2,6-Diaminopurine in TNA: Effect on Duplex Stabilities and on the Efficiency of Template-Controlled Ligations

Organic Letters

Volumn 4, Issue 8, 2002, Pages 1283-1286

  Wu, Xiaolin ^a   Delgado, Guillermo ^a   Krishnamurthy, Ramanarayanan ^a   Eschenmoser, Albert ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPURINE; 2,6 DIAMINOPURINE; 2,6-DIAMINOPURINE; DNA; DRUG DERIVATIVE; FURAN DERIVATIVE; LIGAND; OLIGONUCLEOTIDE; RNA;

ARTICLE; BASE PAIRING; CHEMISTRY; DNA TEMPLATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; ULTRAVIOLET SPECTROPHOTOMETRY; X RAY CRYSTALLOGRAPHY;

2-AMINOPURINE; BASE PAIRING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; DNA; FURANS; LIGANDS; MASS SPECTROMETRY; OLIGONUCLEOTIDES; RNA; SPECTROPHOTOMETRY, ULTRAVIOLET; TEMPLATES, GENETIC;

EID: 0037129409     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol020016p     Document Type: Article

References (42)

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36. Slow ligation rates allow side reactions (due to large excess of the carbodiimide activation agent) to hamper product formation.
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41. m values (c ≈ 5 μM, 1 M NaCl) of template strands: TNA-(A,T), <5 °C; TNA(D,T), 30 °C.
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