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3
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34250870855
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a) G. K. Mittapalli, K. R. Reddy, H. Xiong, O. Munoz, B. Han, F. De Riccardis, R. Krishnamurthy, A. Eschenmoser, Angew. Chem. 2007, 119 2522
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7
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70349967495
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Recent elegant work has demonstrated that this "nucleosidation problem" can be circumvented
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Recent elegant work has demonstrated that this "nucleosidation problem" can be circumvented
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15
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70349939419
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2,3-Diaminoacids have been identified in Murchison meteorite
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2,3-Diaminoacids have been identified in Murchison meteorite
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16
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4043061359
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in experiments simulating chemistry of interstellar medium
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U. J. Meierhenrich, G M. Munoz Caro, J. H. Bredehoft, E. K. Jessberger, W. H.-P. Thiemann, Proc. Natl. Acad. Sci. USA 2004, 101 9182 in experiments simulating chemistry of interstellar medium
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Meierhenrich, U.J.1
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Thiemann, W.H.-P.5
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17
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0037187544
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and in hydrolysis of dilute HCN solutions
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G M. Munoz Caro, U. J. Meierhenrich, W. A. Schutte, B. Barbier, A. Arcones Segovia, H. Rosenbauer, W. H.-P. Thiemann, A. Brack, J. M. Greenberg, Nature 2002, 416 403 and in hydrolysis of dilute HCN solutions
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Munoz Caro G, M.1
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Brack, A.8
Greenberg, J.M.9
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22
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70349961423
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See the Supporting Information for additional details.
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See the Supporting Information for additional details.
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23
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0003836971
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Oxford, Clarendon Press
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24
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70349943754
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2EDTA, pH 7.0).
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2EDTA, pH 7.0).
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25
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0034615181
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a) F Seela, C. Wei. G Becher, M. Zulauf, P. Leonard, Bioorg. Med. Chem. Lett. 2000, 10 289
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70349975636
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Exceptions are found for nucleobases that form base pairs upon protonation, for example, cytosine self pairing
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Exceptions are found for nucleobases that form base pairs upon protonation, for example, cytosine self pairing
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39
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R. Eritja, D M. Horowitz, P. A. Walker, J. P. Ziehler-Martin, M. S. Boosalis, M. F. Goodman, K. Itakura, B. E. Kaplan, Nucleic Acids Res. 1986, 14 8135
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42
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S. C. Jurczyk, J. Horlacher, K. G. Devined, S. A. Benner, T. R. Battersby, Helv. Chim. Acta 2000, 83 1517
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43
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3242798107
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This purine, as opposed to pyrimidines, is able to base pair despite being ionized at physiological pH, which is in line with observations that charged pyrimdines tend to "unstack" more than charged purines page 132 of reference [20a].
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E. Kulikowska, B. Kierdaszuk, D. Shugar, Acta Biochim. Pol. 2004, 51 493. This purine, as opposed to pyrimidines, is able to base pair despite being ionized at physiological pH, which is in line with observations that charged pyrimdines tend to "unstack" more than charged purines page 132 of reference [20a].
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Kulikowska, E.1
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61849159407
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For a discussion of how this p K a match rule explains stronger duplexes in RNA versus DNA, see
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P. Gilli, L. Pretto, V. Bertolasi, G Gilli, Acc. Chem. Res. 2009, 42 33. For a discussion of how this p K a match rule explains stronger duplexes in RNA versus DNA, see
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Gilli, P.1
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d) P. Acharya, P. Cheruku, S. Chatterjee, S. Acharya, J. Chattopadhyaya, J. Am. Chem. Soc. 2004, 126 2862.
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48
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70349959810
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A striking example is the W-C pairing between guanine (G; pKa = 9.5) and isoguanine (isoG; pKa = 9.0) where the DpKa is less than one however, pKa-pH is approximately 2-3, enabling the partners to be neutral
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A striking example is the W-C pairing between guanine (G; pKa = 9.5) and isoguanine (isoG; pKa = 9.0) where the DpKa is less than one however, pKa-pH is approximately 2-3, enabling the partners to be neutral
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49
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0000584539
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R. Krishnamurthy, S. Pitsch, M. Minton, C. Miculka, N. Windhab, A. Eschenmoser, Angew. Chem. 1996, 108 1619
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51
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70349969469
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reference [15a]
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reference [15a]
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52
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70349957940
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reference [13f].
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reference [13f].
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55
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70349957934
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P. O. P. Ts'o, Basic Principles in Nucleic Acid Chemistry, Vol. I (Ed.: P. O. P. Ts'o), Academic Press, New York, chap. 6
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a) P. O. P. Ts'o, Basic Principles in Nucleic Acid Chemistry, Vol. I (Ed.: P. O. P. Ts'o), Academic Press, New York, 1974, chap. 6
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0021345825
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A. Pohorille, S. K. Burt, R. D. MacElroy, J. Am. Chem. Soc. 1984, 106 402
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Pohorille, A.1
Burt, S.K.2
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61
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70349973369
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The weaker pairing of 2 6-diaminopurine-thymine (DpKa ca. 4) compared to guanine-cytosine (DpKa ca. 5) fits with this correlation (alternative explanations
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The weaker pairing of 2 6-diaminopurine-thymine (DpKa ca. 4) compared to guanine-cytosine (DpKa ca. 5) fits with this correlation (alternative explanations
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64
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0345826095
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[9]
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[9]
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(2003)
Helv. Chim. Acta
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Pitsch, S.1
Wenderborn, S.2
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Holzner, A.4
Minton, M.5
Bolli, M.6
Miculka, C.7
Windhab, N.8
Micura, R.9
Stanek, M.10
Jaun, B.11
Eschenmoser, A.12
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65
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70349964338
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a value (7.2) of dxG may also account for the observations
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a value (7.2) of dxG may also account for the observations
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66
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70349971377
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a ca. 5) combination and b) why the increase in UV spectroscopic Tm values-in going from AT only sequences to mixed ATGC sequences-is larger in the DNA series when compared with corresponding sequences in an xDNA series
-
a ca. 5) combination and b) why the increase in UV spectroscopic Tm values-in going from AT only sequences to mixed ATGC sequences-is larger in the DNA series when compared with corresponding sequences in an xDNA series
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70
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70349928569
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For example, halogenated heterocycles in reference [12]
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For example, halogenated heterocycles in reference [12]
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71
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70349954701
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see also reference [14].
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see also reference [14].
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