Changing a single amino acid in the N-terminus of murine PrP alters TSE incubation time across three species barriers

EMBO Journal

Volumn 20, Issue 18, 2001, Pages 5070-5078

  Barron, Rona M ^a   Thomson, Val ^a   Jamieson, Elizabeth ^a   Melton, David W ^b   Ironside, James ^b   Will, Robert ^b   Manson, Jean C ^a  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

P101L PrP; Prion diseases; Species barrier; Transmissible spongiform encephalopathies; vCJD

Indexed keywords

AMINO ACID; LEUCINE; PRION PROTEIN; PROLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC POLYMORPHISM; HAMSTER; HUMAN; HUMAN TISSUE; INCUBATION TIME; MOUSE; NONHUMAN; PHENOTYPE; PRION DISEASE; PRIORITY JOURNAL; SHEEP;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CREUTZFELDT-JAKOB SYNDROME; CRICETINAE; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; POINT MUTATION; PRION DISEASES; PRIONS; PRPSC PROTEINS; RECOMBINANT PROTEINS; SCRAPIE; SEQUENCE HOMOLOGY, AMINO ACID; SHEEP; SPECIES SPECIFICITY; TIME FACTORS;

EID: 0035903461     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.18.5070     Document Type: Article

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