-
3
-
-
0038169798
-
-
Aitiology" in, 2 nd ed., Oxford University Press, Oxford.
-
"Aitiology" in Oxford Dictionary, 2 nd ed., Oxford University Press, Oxford, 2002.
-
(2002)
Oxford Dictionary
-
-
-
11
-
-
84255195920
-
-
Dover, New York, p. ; see also the English version (published in ref. [9], 199-234) of the original first Russian edition that appeared in 1924
-
A. I. Oparin, Origin of Life, 2nd ed., Dover, New York, 1952, p. 153; see also the English version (published in ref. [9], pp. 199-234) of the original first Russian edition that appeared in 1924
-
(1952)
Origin of Life, 2nd Ed.
, pp. 153
-
-
Oparin, A.I.1
-
12
-
-
0002988028
-
-
reproduced in Ref. [9] ( 242-249).
-
J. B. S. Haldane, Ration. Annu. 1929, 148, 3; reproduced in Ref. [9] (pp. 242-249).
-
(1929)
Ration. Annu.
, vol.148
, pp. 3
-
-
Haldane, J.B.S.1
-
14
-
-
84855654163
-
-
Chapter "Postscript" in ref. [9a], p. 194.
-
Chapter "Postscript" in ref. [9a], p. 194.
-
-
-
-
19
-
-
0000585364
-
-
Y. Wolman, W. J. Haverland, S. L. Miller, Proc. Natl. Acad. Sci. USA 1972, 69, 809
-
(1972)
Proc. Natl. Acad. Sci. USA
, vol.69
, pp. 809
-
-
Wolman, Y.1
Haverland, W.J.2
Miller, S.L.3
-
21
-
-
80052147758
-
-
M. P. Callahan, K. E. Smith, H. J. Cleaves, J. Ruzicka, J. C. Stern, D. P. Glavin, C. H. House, J. P. Dworkin, Proc. Natl. Acad. Sci. USA 2011, 108, 13995.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 13995
-
-
Callahan, M.P.1
Smith, K.E.2
Cleaves, H.J.3
Ruzicka, J.4
Stern, J.C.5
Glavin, D.P.6
House, C.H.7
Dworkin, J.P.8
-
34
-
-
0035106816
-
-
D. Segré, D. Ben-Eli, D. Deamer, D. Lancet, Origins Life Evol. Biosphere 2001, 31, 119
-
(2001)
Origins Life Evol. Biosphere
, vol.31
, pp. 119
-
-
Segré, D.1
Ben-Eli, D.2
Deamer, D.3
Lancet, D.4
-
40
-
-
33749239367
-
-
M. Kindermann, I. Stahl, M. Reimold, W. M. Pankau, G. von Kiedrowski, Angew. Chem. 2005, 117, 6908
-
(2005)
Angew. Chem.
, vol.117
, pp. 6908
-
-
Kindermann, M.1
Stahl, I.2
Reimold, M.3
Pankau, W.M.4
Von Kiedrowski, G.5
-
42
-
-
74549184175
-
-
E. J. Hayden, G. von Kiedrowski, N. Lehman, Angew. Chem. 2008, 120, 8552
-
(2008)
Angew. Chem.
, vol.120
, pp. 8552
-
-
Hayden, E.J.1
Von Kiedrowski, G.2
Lehman, N.3
-
44
-
-
0031442682
-
-
D. H. Lee, K. Severin, Y. Yokobayashi, M. R. Ghadiri, Nature 1997, 390, 591
-
(1997)
Nature
, vol.390
, pp. 591
-
-
Lee, D.H.1
Severin, K.2
Yokobayashi, Y.3
Ghadiri, M.R.4
-
45
-
-
3342885959
-
-
G. Ashkenasy, R. Jagasia, M. Yadav, M. R. Ghadiri, Proc. Natl. Acad. Sci. USA 2004, 101, 10872.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10872
-
-
Ashkenasy, G.1
Jagasia, R.2
Yadav, M.3
Ghadiri, M.R.4
-
48
-
-
0012654365
-
-
Y. Yamada, D. Miljikovic, P. Wehrli, B. Golding, P. Löliger, R. Keese, K. Müller, A. Eschenmoser, Angew. Chem. 1969, 81, 301
-
(1969)
Angew. Chem.
, vol.81
, pp. 301
-
-
Yamada, Y.1
Miljikovic, D.2
Wehrli, P.3
Golding, B.4
Löliger, P.5
Keese, R.6
Müller, K.7
Eschenmoser, A.8
-
50
-
-
84917754970
-
-
For X-ray structure determinations of synthetic A/D-seco-corrin and corrin complexes in both series of corrin model syntheses, see
-
A. Eschenmoser, Pure Appl. Chem. 1969, 20, 1. For X-ray structure determinations of synthetic A/D-seco-corrin and corrin complexes in both series of corrin model syntheses, see
-
(1969)
Pure Appl. Chem.
, vol.20
, pp. 1
-
-
Eschenmoser, A.1
-
55
-
-
0001215610
-
-
Roads to Corrins"
-
"Roads to Corrins", A. Eschenmoser, Quart. Revs. 1970, 24, 366
-
(1970)
Quart. Revs.
, vol.24
, pp. 366
-
-
Eschenmoser, A.1
-
56
-
-
0042576512
-
-
Studies on Organic Synthesis" Supplement 2, Butterworths, London
-
"Studies on Organic Synthesis" A. Eschenmoser in 23rd Int. Congress of Pure and Applied Chemistry, IUPAC, Supplement Vol. 2, Butterworths, London, 1971, p. 69
-
(1971)
23rd Int. Congress of Pure and Applied Chemistry, IUPAC
, pp. 69
-
-
Eschenmoser, A.1
-
57
-
-
0003969499
-
-
(Hrsg.: B. Zagalak, W. Friedrich), Walter de Gruyter, Berlin, 1979
-
12 (Hrsg.:, B. Zagalak, W. Friedrich,), Walter de Gruyter, Berlin, 1979, pp. 89-117
-
(1979)
Chemical Synthesis of Corrinoids: Current Problems and Recent Advances
, pp. 89-117
-
-
Eschenmoser, A.1
-
58
-
-
33845395018
-
-
12 zur Frage nach dem Ursprung der Corrinstruktur.
-
12 zur Frage nach dem Ursprung der Corrinstruktur":, A. Eschenmoser, Nova Acta Leopold. 1982, 55, 5.
-
(1982)
Nova Acta Leopold.
, vol.55
, pp. 5
-
-
Eschenmoser, A.1
-
59
-
-
0012650760
-
-
W. Fuhrer, P. Schneider, W. Schilling, H. Wild, J. Schreiber, A. Eschenmoser, Chimia 1972, 26, 320
-
(1972)
Chimia
, vol.26
, pp. 320
-
-
Fuhrer, W.1
Schneider, P.2
Schilling, W.3
Wild, H.4
Schreiber, J.5
Eschenmoser, A.6
-
60
-
-
84255201461
-
-
H. Maag, N. Obata, A. Holmes, P. Schneider, W. Schilling, J. Schreiber, A. Eschenmoser, Chimia 1972, 26, 320
-
(1972)
Chimia
, vol.26
, pp. 320
-
-
Maag, H.1
Obata, N.2
Holmes, A.3
Schneider, P.4
Schilling, W.5
Schreiber, J.6
Eschenmoser, A.7
-
62
-
-
0017385449
-
-
12 project. All these theses are accessible with their full text (in German) in the Internet under the names of the respective authors
-
12 project. All these theses are accessible with their full text (in German) in the Internet under the names of the respective authors
-
(1977)
Science
, vol.196
, pp. 1410
-
-
Eschenmoser, A.1
Wintner, C.2
-
68
-
-
84985533821
-
-
A. Pfaltz, B. Hardegger, P. M. Müller, S. Farooq, B. Kräutler, A. Eschenmoser, Helv. Chim. Acta 1975, 58, 1444
-
(1975)
Helv. Chim. Acta
, vol.58
, pp. 1444
-
-
Pfaltz, A.1
Hardegger, B.2
Müller, P.M.3
Farooq, S.4
Kräutler, B.5
Eschenmoser, A.6
-
69
-
-
0017312625
-
-
B. Kräutler, A. Pfaltz, R. Nordmann, K. O. Hodgson, J. D. Dunitz, A. Eschenmoser, Helv. Chim. Acta 1976, 59, 924
-
(1976)
Helv. Chim. Acta
, vol.59
, pp. 924
-
-
Kräutler, B.1
Pfaltz, A.2
Nordmann, R.3
Hodgson, K.O.4
Dunitz, J.D.5
Eschenmoser, A.6
-
70
-
-
84981905018
-
-
A. Pfaltz, N. Bühler, R. Neier, K. Hirai, A. Eschenmoser, Helv. Chim. Acta 1977, 60, 2653.
-
(1977)
Helv. Chim. Acta
, vol.60
, pp. 2653
-
-
Pfaltz, A.1
Bühler, N.2
Neier, R.3
Hirai, K.4
Eschenmoser, A.5
-
71
-
-
0019425714
-
-
V. Rasetti, A. Pfaltz, C. Kratky, A. Eschenmoser, Proc. Natl. Acad. Sci. USA 1981, 78, 16
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 16
-
-
Rasetti, V.1
Pfaltz, A.2
Kratky, C.3
Eschenmoser, A.4
-
72
-
-
0040066313
-
-
V. Rasetti, K. Hilpert, A. Fässler, A. Pfaltz, A. Eschenmoser, Angew. Chem. 1981, 93, 1108
-
(1981)
Angew. Chem.
, vol.93
, pp. 1108
-
-
Rasetti, V.1
Hilpert, K.2
Fässler, A.3
Pfaltz, A.4
Eschenmoser, A.5
-
77
-
-
0039213730
-
-
in (Eds.: B. Zagalak, W. Friedrich), Walter de Gruyter, Berlin, .
-
12 (Eds.:, B. Zagalak, W. Friedrich,), Walter de Gruyter, Berlin, 1979, pp. 37-87.
-
(1979)
12
, pp. 37-87
-
-
Woodward, R.B.1
-
80
-
-
84986381122
-
-
G. Ksander, G. Bold, R. Lattmann, C. Lehmann, T. Früh, Y.-B. Xiang, K. Inomata, H. P. Buser, J. Schreiber, E. Zass, A. Eschenmoser, Helv. Chim. Acta 1987, 70, 1115.
-
(1987)
Helv. Chim. Acta
, vol.70
, pp. 1115
-
-
Ksander, G.1
Bold, G.2
Lattmann, R.3
Lehmann, C.4
Früh, T.5
Xiang, Y.-B.6
Inomata, K.7
Buser, H.P.8
Schreiber, J.9
Zass, E.10
Eschenmoser, A.11
-
81
-
-
0004690018
-
-
J. E. Johansen, V. Piermattie, C. Angst, E. Diener, C. Kratky, A. Eschenmoser, Angew. Chem. 1981, 93, 273
-
(1981)
Angew. Chem.
, vol.93
, pp. 273
-
-
Johansen, J.E.1
Piermattie, V.2
Angst, C.3
Diener, E.4
Kratky, C.5
Eschenmoser, A.6
-
86
-
-
33745163521
-
-
A. P. Johnson, P. Wehrli, R. Fletcher, A. Eschenmoser, Angew. Chem. 1968, 80, 622
-
(1968)
Angew. Chem.
, vol.80
, pp. 622
-
-
Johnson, A.P.1
Wehrli, P.2
Fletcher, R.3
Eschenmoser, A.4
-
88
-
-
84981932226
-
-
P. M. Müller, S. Farooq, B. Hardegger, W. S. Salmond, A. Eschenmoser, Angew. Chem. 1973, 85, 914
-
(1973)
Angew. Chem.
, vol.85
, pp. 914
-
-
Müller, P.M.1
Farooq, S.2
Hardegger, B.3
Salmond, W.S.4
Eschenmoser, A.5
-
90
-
-
0001544861
-
-
C. Kratky, R. Waditschatka, C. Angst, J. E. Johansen, J. C. Plaquevent, J. Schreiber, A. Eschenmoser, Helv. Chim. Acta 1985, 68, 1312.
-
(1985)
Helv. Chim. Acta
, vol.68
, pp. 1312
-
-
Kratky, C.1
Waditschatka, R.2
Angst, C.3
Johansen, J.E.4
Plaquevent, J.C.5
Schreiber, J.6
Eschenmoser, A.7
-
91
-
-
0004726370
-
-
Diss. ETH Zürich, Nr. 9458, 1991. In this thesis are incorporated the experimental contributions of Günter Bartels (postdoctorate 1980-1981) and Rolf Nussberger (PhD student, deceased 21.7.1985)
-
12 durch Nukleotidierung von Cobyrinsäure-heptakis(cyanmethyl) ester", Diss. ETH Zürich, Nr. 9458, 1991. In this thesis are incorporated the experimental contributions of Günter Bartels (postdoctorate 1980-1981) and Rolf Nussberger (PhD student, deceased 21.7.1985).
-
12 Durch Nukleotidierung von Cobyrinsäure-heptakis(cyanmethyl)ester
-
-
Kreppelt, F.1
-
92
-
-
77954837038
-
-
12 are described in
-
12 are described in: (, P. Butler, M.-O. Ebert, A. Lyskowski, K. Gruber, C. Kratky, B. Kräutler, Angew. Chem. 2006, 118, 1004
-
(2006)
Angew. Chem.
, vol.118
, pp. 1004
-
-
Butler, P.1
Ebert, M.-O.2
Lyskowski, A.3
Gruber, K.4
Kratky, C.5
Kräutler, B.6
-
96
-
-
77956946089
-
-
S. Murtaza, M. Ruetz, K. Gruber, B. Kräutler, Chem. Eur. J. 2010, 16, 10984).
-
(2010)
Chem. Eur. J.
, vol.16
, pp. 10984
-
-
Murtaza, S.1
Ruetz, M.2
Gruber, K.3
Kräutler, B.4
-
98
-
-
0001262182
-
-
F. Blanche, B. Cameron, J. Crouzet, L. Debussche, D. Thibaut, M. Vuilhorgne, F. J. Leeer, A. R. Battersby, Angew. Chem. 1995, 107, 421
-
(1995)
Angew. Chem.
, vol.107
, pp. 421
-
-
Blanche, F.1
Cameron, B.2
Crouzet, J.3
Debussche, L.4
Thibaut, D.5
Vuilhorgne, M.6
Leeer, F.J.7
Battersby, A.R.8
-
106
-
-
34848859501
-
-
G. L. Holliday, J. M. Thorton, A. Marquet, A. G. Smith, F. Rébeillé, R. Mendel, H. L. Schubert, A. D. Lawrence, M. J. Warren, Nat. Prod. Rep. 2007, 24, 972.
-
(2007)
Nat. Prod. Rep.
, vol.24
, pp. 972
-
-
Holliday, G.L.1
Thorton, J.M.2
Marquet, A.3
Smith, A.G.4
Rébeillé, F.5
Mendel, R.6
Schubert, H.L.7
Lawrence, A.D.8
Warren, M.J.9
-
107
-
-
0004691075
-
-
R. Waditschatka, E. Diener, A. Eschenmoser, Angew. Chem. 1983, 95, 641
-
(1983)
Angew. Chem.
, vol.95
, pp. 641
-
-
Waditschatka, R.1
Diener, E.2
Eschenmoser, A.3
-
109
-
-
84255201460
-
-
C. Leumann, K. Hilpert, J. Schreiber, A. Eschenmoser, J. Chem. Soc. Chem. Commun. 1983, 1401.
-
(1983)
J. Chem. Soc. Chem. Commun.
, pp. 1401
-
-
Leumann, C.1
Hilpert, K.2
Schreiber, J.3
Eschenmoser, A.4
-
110
-
-
0001538398
-
-
Polynucleotide Replication and the Origin of Life"
-
R. E. Eakin, Proc. Natl. Acad. Sci. USA 1963, 49, 360; "Polynucleotide Replication and the Origin of Life"
-
(1963)
Proc. Natl. Acad. Sci. USA
, vol.49
, pp. 360
-
-
Eakin, R.E.1
-
111
-
-
3042814685
-
-
in (Eds.: A. P. Kimball, J. Oro), North-Holland, Amsterdam
-
L. E. Orgel, J. E. Sulston, in Prebiotic and Biochemical Evolution (Eds.:, A. P. Kimball, J. Oro,), North-Holland, Amsterdam, 1971, pp. 89-94
-
(1971)
Prebiotic and Biochemical Evolution
, pp. 89-94
-
-
Orgel, L.E.1
Sulston, J.E.2
-
113
-
-
84255209531
-
-
H. von Dobeneck, B. Hansen, E. Vollmann, Z. Naturforsch. B 1972, 27, 922.
-
(1972)
Z. Naturforsch. B
, vol.27
, pp. 922
-
-
Von Dobeneck, H.1
Hansen, B.2
Vollmann, E.3
-
116
-
-
0015542241
-
-
A. I. Scott, A. Townsend, K. Okada, M. Kajiwara, Trans. N. Y. Acad. Sci. 1973, 35, 72
-
(1973)
Trans. N. Y. Acad. Sci.
, vol.35
, pp. 72
-
-
Scott, A.I.1
Townsend, A.2
Okada, K.3
Kajiwara, M.4
-
120
-
-
78650436322
-
-
J. S. Lindsey, V. Chandrashaker, M. Taniguchi, M. Ptasek, New J. Chem. 2011, 35, 65.
-
(2011)
New J. Chem.
, vol.35
, pp. 65
-
-
Lindsey, J.S.1
Chandrashaker, V.2
Taniguchi, M.3
Ptasek, M.4
-
121
-
-
0041750934
-
-
S. I. Beale, M. H. Gold, S. Granick, Phytochemistry 1979, 18, 441.
-
(1979)
Phytochemistry
, vol.18
, pp. 441
-
-
Beale, S.I.1
Gold, M.H.2
Granick, S.3
-
124
-
-
84255189395
-
-
C. Lehmann, B. Schweizer, C. Leumann, A. Eschenmoser, Helv. Chim. Acta 1997, 80, 1412.
-
(1997)
Helv. Chim. Acta
, vol.80
, pp. 1412
-
-
Lehmann, C.1
Schweizer, B.2
Leumann, C.3
Eschenmoser, A.4
-
133
-
-
0018665618
-
-
P. Schönheit, J. Moll, R. K. Thauer, Arch. Microbiol. 1979, 123, 105
-
(1979)
Arch. Microbiol.
, vol.123
, pp. 105
-
-
Schönheit, P.1
Moll, J.2
Thauer, R.K.3
-
134
-
-
0018936162
-
-
G. Diekert, B. Klee, R. K. Thauer, Arch. Microbiol. 1980, 124, 103.
-
(1980)
Arch. Microbiol.
, vol.124
, pp. 103
-
-
Diekert, G.1
Klee, B.2
Thauer, R.K.3
-
135
-
-
84985062134
-
-
A. Pfaltz, B. Jaun, A. Fässler, A. Eschenmoser, R. Jaenchen, H. H. Gilles, G. Diekert, R. K. Thauer, Helv. Chim. Acta 1982, 65, 828
-
(1982)
Helv. Chim. Acta
, vol.65
, pp. 828
-
-
Pfaltz, A.1
Jaun, B.2
Fässler, A.3
Eschenmoser, A.4
Jaenchen, R.5
Gilles, H.H.6
Diekert, G.7
Thauer, R.K.8
-
136
-
-
84986382856
-
-
D. A. Livingston, A. Pfaltz, J. Schreiber, A. Eschenmoser, D. Ankel-Fuchs, J. Moll, R. Jaenchen, R. K. Thauer, Helv. Chim. Acta 1984, 67, 334
-
(1984)
Helv. Chim. Acta
, vol.67
, pp. 334
-
-
Livingston, D.A.1
Pfaltz, A.2
Schreiber, J.3
Eschenmoser, A.4
Ankel-Fuchs, D.5
Moll, J.6
Jaenchen, R.7
Thauer, R.K.8
-
137
-
-
84855663559
-
-
A. Fässler, A. Kobelt, A. Pfaltz, A. Eschenmoser, C. Bladon, A. R. Battersby, R. K. Thauer, Helv. Chim. Acta 1985, 68, 2287.
-
(1985)
Helv. Chim. Acta
, vol.68
, pp. 2287
-
-
Fässler, A.1
Kobelt, A.2
Pfaltz, A.3
Eschenmoser, A.4
Bladon, C.5
Battersby, A.R.6
Thauer, R.K.7
-
138
-
-
84949116644
-
-
G. Färber, W. Keller, C. Kratky, B. Jaun, S. Spinner, A. Kobelt, A. Eschenmoser, Helv. Chim. Acta 1991, 74, 697.
-
(1991)
Helv. Chim. Acta
, vol.74
, pp. 697
-
-
Färber, G.1
Keller, W.2
Kratky, C.3
Jaun, B.4
Spinner, S.5
Kobelt, A.6
Eschenmoser, A.7
-
139
-
-
37049106309
-
-
A. Fässler, A. Pfaltz, B. Kräutler, A. Eschenmoser, J. Chem. Soc. Chem. Commun. 1984, 1365
-
(1984)
J. Chem. Soc. Chem. Commun.
, pp. 1365
-
-
Fässler, A.1
Pfaltz, A.2
Kräutler, B.3
Eschenmoser, A.4
-
140
-
-
37049101768
-
-
C. Kratky, A. Fässler, A. Pfaltz, B. Kräutler, B. Jaun, A. Eschenmoser, J. Chem. Soc. Chem. Commun. 1984, 1368.
-
(1984)
J. Chem. Soc. Chem. Commun.
, pp. 1368
-
-
Kratky, C.1
Fässler, A.2
Pfaltz, A.3
Kräutler, B.4
Jaun, B.5
Eschenmoser, A.6
-
141
-
-
77953222884
-
-
S. Scheller, M. Goenrich, R. Boecher, R. K. Thauer, B. Jaun, Nature 2010, 465, 606
-
(2010)
Nature
, vol.465
, pp. 606
-
-
Scheller, S.1
Goenrich, M.2
Boecher, R.3
Thauer, R.K.4
Jaun, B.5
-
142
-
-
84255201455
-
-
S. Scheller, M. Goenrich, S. Mayr, R. K. Thauer, B. Jaun, Angew. Chem. 2010, 122, 8289
-
(2010)
Angew. Chem.
, vol.122
, pp. 8289
-
-
Scheller, S.1
Goenrich, M.2
Mayr, S.3
Thauer, R.K.4
Jaun, B.5
-
146
-
-
0023785307
-
-
A. Lazcano, R. Guerrero, L. Margulis, J. Oro, J. Mol. Evol. 1988, 27, 283.
-
(1988)
J. Mol. Evol.
, vol.27
, pp. 283
-
-
Lazcano, A.1
Guerrero, R.2
Margulis, L.3
Oro, J.4
-
147
-
-
0002622819
-
-
Prospects for Understanding the Origin of the RNA World", in (Eds.: R. F. Gesteland, T. R. Cech, J. F. Atkins), Cold Spring Harbor Laboratory Press, Plainview, .
-
"Prospects for Understanding the Origin of the RNA World", G. F. Joyce, L. E. Orgel, in The RNA World, 2nd ed. (Eds.:, R. F. Gesteland, T. R. Cech, J. F. Atkins,), Cold Spring Harbor Laboratory Press, Plainview, 1999, pp. 49.
-
(1999)
The RNA World, 2nd Ed.
, pp. 49
-
-
Joyce, G.F.1
Orgel, L.E.2
-
148
-
-
79959926535
-
-
D. Müller, S. Pitsch, A. Kittaka, E. Wagner, C. E. Wintner, A. Eschenmoser, Helv. Chim. Acta 1990, 73, 1410.
-
(1990)
Helv. Chim. Acta
, vol.73
, pp. 1410
-
-
Müller, D.1
Pitsch, S.2
Kittaka, A.3
Wagner, E.4
Wintner, C.E.5
Eschenmoser, A.6
-
150
-
-
77953587668
-
-
cf. a summary of literature referring to the "formose reaction" in ref. [60].
-
A. Butlerow, Justus Liebigs Ann. Chem. 1861, 120, 295; cf. a summary of literature referring to the "formose reaction" in ref. [60].
-
(1861)
Justus Liebigs Ann. Chem.
, vol.120
, pp. 295
-
-
Butlerow, A.1
-
152
-
-
49049130810
-
-
P. Decker, H. Schweer, R. Pohlmann, J. Chromatogr. 1982, 244, 281.
-
(1982)
J. Chromatogr.
, vol.244
, pp. 281
-
-
Decker, P.1
Schweer, H.2
Pohlmann, R.3
-
156
-
-
84255209528
-
-
A. Ricardo, M. A. Carrigan, A. N. Olcott, S. A. Benner, Science 2004, 303, 165
-
(2004)
Science
, vol.303
, pp. 165
-
-
Ricardo, A.1
Carrigan, M.A.2
Olcott, A.N.3
Benner, S.A.4
-
157
-
-
27544516414
-
-
Vgl. auch
-
Q. Li, A. Ricardo, S. A. Benner, J. D. Winefordner D. H. Powell, Anal. Chem. 2005, 77, 4503. Vgl. auch
-
(2005)
Anal. Chem.
, vol.77
, pp. 4503
-
-
Li, Q.1
Ricardo, A.2
Benner, S.A.3
Powell, J.D.W.D.H.4
-
159
-
-
55349085086
-
-
A. F. Amaral, M. M. Marques, J. A. L. da Silva, J. J. F. Frausto da Silva, New J. Chem. 2008, 32, 2043
-
(2008)
New J. Chem.
, vol.32
, pp. 2043
-
-
Amaral, A.F.1
Marques, M.M.2
Da Silva, J.A.L.3
Da Silva, J.J.F.F.4
-
161
-
-
0004312524
-
-
Verlag Helvetica Chimica Acta, Basel, p.
-
G. Quinkert, E. Egert, C. Griesinger, Apekte der Organischen Chemie-Struktur, Verlag Helvetica Chimica Acta, Basel, 1995, p. 102
-
(1995)
Apekte der Organischen Chemie - Struktur
, pp. 102
-
-
Quinkert, G.1
Egert, E.2
Griesinger, C.3
-
162
-
-
0004000417
-
-
Verlag Helvetica Chimica Acta, Basel, p. .
-
G. Quinkert, E. Egert, C. Griesinger, Apects in Organic Chemistry-Structure, Verlag Helvetica Chimica Acta, Basel, 1996, p. 101.
-
(1996)
Apects in Organic Chemistry-Structure
, pp. 101
-
-
Quinkert, G.1
Egert, E.2
Griesinger, C.3
-
163
-
-
0024857066
-
-
K. Kuma, B. Gedulin, B. Paplawski, G. Arrhenius, Origins Life Evol. Biosphere 1989, 19, 573.
-
(1989)
Origins Life Evol. Biosphere
, vol.19
, pp. 573
-
-
Kuma, K.1
Gedulin, B.2
Paplawski, B.3
Arrhenius, G.4
-
164
-
-
0029347777
-
-
S. Pitsch, A. Eschenmoser, H. Gedulin, S. Hui, G. Arrhenius, Origins Life Evol. Biosphere 1995, 25, 297.
-
(1995)
Origins Life Evol. Biosphere
, vol.25
, pp. 297
-
-
Pitsch, S.1
Eschenmoser, A.2
Gedulin, H.3
Hui, S.4
Arrhenius, G.5
-
165
-
-
0033102305
-
-
R. Krishnamurthy, S. Pitsch, G. Arrhenius, Origins Life Evol. Biosphere 1999, 29, 139.
-
(1999)
Origins Life Evol. Biosphere
, vol.29
, pp. 139
-
-
Krishnamurthy, R.1
Pitsch, S.2
Arrhenius, G.3
-
166
-
-
0025697732
-
-
S. Drenkard, J. Ferris, A. Eschenmoser, Helv. Chim. Acta 1990, 73, 1373
-
(1990)
Helv. Chim. Acta
, vol.73
, pp. 1373
-
-
Drenkard, S.1
Ferris, J.2
Eschenmoser, A.3
-
167
-
-
0000668728
-
-
E. Wagner, Y.-B. Xiang, K. Baumann, J. Gück, A. Eschenmoser, Helv. Chim. Acta 1990, 73, 1391
-
(1990)
Helv. Chim. Acta
, vol.73
, pp. 1391
-
-
Wagner, E.1
Xiang, Y.-B.2
Baumann, K.3
Gück, J.4
Eschenmoser, A.5
-
168
-
-
84987350023
-
-
Y.-B. Xiang, S. Drenkard, K. Baumann, D. Hickey, A. Eschenmoser, Helv. Chim. Acta 1994, 77, 2209
-
(1994)
Helv. Chim. Acta
, vol.77
, pp. 2209
-
-
Xiang, Y.-B.1
Drenkard, S.2
Baumann, K.3
Hickey, D.4
Eschenmoser, A.5
-
169
-
-
0030112242
-
-
J. E. Dickens, W. M. Irvine, M. Ohishi, G. Arrhenius, S. Pitsch, A. Bauder, F. Müller, A. Eschenmoser, Origins Life Evol. Biosphere 1996, 26, 97.
-
(1996)
Origins Life Evol. Biosphere
, vol.26
, pp. 97
-
-
Dickens, J.E.1
Irvine, W.M.2
Ohishi, M.3
Arrhenius, G.4
Pitsch, S.5
Bauder, A.6
Müller, F.7
Eschenmoser, A.8
-
170
-
-
84985569717
-
-
vgl. auch
-
S. Pitsch, E. Pombo-Villar, A. Eschenmoser, Helv. Chim. Acta 1994, 77, 2251; vgl. auch
-
(1994)
Helv. Chim. Acta
, vol.77
, pp. 2251
-
-
Pitsch, S.1
Pombo-Villar, E.2
Eschenmoser, A.3
-
172
-
-
84855685856
-
-
[71]
-
[71]
-
-
-
-
173
-
-
84255201456
-
-
Cf. the literature survey in ref. [81].
-
Cf. the literature survey in ref. [81].
-
-
-
-
174
-
-
84943860683
-
-
In the context of attempts made at TSO to achieve a direct phosphorylation of glycolaldehyde with cyclo-triphosphate, R. Krishnamurthy had made a literature search on phosphorylations by this reagent and thereby encountered the work of Quimby and Feldmann (see below) on the ammonolysis of cyclotriphosphate to amidotriphosphate. Later at TSRO, it was our awareness of the existence of this work that inspired recognition and subsequent experimental testing of the concept of intramolecular phosphorylation as depicted in Figure 20.
-
In the context of attempts made at TSO to achieve a direct phosphorylation of glycolaldehyde with cyclo-triphosphate, R. Krishnamurthy had made a literature search on phosphorylations by this reagent and thereby encountered the work of Quimby and Feldmann (see below) on the ammonolysis of cyclotriphosphate to amidotriphosphate. Later at TSRO, it was our awareness of the existence of this work that inspired recognition and subsequent experimental testing of the concept of intramolecular phosphorylation as depicted in Figure 20., O. T. Quimby, T. J. Flautt, Z. Anorg. Allg. Chem. 1958, 296, 220
-
(1958)
Z. Anorg. Allg. Chem.
, vol.296
, pp. 220
-
-
Quimby, O.T.1
Flautt, T.J.2
-
176
-
-
0032881815
-
-
R. Krishnamurthy, G. Arrhenius, A. Eschenmoser, Origins Life Evol. Biosphere 1999, 29, 333.
-
(1999)
Origins Life Evol. Biosphere
, vol.29
, pp. 333
-
-
Krishnamurthy, R.1
Arrhenius, G.2
Eschenmoser, A.3
-
177
-
-
0038713839
-
-
R. Krishnamurthy, S. Guntha, A. Eschenmoser, Angew. Chem. 2000, 112, 2369
-
(2000)
Angew. Chem.
, vol.112
, pp. 2369
-
-
Krishnamurthy, R.1
Guntha, S.2
Eschenmoser, A.3
-
183
-
-
0004403736
-
-
Kon-Tiki-Experimente zur Frage nach dem Ursprung von Biomolekü len" in (Eds.: W. Gerok et al.), Wiss. Verlagsges. Stuttgart, , Verh. Ges. Dtsch. Naturforsch. Aerzte, 116. Vers. Berlin, 1990; "Warum Pentose- und nicht Hexose-Nukleinsäuren?"
-
"Kon-Tiki-Experimente zur Frage nach dem Ursprung von Biomolekülen", A. Eschenmoser, in Materie und Prozesse. Vom Elementaren zum Komplexen (Eds.:, W. Gerok et al.,), Wiss. Verlagsges., Stuttgart, 1991, pp. 135, Verh. Ges. Dtsch. Naturforsch. Aerzte, 116. Vers. Berlin, 1990; "Warum Pentose- und nicht Hexose-Nukleinsäuren?"
-
(1991)
Materie und Prozesse. Vom Elementaren Zum Komplexen
, pp. 135
-
-
Eschenmoser, A.1
-
184
-
-
0012732487
-
-
(the date of the lecture mentioned in the editor's preface is a misprint, and should read Nov. 9, 1990); "Chemie potentiell präbiologischer Naturstoffe"
-
A. Eschenmoser, Nachr. Chem. Tech. Lab. 1991, 39, 795 (the date of the lecture mentioned in the editor's preface is a misprint, and should read Nov. 9, 1990); "Chemie potentiell präbiologischer Naturstoffe"
-
(1991)
Nachr. Chem. Tech. Lab.
, vol.39
, pp. 795
-
-
Eschenmoser, A.1
-
185
-
-
84987501483
-
-
(English version, ref. [126]).
-
A. Eschenmoser, Nova Acta Leopoldina 1992, 67, 201-233 (English version, ref. [126]).
-
(1992)
Nova Acta Leopoldina
, vol.67
, pp. 201-233
-
-
Eschenmoser, A.1
-
186
-
-
0026537060
-
-
see also the supplement in ref. [98], footnote 17 on p. 1448, as well as in ref. [99], Scheme 19 on p. 340.
-
A. Eschenmoser, M. Dobler, Helv. Chim. Acta 1992, 75, 218; see also the supplement in ref. [98], footnote 17 on p. 1448, as well as in ref. [99], Scheme 19 on p. 340.
-
(1992)
Helv. Chim. Acta
, vol.75
, pp. 218
-
-
Eschenmoser, A.1
Dobler, M.2
-
187
-
-
75449111907
-
-
In this context, see also the theoretical models published at the outset of Herdewijn's involvement in the chemistry of the pyranose forms of nucleic acids:, 838, 1693, 2245.
-
In this context, see also the theoretical models published at the outset of Herdewijn's involvement in the chemistry of the pyranose forms of nucleic acids:, H. L. De Winter, N. M. Blaton, O. M. Peeters, C. J. De Ranter, A. Van Aerschot, P. Herdewijn, Acta Crystallogr. Sect. C 1991, 47, 835, 838, 1693, 2245.
-
(1991)
Acta Crystallogr. Sect. C
, vol.47
, pp. 835
-
-
De Winter, H.L.1
Blaton, N.M.2
Peeters, O.M.3
De Ranter, C.J.4
Van Aerschot, A.5
Herdewijn, P.6
-
189
-
-
33846105274
-
-
Fifty Years with Double-Stranded RNA
-
"Fifty Years with Double-Stranded RNA":, A. Rich, Scientist 2006, 34.
-
(2006)
Scientist
, pp. 34
-
-
Rich, A.1
-
190
-
-
0343065617
-
-
S. K. Singh, P. Nielsen, A. A. Koshkin, J. Wengel, Chem. Commun. 1998, 455
-
(1998)
Chem. Commun.
, pp. 455
-
-
Singh, S.K.1
Nielsen, P.2
Koshkin, A.A.3
Wengel, J.4
-
191
-
-
0032561794
-
-
vgl. auch
-
A. A. Koshkin, P. Nielsen, M. Meldgard, V. K. Rajwanshi, S. K. Singh, J. Wengel, J. Am. Chem. Soc. 1998, 120, 13252; vgl. auch
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 13252
-
-
Koshkin, A.A.1
Nielsen, P.2
Meldgard, M.3
Rajwanshi, V.K.4
Singh, S.K.5
Wengel, J.6
-
192
-
-
0030862285
-
-
S. Obika, D. Nanbu, Y. Hari, K. Morio, Y. In, T. Ishida, T. Imanishi, Tetrahedron Lett. 1997, 38, 8735
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 8735
-
-
Obika, S.1
Nanbu, D.2
Hari, Y.3
Morio, K.4
In, Y.5
Ishida, T.6
Imanishi, T.7
-
193
-
-
0032560835
-
-
S. Obika, D. Nanbu, Y. Hari, J. Andoh, K. Morio, T. Doi, T. Imanishi, Tetrahedron Lett. 1998, 39, 5401.
-
(1998)
Tetrahedron Lett.
, vol.39
, pp. 5401
-
-
Obika, S.1
Nanbu, D.2
Hari, Y.3
Andoh, J.4
Morio, K.5
Doi, T.6
Imanishi, T.7
-
194
-
-
0000703994
-
-
A. Van Aerschot, O. Verheggen, C. Hendrix, P. Herdewijn, Angew. Chem. 1995, 107, 1483
-
(1995)
Angew. Chem.
, vol.107
, pp. 1483
-
-
Van Aerschot, A.1
Verheggen, O.2
Hendrix, C.3
Herdewijn, P.4
-
196
-
-
0026641180
-
-
A. Augustyns, F. Vandendriessche, A. Van Aerschot, R. Busson, C. Urbanke, P. Herdewijn, Nucleic Acids Res. 1992, 20, 4711
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 4711
-
-
Augustyns, A.1
Vandendriessche, F.2
Van Aerschot, A.3
Busson, R.4
Urbanke, C.5
Herdewijn, P.6
-
197
-
-
0037065662
-
-
R. Declercq, A. Van Aerschot, R. J. Read, P. Herdewijn, L. Van Meervelt, J. Am. Chem. Soc. 2002, 124, 928.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 928
-
-
Declercq, R.1
Van Aerschot, A.2
Read, R.J.3
Herdewijn, P.4
Van Meervelt, L.5
-
198
-
-
0027724746
-
-
G. Otting, M. Billeter, K. Wüthrich, H.-J. Roth, C. Leumann, A. Eschenmoser, Helv. Chim. Acta 1993, 76, 2701.
-
(1993)
Helv. Chim. Acta
, vol.76
, pp. 2701
-
-
Otting, G.1
Billeter, M.2
Wüthrich, K.3
Roth, H.-J.4
Leumann, C.5
Eschenmoser, A.6
-
199
-
-
33747792737
-
-
M. Egli, P. S. Pallan, R. Pattanayek, C. J. Wilds, P. Lubini, G. Misanov, M. Dobler, C. Leumann, A. Eschenmoser, J. Am. Chem. Soc. 2006, 128, 10847.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 10847
-
-
Egli, M.1
Pallan, P.S.2
Pattanayek, R.3
Wilds, C.J.4
Lubini, P.5
Misanov, G.6
Dobler, M.7
Leumann, C.8
Eschenmoser, A.9
-
200
-
-
84987487305
-
-
M. Böhringer, H.-J. Roth, J. Hunziker, M. Göbel, R. Krishnan, A. Giger, B. Schweizer, J. Schreiber, C. Leumann, A. Eschenmoser, Helv. Chim. Acta 1992, 75, 1416.
-
(1992)
Helv. Chim. Acta
, vol.75
, pp. 1416
-
-
Böhringer, M.1
Roth, H.-J.2
Hunziker, J.3
Göbel, M.4
Krishnan, R.5
Giger, A.6
Schweizer, B.7
Schreiber, J.8
Leumann, C.9
Eschenmoser, A.10
-
201
-
-
84987594005
-
-
J. Hunziker, H.-J. -Roth, M. Böhringer, A. Giger, U. Diederichsen, M. Göbel, R. Krishnan, B. Jaun, C. Leumann, A. Eschenmoser, Helv. Chim. Acta 1993, 76, 259.
-
(1993)
Helv. Chim. Acta
, vol.76
, pp. 259
-
-
Hunziker, J.1
Roth, H.-J.2
Böhringer, M.3
Giger, A.4
Diederichsen, U.5
Göbel, M.6
Krishnan, R.7
Jaun, B.8
Leumann, C.9
Eschenmoser, A.10
-
202
-
-
0000242653
-
-
K. Groebke, J. Hunziker, W. Fraser, L. Peng, U. Diederichsen, K. Zimmermann, A. Holzner, C. Leumann, A. Eschenmoser, Helv. Chim. Acta 1998, 81, 375.
-
(1998)
Helv. Chim. Acta
, vol.81
, pp. 375
-
-
Groebke, K.1
Hunziker, J.2
Fraser, W.3
Peng, L.4
Diederichsen, U.5
Zimmermann, K.6
Holzner, A.7
Leumann, C.8
Eschenmoser, A.9
-
206
-
-
84855660279
-
-
Diss. ETH Zürich, Nr. 10149, 1993. For a recent publication dealing with Watson-Crick purine-purine pairing in the DNA series cf.
-
K. Groebke, "Ueber Purin-Purin-Paarungen bei Hexopyranose- Nukleisäuren", Diss. ETH Zürich, Nr. 10149, 1993. For a recent publication dealing with Watson-Crick purine-purine pairing in the DNA series cf.
-
Ueber Purin-Purin-Paarungen Bei Hexopyranose-Nukleisäuren
-
-
Groebke, K.1
-
208
-
-
84987491049
-
-
M. Tarköy, M. Bolli, B. Schweizer, C. Leumann, Helv. Chim. Acta 1993, 76, 481
-
(1993)
Helv. Chim. Acta
, vol.76
, pp. 481
-
-
Tarköy, M.1
Bolli, M.2
Schweizer, B.3
Leumann, C.4
-
212
-
-
85004699062
-
-
In one of his reviews (ref. [107]), Herdewijn referred to "conformationally constrained oligonucleotides that were first studied by M. Ikehara". However, those studies did not relate to pre-organization of an oligonucleotide backbone.
-
In one of his reviews (ref. [107]), Herdewijn referred to "conformationally constrained oligonucleotides that were first studied by M. Ikehara" (, M. Ikehara, S. Uesugi, T. Shida, Chem. Pharm. Bull. 1980, 28, 189). However, those studies did not relate to pre-organization of an oligonucleotide backbone.
-
(1980)
Chem. Pharm. Bull.
, vol.28
, pp. 189
-
-
Ikehara, M.1
Uesugi, S.2
Shida, T.3
-
213
-
-
84988073690
-
-
K. Augustyns, A. Van Aerschot, C. Urbanke, P. Herdewijn, Bull. Soc. Chim. Belg. 1992, 101, 119.
-
(1992)
Bull. Soc. Chim. Belg.
, vol.101
, pp. 119
-
-
Augustyns, K.1
Van Aerschot, A.2
Urbanke, C.3
Herdewijn, P.4
-
216
-
-
0035802936
-
-
M. Froeyen, E. Lescrenier, L. Kerremans, H. Rosemeyer, F. Seela, B. Verbeure, I. Lagoja, J. Rozenski, A. Van Aerschot, R. Busson, P. Herdewijn, Chem. Eur. J. 2001, 7, 5183.
-
(2001)
Chem. Eur. J.
, vol.7
, pp. 5183
-
-
Froeyen, M.1
Lescrenier, E.2
Kerremans, L.3
Rosemeyer, H.4
Seela, F.5
Verbeure, B.6
Lagoja, I.7
Rozenski, J.8
Van Aerschot, A.9
Busson, R.10
Herdewijn, P.11
-
217
-
-
0038239273
-
-
(review)
-
E. Lescrinier, M. Froeyen, P. Herdewijn, Nucleic Acids Res. 2003, 31, 2975 (review)
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 2975
-
-
Lescrinier, E.1
Froeyen, M.2
Herdewijn, P.3
-
218
-
-
33845948585
-
-
K. Nauwelaerts, E. Lescrenier, P. Herdewijn, Chem. Eur. J. 2007, 13, 90.
-
(2007)
Chem. Eur. J.
, vol.13
, pp. 90
-
-
Nauwelaerts, K.1
Lescrenier, E.2
Herdewijn, P.3
-
219
-
-
0012426268
-
-
(review).
-
C. Leumann, Chimia 2001, 55, 295 (review).
-
(2001)
Chimia
, vol.55
, pp. 295
-
-
Leumann, C.1
-
223
-
-
0002722186
-
-
C. R. Noe, M. Knollmüller, P. Ettmayer, J. Freissmuth, Liebigs Ann. Chem. 1994, 611.
-
(1994)
Liebigs Ann. Chem.
, pp. 611
-
-
Noe, C.R.1
Knollmüller, M.2
Ettmayer, P.3
Freissmuth, J.4
-
224
-
-
84255201453
-
-
R. W. Fischer, A. G. Helg, K. Groebke, U. Diederichsen, A. Giger, R. Hammer, R. Krishnamurthy, C. Miculka, P. Seiler, B. Jaun, S. Pitsch, C. Leumann, A. Eschenmoser, unpublished.
-
R. W. Fischer, A. G. Helg, K. Groebke, U. Diederichsen, A. Giger, R. Hammer, R. Krishnamurthy, C. Miculka, P. Seiler, B. Jaun, S. Pitsch, C. Leumann, A. Eschenmoser, unpublished.
-
-
-
-
228
-
-
0345896680
-
-
Diss. ETH Zürich, Nr. 9975
-
A. Giger, "Untersuchungen über Oligonukleotide mit 2-Deoxy- D -ribose, 2,3-Dideox- D -Glucopyranose und D -Allopyranose als Zuckerbausteine", Diss. ETH Zürich, Nr. 9975, 1992.
-
(1992)
Untersuchungen Über Oligonukleotide Mit 2-Deoxy- D -ribose, 2,3-Dideox- D -Glucopyranose und D -Allopyranose Als Zuckerbausteine
-
-
Giger, A.1
-
231
-
-
0038500616
-
-
Chemistry of Potentially Prebiological Natural Products"
-
"Chemistry of Potentially Prebiological Natural Products":, A. Eschenmoser, E. Loewenthal, Chem. Soc. Rev. 1992, 21, 1
-
(1992)
Chem. Soc. Rev.
, vol.21
, pp. 1
-
-
Eschenmoser, A.1
Loewenthal, E.2
-
233
-
-
0004449881
-
-
Hexose Nucleic Acids
-
"Hexose Nucleic Acids":, A. Eschenmoser, Pure Appl. Chem. 1993, 65, 1179.
-
(1993)
Pure Appl. Chem.
, vol.65
, pp. 1179
-
-
Eschenmoser, A.1
-
234
-
-
0001361409
-
-
Towards a Chemical Etiology of the Natural Nucleic Acids Structure": in (Eds.: C. Chatgilialoglu, V. Snieckus), Kluwer, Dordrecht, (NATO ASI Ser. Ser. E, 320).
-
Towards a Chemical Etiology of the Natural Nucleic Acids Structure":, A. Eschenmoser, in Chemical Synthesis: Gnosis to Prognosis (Eds.:, C. Chatgilialoglu, V. Snieckus,), Kluwer, Dordrecht, 1996, 293 (NATO ASI Ser. Ser. E, Vol. 320).
-
(1996)
Chemical Synthesis: Gnosis to Prognosis
, pp. 293
-
-
Eschenmoser, A.1
-
235
-
-
0001182323
-
-
H. Moser, A. Fliri, A. Steiger, G. Costello, J. Schreiber, A. Eschenmoser, Helv. Chim. Acta 1986, 69, 1224.
-
(1986)
Helv. Chim. Acta
, vol.69
, pp. 1224
-
-
Moser, H.1
Fliri, A.2
Steiger, A.3
Costello, G.4
Schreiber, J.5
Eschenmoser, A.6
-
236
-
-
84987564724
-
-
S. Pitsch, S. Wendeborn, B. Jaun, A. Eschenmoser, Helv. Chim. Acta 1993, 76, 2161.
-
(1993)
Helv. Chim. Acta
, vol.76
, pp. 2161
-
-
Pitsch, S.1
Wendeborn, S.2
Jaun, B.3
Eschenmoser, A.4
-
237
-
-
84987367507
-
-
S. Pitsch, R. Krishnamurthy, M. Bolli, S. Wendeborn, A. Holzner, M. Minton, C. Lesueur, I. Schlönvogt, B. Jaun, A. Eschenmoser, Helv. Chim. Acta 1995, 78, 1621.
-
(1995)
Helv. Chim. Acta
, vol.78
, pp. 1621
-
-
Pitsch, S.1
Krishnamurthy, R.2
Bolli, M.3
Wendeborn, S.4
Holzner, A.5
Minton, M.6
Lesueur, C.7
Schlönvogt, I.8
Jaun, B.9
Eschenmoser, A.10
-
238
-
-
0000584539
-
-
R. Krishnamurthy, S. Pitsch, M. Minton, C. Miculka, N. Windhab, A. Eschenmoser, Angew. Chem. 1996, 108, 1619
-
(1996)
Angew. Chem.
, vol.108
, pp. 1619
-
-
Krishnamurthy, R.1
Pitsch, S.2
Minton, M.3
Miculka, C.4
Windhab, N.5
Eschenmoser, A.6
-
240
-
-
84855643667
-
-
I. Schlönvogt, S. Pitsch, C. Lesueur, A. Eschenmoser, B. Jaun, R. M. Wolf, Helv. Chim. Acta 1996, 79, 1249.
-
(1996)
Helv. Chim. Acta
, vol.79
, pp. 1249
-
-
Schlönvogt, I.1
Pitsch, S.2
Lesueur, C.3
Eschenmoser, A.4
Jaun, B.5
Wolf, R.M.6
-
241
-
-
0008893163
-
-
R. Micura, M. Bolli, N. Windhab, A. Eschenmoser, Angew. Chem. 1997, 109, 899;
-
(1997)
Angew. Chem.
, vol.109
, pp. 899
-
-
Micura, R.1
Bolli, M.2
Windhab, N.3
Eschenmoser, A.4
-
244
-
-
0030611061
-
-
M. Bolli, R. Micura, A. Eschenmoser, Chem. Biol. 1997, 4, 309.
-
(1997)
Chem. Biol.
, vol.4
, pp. 309
-
-
Bolli, M.1
Micura, R.2
Eschenmoser, A.3
-
245
-
-
0030846261
-
-
M. Bolli, R. Micura, S. Pitsch, A. Eschenmoser, Helv. Chim. Acta 1997, 80, 1901.
-
(1997)
Helv. Chim. Acta
, vol.80
, pp. 1901
-
-
Bolli, M.1
Micura, R.2
Pitsch, S.3
Eschenmoser, A.4
-
246
-
-
0000317999
-
-
R. Micura, R. Kudick, S. Pitsch, A. Eschenmoser, Angew. Chem. 1999, 111, 715
-
(1999)
Angew. Chem.
, vol.111
, pp. 715
-
-
Micura, R.1
Kudick, R.2
Pitsch, S.3
Eschenmoser, A.4
-
248
-
-
0345826095
-
-
S. Pitsch, S. Wendeborn, R. Krishnamurthy, A. Holzner, M. Minton, M. Bolli, C. Miculka, N. Windhab, R. Micura, M. Stanek, B. Jaun, A. Eschenmoser, Helv. Chim. Acta 2003, 86, 4270.
-
(2003)
Helv. Chim. Acta
, vol.86
, pp. 4270
-
-
Pitsch, S.1
Wendeborn, S.2
Krishnamurthy, R.3
Holzner, A.4
Minton, M.5
Bolli, M.6
Miculka, C.7
Windhab, N.8
Micura, R.9
Stanek, M.10
Jaun, B.11
Eschenmoser, A.12
-
249
-
-
0037016632
-
-
S. Ilin, I. Schlönvogt, M.-O. Ebert, B. Jaun, H. Schwalbe, ChemBioChem 2002, 3, 93.
-
(2002)
ChemBioChem
, vol.3
, pp. 93
-
-
Ilin, S.1
Schlönvogt, I.2
Ebert, M.-O.3
Jaun, B.4
Schwalbe, H.5
-
251
-
-
0026634324
-
-
L. E. Orgel, Nature 1992, 358, 203
-
(1992)
Nature
, vol.358
, pp. 203
-
-
Orgel, L.E.1
-
252
-
-
0027746565
-
-
A. R. Hill, L. E. Orgel, T. Wu, Origins Life Evol. Biosphere 1993, 23, 285.
-
(1993)
Origins Life Evol. Biosphere
, vol.23
, pp. 285
-
-
Hill, A.R.1
Orgel, L.E.2
Wu, T.3
-
256
-
-
0015244442
-
-
M. Renz, R. Lohrman, L. E. Orgel, Biochim. Biophys. Acta Nucleic Acids Protein Synth. 1971, 240, 463.
-
(1971)
Biochim. Biophys. Acta Nucleic Acids Protein Synth.
, vol.240
, pp. 463
-
-
Renz, M.1
Lohrman, R.2
Orgel, L.E.3
-
257
-
-
0014932468
-
-
K. L. Agarwal, H. Büchi, M. H. Caruthers, N. Gupta, H. G. Khorana, K. Kleppe, A. Kumar, E. Ohtsuka, U. L. Rajbhandary, J. H. Van de Sande, V. Sgaramella, H. Weber, T. Yamada, Nature 1970, 227, 27.
-
(1970)
Nature
, vol.227
, pp. 27
-
-
Agarwal, K.L.1
Büchi, H.2
Caruthers, M.H.3
Gupta, N.4
Khorana, H.G.5
Kleppe, K.6
Kumar, A.7
Ohtsuka, E.8
Rajbhandary, U.L.9
Sande, J.H.V.D.10
Sgaramella, V.11
Weber, H.12
Yamada, T.13
-
258
-
-
0034131376
-
-
G. Karig, A. Fuchs, A. Büsing, T. Brandstetter, S. Scherer, J. W. Bats, A. Eschenmoser, G. Quinkert, Helv. Chim. Acta 2000, 83, 1049
-
(2000)
Helv. Chim. Acta
, vol.83
, pp. 1049
-
-
Karig, G.1
Fuchs, A.2
Büsing, A.3
Brandstetter, T.4
Scherer, S.5
Bats, J.W.6
Eschenmoser, A.7
Quinkert, G.8
-
259
-
-
0034053710
-
-
H. Schwalbe, J. Wermuth, C. Richter, S. Szalma, A. Eschenmoser, G. Quinkert, Helv. Chim. Acta 2000, 83, 1079.
-
(2000)
Helv. Chim. Acta
, vol.83
, pp. 1079
-
-
Schwalbe, H.1
Wermuth, J.2
Richter, C.3
Szalma, S.4
Eschenmoser, A.5
Quinkert, G.6
-
260
-
-
33744465997
-
-
2′-Deoxy-xylofuranose-NA ("Xylo-DNA")
-
2′-Deoxy-xylofuranose-NA ("Xylo-DNA"):, H. Rosemeyer, M. Krecmerova, F- Seela, Helv. Chim. Acta 1991, 74, 2054
-
(1991)
Helv. Chim. Acta
, vol.74
, pp. 2054
-
-
Rosemeyer, H.1
Krecmerova, M.2
Seela, F.3
-
261
-
-
0029956058
-
-
A. Schöppe, H.-J. Hinz, H. Rosemeyer, Eur. J. Biochem. 1996, 239, 33
-
(1996)
Eur. J. Biochem.
, vol.239
, pp. 33
-
-
Schöppe, A.1
Hinz, H.-J.2
Rosemeyer, H.3
-
262
-
-
0000925777
-
-
cf. also
-
F. Seela, M. Heckel, H. Rosemeyer, Helv. Chim. Acta 1996, 79, 1451); cf. also
-
(1996)
Helv. Chim. Acta
, vol.79
, pp. 1451
-
-
Seela, F.1
Heckel, M.2
Rosemeyer, H.3
-
263
-
-
0038004031
-
-
N. E. Poopeiko, M. Juhl, B. Vester, M. D. Sorensen, J. Wengel, Bioorg. Med. Chem. Lett. 2003, 13, 2285
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 2285
-
-
Poopeiko, N.E.1
Juhl, M.2
Vester, B.3
Sorensen, M.D.4
Wengel, J.5
-
264
-
-
75149136228
-
-
A. Ramaswamy, M. Froeyen, P. Herdewijn, A. Ceulemans, J. Am. Chem. Soc. 2010, 132, 587
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 587
-
-
Ramaswamy, A.1
Froeyen, M.2
Herdewijn, P.3
Ceulemans, A.4
-
266
-
-
0035504940
-
-
A. Y. Denisov, A. M. Noronha, D. J. Wilds, J.-F. Trempe, R. T. Pon, K. Gehring, M. J. Damha, Nucleic Acids Res. 2001, 29, 4284
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 4284
-
-
Denisov, A.Y.1
Noronha, A.M.2
Wilds, D.J.3
Trempe, J.-F.4
Pon, R.T.5
Gehring, K.6
Damha, M.J.7
-
268
-
-
0026572607
-
-
R. Kierzek, L. He, D. H. Turner, Nucleic Acids Res. 1992, 20, 1685
-
(1992)
Nucleic Acids Res.
, vol.20
, pp. 1685
-
-
Kierzek, R.1
He, L.2
Turner, D.H.3
-
270
-
-
3242796597
-
-
B. J. Premraj, S. Raja, N. S. Bhavesh, K. Shi, R. V. Hosur, M. Sundaralingam, N. Ybathindra, Eur. J. Biochem. 2004, 271, 2956
-
(2004)
Eur. J. Biochem.
, vol.271
, pp. 2956
-
-
Premraj, B.J.1
Raja, S.2
Bhavesh, N.S.3
Shi, K.4
Hosur, R.V.5
Sundaralingam, M.6
Ybathindra, N.7
-
271
-
-
0028293103
-
-
anomer of RNA
-
α-anomer of RNA:, F. Debart, G. Tosquellas, B. Rayner, J.-L. Imbach, Bioorg. Med. Chem. Lett. 1994, 4, 1041
-
(1994)
Bioorg. Med. Chem. Lett.
, vol.4
, pp. 1041
-
-
Debart, F.1
Tosquellas, G.2
Rayner, B.3
Imbach, J.-L.4
-
272
-
-
0028235072
-
-
M. J. Damha, P. A. Giannaris, P. Marfey, Biochemistry 1994, 33, 7877
-
(1994)
Biochemistry
, vol.33
, pp. 7877
-
-
Damha, M.J.1
Giannaris, P.A.2
Marfey, P.3
-
273
-
-
84987576460
-
-
(5′→2′)-DNA
-
(5′→2′)-DNA:, J. P. Dougherty, C. J. Rizzo, R. C. Breslow, J. Am. Chem. Soc. 1992, 114, 6254
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 6254
-
-
Dougherty, J.P.1
Rizzo, C.J.2
Breslow, R.C.3
-
275
-
-
0033613846
-
-
M. Beier, F. Reck, T. Wagner, R. Krishnamurthy, A. Eschenmoser, Science 1999, 283, 699.
-
(1999)
Science
, vol.283
, pp. 699
-
-
Beier, M.1
Reck, F.2
Wagner, T.3
Krishnamurthy, R.4
Eschenmoser, A.5
-
276
-
-
0347155565
-
-
M.-O. Ebert, A. Luther, H. K. Huynh, R. Krishnamurthy, A. Eschenmoser, B. Jaun, Helv. Chim. Acta 2002, 85, 4055.
-
(2002)
Helv. Chim. Acta
, vol.85
, pp. 4055
-
-
Ebert, M.-O.1
Luther, A.2
Huynh, H.K.3
Krishnamurthy, R.4
Eschenmoser, A.5
Jaun, B.6
-
277
-
-
0038749594
-
-
O. Jungmann, M. Beier, A. Luther, H. K. Huynh, M.-O. Ebert, B. Jaun, R. Krishnamurthy, A. Eschenmoser, Helv. Chim. Acta 2003, 86, 1259.
-
(2003)
Helv. Chim. Acta
, vol.86
, pp. 1259
-
-
Jungmann, O.1
Beier, M.2
Luther, A.3
Huynh, H.K.4
Ebert, M.-O.5
Jaun, B.6
Krishnamurthy, R.7
Eschenmoser, A.8
-
278
-
-
0033581763
-
-
The relatively strong self-pairing of the non-self-complementary sequences 4′-TATTTTAA and 4′-TTAAAATA observed in all four pentapyranosyl systems shown in Figure 57 is presumably the result of a shift of the reading frame: an "upstream frame-shift" by one unit in both sequences leads to four stabilizing A/T-pairs, three destabilizing T/T- and three A/A-mismatches, as well as one stabilizing base-stacking of a dangling A- and T-base, respectively, at the 2′-ends.
-
O. Jungmann, H. Wippo, M. Stanek, H. K. Huynh, R. Krishnamurthy, A. Eschenmoser, Org. Lett. 1999, 1, 1527. The relatively strong self-pairing of the non-self-complementary sequences 4′-TATTTTAA and 4′-TTAAAATA observed in all four pentapyranosyl systems shown in Figure 57 is presumably the result of a shift of the reading frame: an "upstream frame-shift" by one unit in both sequences leads to four stabilizing A/T-pairs, three destabilizing T/T- and three A/A-mismatches, as well as one stabilizing base-stacking of a dangling A- and T-base, respectively, at the 2′-ends.
-
(1999)
Org. Lett.
, vol.1
, pp. 1527
-
-
Jungmann, O.1
Wippo, H.2
Stanek, M.3
Huynh, H.K.4
Krishnamurthy, R.5
Eschenmoser, A.6
-
279
-
-
0034835910
-
-
H. Wippo, F. Reck, R. Kudick, M. Ramaseshan, G. Ceulemens, M. Bolli, R. Krishnamurthy, A. Eschenmoser, Bioorg. Med. Chem. 2001, 9, 2411.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2411
-
-
Wippo, H.1
Reck, F.2
Kudick, R.3
Ramaseshan, M.4
Ceulemens, G.5
Bolli, M.6
Krishnamurthy, R.7
Eschenmoser, A.8
-
280
-
-
0033581786
-
-
F. Reck, H. Wippo, R. Kudick, M. Bolli, G. Ceulemenas, R. Krishnamurthy, A. Eschenmoser, Org. Lett. 1999, 1, 1531.
-
(1999)
Org. Lett.
, vol.1
, pp. 1531
-
-
Reck, F.1
Wippo, H.2
Kudick, R.3
Bolli, M.4
Ceulemenas, G.5
Krishnamurthy, R.6
Eschenmoser, A.7
-
281
-
-
0034906323
-
-
F. Reck, H. Wippo, R. Kudick, R. Krishnamurthy, A. Eschenmoser, Helv. Chim. Acta 2001, 84, 1778.
-
(2001)
Helv. Chim. Acta
, vol.84
, pp. 1778
-
-
Reck, F.1
Wippo, H.2
Kudick, R.3
Krishnamurthy, R.4
Eschenmoser, A.5
-
282
-
-
0036119469
-
-
T. Wagner, H. K. Huynh, R. Krishnamurthy, A. Eschenmoser, Helv. Chim. Acta 2002, 85, 399.
-
(2002)
Helv. Chim. Acta
, vol.85
, pp. 399
-
-
Wagner, T.1
Huynh, H.K.2
Krishnamurthy, R.3
Eschenmoser, A.4
-
283
-
-
0034680801
-
-
K.-U. Schöning, P. Scholz, S. Guntha, X. Wu, R. Krishnamurthy, A. Eschenmoser, Science 2000, 290, 1347.
-
(2000)
Science
, vol.290
, pp. 1347
-
-
Schöning, K.-U.1
Scholz, P.2
Guntha, S.3
Wu, X.4
Krishnamurthy, R.5
Eschenmoser, A.6
-
284
-
-
0036962077
-
-
K.-U. Schöning, P. Scholz, X. Wu, S. Guntha, G. Delgado, R. Kirshnamurthy, A. Eschenmoser, Helv. Chim. Acta 2002, 85, 4111.
-
(2002)
Helv. Chim. Acta
, vol.85
, pp. 4111
-
-
Schöning, K.-U.1
Scholz, P.2
Wu, X.3
Guntha, S.4
Delgado, G.5
Kirshnamurthy, R.6
Eschenmoser, A.7
-
286
-
-
57349101822
-
-
M.-O. Ebert, C. Mang, R. Krishnamurthy, A. Eschenmoser, B. Jaun, J. Am. Chem. Soc. 2008, 130, 15105.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 15105
-
-
Ebert, M.-O.1
Mang, C.2
Krishnamurthy, R.3
Eschenmoser, A.4
Jaun, B.5
-
288
-
-
2242462219
-
-
C. J. Wilds, Z. Wawrzak, R. Krishnamurthy, A. Eschenmoser, M. Egli, J. Am. Chem. Soc. 2002, 124, 13716
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 13716
-
-
Wilds, C.J.1
Wawrzak, Z.2
Krishnamurthy, R.3
Eschenmoser, A.4
Egli, M.5
-
289
-
-
84255195901
-
-
P. S. Pallan, C. J. Wilds, Z. Wawrzkak, R. Krishnamurthy, A. Eschenmoser, M. Egli, Angew. Chem. 2003, 115, 6073
-
(2003)
Angew. Chem.
, vol.115
, pp. 6073
-
-
Pallan, P.S.1
Wilds, C.J.2
Wawrzkak, Z.3
Krishnamurthy, R.4
Eschenmoser, A.5
Egli, M.6
-
291
-
-
0034680495
-
-
L. E. Orgel, Science 2000, 290, 1306
-
(2000)
Science
, vol.290
, pp. 1306
-
-
Orgel, L.E.1
-
294
-
-
0030699122
-
-
J. G. Schmidt, P. E. Nielsen, L. E. Orgel, Nucleic Acids Res. 1997, 25, 4797
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 4797
-
-
Schmidt, J.G.1
Nielsen, P.E.2
Orgel, L.E.3
-
295
-
-
0033618111
-
-
I. A. Kozlov, B. de Bouevere, A. Aeschot, P. Herdewijn, L. E. Orgel, J. Am. Chem. Soc. 1999, 121, 5856.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 5856
-
-
Kozlov, I.A.1
De Bouevere, B.2
Aeschot, A.3
Herdewijn, P.4
Orgel, L.E.5
-
297
-
-
0037129409
-
-
X. Wu, G. Delgado, R. Krishnamurthy, A. Eschenmoser, Org. Lett. 2002, 4, 1283.
-
(2002)
Org. Lett.
, vol.4
, pp. 1283
-
-
Wu, X.1
Delgado, G.2
Krishnamurthy, R.3
Eschenmoser, A.4
-
298
-
-
0037129417
-
-
X. Wu, S. Guntha, M. Ferencic, R. Krishnamurthy, A. Eschenmoser, Org. Lett. 2002, 4, 1279.
-
(2002)
Org. Lett.
, vol.4
, pp. 1279
-
-
Wu, X.1
Guntha, S.2
Ferencic, M.3
Krishnamurthy, R.4
Eschenmoser, A.5
-
299
-
-
0014027997
-
-
F. B. Howard, J. Frazier, H. T. Miles, J. Biol. Chem. 1966, 241, 4293
-
(1966)
J. Biol. Chem.
, vol.241
, pp. 4293
-
-
Howard, F.B.1
Frazier, J.2
Miles, H.T.3
-
303
-
-
0004589595
-
-
G. von Kiedrowski, B. Wlotzka, J. Helbing, M. Matzen, S. Jordan, Angew. Chem. 1991, 103, 456
-
(1991)
Angew. Chem.
, vol.103
, pp. 456
-
-
Von Kiedrowski, G.1
Wlotzka, B.2
Helbing, J.3
Matzen, M.4
Jordan, S.5
-
305
-
-
0025760436
-
-
N. G. Dolinnaya, N. I. Sokolova, D. T. Ashirbekova, D. T. Shabarova, Nucleic Acids Res. 1991, 19, 3067.
-
(1991)
Nucleic Acids Res.
, vol.19
, pp. 3067
-
-
Dolinnaya, N.G.1
Sokolova, N.I.2
Ashirbekova, D.T.3
Shabarova, D.T.4
-
307
-
-
0037471633
-
-
J. C. Chaput, J. K. Ichida, J. W. Szostak, J. Am. Chem. Soc. 2003, 125, 856.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 856
-
-
Chaput, J.C.1
Ichida, J.K.2
Szostak, J.W.3
-
308
-
-
14844327763
-
-
J. K. Ichida, K. Zou, A. Horhota, B. Yu, L. W. McLaughlin, J.-W. Szostak, J. Am. Chem. Soc. 2005, 127, 2802.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 2802
-
-
Ichida, J.K.1
Zou, K.2
Horhota, A.3
Yu, B.4
McLaughlin, L.W.5
Szostak, J.-W.6
-
309
-
-
0344874225
-
-
V. Kempeneers, K. Vastmans, J. Rozenski, P. Herdewijn, Nucleic Acids Res. 2003, 31, 6221.
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 6221
-
-
Kempeneers, V.1
Vastmans, K.2
Rozenski, J.3
Herdewijn, P.4
-
311
-
-
16244417170
-
-
L. Zhang, A. Peritz, E. Meggers, J. Am. Chem. Soc. 2005, 127, 4175.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 4175
-
-
Zhang, L.1
Peritz, A.2
Meggers, E.3
-
313
-
-
0026341239
-
-
P. E. Nielsen, M. Egholm, R. H. Berg, O. Buchardt, Science 1991, 254, 1497.
-
(1991)
Science
, vol.254
, pp. 1497
-
-
Nielsen, P.E.1
Egholm, M.2
Berg, R.H.3
Buchardt, O.4
-
317
-
-
0033709099
-
-
[187] For pairing properties of acyclic phosphodiester oligomers derived from glycerol derivatives see for example, and for recently reported nucleic acid analogues derived from 2-amino-1,3-dihydroxymonophosphate see
-
[187] For pairing properties of acyclic phosphodiester oligomers derived from glycerol derivatives see for example, J. C. Chaput, C. Switzer, J. Mol. Evol. 2000, 51, 464; and for recently reported nucleic acid analogues derived from 2-amino-1,3-dihydroxymonophosphate see
-
(2000)
J. Mol. Evol.
, vol.51
, pp. 464
-
-
Chaput, J.C.1
Switzer, C.2
-
318
-
-
84255195902
-
-
H. Kashida, K. Murayama, T. Toda, H. Asanuma, Angew. Chem. 2011, 123, 1321-1324
-
(2011)
Angew. Chem.
, vol.123
, pp. 1321-1324
-
-
Kashida, H.1
Murayama, K.2
Toda, T.3
Asanuma, H.4
-
319
-
-
79551667548
-
-
Angew. Chem. Int. Ed. 2011, 50, 1285-1288.
-
(2011)
Angew. Chem. Int. Ed.
, vol.50
, pp. 1285-1288
-
-
-
320
-
-
55349085086
-
-
Cf. for example, roughly two thirds of the 2,3-cyclophosphate of ribose exists as furanose derivative
-
Cf. for example, A. F. Amaral, M. M. Marques, J. A. L. da Silva, J. J. R. Frausto da Silva, New J. Chem. 2008, 32, 2043; roughly two thirds of the 2,3-cyclophosphate of ribose exists as furanose derivative
-
(2008)
New J. Chem.
, vol.32
, pp. 2043
-
-
Amaral, A.F.1
Marques, M.M.2
Da Silva, J.A.L.3
Da Silva, J.J.R.F.4
-
321
-
-
17944401513
-
-
a propos "why ribose?" cf. also for example
-
S. Pitsch, C. Spinner, K. Atsumi, P. Ermert, Chimia 1999, 53, 291); a propos "why ribose?" cf. also for example
-
(1999)
Chimia
, vol.53
, pp. 291
-
-
Pitsch, S.1
Spinner, C.2
Atsumi, K.3
Ermert, P.4
-
323
-
-
0001409790
-
-
For a discussion in an etiological context of thermodynamic data of RNA's pairing structure, see D. H. Turner, P. C. Bevilacqua, "Thermodynamic Considerations for Evolution by RNA":, in (Eds.: R. F. Gesteland, J. F. Atkins), Cold Spring Harbor Laboratory Press, Cold Spring, chap. , p. .
-
For a discussion in an etiological context of thermodynamic data of RNA's pairing structure, see D. H. Turner, P. C. Bevilacqua, "Thermodynamic Considerations for Evolution by RNA":, D. H. Turner, P. C. Bevilacqua, in The RNA World (Eds.:, R. F. Gesteland, J. F. Atkins,), Cold Spring Harbor Laboratory Press, Cold Spring, 1993, chap. 17, p. 447.
-
(1993)
The RNA World
, pp. 447
-
-
Turner, D.H.1
Bevilacqua, P.C.2
-
324
-
-
36849148382
-
-
W. Gilbert, Nature 1986, 319, 618.
-
(1986)
Nature
, vol.319
, pp. 618
-
-
Gilbert, W.1
-
325
-
-
0020417286
-
-
K. Kruger, P. J. Grabowski, A. J. Zaug, J. Sands, D. E. Gottschling, T.
-
(1982)
Cell
, vol.31
, pp. 147
-
-
Kruger, K.1
Grabowski, P.J.2
Zaug, A.J.3
Sands, J.4
Gottschling, D.E.5
Cech, T.R.6
-
326
-
-
0021013526
-
-
C. Guerrier-Takada, K. Gardiner, T. Marsh, N. Pace, S. Altman, Cell 1983, 35, 849.
-
(1983)
Cell
, vol.35
, pp. 849
-
-
Guerrier-Takada, C.1
Gardiner, K.2
Marsh, T.3
Pace, N.4
Altman, S.5
-
333
-
-
79953809654
-
-
A. Wochner, J. Attwater, A. Coulson, P. Holliger, Science 2011, 332, 209.
-
(2011)
Science
, vol.332
, pp. 209
-
-
Wochner, A.1
Attwater, J.2
Coulson, A.3
Holliger, P.4
-
336
-
-
23944508560
-
-
S. Fusz, A. Eisenführ, S. G. Srivatsan, A. Heckel, M. Famulok, Chem. Biol. 2005, 12, 941.
-
(2005)
Chem. Biol.
, vol.12
, pp. 941
-
-
Fusz, S.1
Eisenführ, A.2
Srivatsan, S.G.3
Heckel, A.4
Famulok, M.5
-
338
-
-
34548311711
-
-
(review).
-
Angew. Chem. Int. Ed. 2007, 46, 6420 (review).
-
(2007)
Angew. Chem. Int. Ed.
, vol.46
, pp. 6420
-
-
-
340
-
-
0023372377
-
-
G. J. Joyce, A. W. Schwartz, S. L. Miller, L. E. Orgel, Proc. Natl. Acad. Sci. USA 1987, 84, 4398.
-
(1987)
Proc. Natl. Acad. Sci. USA
, vol.84
, pp. 4398
-
-
Joyce, G.J.1
Schwartz, A.W.2
Miller, S.L.3
Orgel, L.E.4
-
341
-
-
84855685847
-
-
Was RNA the first Genetic Polymer?": in (Eds.: M. Grunberg-Manago, B. F. C. Clark, H. G. Zachau), Plenum, New York.
-
"Was RNA the first Genetic Polymer?":, L. E. Orgel, in Evolutionary Tinkering in Gene Expression (Eds.:, M. Grunberg-Manago, B. F. C. Clark, H. G. Zachau,), Plenum, New York, 1989.
-
(1989)
Evolutionary Tinkering in Gene Expression
-
-
Orgel, L.E.1
-
342
-
-
0032550619
-
-
M. Koppitz, P. E. Nielsen, L. E. Orgel, J. Am. Chem. Soc. 1998, 120, 4563.
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 4563
-
-
Koppitz, M.1
Nielsen, P.E.2
Orgel, L.E.3
-
343
-
-
0015436957
-
-
W. D. Fuller, R. A. Sanchez, L. E. Orgel, J. Mol. Evol. 1972, 1, 249.
-
(1972)
J. Mol. Evol.
, vol.1
, pp. 249
-
-
Fuller, W.D.1
Sanchez, R.A.2
Orgel, L.E.3
-
350
-
-
0026634324
-
-
L. E. Orgel, Nature 1992, 358, 203.
-
(1992)
Nature
, vol.358
, pp. 203
-
-
Orgel, L.E.1
-
351
-
-
0028234664
-
-
V. M. Kolb, J. P. Dworkin, S. L. Miller, J. Mol. Evol. 1994, 38, 549.
-
(1994)
J. Mol. Evol.
, vol.38
, pp. 549
-
-
Kolb, V.M.1
Dworkin, J.P.2
Miller, S.L.3
-
356
-
-
0029876064
-
-
J. P. Ferris, A. R. Hill, R. Liu, L. E. Orgel, Nature 1996, 381, 59.
-
(1996)
Nature
, vol.381
, pp. 59
-
-
Ferris, J.P.1
Hill, A.R.2
Liu, R.3
Orgel, L.E.4
-
358
-
-
34249694962
-
-
C. Anastasi, F. F. Buchet, M. A. Crowe, A.;L. Parkes, M. W. Powner, J. M. Smith, J. D. Sutherland, Chem. Biodiversity 2007, 4, 721.
-
(2007)
Chem. Biodiversity
, vol.4
, pp. 721
-
-
Anastasi, C.1
Buchet, F.F.2
Crowe, M.A.3
Parkes, A.L.4
Powner, M.W.5
Smith, J.M.6
Sutherland, J.D.7
-
359
-
-
66149108671
-
-
M. W. Powner, B. Gerland, J. D. Sutherland, Nature 2009, 459, 239
-
(2009)
Nature
, vol.459
, pp. 239
-
-
Powner, M.W.1
Gerland, B.2
Sutherland, J.D.3
-
360
-
-
77955040270
-
-
A. Choudhary, K. J. Kamer, M. W. Powner, J. D. Sutherland, R. T. Raines, ACS Chem. Biol. 2010, 5, 655
-
(2010)
ACS Chem. Biol.
, vol.5
, pp. 655
-
-
Choudhary, A.1
Kamer, K.J.2
Powner, M.W.3
Sutherland, J.D.4
Raines, R.T.5
-
361
-
-
78649927354
-
-
M. W. Powner, J. D. Sutherland, J. W. Szostak, J. Am. Chem. Soc. 2010, 132, 16677.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 16677
-
-
Powner, M.W.1
Sutherland, J.D.2
Szostak, J.W.3
-
363
-
-
84255201447
-
-
S. Zahng, C. Switzer, J. C. Chaput, Chem. Biodiversity 2010, 7, 24.
-
(2010)
Chem. Biodiversity
, vol.7
, pp. 24
-
-
Zahng, S.1
Switzer, C.2
Chaput, J.C.3
-
364
-
-
64549154434
-
-
J. J. Chen, X. Cai, J. W. Szostak, J. Am. Chem. Soc. 2009, 131, 2119
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 2119
-
-
Chen, J.J.1
Cai, X.2
Szostak, J.W.3
-
365
-
-
33845235208
-
-
A. T. Horhota, J. W. Szostak, L. W. McLaughlin, Org. Lett. 2006, 8, 5345
-
(2006)
Org. Lett.
, vol.8
, pp. 5345
-
-
Horhota, A.T.1
Szostak, J.W.2
McLaughlin, L.W.3
-
366
-
-
35248846894
-
-
Y.-W. Yang, S. Zhang, E. O. McCollum, J.-C. Chaput, J. Mol. Evol. 2007, 65, 289.
-
(2007)
J. Mol. Evol.
, vol.65
, pp. 289
-
-
Yang, Y.-W.1
Zhang, S.2
McCollum, E.O.3
Chaput, J.-C.4
-
370
-
-
84981785518
-
-
S. Hoffmann, Z. Chem. 1979, 19, 241-249.
-
(1979)
Z. Chem.
, vol.19
, pp. 241-249
-
-
Hoffmann, S.1
-
371
-
-
0342829571
-
-
Synthetic Analogues of Nucleic acids-a Review
-
"Synthetic Analogues of Nucleic acids-a Review":, A. S. Jones, Int. J. Biol. Macromol. 1979, 1, 194.
-
(1979)
Int. J. Biol. Macromol.
, vol.1
, pp. 194
-
-
Jones, A.S.1
-
372
-
-
0002420070
-
-
J. D. Buttrey, A. S. Jones, R. T. Walker, Tetrahedron 1975, 31, 73.
-
(1975)
Tetrahedron
, vol.31
, pp. 73
-
-
Buttrey, J.D.1
Jones, A.S.2
Walker, R.T.3
-
374
-
-
0024382446
-
-
E. P. Stirchak, J. E. Summerton, D. D. Weller, Nucleic Acids Res. 1989, 17, 6129
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 6129
-
-
Stirchak, E.P.1
Summerton, J.E.2
Weller, D.D.3
-
376
-
-
27744461386
-
-
in (Ed.: P. E. Nielsen), Wiley-VCH, Weinheim, p. .
-
P. E. Nielsen, in Pseudo-peptides in Drug Discovery (Ed.:, P. E. Nielsen,), Wiley-VCH, Weinheim, 2004, p. 153.
-
(2004)
Pseudo-peptides in Drug Discovery
, pp. 153
-
-
Nielsen, P.E.1
-
378
-
-
1842738560
-
-
Y. Huang, S. Dey, X. Zhang, F. Sönnichsen, P. Garner, J. Am. Chem. Soc. 2004, 126, 4626.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 4626
-
-
Huang, Y.1
Dey, S.2
Zhang, X.3
Sönnichsen, F.4
Garner, P.5
-
383
-
-
0033786585
-
-
M. F. H. Hoffmann, A. M. Brückner, T. Hupp, B. Engels, U. Diederichsen, Helv. Chim. Acta 2000, 83, 2580.
-
(2000)
Helv. Chim. Acta
, vol.83
, pp. 2580
-
-
Hoffmann, M.F.H.1
Brückner, A.M.2
Hupp, T.3
Engels, B.4
Diederichsen, U.5
-
386
-
-
0036939573
-
-
A. M. Brückner, H. W. Schmitt, U. Diederichsen, Helv. Chim. Acta 2002, 85, 3855
-
(2002)
Helv. Chim. Acta
, vol.85
, pp. 3855
-
-
Brückner, A.M.1
Schmitt, H.W.2
Diederichsen, U.3
-
388
-
-
0034635960
-
-
K. E. Nelson, M. Levy, S. L. Miller, Proc. Natl. Acad. Sci. USA 2000, 97, 3868.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 3868
-
-
Nelson, K.E.1
Levy, M.2
Miller, S.L.3
-
389
-
-
5044231756
-
-
For recent investigations on this question see
-
For recent investigations on this question see, L. J. Leman, L. E. Orgel, M. R. Ghadiri, Science 2004, 306, 283
-
(2004)
Science
, vol.306
, pp. 283
-
-
Leman, L.J.1
Orgel, L.E.2
Ghadiri, M.R.3
-
390
-
-
30744450953
-
-
L. J. Leman, L. E. Orgel, M. R. Ghadiri, J. Am. Chem. Soc. 2006, 128, 20.
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 20
-
-
Leman, L.J.1
Orgel, L.E.2
Ghadiri, M.R.3
-
391
-
-
0001182323
-
-
H. Moser, A. Fliri, A. Steiger, G. Costello, J. Schreiber, A. Eschenmoser, Helv. Chim. Acta 1986, 69, 1224.
-
(1986)
Helv. Chim. Acta
, vol.69
, pp. 1224
-
-
Moser, H.1
Fliri, A.2
Steiger, A.3
Costello, G.4
Schreiber, J.5
Eschenmoser, A.6
-
394
-
-
0343852708
-
-
K. H. Altmann, C. Schmit Chiesi, G. Garcia-Escheverria, Bioorg. Med. Chem. Lett. 1997, 7, 1119
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 1119
-
-
Altmann, K.H.1
Schmit Chiesi, C.2
Garcia-Escheverria, G.3
-
395
-
-
0041757211
-
-
C. García-Escheverría, D. Hüsken, C. Schmit Chiesi, K. H. Altmann, Bioorg. Med. Chem. Lett. 1997, 7, 1123
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 1123
-
-
García-Escheverría, C.1
Hüsken, D.2
Schmit Chiesi, C.3
Altmann, K.H.4
-
396
-
-
0033550517
-
-
M. Kuwahara, M. Arimitsu, M. Sisido, J. Am. Chem. Soc. 1999, 121, 256).
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 256
-
-
Kuwahara, M.1
Arimitsu, M.2
Sisido, M.3
-
398
-
-
0025008851
-
-
For earlier studies on alternative nucleobases that were not, however, carried out in an etiological context, see, e.g.
-
For earlier studies on alternative nucleobases that were not, however, carried out in an etiological context, see, e.g., J. A. Piccirilli, T. Krauch, S. A. Moroney, S. A. Benner, Nature 1990, 343, 33
-
(1990)
Nature
, vol.343
, pp. 33
-
-
Piccirilli, J.A.1
Krauch, T.2
Moroney, S.A.3
Benner, S.A.4
-
401
-
-
0036591543
-
-
S. Miyakawa, H. Cleaves, S. L. Miller, Origins Life Evol. Biosphere 2002, 32, 209.
-
(2002)
Origins Life Evol. Biosphere
, vol.32
, pp. 209
-
-
Miyakawa, S.1
Cleaves, H.2
Miller, S.L.3
-
403
-
-
34250870855
-
-
G. K. Mittapalli, K. R. Reddy, H. Xiong, O. Munoz, B. Han, F. De Riccardis, R. Krishnamurthy, A. Eschenmoser, Angew. Chem. 2007, 119, 2522
-
(2007)
Angew. Chem.
, vol.119
, pp. 2522
-
-
Mittapalli, G.K.1
Reddy, K.R.2
Xiong, H.3
Munoz, O.4
Han, B.5
De Riccardis, F.6
Krishnamurthy, R.7
Eschenmoser, A.8
-
405
-
-
34250899957
-
-
G. K. Mittapalli, Y. M. Osornio, M. A. Guerrero, K. R. Reddy, R. Krishnamurthy, A. Eschenmoser, Angew. Chem. 2007, 119, 2530
-
(2007)
Angew. Chem.
, vol.119
, pp. 2530
-
-
Mittapalli, G.K.1
Osornio, Y.M.2
Guerrero, M.A.3
Reddy, K.R.4
Krishnamurthy, R.5
Eschenmoser, A.6
-
410
-
-
77649219347
-
-
J. E. Šponer, A. Vásquez-Mayagoitia, B. G. Sumpter, J. Leszczynski, J. Šponer, M. Otyepka, P. Banáš, M. Fuentes-Cabrera, Chem. Eur. J. 2010, 16, 3057.
-
(2010)
Chem. Eur. J.
, vol.16
, pp. 3057
-
-
Šponer, J.E.1
Vásquez-Mayagoitia, A.2
Sumpter, B.G.3
Leszczynski, J.4
Šponer, J.5
Otyepka, M.6
Banáš, P.7
Fuentes-Cabrera, M.8
-
411
-
-
79955591544
-
-
H.-R. Marcos, M. Hernandez-Rodriguez, J. Xie, Y. M. Osornio, R. Krishnamurthy, Chem. Asian J. 2011, 6, 1252.
-
(2011)
Chem. Asian J.
, vol.6
, pp. 1252
-
-
Marcos, H.-R.1
Hernandez-Rodriguez, M.2
Xie, J.3
Osornio, Y.M.4
Krishnamurthy, R.5
-
412
-
-
0029111395
-
-
R. Larralde, M. P. Robertson, S. L. Miller, Proc. Natl. Acad. Sci. USA 1995, 92, 8158.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 8158
-
-
Larralde, R.1
Robertson, M.P.2
Miller, S.L.3
-
413
-
-
0141952368
-
-
in (Ed.: W. Schopf), University of California Press, Berkeley, 2002, .
-
S. L. Miller, A. Lazcano, in Life's Origin: The Beginnings of Biological Evolution (Ed.:, W. Schopf,), University of California Press, Berkeley, 2002, pp. 78-112.
-
Life's Origin: The Beginnings of Biological Evolution
, pp. 78-112
-
-
Miller, S.L.1
Lazcano, A.2
-
417
-
-
0037076974
-
-
cf. also ref. [250].
-
J. L. Bada, A. Lazcano, Science 2002, 296, 1982; cf. also ref. [250].
-
(2002)
Science
, vol.296
, pp. 1982
-
-
Bada, J.L.1
Lazcano, A.2
-
418
-
-
84974892963
-
-
See in this context John Cornforth's notion on the role of hydrolysis in the origin of life.
-
See in this context John Cornforth's notion on the role of hydrolysis in the origin of life (, J. Cornforth, Interdiscip. Sci. Rev. 1984, 9, 107).
-
(1984)
Interdiscip. Sci. Rev.
, vol.9
, pp. 107
-
-
Cornforth, J.1
-
419
-
-
1842427379
-
-
For the concept of a "dynamic combinatorial library" cf.
-
For the concept of a "dynamic combinatorial library" cf.:, P. A. Brady, R. P. Bonar Law, S. I. Rowan, C. J. Suckling, J. Brady, K. M. Sanders, Chem. Commun. 1996, 319
-
(1996)
Chem. Commun.
, pp. 319
-
-
Brady, P.A.1
Bonar Law, R.P.2
Rowan, S.I.3
Suckling, C.J.4
Brady, J.5
Sanders, K.M.6
-
422
-
-
84255195898
-
-
G. K. Mittapalli, R. Krishnamurthy, A. Eschenmoser, unpublished.
-
G. K. Mittapalli, R. Krishnamurthy, A. Eschenmoser, unpublished.
-
-
-
-
423
-
-
67650079176
-
-
In this context see also the work of David Lynn
-
Y. Ura, J. M. Beierle, L. J. Leman, L. S. Orgel, M. R. Ghadiri, Science 2009, 325, 73. In this context see also the work of David Lynn
-
(2009)
Science
, vol.325
, pp. 73
-
-
Ura, Y.1
Beierle, J.M.2
Leman, L.J.3
Orgel, L.S.4
Ghadiri, M.R.5
-
425
-
-
0037028553
-
-
X. Li, Z.-Y. J. Zhan, R. Knipe, D. G. Lynn, J. Am. Chem. Soc. 2002, 124, 746
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 746
-
-
Li, X.1
Zhan, Z.-Y.J.2
Knipe, R.3
Lynn, D.G.4
-
426
-
-
79952769111
-
-
and David Liu
-
X. Li, A. F. Hernandez, M. A. Grover, N. V. Hud, D. G. Lynn, Heterocycles 2011, 82, 1477) and David Liu
-
(2011)
Heterocycles
, vol.82
, pp. 1477
-
-
Li, X.1
Hernandez, A.F.2
Grover, M.A.3
Hud, N.V.4
Lynn, D.G.5
-
429
-
-
0034608818
-
-
H. J. Morowitz, J. D. Kostelnik, J. Yang, G. D. Cody, Proc. Natl. Acad. Sci. USA 2000, 97, 7704
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7704
-
-
Morowitz, H.J.1
Kostelnik, J.D.2
Yang, J.3
Cody, G.D.4
-
435
-
-
0002681342
-
-
Life is a self-sustained chemical system capable of undergoing Darwinian Evolution"; from the definition employed by NASA; cf. G. J. Joyce in the preface to (Hrsg.: E. W. Deamer, G. R. Fleischacker), Jones and Bartlett, Boston.
-
"Life is a self-sustained chemical system capable of undergoing Darwinian Evolution"; from the definition employed by NASA; cf. G. J. Joyce in the preface to Origins of Life (Hrsg.:, E. W. Deamer, G. R. Fleischacker,), Jones and Bartlett, Boston, 1994.
-
(1994)
Origins of Life
-
-
-
436
-
-
0034731006
-
-
On "Replicators in Chemistry and Biology" see, A strategy for searching experimentally for autocatalytic reactions cycles (including potentially primordial ones) would be: target an organocatalyst of known catalytic capacity and design for the structure of this organocatalyst a "one-pot synthesis" in such a way that at least one of the reaction steps would be expected to be catalyzed by that organocatalyst. If the latter was supposed to be a primordial catalyst (e.g., one of the "archaic" cofactors), the designed synthesis would need to operate within the constraints of prebiotic chemistry.
-
On "Replicators in Chemistry and Biology" see, E. Szathmary, Phil. Trans. R. Soc. London B 2000, 355, 1669. A strategy for searching experimentally for autocatalytic reactions cycles (including potentially primordial ones) would be: target an organocatalyst of known catalytic capacity and design for the structure of this organocatalyst a "one-pot synthesis" in such a way that at least one of the reaction steps would be expected to be catalyzed by that organocatalyst. If the latter was supposed to be a primordial catalyst (e.g., one of the "archaic" cofactors), the designed synthesis would need to operate within the constraints of prebiotic chemistry.
-
(2000)
Phil. Trans. R. Soc. London B
, vol.355
, pp. 1669
-
-
Szathmary, E.1
-
437
-
-
0029559848
-
-
K. Soai, T. Shibata, H. Marioka, K. Choji, Nature 1995, 378, 767
-
(1995)
Nature
, vol.378
, pp. 767
-
-
Soai, K.1
Shibata, T.2
Marioka, H.3
Choji, K.4
-
438
-
-
68949112774
-
-
T. Kawasaki, K. Suzuki, Y. Hakoda, K. Soai, Angew. Chem. 2008, 120, 506
-
(2008)
Angew. Chem.
, vol.120
, pp. 506
-
-
Kawasaki, T.1
Suzuki, K.2
Hakoda, Y.3
Soai, K.4
-
440
-
-
65449159829
-
-
T. Kawasaki, T. Tutsumi, K. Suzuki, M. Ito, K. Soai, Science 2009, 324, 492.
-
(2009)
Science
, vol.324
, pp. 492
-
-
Kawasaki, T.1
Tutsumi, T.2
Suzuki, K.3
Ito, M.4
Soai, K.5
-
441
-
-
0034654216
-
-
B. List, R. A. Lerner, C. F. Barbas, J. Am. Chem. Soc. 2000, 122, 2395
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 2395
-
-
List, B.1
Lerner, R.A.2
Barbas, C.F.3
-
443
-
-
38349142750
-
-
B. List, Chem. Rev. 2007, 107, 5413
-
(2007)
Chem. Rev.
, vol.107
, pp. 5413
-
-
List, B.1
-
449
-
-
0035203064
-
-
G. D. Cody, N. Z. Boctor, R. M. Hazen, J. A. Brandes, H. J. Morowitz, H. S. Yoder, Jr., Geochim. Cosmochim. Acta 2001, 65, 3557
-
(2001)
Geochim. Cosmochim. Acta
, vol.65
, pp. 3557
-
-
Cody, G.D.1
Boctor, N.Z.2
Hazen, R.M.3
Brandes, J.A.4
Morowitz, H.J.5
Yoder Jr., H.S.6
-
454
-
-
84255209517
-
-
DOI
-
H. J. Kim, A. Ricardo, H. I. Illangkoon, M. J. Kim, M. A. Carrigan, F. Frye, S. A. Benner, J. Am. Chem. Soc. 2011, DOI:.
-
(2011)
J. Am. Chem. Soc.
-
-
Kim, H.J.1
Ricardo, A.2
Illangkoon, H.I.3
Kim, M.J.4
Carrigan, M.A.5
Frye, F.6
Benner, S.A.7
-
461
-
-
84255201442
-
-
V. N. Sagi, F. Hu, P. Karri, V. Punna, G. Meher, R. Krishnamurthy; unpublished work at TSRI
-
V. N. Sagi, F. Hu, P. Karri, V. Punna, G. Meher, R. Krishnamurthy; unpublished work at TSRI.
-
-
-
-
462
-
-
0010424314
-
-
S. W. Fox, Science 1960, 132, 200
-
(1960)
Science
, vol.132
, pp. 200
-
-
Fox, S.W.1
-
464
-
-
0004190112
-
-
Cambridge University Press, Cambridge
-
F. Dyson, Origins of Life, 2nd ed., Cambridge University Press, Cambridge, 1999
-
(1999)
Origins of Life, 2nd Ed.
-
-
Dyson, F.1
-
465
-
-
33745038851
-
-
R. Pascal, L. Boiteau, A. Commeyras, Top. Curr. Chem. 2005, 259, 69.
-
(2005)
Top. Curr. Chem.
, vol.259
, pp. 69
-
-
Pascal, R.1
Boiteau, L.2
Commeyras, A.3
-
466
-
-
0029761897
-
-
vgl auch
-
D. H. Lee, J. R. Granja, J. A. Martinez, K. Severin, M. R. Ghadiri, Nature 1996, 382, 525; vgl auch
-
(1996)
Nature
, vol.382
, pp. 525
-
-
Lee, D.H.1
Granja, J.R.2
Martinez, J.A.3
Severin, K.4
Ghadiri, M.R.5
-
467
-
-
0032481038
-
-
S. Yao, S. Gosh, R. Zutshi, J. Chmielewski, Nature 1998, 396, 447.
-
(1998)
Nature
, vol.396
, pp. 447
-
-
Yao, S.1
Gosh, S.2
Zutshi, R.3
Chmielewski, J.4
-
469
-
-
0000339375
-
-
U. Eder, G. Sauer, R. Wiechert, Angew. Chem. 1971, 83, 492
-
(1971)
Angew. Chem.
, vol.83
, pp. 492
-
-
Eder, U.1
Sauer, G.2
Wiechert, R.3
-
473
-
-
18244393987
-
-
P. Krattiger, R. Kovasy, J. D. Revell, S. Ivan, H. Wennemers, Org. Lett. 2005, 7, 1101
-
(2005)
Org. Lett.
, vol.7
, pp. 1101
-
-
Krattiger, P.1
Kovasy, R.2
Revell, J.D.3
Ivan, S.4
Wennemers, H.5
-
478
-
-
77949411307
-
-
(Special Issue: Emergence of Biochemical Homochirality)
-
S. Pizzarello, M. Lahav, Origins Life Evol. Biosphere 2010, 40, 1 (Special Issue: Emergence of Biochemical Homochirality)
-
(2010)
Origins Life Evol. Biosphere
, vol.40
, pp. 1
-
-
Pizzarello, S.1
Lahav, M.2
-
479
-
-
68949112774
-
-
T. Kawasaki, K. Suzuki, Y. Hakoda, K. Soai, Angew. Chem. 2008, 120, 506
-
(2008)
Angew. Chem.
, vol.120
, pp. 506
-
-
Kawasaki, T.1
Suzuki, K.2
Hakoda, Y.3
Soai, K.4
-
482
-
-
0001446204
-
-
The (chemical) question to be asked on the origin of biological homochirality (why are families of biomolecules homochiral?) is to be distinguished from the question (referring to physics) on the origin of the sense of the biomolecules's chirality. (cf.).
-
The (chemical) question to be asked on the origin of biological homochirality (why are families of biomolecules homochiral?) is to be distinguished from the question (referring to physics) on the origin of the sense of the biomolecules's chirality. (cf., S. Mason, Chem. Soc. Rev. 1988, 17, 347).
-
(1988)
Chem. Soc. Rev.
, vol.17
, pp. 347
-
-
Mason, S.1
-
484
-
-
0035905809
-
-
J. W. Szostak, D. P. Bartel, P. L. Luisi, Nature 2001, 409, 387
-
(2001)
Nature
, vol.409
, pp. 387
-
-
Szostak, J.W.1
Bartel, D.P.2
Luisi, P.L.3
-
487
-
-
1542579763
-
-
2) from calcium carbide and molecular nitrogen at temperatures over 1000 °C, or the Lassaigne test that the older generation of chemists may still remember (fusion of organic material with metallic sodium, plunging everything into water, and then testing for cyanide). The question of whether the Earth's crust could have been a source of organics relevant to the origin of life is addressed to the earth sciences, and only secondarily to chemistry. If such a scenario could not be positively excluded, the question posed would be of considerable etiological interest. The nearest counterargument, namely that no geochemical traces of such "reservoirs of organic material" are found today, would certainly not-after billions of years of a "hydrolyzing" earth history-be a valid reason for negating the question. (for previous comments on this subject cf. Figure 36 in Origins Life Evol. Biosphere 2004, 34, 277; and ref. [252]).
-
(2004)
Origins Life Evol. Biosphere
, vol.34
, pp. 277
-
-
-
488
-
-
0002194561
-
-
The statement refers to the condensation of 6,7-dimethyl-8- D -ribityl-lumazine with itself to produce riboflavin with concomitant re-formation of one equivalent of 5-amino-6- D -ribitylaminouracil, the molecule that happens to be the precursor of that very lumazine. This uracil derivative produces the lumazine by condensation with either 2,3-dioxobutane or 3,4-dihydroxy-2-butanone-4-phosphate, or even ribulose-1,5-diphosphate. The uracil derivative, the lumazine derivative and the dihydroxy-2-butanone derivative are intermediates in the biosynthesis of riboflavin; the two overall reaction steps that connect them have been shown also to occur non-enzymatically, the riboflavin-producing step (simple heating of the lumazine derivative in aqueous solution) displaying marvelously complex chemistry [cf. the work of H. C. S. Wood
-
The statement refers to the condensation of 6,7-dimethyl-8- D -ribityl-lumazine with itself to produce riboflavin with concomitant re-formation of one equivalent of 5-amino-6- D -ribitylaminouracil, the molecule that happens to be the precursor of that very lumazine. This uracil derivative produces the lumazine by condensation with either 2,3-dioxobutane or 3,4-dihydroxy-2-butanone-4-phosphate, or even ribulose-1,5-diphosphate. The uracil derivative, the lumazine derivative and the dihydroxy-2-butanone derivative are intermediates in the biosynthesis of riboflavin; the two overall reaction steps that connect them have been shown also to occur non-enzymatically, the riboflavin-producing step (simple heating of the lumazine derivative in aqueous solution) displaying marvelously complex chemistry [cf. the work of H. C. S. Wood (, T. Patterson, H. C. S. Wood, J. Chem. Soc. Chem. Commun. 1969, 290
-
(1969)
J. Chem. Soc. Chem. Commun.
, pp. 290
-
-
Patterson, T.1
Wood, H.C.S.2
-
490
-
-
0035917362
-
-
and the dissertation of C. Strupp (thesis. ETH, Nr. 9832, 1992); for structural formulas see Figure 9 of ref. [126].
-
K. Kis, K. Kugelbrey, A. Bacher, J. Org. Chem. 2001, 66, 2555), and the dissertation of C. Strupp (thesis. ETH, Nr. 9832, 1992); for structural formulas see Figure 9 of ref. [126].
-
(2001)
J. Org. Chem.
, vol.66
, pp. 2555
-
-
Kis, K.1
Kugelbrey, K.2
Bacher, A.3
-
491
-
-
0040981266
-
-
Whereas the biosynthetic pathway to riboflavin is-while mechanistically complex-clearly "chemomimetic" and, therefore, ultimately "simple", the pathways leading to thiamin uncovered thus far (see, e.g.
-
Whereas the biosynthetic pathway to riboflavin is-while mechanistically complex-clearly "chemomimetic" and, therefore, ultimately "simple", the pathways leading to thiamin uncovered thus far (see, e.g., I. D. Spenser, R. L. White, Angew. Chem. 1997, 109, 1096
-
(1997)
Angew. Chem.
, vol.109
, pp. 1096
-
-
Spenser, I.D.1
White, R.L.2
-
493
-
-
33644989816
-
-
and to pyridoxal (see, e.g.
-
T. P. Begley, Nat. Prod. Rep. 2006, 23, 15) and to pyridoxal (see, e.g.
-
(2006)
Nat. Prod. Rep.
, vol.23
, pp. 15
-
-
Begley, T.P.1
-
494
-
-
77953381350
-
-
are-in part-of extraordinary chemical complexity. Such a degree of complexity in a biosynthetic pathway to a potentially primordial biomolecule may be a hint at a scenario in which the molecule (or one of its type) would have fulfilled a catalytic role before its biosynthesis became established, which (in the extreme case) means that it may have been formed pre-biotically. Extraordinary complexity of biosynthetic pathway might reflect extraordinary evolutionary pressure that acted upon the emergence of biosynthetic access to a primordially pre-existing molecule (or its structural type), the functional potential of which was essential to the system's evolution (cf. for example, ref. [17]). As regards the structural type and/or function of thiamine and pyridoxal, demonstrating the existence of potentially prebiotic pathways to these molecules remains an open challenge.
-
T. B. Fitzpatrick, C. Moccand, C. Roux, ChemBioChem 2010, 11, 1185) are-in part-of extraordinary chemical complexity. Such a degree of complexity in a biosynthetic pathway to a potentially primordial biomolecule may be a hint at a scenario in which the molecule (or one of its type) would have fulfilled a catalytic role before its biosynthesis became established, which (in the extreme case) means that it may have been formed pre-biotically. Extraordinary complexity of biosynthetic pathway might reflect extraordinary evolutionary pressure that acted upon the emergence of biosynthetic access to a primordially pre-existing molecule (or its structural type), the functional potential of which was essential to the system's evolution (cf. for example, ref. [17]). As regards the structural type and/or function of thiamine and pyridoxal, demonstrating the existence of potentially prebiotic pathways to these molecules remains an open challenge.
-
(2010)
ChemBioChem
, vol.11
, pp. 1185
-
-
Fitzpatrick, T.B.1
Moccand, C.2
Roux, C.3
|