Aphidicolin-induced FRA3B breakpoints cluster in two distinct regions

Genomics

Volumn 41, Issue 3, 1997, Pages 485-488

  Wang, Liang ^a   Paradee, William ^b   Mullins, Chadwick ^c   Shridhar, Ravi ^c   Rosati, Rita ^c   Wilke, Charles M ^d   Glover, Thomas W ^d   Smith, David I ^a  

^a MAYO CLINIC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APHIDICOLIN;

ARTICLE; CHROMOSOME 3P; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILITY; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CLUSTER; HUMAN; HUMAN CELL; HYBRID CELL; PRIORITY JOURNAL;

EID: 0031148646     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1997.4690     Document Type: Article

References (21)

1. 1. Boldog, F. L., Gemmill, R. M., Wilke, C. M., Glover, T. W., Nilsson, A.-S., Chandrasekharappa, S. C., Brown, R. S., Li, F. P., and Drabkin, H. A. (1993). Positional cloning of the hereditary renal carcinoma 3;8 translocation breakpoint. Proc. Natl. Acad. Sci. USA 90: 8509-8513.
2. 2. Chong, S., Taylor, K. A., and Piper, A. A. (1995). Intragenic matrix attachment and DNA-protein interactions in the human X-linked HPRT gene. Biochem. Biophys. Acta 1264: 103-114.
3. 3. Cockerill, P. N., and Garrard, W. T. (1986). Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites. Cell 44: 273-282.
4. 4. Cohen, A. J., Li, F. P., Berg, S., Marchetto, D. J., Tsai, S., Jacobs, S. C., and Brown, R. S. (1979). Hereditary renal cell carcinoma associated with a chromosomal translocation. N. Engl. J. Med. 301: 592-595.
5. 5. Dickenson, L. A., Joh, T., Kohwi, Y., and Kohwi-Shigematsu, T. (1992). A tissue-specific MAR/SAR DNA binding protein with unusual binding site recognition. Cell 70: 631-645.
6. 6. Druck, T., Kastury, K., Hadeczek, P., et al. (1995). Loss of heterozygosity of the familial RCC t(3;8) locus in most clear cell renal cell carcinomas. Cancer Res. 55: 5348-5353.
7. 7. Flint, J., Rochette, J., Craddock, C. F., Dode, C., Vignes, B., Horsley, S. W., Kearney, L., Buckle, V. J., Ayyub, H., and Higgs, D. R. (1996). Chromosomal stabilization by a subtelomeric rearrangement involving two closely related Alu elements. Hum. Mol. Genet. 5: 1163-1169.
8. 8. Gasser, S. M., and Laemmli, U. K. (1986). Cohabitation of scaffold binding regions with upstream enhancer elements of three developmentally regulated genes of D. Melanogaster. Cell 46: 521-530.
9. 9. Glover, T. W., Berger, C., Coyle-Morris, J., and Echo, B. (1984). DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites. Hum. Genet. 67: 136-142.
10. 10. Glover, T. W., and Stein, C. K. (1988). Chromosomal breakage and recombination at fragile sites. Am. J. Hum. Genet. 43: 265-273.
11. 11. Ketterling, R. P., Liao, D., and Sommer, S. S. (1995). Are some apparently simple deletions actually two concerted deletions that result from interacting RY(i) hairpin loops? Am. J. Hum. Genet. 56: 343-346.
12. 12. Paradee, W., Mullins, C., He, Z., Glover, T. W., Wilke, C., Opalka, B., Schutte, J., and Smith, D. I. (1995). Precise localization of aphidicolin-induced breakpoints on the short arm of human chromosome 3. Genomics 27: 358-361.
13. 13. Paradee, W., Wilke, C. M., Hoge, A., Glover, T. W., and Smith, D. I. (1996). A 350 kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics 35: 87-93.
14. 14. Reiter, L. T., Murakami, T., Koeuth, T., Pentao, L., Muzny, D. M., Biggs, R. A., and Lupski, J. R. (1996). A recombination hotspot responsible for two inherited peripheral neuropathies is located near a mariner transposon-like element. Nature Genet. 12: 288-297.
15. 15. Shridhar, R., Shridhar, V., Wang, X., Paradee, W., Dugan, M., Sarkar, F., Wilke, C., Glover, T. W., Vaitkevicius, V. K., and Smith, D. I. (1996). Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors. Cancer Res. 56: 4347-4350.
16. 16. Sutherland, G. R., and Hecht, F. (1985). Fragile Sites on Hu" man Chromosomes," Oxford Monographs on Medical Genetics No. 13, Oxford Univ. Press, New York.
17. 17. Wang, N., and Perkins, K. L. (1984). Involvement of band 3p14 in t(3;8) hereditary renal carcinoma. Cancer Genet. Cytogenet. 11: 479-481.
18. 18. Wang, N.-D., Testa, J. R., and Smith, D. I. (1993). Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. Genomics 17: 341-347.
19. 19. Wilke, C. M., Guo, S.-W., Hall, B. K., Boldog, F., Gemmill, R. M., Chandrasekharappa, S. C., Barcroft, C. L., Drabkin, H. A., and Glover, T. W. (1994). Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with renal cell carcinoma. Genomics 22: 319-326.
20. 20. Wilke, C. M., Hall, B. K., Miller, D., Hoge, A., Paradee, W., Smith, D. I., and Glover, T. W. (1996). Identification of a spontaneous HPV16 integration site within the FRA3B region: Direct evidence for the coincidence of viral integration sites and fragile sites. Hum. Mol. Genet. 52: 973-977.
21. 21. Yunis, J. J., and Soreng, A. L. (1984). Constitutive fragile sites and cancer. Science 226: 1199-1204.