Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation

Journal of Biological Chemistry

Volumn 279, Issue 21, 2004, Pages 21948-21956

  Yadavalli, Rajgopal ^a   Guttmann, Rodney P ^a   Seward, Tanya ^a   Centers, Adrian P ^a   Williamson, R Anthony ^c   Telling, Glenn C ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL CULTURE; CELLS; DISEASES; MOLECULAR WEIGHT;

BRAIN EXTRACTS; CLEAVAGE PRODUCTS;

BIOCHEMISTRY;

CALCIUM ION; CALPAIN; CALPASTATIN; CASPASE; PRION PROTEIN; PROTEASOME; PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; GENE OVEREXPRESSION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SCRAPIE;

ANIMALS; BIOLOGICAL ASSAY; BRAIN; CALCIUM; CALCIUM-BINDING PROTEINS; CALPAIN; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; IONOPHORES; KINETICS; MICE; PRIONS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; PRPSC PROTEINS; SCRAPIE; TIME FACTORS;

ANIMALIA; SCRAPIE PRION;

EID: 2542434845     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400793200     Document Type: Article

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