Ribozyme-catalyzed transcription of an active ribozyme

Science

Volumn 332, Issue 6026, 2011, Pages 209-212

  Wochner, Aniela ^a   Attwater, James ^a   Coulson, Alan ^a   Holliger, Philipp ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE; RIBOZYME; RNA; RNA POLYMERASE;

ACCURACY ASSESSMENT; CATALYSIS; GENETIC ANALYSIS; MOLECULAR ANALYSIS; POLYMERASE CHAIN REACTION;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME SYNTHESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA REPLICATION; RNA SEQUENCE; TRANSCRIPTION INITIATION;

BASE SEQUENCE; BIOCATALYSIS; DIRECTED MOLECULAR EVOLUTION; GENETIC ENGINEERING; MUTATION; NUCLEIC ACID CONFORMATION; RNA; RNA REPLICASE; RNA, CATALYTIC; SELECTION, GENETIC; TEMPLATES, GENETIC; TRANSCRIPTION, GENETIC;

EID: 79953809654     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1200752     Document Type: Article

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28. We are grateful to M. Daly for assistance with FACS and to our colleagues V. B. Pinheiro, C. Cozens, A. Taylor, and J. Sutherland for helpful discussions. This work was supported by the Medical Research Council (MRC) program grant MC-US-A024-0014.