Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue

Physics in Medicine and Biology

Volumn 47, Issue 21, 2002, Pages 3853-3863

  Woodward, Ruth M ^a,b   Cole, Bryan E ^b   Wallace, Vincent P ^b   Pye, Richard J ^c   Arnone, Donald D ^b   Linfield, Edmund H ^a   Pepper, Michael ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b TERAVIEW LTD   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; HYDRATION; RADIATION; TUMORS; VISUALIZATION;

TERAHERTZ PULSE IMAGING (TPI);

SKIN;

WATER; DIAGNOSTIC AGENT;

ARTICLE; BASAL CELL CARCINOMA; CANCER GROWTH; CONTRAST ENHANCEMENT; CONTROLLED STUDY; ECZEMA; EPIDERMIS; GEOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYDRATION; IMAGE ANALYSIS; IMAGING SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MEASUREMENT; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PSORIASIS; RADIOSENSITIVITY; SCAR; SKIN CARCINOMA; SKIN INFLAMMATION; STRATUM CORNEUM; TETRAHERTZ PULSE IMAGING; TIME; TISSUE DIFFERENTIATION; ARM; CELL CULTURE; DERMATITIS; DIAGNOSTIC IMAGING; ELECTROMAGNETIC FIELD; HISTOLOGY; INSTRUMENTATION; METHODOLOGY; MICROWAVE RADIATION; PATHOLOGY; REVIEW; SKIN; SKIN TUMOR; SPECTROSCOPY;

CARCINOMA, BASAL CELL; CELLS, CULTURED; DERMATITIS; DIAGNOSTIC IMAGING; ELECTROMAGNETICS; HUMANS; MICROWAVES; SKIN; SKIN NEOPLASMS; SPECTRUM ANALYSIS; UPPER EXTREMITY;

EID: 0037038574     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/47/21/325     Document Type: Article

References (22)

1. Alonso A, Meirelles N and Tabak M 1995 Effect of hydration upon the fluidity of intercellular membranes of stratum corneum: an EPR study Biochem. Biophys. Acta 1237 6-15
2. Alonso A, Meirelles N, Yushmanov V and Tabak M 1996 Water increase the fluidity of intercellular membranes of stratum corneum: correlation with water permeability, elastic, and electrical resistance properties J. Invest. Dermatol. 106 1058-63
3. Arnone D D, Ciesla C M and Corchia A et al 1999 Application of terahertz (THz) technology to medical imaging Proc. SPIE 3823 209-19
4. Branagan M, Chenery D and Nicholson S 2000 Use of infrared attenuated total reflectance spectroscopy for the in vivo measurement of hydration level and silicone distribution in the stratum corneum following skin coverage by polymeric dressings Skin Pharmacol. Appl. Skin Physiol. 13 157-64
5. Cole B E, Woodward R M and Crawley D et al 2001 Terahertz imaging and spectroscopy of human skin, in vivo Proc. SPIE 4276 1-10
6. Darrow J, Hu B, Zhnag X-C and Auston D 1990 Sub-picosecond electromagnetic pulses form large aperture photoconducting antennas Opt. Lett. 15 323-5
7. Dreassi E, Ceramelli G and Fabbri L et al 1997 Application of near infrared reflectance spectrometry in the study of atopy: Part 1. investigation of skin spectra Analyst 122 767-70
8. Elbaum M, Kopf A W and Rabinovitz H S et al 2001 Automatic differentiation of melanoma from melanocytic nevi with multispectral digital dermoscopy: a feasibility study J. Am. Acad. Dermatol. 44 207-18
9. Fornage B D, McGavran M H, Duvic M and Waldron C A 1993 Imaging of the skin with 20-MHz US Radiology 189 69-76
10. Hoffmann K, Happe M and Schuller S et al 1999 Ranking of 20 MHz sonography of malignant melanoma and pigmented lesions in routine diagnosis Ultraschall Med. 20 104-9
11. Huzaira M, Rius F, Rajadhyaksha M, Anderson R R and Gonzalez S 2001 Topographic variation in normal skin, as viewed by in vivo reflectance confocal microscopy J. Invest. Dermatol. 116 846-52
12. Knuttel A and Boehlau -Godau M 2000 Spatially confined and temporally resolved refractive index and scattering evaluation in human skin performed with optical coherence tomography J. Biomed. Opt. 5 83-92
13. Lassau N, Spatz A and Avril MF et al 1997 Value of high-frequency US for preoperative assessment of skin tumors Radiographics 17 1559-65
14. Mouret G, Chen W and Boucher D et al 1998 High-power terahertz radiation from a high-repetition-rate large-aperture photoconducting antenna Microw. Opt. Technol. Lett. 17 23-7
15. Pye R J 2000 The hidden epidemic of basal cell carcinoma Horizons in Medicine vol 12 (London: The Royal College of Physicians) pp 339-46
16. Shriner D L, McCoy D K and Goldberg D J et al 1998 Mohs' micrographic surgery J. Am. Acad. Dermatol. 39 79-97
17. Telfer N R, Colver G B and Bowers P W 1999 Guidelines for the management of basal cell carcinoma Br. J. Dermatol. 141 415-23
18. Thrane L, Jacobsen R H, Uhd Jepsen P and Keiding S R 1995 THz reflection spectroscopy of liquid water Chem. Phys. Lett. 240 330-3
19. Van Exter M and Grischkowsky D R 1990 Characterization of an optoelectronic terahertz beam system IEEE Trans. Microw. Theory Tech. 38 1684-91
20. Woodward R M, Cole B E and Wallace V P et al 2001 Terahertz pulse imaging of in vitro basal cell carcinoma samples TOPS 56 329-30
21. Woodward R M, Wallace V P and Pye R J et al 2002 Terahertz pulse imaging in reflection geometry of skin tissue using time domain analysis techniques Proc. SPIE 4625 160-9
22. Wu Q T and Zhang X C 1995 Free-space electro-optic sampling of terahertz beams Appl. Phys. Lett. 67 3523-5