The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations

Genomics

Volumn 69, Issue 1, 2000, Pages 37-46

  Krummel, Kurt A ^a   Roberts, Lewis R ^a   Kawakami, Masako ^a   Glover, Thomas W ^b   Smith, David I ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 14Q; CHROMOSOME 16Q; CHROMOSOME BREAKAGE; GENE MAPPING; HUMAN; HUMAN CELL; METAPHASE; MICROSATELLITE INSTABILITY; MULTIPLE MYELOMA; PRIORITY JOURNAL;

MAMMALIA;

EID: 0034306548     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6321     Document Type: Article

References (44)

1. Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: Refining a putative tumor suppressor gene region
2. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
3. Allele loss on chromosome arm
4. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
5. Allelic imbalance study of 16q in human primary breast carcinomas using microsatellite markers
6. Loss of heterozygosity on chromosome arm 16q in breast cancer metastases
7. Loss of heterozygosity at 16q24.1-q24.2 is significantly associated with metastatic and aggressive behavior of prostate cancer
8. DNA polymerase alpha inhibition by aphidicolin induces gaps and braks at common fragile sites in human chromosomes
9. Induction of sister chromatid exchanges at common fragile sites
10. Chromosome breakage and recombination at fragile sites
11. Multiple myeloma: Increasing evidence for a multistep transformation process
12. FRA10B structure reveals common elements in repeat expansion and chromosomal fragile site genesis
13. FRA7G extends over a broad region: Coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites
14. Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACs spanning FRA7G within the common region of LOH in breast and prostate cancer
15. BAC and PAC contigs covering 3.5 Mb of the Down syndrome congenital heart
16. Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2
17. Trinucleotide repeat amplificaiton and hypermethylation of a CpG island in FRAXE metal retardation
18. Mapping of DNA instabillity at the Fragile X to a trinucleotide repeat sequence p(CCG)n
19. Loss of heterozygosity at chromosome 16q in prostate adenocarcinoma: Identification of three independent regions
20. Localization of a breast cancer tumor-suppressor gene to a 3-cM interval within chromosomal region 16q22
21. Comparative genomic analysis of tumors: Detection of DNA losses and amplification
22. Chromosomal fragile site FRA16D and DNA instability in cancer
23. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site
24. Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis
25. Instability of a 550bp DNA segment and abnormal methylation in fragile X syndrome
26. A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D
27. Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE
28. Deletion mapping of chromosome 16q in hepatocellular carcinoma
29. Viral integration, fragile sites and proto-oncogenes in human neoplasia
30. Allelotyping of ductal carcinoma in situ of the breast: Deletion of loci on 8p, 13q, 16q, 17p and 17q
31. Preferential integration of marker DNA into the chromosomal fragile site at 3p14: An approach to cloning fragile sites
32. Fine-scale deletion mapping of the distal long arm of chromosome 6 in 70 human ovarian cancers
33. Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture
34. Fragile sites still breaking
35. New classes of common fragile sites induced by 5-azacytidine and bromodeoxyuridine
36. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma
37. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
38. Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site
39. The fragile X genotype is characterised by an unstable region of DNA
40. Human chromosomal fragile site FRA16B is an amplified AT-rich minisatellite repeat
41. Constitutive fragile sites and cancer