardossi Piquard, Raphaëlle ^a   Böhm, Christopher ^a   Chen, Fusheng ^a   Kanemoto, Soshi ^a   Checler, Frédéric ^b   Schmitt Ulms, Gerold ^c   St George Hyslop, Peter ^a,d,e   Fraser, Paul E ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c UNIVERSITY OF TORONTO   (Canada)

^d TORONTO WESTERN HOSPITAL   (Canada)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLEAVAGE ACTIVITIES; CO-EXPRESSION; DOSE-DEPENDENT; FUNCTIONAL DOMAINS; INTRACELLULAR DOMAIN; PRECURSOR PROTEINS; PRESENILINS; PROTEOLYTIC PROCESSING; SECRETASE COMPLEX; SECRETASES; SYNTHETIC PEPTIDE; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE HELICES;

ACTIVATION ANALYSIS; AMINES; ENZYME ACTIVITY; GLYCOPROTEINS; PEPTIDES; PUMPING PLANTS;

CELL MEMBRANES;

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; MEMBRANE PROTEIN; PRESENILIN; TRANSMEMBRANE TRAFFICKING PROTEIN 21; UNCLASSIFIED DRUG;

ARTICLE; CHIMERA; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE; CELL MEMBRANE; CELL-FREE SYSTEM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENES, REPORTER; HUMANS; LYSINE; MEMBRANE PROTEINS; MUTAGENESIS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 70350389740     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.059345     Document Type: Article

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