-
1
-
-
84880187014
-
Alzheimer's disease: The amyloid cascade hypothesis: an update and reappraisal
-
Hardy J. Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal. J Alzheimers Dis 9: 151-3 (2006).
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 151-153
-
-
Hardy, J.1
-
2
-
-
10744232413
-
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
-
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 55: 306-19 (2004).
-
(2004)
Ann Neurol
, vol.55
, pp. 306-319
-
-
Klunk, W.E.1
Engler, H.2
Nordberg, A.3
Wang, Y.4
Blomqvist, G.5
Holt, D.P.6
-
4
-
-
34248579291
-
Imaging β-amyloid burden in aging and dementia
-
Rowe CC, Ng S, Ackermann U, Gong SJ, Pike K, Savage G, Cowie TF, et al. Imaging β-amyloid burden in aging and dementia. Neurology 68: 1718-25 (2007).
-
(2007)
Neurology
, vol.68
, pp. 1718-1725
-
-
Rowe, C.C.1
Ng, S.2
Ackermann, U.3
Gong, S.J.4
Pike, K.5
Savage, G.6
Cowie, T.F.7
-
5
-
-
0042020173
-
Treatment of Alzheimer's disease: Current status and new perspectives
-
Scarpini E, Scheltens P and Feldman H. Treatment of Alzheimer's disease: current status and new perspectives. Lancet Neurol 2: 539-47 (2003).
-
(2003)
Lancet Neurol
, vol.2
, pp. 539-547
-
-
Scarpini, E.1
Scheltens, P.2
Feldman, H.3
-
6
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173-7 (1999).
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
-
7
-
-
84984755327
-
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408: 982-85 (2000).
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
-
8
-
-
27944471285
-
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain
-
Klunk WE, Lopresti BJ, Ikonomovic MD, Lefterov IM, Koldamova RP, Abrahamson EE, et al. Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-β in Alzheimer's disease brain but not in transgenic mouse brain. J Neurosci 25: 10598-606 (2005).
-
(2005)
J Neurosci
, vol.25
, pp. 10598-10606
-
-
Klunk, W.E.1
Lopresti, B.J.2
Ikonomovic, M.D.3
Lefterov, I.M.4
Koldamova, R.P.5
Abrahamson, E.E.6
-
9
-
-
24044535149
-
11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
-
11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease. Eur J Nucl Med Mol Imaging 32: 593-600 (2005).
-
(2005)
Eur J Nucl Med Mol Imaging
, vol.32
, pp. 593-600
-
-
Toyama, H.1
Ye, D.2
Ichise, M.3
Liow, J.S.4
Cai, L.5
Jacobowitz, D.6
-
10
-
-
33845768784
-
Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
-
Block ML, Zecca L and Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69 (2007).
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 57-69
-
-
Block, M.L.1
Zecca, L.2
Hong, J.S.3
-
11
-
-
33846538660
-
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
-
Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53: 337-51 (2007).
-
(2007)
Neuron
, vol.53
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.M.4
Iwata, N.5
Saido, T.C.6
-
12
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, et al. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94: 13287-92 (1997).
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Rothacher, S.6
-
13
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274: 99-102 (1996).
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
-
14
-
-
35348821915
-
Longitudinal, quantitative assessment of amyloid, neuroinflammation and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
-
Maeda J, Ji B, Irie T, Tomiyama T, Maruyama M, Okauchi T, et al. Longitudinal, quantitative assessment of amyloid, neuroinflammation and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography. J Neurosci 27: 10957-68 (2007).
-
(2007)
J Neurosci
, vol.27
, pp. 10957-10968
-
-
Maeda, J.1
Ji, B.2
Irie, T.3
Tomiyama, T.4
Maruyama, M.5
Okauchi, T.6
-
15
-
-
11144353899
-
18F]fluoroethyl-5-methoxybenzyl)acetamide, for PET imaging of peripheral benzodiazepine receptor in primate brain
-
18F]fluoroethyl-5-methoxybenzyl)acetamide, for PET imaging of peripheral benzodiazepine receptor in primate brain. J Med Chem 47: 2228-35 (2004).
-
(2004)
J Med Chem
, vol.47
, pp. 2228-2235
-
-
Zhang, M.R.1
Maeda, J.2
Ogawa, M.3
Noguchi, J.4
Ito, T.5
Yoshida, Y.6
-
17
-
-
17844363989
-
Performance evaluation of the microPET focus: A third-generation microPET scanner dedicated to animal imaging
-
Tai YC, Ruangma A, Rowland D, Siegel S, Newport DF, Chow PL, et al. Performance evaluation of the microPET focus: a third-generation microPET scanner dedicated to animal imaging. J Nucl Med 46: 455-63 (2005).
-
(2005)
J Nucl Med
, vol.46
, pp. 455-463
-
-
Tai, Y.C.1
Ruangma, A.2
Rowland, D.3
Siegel, S.4
Newport, D.F.5
Chow, P.L.6
-
18
-
-
0028855851
-
N3(pE), in senile plaques
-
N3(pE), in senile plaques. Neuron 14: 457-66 (1995).
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.A.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
19
-
-
22144433066
-
In vivo detection of amyloid-β deposits by near-infrared imaging using an oxazine-derivative probe
-
Hintersteiner M, Enz A, Frey P, Jaton AL, Kinzy W, Kneuer R, et al. In vivo detection of amyloid-β deposits by near-infrared imaging using an oxazine-derivative probe. Nat Biotechnol 23: 577-83 (2005).
-
(2005)
Nat Biotechnol
, vol.23
, pp. 577-583
-
-
Hintersteiner, M.1
Enz, A.2
Frey, P.3
Jaton, A.L.4
Kinzy, W.5
Kneuer, R.6
-
20
-
-
84880189661
-
Alzheimer's disease immunotherapy: From in vitro amyloid immunomodulation to in vivo vaccination
-
Solomon B. Alzheimer's disease immunotherapy: from in vitro amyloid immunomodulation to in vivo vaccination. J Alzheimers Dis 9: 433-8 (2006).
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 433-438
-
-
Solomon, B.1
-
21
-
-
0035947207
-
Metabolic regulation of brain Aβ by neprilysin
-
Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, et al. Metabolic regulation of brain Aβ by neprilysin. Science 292: 1550-2 (2001).
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.P.6
|