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Volumn 95, Issue 4, 2011, Pages 547-556

Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression

Author keywords

Alzheimer disease; Amyloid pathology; Molecular imaging; PET; Transgenic models; Ultra highfield MRI

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER;

EID: 82755193805     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2011.05.004     Document Type: Review
Times cited : (27)

References (104)
  • 1
    • 33846442858 scopus 로고    scopus 로고
    • The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging
    • Beekman F., van der Have F. The pinhole: gateway to ultra-high-resolution three-dimensional radionuclide imaging. Eur. J. Nucl. Med. Mol. Imaging 2007, 34:151-161.
    • (2007) Eur. J. Nucl. Med. Mol. Imaging , vol.34 , pp. 151-161
    • Beekman, F.1    van der Have, F.2
  • 4
    • 0032983334 scopus 로고    scopus 로고
    • Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
    • Bianca V.D., Dusi S., Bianchini E., Dal Pra I., Rossi F. Beta-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease. J. Biol. Chem. 1999, 274:15493-15499.
    • (1999) J. Biol. Chem. , vol.274 , pp. 15493-15499
    • Bianca, V.D.1    Dusi, S.2    Bianchini, E.3    Dal Pra, I.4    Rossi, F.5
  • 5
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers_Definitions_Working_Group
    • Biomarkers_Definitions_Working_Group Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin. Pharmacol. Ther. 2001, 69:89-95.
    • (2001) Clin. Pharmacol. Ther. , vol.69 , pp. 89-95
  • 8
    • 57049106701 scopus 로고    scopus 로고
    • Differential MRI patterns of brain atrophy in double or single transgenic mice for APP and/or SOD
    • Borg J., Chereul E. Differential MRI patterns of brain atrophy in double or single transgenic mice for APP and/or SOD. J. Neurosci. Res. 2008, 86:3275-3284.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 3275-3284
    • Borg, J.1    Chereul, E.2
  • 9
    • 33748252675 scopus 로고    scopus 로고
    • Longitudinal assessment of Alzheimer's beta-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging
    • Braakman N., Matysik J., van Duinen S.G., Verbeek F., Schliebs R., de Groot H.J., Alia A. Longitudinal assessment of Alzheimer's beta-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimaging. J. Magn. Reson. Imaging 2006, 24:530-536.
    • (2006) J. Magn. Reson. Imaging , vol.24 , pp. 530-536
    • Braakman, N.1    Matysik, J.2    van Duinen, S.G.3    Verbeek, F.4    Schliebs, R.5    de Groot, H.J.6    Alia, A.7
  • 13
    • 74949109430 scopus 로고    scopus 로고
    • The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain: a review of one company's experience
    • Carpenter A.P., Pontecorvo M.J., Hefti F.F., Skovronsky D.M. The use of the exploratory IND in the evaluation and development of 18F-PET radiopharmaceuticals for amyloid imaging in the brain: a review of one company's experience. Q. J. Nucl. Med. Mol. Imaging 2009, 53:387-393.
    • (2009) Q. J. Nucl. Med. Mol. Imaging , vol.53 , pp. 387-393
    • Carpenter, A.P.1    Pontecorvo, M.J.2    Hefti, F.F.3    Skovronsky, D.M.4
  • 14
    • 9144272296 scopus 로고    scopus 로고
    • Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
    • Cheng I.H., Palop J.J., Esposito L.A., Bien-Ly N., Yan F., Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat. Med. 2004, 10:1190-1192.
    • (2004) Nat. Med. , vol.10 , pp. 1190-1192
    • Cheng, I.H.1    Palop, J.J.2    Esposito, L.A.3    Bien-Ly, N.4    Yan, F.5    Mucke, L.6
  • 17
    • 2442582930 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile
    • Dedeoglu A., Choi J.K., Cormier K., Kowall N.W., Jenkins B.G. Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile. Brain Res. 2004, 1012:60-65.
    • (2004) Brain Res. , vol.1012 , pp. 60-65
    • Dedeoglu, A.1    Choi, J.K.2    Cormier, K.3    Kowall, N.W.4    Jenkins, B.G.5
  • 18
    • 33646173272 scopus 로고    scopus 로고
    • In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice
    • Delatour B., Guegan M., Volk A., Dhenain M. In vivo MRI and histological evaluation of brain atrophy in APP/PS1 transgenic mice. Neurobiol. Aging 2006, 27:835-847.
    • (2006) Neurobiol. Aging , vol.27 , pp. 835-847
    • Delatour, B.1    Guegan, M.2    Volk, A.3    Dhenain, M.4
  • 19
    • 75149140513 scopus 로고    scopus 로고
    • Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain
    • Duan X.H., Qiao J.P., Yang Y., Cui M.C., Zhou J.N., Liu B.L. Novel anilinophthalimide derivatives as potential probes for beta-amyloid plaque in the brain. Bioorg. Med. Chem. 2010, 18:1337-1343.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 1337-1343
    • Duan, X.H.1    Qiao, J.P.2    Yang, Y.3    Cui, M.C.4    Zhou, J.N.5    Liu, B.L.6
  • 21
    • 67650828141 scopus 로고    scopus 로고
    • Early detection of Alzheimer's disease: new diagnostic criteria
    • Dubois B., Picard G., Sarazin M. Early detection of Alzheimer's disease: new diagnostic criteria. Dial. Clin. Neurosci. 2009, 11:135-139.
    • (2009) Dial. Clin. Neurosci. , vol.11 , pp. 135-139
    • Dubois, B.1    Picard, G.2    Sarazin, M.3
  • 22
    • 34248344561 scopus 로고    scopus 로고
    • Gradient-echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I×ADAM10-dn mouse model
    • Faber C., Zahneisen B., Tippmann F., Schroeder A., Fahrenholz F. Gradient-echo and CRAZED imaging for minute detection of Alzheimer plaques in an APPV717I×ADAM10-dn mouse model. Magn. Reson. Med. 2007, 57:696-703.
    • (2007) Magn. Reson. Med. , vol.57 , pp. 696-703
    • Faber, C.1    Zahneisen, B.2    Tippmann, F.3    Schroeder, A.4    Fahrenholz, F.5
  • 23
    • 17444402483 scopus 로고    scopus 로고
    • Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology
    • Falangola M.F., Ardekani B.A., Lee S.P., Babb J.S., Bogart A., Dyakin V.V., Nixon R., Duff K., Helpern J.A. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. J. Neurosci. Methods 2005, 144:91-97.
    • (2005) J. Neurosci. Methods , vol.144 , pp. 91-97
    • Falangola, M.F.1    Ardekani, B.A.2    Lee, S.P.3    Babb, J.S.4    Bogart, A.5    Dyakin, V.V.6    Nixon, R.7    Duff, K.8    Helpern, J.A.9
  • 25
    • 75749128304 scopus 로고    scopus 로고
    • Translational neuroimaging of the CNS: novel pathways to drug development
    • Fox G.B., Chin C.L., Luo F., Day M., Cox B.F. Translational neuroimaging of the CNS: novel pathways to drug development. Mol. Interv. 2009, 9:302-313.
    • (2009) Mol. Interv. , vol.9 , pp. 302-313
    • Fox, G.B.1    Chin, C.L.2    Luo, F.3    Day, M.4    Cox, B.F.5
  • 29
    • 0032809776 scopus 로고    scopus 로고
    • The shorter amyloid cascade hypothesis
    • discussion 87
    • Hardy J. The shorter amyloid cascade hypothesis. Neurobiol. Aging 1999, 20:85. discussion 87.
    • (1999) Neurobiol. Aging , vol.20 , pp. 85
    • Hardy, J.1
  • 30
    • 0036861112 scopus 로고    scopus 로고
    • Testing times for the "amyloid cascade hypothesis"
    • Hardy J. Testing times for the "amyloid cascade hypothesis". Neurobiol. Aging 2002, 23:1073-1074.
    • (2002) Neurobiol. Aging , vol.23 , pp. 1073-1074
    • Hardy, J.1
  • 31
    • 0022921664 scopus 로고
    • An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease
    • Hardy J.A., Mann D.M., Wester P., Winblad B. An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiol. Aging 1986, 7:489-502.
    • (1986) Neurobiol. Aging , vol.7 , pp. 489-502
    • Hardy, J.A.1    Mann, D.M.2    Wester, P.3    Winblad, B.4
  • 34
    • 64549127780 scopus 로고    scopus 로고
    • Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease
    • Higuchi M. Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease. Curr. Alzheimers Res. 2009, 6:137-143.
    • (2009) Curr. Alzheimers Res. , vol.6 , pp. 137-143
    • Higuchi, M.1
  • 35
    • 76749104184 scopus 로고    scopus 로고
    • In vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: insights from neuroimaging research in humans and rodent models
    • Higuchi M., Maeda J., Ji B., Maruyama M., Okauchi T., Tokunaga M., Ono M., Suhara T. In vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: insights from neuroimaging research in humans and rodent models. Biochim. Biophys. Acta 2011, 1802:373-388.
    • (2011) Biochim. Biophys. Acta , vol.1802 , pp. 373-388
    • Higuchi, M.1    Maeda, J.2    Ji, B.3    Maruyama, M.4    Okauchi, T.5    Tokunaga, M.6    Ono, M.7    Suhara, T.8
  • 39
    • 0030611097 scopus 로고    scopus 로고
    • Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse
    • Irizarry M.C., Soriano F., McNamara M., Page K.J., Schenk D., Games D., Hyman B.T. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J. Neurosci. 1997, 17:7053-7059.
    • (1997) J. Neurosci. , vol.17 , pp. 7053-7059
    • Irizarry, M.C.1    Soriano, F.2    McNamara, M.3    Page, K.J.4    Schenk, D.5    Games, D.6    Hyman, B.T.7
  • 42
    • 33747038088 scopus 로고    scopus 로고
    • Treatment monitoring and response prediction with proton MR spectroscopy in AD
    • Jessen F., Traeber F., Freymann K., Maier W., Schild H.H., Block W. Treatment monitoring and response prediction with proton MR spectroscopy in AD. Neurology 2006, 67:528-530.
    • (2006) Neurology , vol.67 , pp. 528-530
    • Jessen, F.1    Traeber, F.2    Freymann, K.3    Maier, W.4    Schild, H.H.5    Block, W.6
  • 43
    • 3042770430 scopus 로고    scopus 로고
    • 1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia
    • Jones R.S., Waldman A.D. 1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia. Neurol. Res. 2004, 26:488-495.
    • (2004) Neurol. Res. , vol.26 , pp. 488-495
    • Jones, R.S.1    Waldman, A.D.2
  • 45
    • 43549126232 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy in dementia
    • Kantarci K. 1H magnetic resonance spectroscopy in dementia. Br. J. Radiol. 2007, 80(Spec No 2):S146-S152.
    • (2007) Br. J. Radiol. , vol.80 , Issue.SPEC NO 2
    • Kantarci, K.1
  • 46
    • 64549141924 scopus 로고    scopus 로고
    • NEMA NU 2-2007 performance measurements of the Siemens Inveon preclinical small animal PET system
    • Kemp B.J., Hruska C.B., McFarland A.R., Lenox M.W., Lowe V.J. NEMA NU 2-2007 performance measurements of the Siemens Inveon preclinical small animal PET system. Phys. Med. Biol. 2009, 54:2359-2376.
    • (2009) Phys. Med. Biol. , vol.54 , pp. 2359-2376
    • Kemp, B.J.1    Hruska, C.B.2    McFarland, A.R.3    Lenox, M.W.4    Lowe, V.J.5
  • 47
    • 0021261066 scopus 로고
    • Analysis of emission tomographic scan data: limitations imposed by resolution and background
    • Kessler R.M., Ellis J.R., Eden M. Analysis of emission tomographic scan data: limitations imposed by resolution and background. J. Comput. Assist. Tomogr. 1984, 8:514-522.
    • (1984) J. Comput. Assist. Tomogr. , vol.8 , pp. 514-522
    • Kessler, R.M.1    Ellis, J.R.2    Eden, M.3
  • 51
    • 56749112290 scopus 로고    scopus 로고
    • The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation
    • Klunk W.E., Mathis C.A. The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation. Curr. Opin. Neurol. 2008, 21:683-687.
    • (2008) Curr. Opin. Neurol. , vol.21 , pp. 683-687
    • Klunk, W.E.1    Mathis, C.A.2
  • 53
    • 45849094758 scopus 로고    scopus 로고
    • Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease
    • Lau J.C., Lerch J.P., Sled J.G., Henkelman R.M., Evans A.C., Bedell B.J. Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease. Neuroimage 2008, 42:19-27.
    • (2008) Neuroimage , vol.42 , pp. 19-27
    • Lau, J.C.1    Lerch, J.P.2    Sled, J.G.3    Henkelman, R.M.4    Evans, A.C.5    Bedell, B.J.6
  • 54
  • 56
  • 57
    • 0014474636 scopus 로고
    • Brain level of N-acetyl-l-aspartate in different strains of mouse and rat
    • Marcucci F., Airoldi L., Mussini E. Brain level of N-acetyl-l-aspartate in different strains of mouse and rat. J. Neurochem. 1969, 16:272-273.
    • (1969) J. Neurochem. , vol.16 , pp. 272-273
    • Marcucci, F.1    Airoldi, L.2    Mussini, E.3
  • 59
    • 0037338436 scopus 로고    scopus 로고
    • Molecular imaging in living subjects: seeing fundamental biological processes in a new light
    • Massoud T.F., Gambhir S.S. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev. 2003, 17:545-580.
    • (2003) Genes Dev. , vol.17 , pp. 545-580
    • Massoud, T.F.1    Gambhir, S.S.2
  • 60
    • 0038792263 scopus 로고    scopus 로고
    • Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    • Mathis C.A., Wang Y., Holt D.P., Huang G.F., Debnath M.L., Klunk W.E. Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. J. Med. Chem. 2003, 46:2740-2754.
    • (2003) J. Med. Chem. , vol.46 , pp. 2740-2754
    • Mathis, C.A.1    Wang, Y.2    Holt, D.P.3    Huang, G.F.4    Debnath, M.L.5    Klunk, W.E.6
  • 61
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease
    • McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 1984, 34:939-944.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 62
    • 66149090377 scopus 로고    scopus 로고
    • MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
    • Meadowcroft M.D., Connor J.R., Smith M.B., Yang Q.X. MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. J. Magn. Reson. Imaging 2009, 29:997-1007.
    • (2009) J. Magn. Reson. Imaging , vol.29 , pp. 997-1007
    • Meadowcroft, M.D.1    Connor, J.R.2    Smith, M.B.3    Yang, Q.X.4
  • 63
    • 0029788383 scopus 로고    scopus 로고
    • Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging
    • Meltzer C.C., Zubieta J.K., Brandt J., Tune L.E., Mayberg H.S., Frost J.J. Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging. Neurology 1996, 47:454-461.
    • (1996) Neurology , vol.47 , pp. 454-461
    • Meltzer, C.C.1    Zubieta, J.K.2    Brandt, J.3    Tune, L.E.4    Mayberg, H.S.5    Frost, J.J.6
  • 64
    • 0030874251 scopus 로고    scopus 로고
    • Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
    • Minoshima S., Giordani B., Berent S., Frey K.A., Foster N.L., Kuhl D.E. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann. Neurol. 1997, 42:85-94.
    • (1997) Ann. Neurol. , vol.42 , pp. 85-94
    • Minoshima, S.1    Giordani, B.2    Berent, S.3    Frey, K.A.4    Foster, N.L.5    Kuhl, D.E.6
  • 66
    • 41549112467 scopus 로고    scopus 로고
    • In vivo visualization of senile-plaque-like pathology in Alzheimer's disease patients by MR microscopy on a 7T system
    • Nakada T., Matsuzawa H., Igarashi H., Fujii Y., Kwee I.L. In vivo visualization of senile-plaque-like pathology in Alzheimer's disease patients by MR microscopy on a 7T system. J. Neuroimaging 2008, 18:125-129.
    • (2008) J. Neuroimaging , vol.18 , pp. 125-129
    • Nakada, T.1    Matsuzawa, H.2    Igarashi, H.3    Fujii, Y.4    Kwee, I.L.5
  • 67
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    • Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J. Neurosci. 2006, 26:10129-10140.
    • (2006) J. Neurosci. , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 69
    • 0344845132 scopus 로고    scopus 로고
    • Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
    • Oddo S., Caccamo A., Kitazawa M., Tseng B.P., LaFerla F.M. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol. Aging 2003, 24:1063-1070.
    • (2003) Neurobiol. Aging , vol.24 , pp. 1063-1070
    • Oddo, S.1    Caccamo, A.2    Kitazawa, M.3    Tseng, B.P.4    LaFerla, F.M.5
  • 71
    • 67649518011 scopus 로고    scopus 로고
    • Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?
    • Pahnke J., Walker L.C., Scheffler K., Krohn M. Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?. Neurosci. Biobehav. Rev. 2009, 33:1099-1108.
    • (2009) Neurosci. Biobehav. Rev. , vol.33 , pp. 1099-1108
    • Pahnke, J.1    Walker, L.C.2    Scheffler, K.3    Krohn, M.4
  • 73
    • 0034126959 scopus 로고    scopus 로고
    • PET: the merging of biology and imaging into molecular imaging
    • Phelps M.E. PET: the merging of biology and imaging into molecular imaging. J. Nucl. Med. 2000, 41:661-681.
    • (2000) J. Nucl. Med. , vol.41 , pp. 661-681
    • Phelps, M.E.1
  • 75
    • 70350266228 scopus 로고    scopus 로고
    • Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo
    • Rabinovici G.D., Jagust W.J. Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. Behav. Neurol. 2009, 21:117-128.
    • (2009) Behav. Neurol. , vol.21 , pp. 117-128
    • Rabinovici, G.D.1    Jagust, W.J.2
  • 81
    • 78649846020 scopus 로고    scopus 로고
    • PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease
    • Rosen R.F., Walker L.C., Levine H. PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease. Neurobiol. Aging 2011, 32:223-234.
    • (2011) Neurobiol. Aging , vol.32 , pp. 223-234
    • Rosen, R.F.1    Walker, L.C.2    Levine, H.3
  • 82
    • 41549110644 scopus 로고    scopus 로고
    • Small-animal preclinical nuclear medicine instrumentation and methodology
    • Rowland D.J., Cherry S.R. Small-animal preclinical nuclear medicine instrumentation and methodology. Semin. Nucl. Med. 2008, 38:209-222.
    • (2008) Semin. Nucl. Med. , vol.38 , pp. 209-222
    • Rowland, D.J.1    Cherry, S.R.2
  • 83
    • 84873082730 scopus 로고    scopus 로고
    • Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease. Curr. Alzhe
    • Scheffler, K., Stenzel, J., Krohn, M., Lange, C., Hofrichter, J., Schumacher, T., Brüning, T., Plath, A.-S., Walker, L., Pahnke, J., Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer's disease. Curr. Alzheimer Res., in press.
    • Scheffler, K.1    Stenzel, J.2    Krohn, M.3    Lange, C.4    Hofrichter, J.5    Schumacher, T.6    Brüning, T.7    Plath, A.-S.8    Walker, L.9    Pahnke, J.10
  • 84
    • 70949084460 scopus 로고    scopus 로고
    • Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents
    • Serdons K., Van Laere K., Janssen P., Kung H.F., Bormans G., Verbruggen A. Synthesis and evaluation of three 18F-labeled aminophenylbenzothiazoles as amyloid imaging agents. J. Med. Chem. 2009, 52:7090-7102.
    • (2009) J. Med. Chem. , vol.52 , pp. 7090-7102
    • Serdons, K.1    Van Laere, K.2    Janssen, P.3    Kung, H.F.4    Bormans, G.5    Verbruggen, A.6
  • 85
    • 38049090555 scopus 로고    scopus 로고
    • SPECT neuroimaging in translational research of CNS disorders
    • Sharma S., Ebadi M. SPECT neuroimaging in translational research of CNS disorders. Neurochem. Int. 2008, 52:352-362.
    • (2008) Neurochem. Int. , vol.52 , pp. 352-362
    • Sharma, S.1    Ebadi, M.2
  • 92
    • 82755198134 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services, F.a.D.A., Center for Drug Evaluation and Research. Guidance for Industry, Investigators, and Reviewers: Explanatory IND Studies.
    • U.S. Department of Health and Human Services, F.a.D.A., Center for Drug Evaluation and Research, 2006. Guidance for Industry, Investigators, and Reviewers: Explanatory IND Studies.
    • (2006)
  • 93
    • 0036338823 scopus 로고    scopus 로고
    • Effects of image resolution on autoradiographic measurements of posterior cingulate activity in PDAPP mice: implications for functional brain imaging studies of transgenic mouse models of Alzheimer's disease
    • Valla J., Chen K., Berndt J.D., Gonzalez-Lima F., Cherry S.R., Games D., Reiman E.M. Effects of image resolution on autoradiographic measurements of posterior cingulate activity in PDAPP mice: implications for functional brain imaging studies of transgenic mouse models of Alzheimer's disease. Neuroimage 2002, 16:1-6.
    • (2002) Neuroimage , vol.16 , pp. 1-6
    • Valla, J.1    Chen, K.2    Berndt, J.D.3    Gonzalez-Lima, F.4    Cherry, S.R.5    Games, D.6    Reiman, E.M.7
  • 94
    • 14744298662 scopus 로고    scopus 로고
    • Non-invasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease
    • Vanhoutte G., Dewachter I., Borghgraef P., Van Leuven F., Van der Linden A. Non-invasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magn. Reson. Med. 2005, 53:607-613.
    • (2005) Magn. Reson. Med. , vol.53 , pp. 607-613
    • Vanhoutte, G.1    Dewachter, I.2    Borghgraef, P.3    Van Leuven, F.4    Van der Linden, A.5
  • 99
    • 65449150553 scopus 로고    scopus 로고
    • In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
    • Westman E., Spenger C., Oberg J., Reyer H., Pahnke J., Wahlund L.O. In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment. BMC Neurosci. 2009, 10:33.
    • (2009) BMC Neurosci. , vol.10 , pp. 33
    • Westman, E.1    Spenger, C.2    Oberg, J.3    Reyer, H.4    Pahnke, J.5    Wahlund, L.O.6
  • 100
    • 69949135716 scopus 로고    scopus 로고
    • Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
    • Wirths O., Breyhan H., Cynis H., Schilling S., Demuth H.U., Bayer T.A. Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol. 2009, 118:487-496.
    • (2009) Acta Neuropathol. , vol.118 , pp. 487-496
    • Wirths, O.1    Breyhan, H.2    Cynis, H.3    Schilling, S.4    Demuth, H.U.5    Bayer, T.A.6
  • 101
    • 57649136969 scopus 로고    scopus 로고
    • The role of imaging in proof of concept for CNS drug discovery and development
    • Wong D.F., Tauscher J., Grunder G. The role of imaging in proof of concept for CNS drug discovery and development. Neuropsychopharmacology 2009, 34:187-203.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 187-203
    • Wong, D.F.1    Tauscher, J.2    Grunder, G.3
  • 102
    • 78650930400 scopus 로고    scopus 로고
    • Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510)
    • Yang D., Xie Z., Stephenson D., Morton D., Hicks C.D., Brown T.M., Sriram R., O'Neill S., Raunig D., Bocan T. Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). Neuroimage 2011, 54:2652-2658.
    • (2011) Neuroimage , vol.54 , pp. 2652-2658
    • Yang, D.1    Xie, Z.2    Stephenson, D.3    Morton, D.4    Hicks, C.D.5    Brown, T.M.6    Sriram, R.7    O'Neill, S.8    Raunig, D.9    Bocan, T.10


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