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Volumn 48, Issue 43, 2009, Pages 8124-8128

Mapping the landscape of potentially primordial informational oligomers: Oligo-dipeptides tagged with orotic acid derivatives as recognition elements

Author keywords

DNA; Nucleic acids; Oligonucleotides; Oligopeptides; RNA

Indexed keywords

ACID DERIVATIVE; BASE-PAIRING; DI-PEPTIDES; OLIGOPEPTIDES; RECOGNITION ELEMENT;

EID: 70349972268     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904188     Document Type: Article
Times cited : (17)

References (71)
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    • Recent elegant work has demonstrated that this "nucleosidation problem" can be circumvented
    • Recent elegant work has demonstrated that this "nucleosidation problem" can be circumvented
  • 15
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    • 2,3-Diaminoacids have been identified in Murchison meteorite
    • 2,3-Diaminoacids have been identified in Murchison meteorite
  • 22
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    • See the Supporting Information for additional details.
    • See the Supporting Information for additional details.
  • 24
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    • 2EDTA, pH 7.0).
    • 2EDTA, pH 7.0).
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    • Exceptions are found for nucleobases that form base pairs upon protonation, for example, cytosine self pairing
    • Exceptions are found for nucleobases that form base pairs upon protonation, for example, cytosine self pairing
  • 43
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    • This purine, as opposed to pyrimidines, is able to base pair despite being ionized at physiological pH, which is in line with observations that charged pyrimdines tend to "unstack" more than charged purines page 132 of reference [20a].
    • E. Kulikowska, B. Kierdaszuk, D. Shugar, Acta Biochim. Pol. 2004, 51 493. This purine, as opposed to pyrimidines, is able to base pair despite being ionized at physiological pH, which is in line with observations that charged pyrimdines tend to "unstack" more than charged purines page 132 of reference [20a].
    • (2004) Acta Biochim. Pol. , vol.51 , pp. 493
    • Kulikowska, E.1    Kierdaszuk, B.2    Shugar, D.3
  • 46
    • 61849159407 scopus 로고    scopus 로고
    • For a discussion of how this p K a match rule explains stronger duplexes in RNA versus DNA, see
    • P. Gilli, L. Pretto, V. Bertolasi, G Gilli, Acc. Chem. Res. 2009, 42 33. For a discussion of how this p K a match rule explains stronger duplexes in RNA versus DNA, see
    • (2009) Acc. Chem. Res. , vol.42 , pp. 33
    • Gilli, P.1    Pretto, L.2    Bertolasi, V.3    Gilli, G.4
  • 48
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    • A striking example is the W-C pairing between guanine (G; pKa = 9.5) and isoguanine (isoG; pKa = 9.0) where the DpKa is less than one however, pKa-pH is approximately 2-3, enabling the partners to be neutral
    • A striking example is the W-C pairing between guanine (G; pKa = 9.5) and isoguanine (isoG; pKa = 9.0) where the DpKa is less than one however, pKa-pH is approximately 2-3, enabling the partners to be neutral
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    • reference [15a]
    • reference [15a]
  • 52
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    • reference [13f].
    • reference [13f].
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    • 70349957934 scopus 로고
    • P. O. P. Ts'o, Basic Principles in Nucleic Acid Chemistry, Vol. I (Ed.: P. O. P. Ts'o), Academic Press, New York, chap. 6
    • a) P. O. P. Ts'o, Basic Principles in Nucleic Acid Chemistry, Vol. I (Ed.: P. O. P. Ts'o), Academic Press, New York, 1974, chap. 6
    • (1974)
  • 61
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    • The weaker pairing of 2 6-diaminopurine-thymine (DpKa ca. 4) compared to guanine-cytosine (DpKa ca. 5) fits with this correlation (alternative explanations
    • The weaker pairing of 2 6-diaminopurine-thymine (DpKa ca. 4) compared to guanine-cytosine (DpKa ca. 5) fits with this correlation (alternative explanations
  • 65
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    • a value (7.2) of dxG may also account for the observations
    • a value (7.2) of dxG may also account for the observations
  • 66
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    • a ca. 5) combination and b) why the increase in UV spectroscopic Tm values-in going from AT only sequences to mixed ATGC sequences-is larger in the DNA series when compared with corresponding sequences in an xDNA series
    • a ca. 5) combination and b) why the increase in UV spectroscopic Tm values-in going from AT only sequences to mixed ATGC sequences-is larger in the DNA series when compared with corresponding sequences in an xDNA series
  • 70
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    • For example, halogenated heterocycles in reference [12]
    • For example, halogenated heterocycles in reference [12]
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    • see also reference [14].
    • see also reference [14].


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.