Testing times for the "amyloid cascade hypothesis"

Neurobiology of Aging

Volumn 23, Issue 6, 2002, Pages 1073-1074

  Hardy, John ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BEHAVIOR; DISEASE COURSE; DOWN SYNDROME; GENE MUTATION; HYPOTHESIS; MOLECULAR EVOLUTION; NOTE; PATHOGENESIS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOIDOSIS; ANIMALS; BRAIN; FLOCCULATION; HUMANS; METALS; MICE; MICE, TRANSGENIC; SENILE PLAQUES;

EID: 0036861112     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(02)00042-8     Document Type: Note

References (11)

1. Ertekin-Taner N., Graff-Radford N., Younkin L.H., Eckman C., Baker M., Adamson J.et al. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late onset Alzheimer's disease pedigrees. Science. 290:2000;2303-2304.
2. Gotz J., Chen F., van Dorpe J., Nitsch R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta42 fibrils. Science. 293:2001;1491-1495.
3. Janus C., Pearson J., McLaurin J., Mathews P.M., Jiang Y., Schmidt S.D.et al. A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature. 408:2000;979-982.
4. Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., Jones G.et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 293:2001;1487-1491.
5. Morgan D., Diamond D.M., Gottschall P., Ugen K.E., Dickey C., Hardy J.et al. Vaccination with Aβ peptide prevents memory deficits in an animal model of Alzheimer's disease. Nature. 408:2000;982-985.
6. Myers A., Holmans P., Marshall H., Kwon J., Meyer D., Ramic D.et al. Susceptibility locus for Alzheimer's disease on chromosome 10. Science. 290:2000;2304-2305.
7. Olson J.M., Goddard K.A.B., Dudek D.M. The amyloid precursor protein locus and very late onset Alzheimer's disease. Am. J. Hum. Genet. 69:2001;895-899.
8. Prasher V.P., Farrer M.J., Kessling A.M., Fisher E.M., West R.J., Barber P.C.et al. Molecular mapping of Alzheimer-type dementia in Down's syndrome. Ann. Neurol. 43:1998;380-383.
9. Robinson SR, Bishop GM. Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer's disease. Neurobiol Dis 2002 (in press).
10. Terry R.D. An honorable compromise regarding amyloid in Alzheimer disease. Ann. Neurol. 49:2000;684.
11. Wavrant-De Vrieze F., Crook R., Holmans P., Kehoe P., Owen M.J., Williams J.et al. Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late onset Alzheimer's disease. Neurosci. Lett. 269:1999;67-70.