Invited review article: Current state of research on biological effects of terahertz radiation

Journal of Infrared, Millimeter, and Terahertz Waves

Volumn 32, Issue 10, 2011, Pages 1074-1122

  Wilmink, Gerald J ^a   Grundt, Jessica E ^a  

^a AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Biological effects; Cellular effects; Gene expression; Invited review; Microarray; Radiation; Review article; Terahertz; Thermal effects; THz

Indexed keywords

BASIC SCIENCE; BIO-EFFECTS; BIOLOGICAL EFFECTS; BIOLOGICAL RESEARCH; BORDER PATROL; CELLULAR EFFECTS; CRITICAL REVIEW; FREQUENCY RANGES; FUTURE APPLICATIONS; HAZARD EVALUATION; INTERNATIONAL AIRPORT; MEDICAL CENTER; SAFETY STANDARD; SCIENTIFIC LITERATURE; SECURITY APPLICATION; SECURITY SCREENING; SENSING TECHNOLOGY; STATE OF RESEARCH; TERA HERTZ; TERAHERTZ IMAGING; TERAHERTZ RADIATION; THZ; THZ TECHNOLOGY;

AIRPORT SECURITY; BIOLOGICAL RADIATION EFFECTS; DIAGNOSIS; GENE EXPRESSION; HEALTH HAZARDS; HEAT RADIATION; MEDICAL IMAGING; MICROARRAYS; MILITARY APPLICATIONS; RESEARCH; THERMAL EFFECTS;

TERAHERTZ WAVES;

EID: 83255185271     PISSN: 18666892     EISSN: 18666906     Source Type: Journal    
DOI: 10.1007/s10762-011-9794-5     Document Type: Conference Paper

References (184)

1. Thruvision. 2010 [cited 15 Nov. 2010]; Available from: http://www.thruvision.com/index.html.
2. Brijot. 2010 [cited 15 Nov. 2010]; Available from: http://www.brijot.com/ contact-us/.
3. Taylor, Z.D., et al., Reflective terahertz imaging of porcine skin burns. Opt. Lett., 2008. 33(11): p. 1258-1260.
4. Ashworth, P.C., et al., Terahertz pulsed spectroscopy of freshly excised human breast cancer. Opt Express, 2009. 17(15): p. 12444-12454.
5. Brun, M.-A. and et al., Terahertz imaging applied to cancer diagnosis. Physics in Medicine and Biology, 2010. 55(16): p. 4615.
6. Wallace, V.P., et al., Terahertz pulsed imaging and spectroscopy for biomedical and pharmaceutical applications. Faraday Discuss, 2004. 126: p. 255-263. (Pubitemid 38365598)
7. Woodward, R.M., et al., Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue. Phys Med Biol, 2002. 47(21): p. 3853-3863. (Pubitemid 35363536)
8. Woodward, R.M., et al., Terahertz pulse imaging of ex vivo basal cell carcinoma. J Invest Dermatol, 2003, 120(1): p. 72-78. (Pubitemid 36120973)
9. Federici, J.F., et al., THz imaging and sensing for security applications: explosives, weapons and drugs. Semiconductor Science and Technology, 2005. 20(7): p. S266-S280. (Pubitemid 40872028)
10. Bogue, R., Terahertz imaging: a report on progress. Sensor Review, 2009. 29(1): p. 6-12.
11. Dobroiu, A., C. Otani, and K. Kawase, Terahertz-wave sources and imaging applications. Measurement Science and Technology, 2006. 17(11): p. R161-R174. (Pubitemid 46069362)
12. Smye, S.W., et al., The interaction between terahertz radiation and biological tissue. Phys Med Biol, 2001. 46(9): p. R101-R112. (Pubitemid 32895526)
13. Walker, G.C., Two Methods for Modelling the Propagation of Terahertz Radiation in a Layered Structure. Journal of Biological Physics, 2003. 29: p. 141-148. (Pubitemid 36876513)
14. Homenko, A., et al., Effects of 100 GHz radiation on alkaline phosphatase activity and antigenantibody interaction. Bioelectromagnetics, 2009. 30(3): p. 167-175.
15. Korenstein-Ilan, A., et al., Terahertz radiation increases genomic instability in human lymphocytes. Radiation Research, 2008. 170(2): p. 224-234.
16. Zeni, O., et al., Cytogenetic observations in human peripheral blood leukocytes following in vitro exposure to THz radiation: a pilot study. Health Phys, 2007. 92(4): p. 349-357. (Pubitemid 46398852)
17. Scarfi, M.R., et al., THz Exposure of Whole Blood for the Study of Biological Effects on Human Lymphocytes. Journal of Biological Physics, 2003. 29(2): p. 171-176.
18. Ramundo-Orlando, A., et al., Permeability changes induced by 130 GHz pulsed radiation on cationic liposomes loaded with carbonic anhydrase. Bioelectromagnetics, 2007. 28(8): p. 587-598. (Pubitemid 350190622)
19. Clothier, R.H. and N. Bourne, Effects of THz Exposure on Human Primary Keratinocyte Differentiation and Viability. Journal of Biological Physics, 2003. 29(2): p. 179-185. (Pubitemid 36876517)
20. Olshevskaya, J.S., et al., Effect of terahertz electromagnetic waves on neurons systems. Computational Technologies in Electrical and Electronics Engineering, 2008. SIBIRCON 2008. IEEE Region 8 International Conference on, 2008: p. 210-211.
21. Fedorov, P. S.S, and P. A.N., Dynamic Effects of Submillimeter Wave Radiation on Biological Objects of Various Levels of Organization. International Journal of Infrared and Millimeter Waves, 2003. 24(8): p. 1235-1254.
22. Cherkasova, O., et al., Influence of terahertz laser radiation on the spectral characteristics and functional properties of albumin. Optics and Spectroscopy, 2009. 107(4): p. 534-537.
23. Jacques, S.L. and D.J. McAuliffe, The melanosome: threshold temperature for explosive vaporization and internal absorption coefficient during pulsed laser irradiation. Photochem Photobiol, 1991. 53(6): p. 769-775.
24. Tewari, P., et al. Role of collagen in terahertz absorption in skin. 2009: SPIE. 7169: p. 71691A1-71691A8.
25. Ruggeri, A. and P.M. Motta, Ultrastructure of the connective tissue matrix. Electron microscopy in biology and medicine. 1984, Boston: M. Nijhoff Publishers. 217 p.
26. Alberts, B., J.H. Wilson, and T. Hunt, Molecular biology of the cell. 5th ed. 2008, New York: Garland Science. xxxiii, 1601, 90 p.
27. Urano, M. and E. Douple, Hyperthermia and Oncology: thermal effects on cells and tissues. Hyperthermia and Oncology. Vol. 1. 1988, Utrecht, Netherlands: VSP BV.
28. Schulze, H., T. Kolter, and K. Sandhoff, Principles of lysosomal membrane degradation: Cellular topology and biochemistry of lysosomal lipid degradation. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009. 1793(4): p. 674-683.
29. Reddy, A., E.V. Caler, and N.W. Andrews, Plasma Membrane Repair Is Mediated by Ca2+-Regulated Exocytosis of Lysosomes. Cell, 2001. 106(2): p. 157-169. (Pubitemid 32772627)
30. Ramzan, R., et al., Mitochondrial respiration and membrane potential are regulated by the allosteric ATP-inhibition of cytochrome c oxidase. Biochim Biophys Acta, 2010. 1797(9): p. 1672-1680.
31. Blokhina, O., E. Virolainen, and K.V. Fagerstedt. Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann Bot, 2003. 91(2): p. 179-194.
32. Kindt, J.T. and C.A. Schmuttenmaer, Far-Infrared Dielectric Properties of Polar Liquids Probed by Femtosecond Terahertz Pulse Spectroscopy. The Journal of Physical Chemistry, 1996. 100(24): p. 10373-10379. (Pubitemid 126789365)
33. Venables, D. and C. Schmuttenmaer, Spectroscopy and dynamics of mixtures of water with acetone, acetonitrile, and methanol. Journal of Chemical Physics, 2000. 113(24): p. 11222-11236. (Pubitemid 32087610)
34. Venables, D.S., A. Chiu, and C.A. Schmuttenmaer, Structure and dynamics of nonaqueous mixtures of dipolar liquids. I. Infrared and far-infrared spectroscopy. The Journal of Chemical Physics, 2000. 113(8): p. 3243-3248.
35. Venables, D.S. and C.A. Schmuttenmaer, Far-infrared spectra and associated dynamics in acetonitrile- water mixtures measured with femtosecond THz pulse spectroscopy. The Journal of Chemical Physics, 1998. 108(12): p. 4935-4944. (Pubitemid 128571307)
36. Segelstein, D., The Complex Refractive Index of Water. 1981, University of Missouri: Kansas City, MO.
37. Thrane, L., THz Reflection Spectroscopy of liquid water. 1995. 240(4): p. 4.
38. Jepsen, P.U. and B.M. Fischer, Dynamic range in terahertz time-domain transmission and reflection spectroscopy. Opt Lett, 2005. 30(1): p. 29-31. (Pubitemid 40120868)
39. Jepsen, P.U., J.K. Jensen, and U. Moller, Characterization of aqueous alcohol solutions in bottles with THz reflection spectroscopy. Opt Express, 2008. 16(13): p. 9318-9331.
40. Jepsen, P.U. and S.R. Keiding, Radiation patterns from lens-coupled terahertz antennas. Opt Lett, 1995. 20(8): p. 807-809.
41. Jepsen, P.U., U. Moller, and H. Merbold, Investigation of aqueous alcohol and sugar solutions with reflection terahertz time-domain spectroscopy. Opt Express, 2007. 15(22): p. 14717-14737. (Pubitemid 350072013)
42. Wilmink, G.J., B.L. Ibey, andW.P. Roach, Development of a Compact Terahertz Time Domain Spectroscopy System for the Measurement of the Optical Properties of Skin. Journal of Biomedical Optics, 2011. 16(4): p. 047006-047006-10.
43. Wilmink, G.J. and W.P. Roach, Measurement of the optical properties of skin using terahertz timedomain spectroscopic techniques. BiOS Proceedings of SPIE, 2010. 7562: p. 75620J-75620J-4.
44. Pal, S.K., J. Peon, and A.H. Zewail, Ultrafast surface hydration dynamics and expression of protein functionality: alpha -Chymotrypsin. Proc Natl Acad Sci U S A, 2002. 99(24): p. 15297-15302. (Pubitemid 35403928)
45. Pal, S.K., J. Peon, and A.H. Zewail, Biological water at the protein surface: dynamical solvation probed directly with femtosecond resolution. Proc Natl Acad Sci USA, 2002. 99(4): p. 1763-8. (Pubitemid 34168964)
46. Pal, S.K. andA.H. Zewail, Dynamics of water in biological recognition. Chem Rev, 2004. 104(4): p. 2099-2123.
47. Pal, S.K., et al., Site- and sequence-selective ultrafast hydration of DNA. Proc Natl Acad Sci USA, 2003. 100(24): p. 13746-51. (Pubitemid 37499137)
48. Pal, S.K., L. Zhao, and A.H. Zewail, Water at DNA surfaces: ultrafast dynamics in minor groove recognition. Proc Natl Acad Sci USA, 2003. 100(14): p. 8113-8118. (Pubitemid 36842507)
49. Ladanyi, B.M. and M.S. Skaf, Computer Simulation of Hydrogen-Bonding Liquids. Annual Review of Physical Chemistry, 1993. 44(1): p. 335-368.
50. Russo, D., G. Hura, and T. Head-Gordon, Hydration dynamics near a model protein surface. Biophys J, 2004. 86(3): p 1852-62. (Pubitemid 38295618)
51. Yada, H., M. Nagai, and K. Tanaka, Origin of the fast relaxation component of water and heavy water revealed by terahertz time-domain attenuated total reflection spectroscopy. Chemical Physics Letters, 2008. 464(4-6): p. 166-170.
52. Walther, M., et al., Far-infrared vibrational spectra of all-trans, 9-cis and 13-cis retinal measured by THz time-domain spectroscopy. Chemical Physics Letters, 2000. 332(3-4): p. 389-395.
53. Globus, T., THz-Spectroscopy of biological molecules. Journal of Biological Physics, 2003. 29(2): p. 89-100. (Pubitemid 36876506)
54. Xie, A., Excited-State Lifetimes of Far-Infrared Collective Modes in Proteins. Journal of Biological Physics, 2002. 28: p. 147-154. (Pubitemid 35012952)
55. Fischer, B., et al., Terahertz time-domain spectroscopy and imaging of artificial RNA. Opt Express, 2005. 13(14): p. 5205-15. (Pubitemid 41029272)
56. Fischer, B.M., Broadband THz Time-Domain Spectroscopy of Biomolecules, in Mathematics and Physics. 2005, Albert-Ludwigs-Universitat: Freiburg im Bresigau. p. 246.
57. Tuchin, V., Handbook of Photonics for Biomedical Science. 1 ed. Series in Medical Physics and Biomedical Engineering ed. C.P.T.F. Group. Vol. 1. 2010, Boca Raton: CRC Press 868.
58. Welch, A.J. and M.J.C.v. Gemert, Optical-thermal response of laser-irradiated tissue. Lasers, photonics, and electro-optics. 1995, New York: Plenum Press. xxvi, 925 p.
59. Pennes, H.H., Analysis of Tissue and Arterial Blood Temperatures in the Resting Human Forearm. Journal of Applied Physiology, 1948. 1(2): p. 93-122.
60. Wang, L.V. and H.-i. Wu, Biomedical optics: principles and imaging. 2007, Hoboken, N.J.: Wiley- Interscience. xiv, 362 p.
61. Moritz, A.R., Studies of Thermal Injury: III. The Pathology and Pathogenesis of Cutaneous Burns. An Experimental Study. Am J Pathol, 1947. 23(6): p. 915-41.
62. Moritz, A.R. and F.C. Henriques, Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns. Am J Pathol, 1947. 23(5): p. 695-720.
63. Henriques, F.C. and A.R. Moritz, Studies of Thermal Injury: I. The Conduction of Heat to and through Skin and the Temperatures Attained Therein. A Theoretical and an Experimental Investigation. Am J Pathol, 1947. 23(4): p. 530-49.
64. Vogel, A. and V. Venugopalan, Mechanisms of pulsed laser ablation of biological tissues. Chem Rev, 2003. 103(2): p. 577-644.
65. Berry, E., et al., Do in vivo terahertz imaging systems comply with safety guidelines? Journal of Laser Applications, 2003. 15(3): p. 192-198.
66. Wilmink, G.J., et al., Molecular imaging-assisted optimization of hsp70 expression during laserinduced thermal preconditioning for wound repair enhancement. J Invest Dermatol, 2009. 129(1): p. 205-16.
67. Wilmink, G.J., et al., Assessing laser-tissue damage with bioluminescent imaging. Journal of Biomedical Optics, 2006. 11(4): p. 041114.
68. Wilmink, G.J., et al., In-vivo optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of skin. Journal of Biomedical Optics, 2008. 13(5): p. 054066.
69. Wilmink, G.J., et al., Identification of microRNAs associated with hyperthermia-induced cellular stress response. Cell Stress Chaperones, 2010. 15(6): p. 1027-38.
70. Dressler, C., et al., Microscopical heat stress investigations under application of quantum dots. Journal of Biomedical Optics, 2005. 10(4): p. 041209-9.
71. Beuthan, J., C. Dressler, and O. Minet, Laser-induced fluorescence detection of quantum dots redistributed in thermally stressed tumor cells. Laser Physics, 2004. 14(2): p. 213-219.
72. de Gannes, F.M.-P., et al., Metabolic and cellular characterization of immortalized humanmicroglial cells under heat stress. Neurochemistry International, 1998. 33(1): p. 61-73. (Pubitemid 28310716)
73. Roti Roti, J.L., N. Uygur, and R. Higashikubo, Nuclear protein following heat shock: protein removal kinetics and cell cycle rearrangements. Radiat Res, 1986. 107(2): p. 250-61. (Pubitemid 16048746)
74. Beckham, J.T., et al., Assessment of cellular response to thermal laser injury through bioluminescence imaging of heat shock protein 70. Photochem Photobiol, 2004. 79(1): p. 76-85.
75. Beckham, J.T., et al., Role of HSP70 in cellular thermotolerance. Lasers Surg Med, 2008. 40(10): p. 704-15.
76. Beckham, J.T., et al., Microarray analysis of cellular thermotolerance. Lasers in Surgery and Medicine, 2010. 42(10): p. 752-765.
77. Diller, K.R., Stress protein expression kinetics. Annu Rev Biomed Eng, 2006. 8: p. 403-24. (Pubitemid 44314823)
78. Kultz, D., Evolution of the cellular stress proteome: from monophyletic origin to ubiquitous function. J Exp Biol, 2003. 206(Pt 18): p. 3119-24. (Pubitemid 37181411)
79. Kultz, D., Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol, 2005. 67: p. 225-57. (Pubitemid 40404492)
80. Harmon, B.V., et al., Cell death induced in a murine mastocytoma by 42-47 degrees C heating in vitro: evidence that the form of death changes from apoptosis to necrosis above a critical heat load. Int J Radiat Biol, 1990. 58(5): p. 845-58. (Pubitemid 20346852)
81. Nishiyama, H., et al., A Glycine-rich RNA-binding Protein Mediating Cold-inducible Suppression of Mammalian Cell Growth. The Journal of Cell Biology, 1997. 137(4): p. 899-908. (Pubitemid 27215512)
82. Kaneko, Y., et al., A Novel hsp110-related Gene, apg-1, That Is Abundantly Expressed in the Testis Responds to a Low Temperature Heat Shock Rather than the Traditional Elevated Temperatures. Journal of Biological Chemistry, 1997. 272(5): p. 2640-2645. (Pubitemid 27053303)
83. Fujita, J., Cold shock response in mammalian cells. J Mol Microbiol Biotechnol, 1999. 1(2): p. 243-55. (Pubitemid 129491946)
84. Roti Roti, J.L., Cellular responses to hyperthermia (40-46 degrees C): cell killing and molecular events. Int J Hyperthermia, 2008. 24(1): p. 3-15.
85. Lepock, J.R., Involvement of membranes in cellular responses to hyperthermia. Radiat Res, 1982. 92 (3): p. 433-8. (Pubitemid 13221296)
86. Dewey, W.C., et al., Cellular responses to combinations of hyperthermia and radiation. Radiology, 1977. 123(2): p. 463-74. (Pubitemid 8096539)
87. Macouillard-Poulletier de Gannes, F., et al., Mitochondrial impairment and recovery after heat shock treatment in a human microglial cell line. Neurochemistry International, 2000. 36(3): p. 233-241.
88. Konings, A.W.T. and A.C.C. Ruifrok, Role of Membrane Lipids and Membrane Fluidity in Thermosensitivity and Thermotolerance of Mammalian Cells. Radiation Research, 1985. 102(1): p. 86-98. (Pubitemid 15112263)
89. Guffy, M.M., et al., Effect of Cellular Fatty Acid Alteration on Hyperthermic Sensitivity in Cultured L1210 Murine Leukemia Cells. Cancer Research, 1982. 42(9): p. 3625-3630. (Pubitemid 12054470)
90. Dressler, C., et al., Fluorescence imaging of heat-stress induced mitochondrial long-term depolarization in breast cancer cells. J Fluoresc, 2006. 16(5): p. 689-95. (Pubitemid 44496674)
91. Nijhuis, E.H., et al., Induction of apoptosis by heat and gamma-radiation in a human lymphoid cell line; role of mitochondrial changes and caspase activation. Int J Hyperthermia, 2006. 22(8): p. 687-98. (Pubitemid 46332054)
92. Doulias, P.T., et al., Involvement of heat shock protein-70 in the mechanism of hydrogen peroxideinduced DNA damage: the role of lysosomes and iron. Free Radic Biol Med, 2007. 42(4): p. 567-77.
93. Turano, C., et al., The biochemical mechanism of selective heat sensitivity of cancer cells. 3. Studies on lysosomes. Eur J Cancer, 1970. 6(2): p. 67-72.
94. Harris, J.W., Factors influencing the apparent radiosensitivity and heat stability of isolated leucocyte lysosomes. Int J Radiat Biol Relat Stud Phys Chem Med, 1966. 11(5): p. 465-76.
95. Hume, S.P., M.A. Rogers, and S.B. Field, Heat-induced thermal resistance and its relationship to lysosomal response. Int J Radiat Biol Relat Stud Phys Chem Med, 1978. 34(6): p. 503-11. (Pubitemid 9097420)
96. Roti Roti, J.L., Heat-induced alterations of nuclear protein associations and their effects on DNA repair and replication. Int J Hyperthermia, 2007. 23(1): p. 3-15. (Pubitemid 46957644)
97. Warters, R.L., et al., Heat shock (45 degrees C) results in an increase of nuclear matrix protein mass in HeLa cells. Int J Radiat Biol Relat Stud Phys Chem Med, 1986. 50(2): p. 253-68. (Pubitemid 16060387)
98. Higashikubo, R., N. Uygur, and J.L. Roti Roti, Role of RNA and protein synthesis and turnover in the heat-induced increase in nuclear protein. Radiat Res, 1986. 106(2): p. 278-82.
99. Frohlich, H., The extraordinary dielectric properties of biological materials and the action of enzymes. Proc Natl Acad Sci USA, 1975. 72(11): p. 4211-5.
100. Frohlich, H., Further evidence for coherent excitations in biological systems. Phys Letters, 1985. 110A (9): p. 80-81.
101. Alexandrov, B.S., et al., DNA breathing dynamics in the presence of a terahertz field. Physics Letters A, 2010. 374(10): p. 1214-1217.
102. Chitanvis, S.M., Can low-power electromagnetic radiation disrupt hydrogen bonds in dsDNA? Journal of Polymer Science Part B: Polymer Physics, 2006. 44(18): p. 2740-2747. (Pubitemid 44482650)
103. Reimers, J.R., et al., Weak, strong, and coherent regimes of Fröhlich condensation and their applications to terahertz medicine and quantum consciousness. Proceedings of the National Academy of Sciences, 2009. 106(11): p. 4219-4224.
104. Alexandrov, B.S., Pre-melting dynamics of DNA and its relation to specific functions. Journal of Physics: Condensed Matter, 2009. 21(3): p. 034107.
105. Swanson, E., Modelling DNA Response to THz Radiation. Phys. Rev. E., 2010.
106. Bock, J., et al., Mammalian stem cells reporgramming in response to Terahertz Radiation PLoS Biol, 2010. 5(12): p. e15806.
107. Ferguson, B. and X.-C. Zhang, Materials for terahertz science and technology. 2002. 1(1): p. 26-33.
108. Hosako, I., et al., At the dawn of a new era in terahertz technology. Proceedings of the IEEE, 2007. 95 (8): p. 1611-1623.
109. Lee, M. and M.C. Wanke, Applied physics. Searching for a solid-state terahertz technology. Science, 2007. 316(5821): p. 64-5. (Pubitemid 46559516)
110. Liu, H.-B., et al., Terahertz spectroscopy and imaging for defense and security applications. Proceedings of the IEEE, 2007. 95(8): p. 1514-1527.
111. Siegel, P.H., Terahertz technology. Microwave Theory and Techniques, IEEE Transactions on, 2002. 50 (3): p. 910-928. (Pubitemid 34255210)
112. Sirtori, C., Quantum cascade lasers: breaking energy bands. 2009. 3(1): p. 13-15.
113. Tonouchi, M., Cutting-edge terahertz technology. Nature Photonics, 2007. 1(2): p. 97-105.
114. Williams, B.S., Terahertz quantum-cascade lasers. Nature Photonics, 2007. 1(9): p. 517-525.
115. Wolbarst, A.B. and W.R. Hendee, Evolving and experimental technologies in medical imaging. Radiology, 2006. 238(1): p. 16-39. (Pubitemid 43010578)
116. Lee, Y.-S., Principles of Terahertz Science and Technology, ed. Springer. 2009, Berlin: Springer
117. Crocker, A., et al., Stimulated Emission in the Far Infra-Red. Nature, 1964. 201(4916): p. 250-251.
118. Dodel, G., On the history of far-infrared (FIR) gas lasers: Thirty-five years of research and application. Infrared Physics & Technology, 1999. 40(3): p. 127-139.
119. Wilmink, G.J., et al. Quantitative investigation of the bioeffects associated with terahertz radiation. in Optical Interactions with Tissues and Cells XXI. 2010: SPIE. 7562: pp. 75620L-75620L-10.
120. Wilmink, G.J., et al., In vitro investigation of the biological effects associated with human dermal fibroblasts exposed to 2.52 THz radiation. Lasers in Surgery and Medicine, 2011. 43(2): p. 152-163.
121. Wilmink, G.J., et al. Determination of death thresholds and identification of terahertz (THz)-specific gene expression signatures. in Optical Interactions with Tissues and Cells XXI. 2010: SPIE. 7562: pp. 75620K-75620K-8.
122. Dalzell, D.R., et al. Damage thresholds for terahertz radiation. in Optical Interactions with Tissues and Cells XXI. 2010: SPIE. 7562: pp. 75620M-75620M-8.
123. Ward, J.S., et al. Tunable broadband frequency-multiplied terahertz sources. in Infrared, Millimeter and Terahertz Waves, 2008. IRMMW-THz 2008. 33 rd International Conference on. 2008.
124. Eisele, H., 480 GHz oscillator with an InP Gunn device. Electronics Letters, 2010. 46(6): p. 422-423.
125. Eisele, H. and R. Kamoua, High-performance oscillators and power combiners with InP Gunn devices at 260-330 GHz. Microwave and Wireless Components Letters, IEEE, 2006. 16(5): p. 284-286.
126. Mukherjee, M., et al., GaN IMPATT diode: a photo-sensitive high power terahertz source. Semiconductor Science and Technology, 2007. 22(12): p. 1258-1267. (Pubitemid 350175510)
127. Mukherjee, M. and S.K. Roy, Wide-Bandgap III-V nitride based avalanche transit-time diode in Terahertz regime: Studies on the effects of punch through on high frequency characteristics and series resistance of the device. Current Applied Physics, 2010. 10(2): p. 646-651.
128. Buniatyan,V.V., et al., Silicon carbide TUNNETT diodes. Solid-State Electronics, 2004. 48(9): p. 1569-1577.
129. Ryzhii, V., Graphene tunneling transit-time terahertz oscillator based on electrically induced p-i-n junction. Applied Physics Express, 2009. 2(3): p. 034503.
130. Nishizawa, J., T. Kurabayashi, and H. Makabe, 706-GHz GaAs CW fundamental-mode TUNNETT diodes fabricated with molecular layer epitaxy. Physica Status Solidi (c), 2008. 5(9): p. 2802-2804.
131. Asada, M., Resonant Tunneling Diodes for Sub-Terahertz and Terahertz Oscillators. Jpn. J. Appl. Phys, 2008. 47: p. 4375-4384.
132. Lee, Y.-S., Principles of terahertz science and technology. 1st ed. 2008, New York, NY: Springer.
133. Daniel, C., Bernard, Epsztein, Backward travelling wave oscillators. 1959, Csf: United States.
134. Rudolf, K., Backward wave tube. 1961, ENGLISH ELECTRIC VALVE CO LTD: United States.
135. Kompfner, R. and N.T.Williams, Backward-Wave Tubes. Proceedings of the IRE, 1953. 41(11): p. 1602-1611.
136. Il'ina, S., Bakaushina GF, Gaǐduk VI, Khrapko AM, Zinov'eva NB., Possible role of water in transmitting the effect of millimeter range radiation to biological objects. Biofizik, 1979. 24(3): p. 513.
137. Carr, G.L., et al., High-power terahertz radiation from relativistic electrons. 2002. 420(6912): p. 153-156.
138. Doria, A., et al., THz radiation studies on biological systems at the ENEA FEL facility. Infrared Physics & Technology, 2004. 45(5.6): p. 339-347.
139. Grosse, E., THz radiation from free electron lasers and its potential for cell and tissue studies. Phys Med Biol, 2002. 47(21): p. 3755-3760. (Pubitemid 35369970)
140. Berns, M., et al., Free electron laser irradiation at 200 microns affects DNA synthesis in living cells. Proceedings of the NationalAcademy of Sciences of the United States of America, 1990. 87(7): p. 2810-2812.
141. Berns, M., et al., Free electron laser irradiation at 200 microns inhibits DNA synthesis in living cells. Journal of Laser Applications, 1994. 6(7): p. 165-169.
142. Berns, M.W. and W. Bewley, Inhibition of nucleic acid synthesis in cells exposed to 200 micrometer radiation from the Free electron laser. Photochemistry and Photobiology, 1987. 46(2): p. 165-167.
143. Richards, P.L., Bolometers for infrared and millimeter waves. J. Applied Physics, 1994. 76(1): p. 1-23.
144. Sizov, F., THz Radiation Sensors. Opto-electronics review 2010. 18(1): p. 10-36.
145. Kleine-Ostmann, T., et al. In vitro field exposition of skin cells between 100 GHz and 2.52 THz. in Infrared, Millimeter, and Terahertz Waves, 2009. IRMMW-THz 2009. 34th International Conference on. 2009.
146. Pikov, V. and P.H. Siegel, Thermal monitoring: Raman spectrometer system for remote measurement of cellular temperature on a microscopic scale. IEEE Eng Med Biol Mag, 2010. 29(1): p. 63-71.
147. Wilmink, G.J., et al., Quantitative investigation of the bioeffects associated with terahertz radiation. Lasers in Surgery and Medicine, 2010. 7562(1): p. 75620L.
148. Kristensen, T., et al., Modeling terahertz heating effects on water. Opt Express, 2010. 18(5): p. 4727-39.
149. Gallerano, G.P. THz-Bridge: Tera-Hertz radiation in Biological Research, Investigation on Diagnostics and study of potential Genotoxic Effects. 2004 [cited 2009; Available from: http://www.frascati.enea.it/THz-BRIDGE/.
150. Jastrow, C., T. Kleine-Ostmann, and T. Schrader, Numerical dosimetric calculations for in vitro field expositions in the THz frequency range. Adv. Radio Sci., 2010. 8: p. 1-5.
151. Ostrovskiy, N.V., et al. Application of the terahertz waves in therapy of burn wounds. in Infrared and Millimeter Waves and 13th International Conference on Terahertz Electronics, 2005. IRMMW-THz 2005.
152. Kirichuck, V., et al., Sex-specific differences in changes of disturbed functional activity of platelets in albino rats under the effect of terahertz electromagnetic radiation at nitric oxide frequencies. Bulletin of Experimental Biology and Medicine, 2008. 145(1): p. 75-77.
153. Kirichuk, V., Efimova, N., & Andronov, E. , Effect of High Power Terahertz Irradiation on Platelet Aggregation and Behavioral Reactions of Albino Rats. Bulletin of Experimental Biology and Medicine, 2009. 148(5): p. 746-9.
154. Kirichuk, V. and A. Tsymbal, Effects of Terahertz Irradiation at Nitric Oxide Frequencies on Intensity of Lipoperoxidation and Antioxidant Properties of the Blood under Stress Conditions. Bulletin of Experimental Biology and Medicine, 2009. 148(2): p. 200-3.
155. Kirichuk, V. and A. Tsymbal, Use of Terahertz Electromagnetic Waves for Correcting Hemostasis Functions. Biomedical Engineering, 2010. 44(1): p. 11-14.
156. Bondar, N., et al., Behavioral effect of terahertz waves in male mice. Bulletin of Experimental Biology and Medicine, 2008. 145(4): p. 401-405.
157. Zhengyu, M., Biological research by optically pumped far infrared lasers. Infrared Physics, 1989. 29 (2-4): p. 631-636.
158. Hu, N., THz irradiation of d. melanogaster. Applied infrared and optoelectronics, 1987. 1: p. 7.
159. Federov, V., Comparative study of the effects of infrared, submillimeter, and millimeter EM radiation. Biophysics, 2001. 46(2): p. 293-297.
160. Xiong, S. and P. Shaomin, Influence of submillimeter laser radiation on the growth of paddy rice. Applied Laser, 1986. 6(33).
161. Peng, S., Influence of submillimeter laser radiation on the growth of black beans. Applied Laser, 1987. 7(33): p. 169.
162. Xu,M. and S. Xiong, FIR laser irradiation in wheat. Applied infrared and optoelectronics 1988. 4: p. 30.
163. He, Z.-P. and J.-W. Su, Preliminary observation on the effect of submillimeter laser radiation on the somaclonal variation of rice. Proc. China-Japan Symposium on Plant Biotechnology, 1988: p. 49-51.
164. Kirichuk, V., et al., Use of terahertz electromagnetic radiation for correction of blood rheology parameters in patients with unstable angina under conditions of treatment with isoket, an NO donor. Bulletin of Experimental Biology and Medicine, 2008. 146(3): p. 293-296.
165. Webb, S.J. and D.D. Dodds, Inhibition of bacterial cell growth by 136 gc microwaves. Nature, 1968. 218(5139): p. 374-375.
166. Nishiyama, H. and J. Fujita, A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth. Journal Cell Biology, 1997. 137: p. 899-908. (Pubitemid 27215512)
167. Zalyubovskaya, N.P., et al., To biological activity of radiation in millimeter and submillimeter ranges. Eksperimental'noy i Klinicheskoy Radiologii, 1970. 6: p. 202-205.
168. Kiselev, V.K., Kuleshov E.M., Kamenev Yu.E., Delevsky Yu.P., Zarzhetskaya N.A., Makolinets V.I. , Use of submillimeter laser technology in immunological studies. Radiotekhnicheskie Systemy Millimetrovogo i Submillimetrovogo Diapazonov, 1991: p. 176-181.
169. Makolinets, V.I., Influence of submillimeter wave radiation on some manifestation of immunoresponsives Medithiskaya Reabilitologia, Kurortologiya i Fizioterapiya, 1996. 1: p. 33-35.
170. Hadjiloucas, S., M. Chahal, and J. Bowen, Preliminary results on the non-thermal effects of 200-350 GHz radiation on the growth rate of S. cerevisiae cells in microcolonies. Physics in Medicine and Biology, 2002. 47(21): p. 3831.
171. Federov, V., Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine (Proceedings Paper). SPIE 2007. 6734(04): p. 1-7.
172. Bourne, N., et al., The effects of terahertz radiation on human keratinocyte primary cultures and neural cell cultures. Altern Lab Anim, 2008. 36(6): p. 667-84.
173. Federov, V., Study of biological effects of electromagnetic radiation of submillimeter part of terahertz range. Biomeditsiknskaya Radioelektronika, 2011.
174. Fedorov, V.I., et al. Investigation of possibility of submillimeter laser using as instrument for diagnostics in medicine. in International Conference on Lasers, Applications, and Technologies 2007: Laser Technologies for Medicine. 2007. Minsk, Belarus: SPIE.
175. Ramundo-Orlando, A., et al., Effect of low frequency, low amplitude magnetic fields onthe permeability of cationic liposomes entrapping carbonic anhydrase. Bioelectromagnetics, 2000. 21: p. 491-498.
176. Ramundo-Orlando, A., Terahertz Radiation Effects and Biological Applications. Journal of Infrared, Millimeter and Terahertz Waves, 2009. 30(12): p. 1308-1318.
177. Bender, M., et al., Current status of cytogenetic procedures to detect and quantify previous exposures to radiation. Mutation Research, 1988. 196: p. 103-159.
178. Preston, R., J. San Sebastian, and A. McFee, The in vitro human lymphocyte assay for assessing the clastogenicity of chemical agents. Mutation Research, 1987. 189: p. 175-183. (Pubitemid 17144431)
179. Vijayalaxmi and T. Prihoda, Genetic damage in mammalian somatic cells exposed to radiofrequency radiation: A meta-analysis of data from 63 publications (1990-2005). Radiation Research, 2008. 169: p. 561-574. (Pubitemid 351671522)
180. Govorun, V.M., et al., Far-infrared radiation effect on the structure and properties of proteins. International Journal of Infrared and Millimeter Waves, 1991. 12(12): p. 1469-1474.
181. Fedorov, V.I., Pogodin A.S., Bespalov V.G., Putilin S.E., Smolyanskaya O.A., Grachev Ya.V., Kozlov S.A. , Influence of pulsed overwide-range terahertz radiation on albumin conformation Millimetrovye Volny v Biologii I Meditsine 2009. 2: p. 50-58.
182. Wilmink, G.J., et al., Development of a compact terahertz time-domain spectrometer for the measurement of the optical properties of biological tissues. Journal of Biomedical Optics, 2011. 16 (4): p. 047006-047010.
183. Nazarov, M., et al., Terahertz time-domain spectroscopy of biological tissues. Quantum Electronics, 2008. 38(7): p. 647.
184. Blackman, C.F., et al., Effects of nonionizing electromagnetic radiation on single cell biologic systems. Annals of the New York Academy of Sciences, 1975. 247(1): p. 352-366.