Vitamin D metabolism and innate immunity

Molecular and Cellular Endocrinology

Volumn 347, Issue 1-2, 2011, Pages 97-105

  Lagishetty, Venu ^a   Liu, Nancy Q ^a   Hewison, Martin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cathelicidin; CYP27B1; Monocyte; Toll like receptor; Vitamin D; Vitamin D receptor

Indexed keywords

CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL; PLACEBO; VITAMIN D; VITAMIN D BINDING PROTEIN;

ANTIBACTERIAL ACTIVITY; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; DENDRITIC CELL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INDUCTION; GENETIC SUSCEPTIBILITY; GRANULOMATOSIS; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; INFECTION PREVENTION; INNATE IMMUNITY; MACROPHAGE FUNCTION; METABOLIC REGULATION; MONOCYTE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; REGULATORY T LYMPHOCYTE; REVIEW; RICKETS; SINGLE DRUG DOSE; TUBERCULOSIS; URINARY TRACT INFECTION; VITAMIN D METABOLISM; VITAMIN D RESPONSIVE ELEMENT;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ANTIGEN PRESENTATION; DENDRITIC CELLS; HUMANS; IMMUNITY, INNATE; IMMUNOMODULATION; MODELS, IMMUNOLOGICAL; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 82455208949     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.04.015     Document Type: Review

References (133)

1. Abe E., Miyaura C., Sakagami H., Takeda M., Konno K., Yamazaki T., Yoshiki S., Suda T. Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3. Proc. Natl. Acad. Sci. USA 1981, 78:4990-4994.
2. Abe E., Miyaura C., Tanaka H., Shiina Y., Kuribayashi T., Suda S., Nishii Y., DeLuca H.F., Suda T. 1 Alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanism. Proc. Natl. Acad. Sci. USA 1983, 80:5583-5587.
3. Adams J.S., Gacad M.A. Characterization of 1 alpha-hydroxylation of vitamin D3 sterols by cultured alveolar macrophages from patients with sarcoidosis. J. Exp. Med. 1985, 161:755-765.
4. Adams J.S., Sharma O.P., Gacad M.A., Singer F.R. Metabolism of 25-hydroxyvitamin D3 by cultured pulmonary alveolar macrophages in sarcoidosis. J. Clin. Invest. 1983, 72:1856-1860.
5. Adams J.S., Chen H., Chun R., Ren S., Wu S., Gacad M., Nguyen L., Ride J., Liu P., Modlin R., Hewison M. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J. Bone Miner. Res. 2007, 22(Suppl. 2):V20-V24.
6. Adams J.S., Ren S., Liu P.T., Chun R.F., Lagishetty V., Gombart A.F., Borregaard N., Modlin R.L., Hewison M. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J. Immunol. 2009, 182:4289-4295.
7. Agostini C., Semenzato G. Cytokines in sarcoidosis. Semin. Respir. Infect. 1998, 13:184-196.
8. Aloia J.F., Li-Ng M. Correspondence. Epidemiol. Infect. 2007, 1:4.
9. Asakura H., Aoshima K., Suga Y., Yamazaki M., Morishita E., Saito M., Miyamoto K., Nakao S. Beneficial effect of the active form of vitamin D3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models. Thromb. Haemost. 2001, 85:287-290.
10. Barbour G.L., Coburn J.W., Slatopolsky E., Norman A.W., Horst R.L. Hypercalcemia in an anephric patient with sarcoidosis: evidence for extrarenal generation of 1,25-dihydroxyvitamin D. N. Engl. J. Med. 1981, 305:440-443.
11. Bell N.H., Stern P.H., Pantzer E., Sinha T.K., DeLuca H.F. Evidence that increased circulating 1 alpha,25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J. Clin. Invest. 1979, 64:218-225.
12. Bergman P., Walter-Jallow L., Broliden K., Agerberth B., Soderlund J. The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr. HIV Res. 2007, 5:410-415.
13. Bettelli E., Korn T., Kuchroo V.K. Th17: the third member of the effector T cell trilogy. Curr. Opin. Immunol. 2007, 19:652-657.
14. Bhalla A.K., Amento E.P., Clemens T.L., Holick M.F., Krane S.M. Specific high-affinity receptors for 1,25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation. J. Clin. Endocrinol. Metab. 1983, 57:1308-1310.
15. Bhalla A.K., Amento E.P., Serog B., Glimcher L.H. 1,25-Dihydroxyvitamin D3 inhibits antigen-induced T cell activation. J. Immunol. 1984, 133:1748-1754.
16. Black P.N., Scragg R. Relationship between serum 25-hydroxyvitamin D and pulmonary function in the third national health and nutrition examination survey. Chest 2005, 128:3792-3798.
17. Bodnar L.M., Krohn M.A., Simhan H.N. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J. Nutr. 2009, 139:1157-1161.
18. Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M., Sibbald W.J. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655.
19. Boonstra A., Barrat F.J., Crain C., Heath V.L., Savelkoul H.F., O'Garra A. 1Alpha,25-Dihydroxyvitamin D3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J. Immunol. 2001, 167:4974-4980.
20. Brennan A., Katz D.R., Nunn J.D., Barker S., Hewison M., Fraher L.J., O'Riordan J.L. Dendritic cells from human tissues express receptors for the immunoregulatory vitamin D3 metabolite, dihydroxycholecalciferol. Immunology 1987, 61:457-461.
21. Cannell J.J., Vieth R., Umhau J.C., Holick M.F., Grant W.B., Madronich S., Garland C.F., Giovannucci E. Epidemic influenza and vitamin D. Epidemiol. Infect. 2006, 134:1129-1140.
22. Chan J., Xing Y., Magliozzo R.S., Bloom B.R. Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med. 1992, 175:1111-1122.
23. Chan T.Y., Poon P., Pang J., Swaminathan R., Chan C.H., Nisar M., Williams C.S., Davies P.D. A study of calcium and vitamin D metabolism in Chinese patients with pulmonary tuberculosis. J. Trop. Med. Hyg. 1994, 97:26-30.
24. Chocano-Bedoya P., Ronnenberg A.G. Vitamin D and tuberculosis. Nutr. Rev. 2009, 67:289-293.
25. Chun R.F., Lauridsen A.L., Suon L., Zella L.A., Pike J.W., Modlin R.L., Martineau A.R., Wilkinson R.J., Adams J., Hewison M. Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1, 25-dihydroxyvitamin D. J. Clin. Endocrinol. Metab. 2010, 95:3368-3376.
26. Colston K., Colston M.J., Feldman D. 1,25-Dihydroxyvitamin D3 and malignant melanoma: the presence of receptors and inhibition of cell growth in culture. Endocrinology 1981, 108:1083-1086.
27. Dam T.N., Moller B., Hindkjaer J., Kragballe K. The vitamin D3 analog calcipotriol suppresses the number and antigen-presenting function of Langerhans cells in normal human skin. J. Investig. Dermatol. Symp. Proc. 1996, 1:72-77.
28. D'Ambrosio D., Cippitelli M., Cocciolo M.G., Mazzeo D., Di Lucia P., Lang R., Sinigaglia F., Panina-Bordignon P. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J. Clin. Invest. 1998, 101:252-262.
29. Daniel C., Sartory N.A., Zahn N., Radeke H.H., Stein J.M. Immune modulatory treatment of TNBS colitis with calcitriol is associated with a change of a Th1/Th17 to a Th2 and regulatory T cell profile. J. Pharmacol. Exp. Ther. 2007, 324:23-33.
30. Davies P.D., Brown R.C., Woodhead J.S. Serum concentrations of vitamin D metabolites in untreated tuberculosis. Thorax 1985, 40:187-190.
31. Davies P.D., Church H.A., Brown R.C., Woodhead J.S. Raised serum calcium in tuberculosis patients in Africa. Eur. J. Respir. Dis. 1987, 71:341-344.
32. Davis L.M., Chang S.C., Mancini J., Nathanson M.S., Witter F.R., O'Brien K.O. Vitamin D insufficiency is prevalent among pregnant African American adolescents. J. Pediatr. Adolesc. Gynecol. 2010, 23:45-52.
33. Deretic V., Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009, 5:527-549.
34. Dimeloe S., Nanzer A., Ryanna K., Hawrylowicz C. Regulatory T cells, inflammation and the allergic response - the role of glucocorticoids and vitamin D. J. Steroid Biochem. Mol. Biol. 2010, 120:86-95.
35. Dowling G.B., Prosser Thomas E.W. Treatment of lupus vulgaris with calciferol. Lancet 1946, 1:919-922.
36. Edfeldt K., Liu P.T., Chun R., Fabri M., Schenk M., Wheelwright M., Keegan C., Krutzik S.R., Adams J.S., Hewison M., Modlin R.L. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc. Natl. Acad. Sci. USA 2010, 107:22593-22598.
37. Eisman J.A., Martin T.J., MacIntyre I., Moseley J.M. 1,25-Dihydroxyvitamin-D-receptor in breast cancer cells. Lancet 1979, 2:1335-1336.
38. Equils O., Naiki Y., Shapiro A.M., Michelsen K., Lu D., Adams J., Jordan S. 1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin. Exp. Immunol. 2006, 143:58-64.
39. Evans K.N., Nguyen L., Chan J., Innes B.A., Bulmer J.N., Kilby M.D., Hewison M. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol. Reprod. 2006, 75:816-822.
40. Fritsche J., Mondal K., Ehrnsperger A., Andreesen R., Kreutz M. Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells. Blood 2003, 102:3314-3316.
41. Froicu M., Cantorna M.T. Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol. 2007, 8:5.
42. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat. Rev. Immunol. 2003, 3:710-720.
43. Gao L., Tao Y., Zhang L., Jin Q. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis. Int. J. Tuberc. Lung Dis. 2010, 14:15-23.
44. Gombart A.F., Borregaard N., Koeffler H.P. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005, 19:1067-1077.
45. Gombart A.F., Bhan I., Borregaard N., Tamez H., Camargo C.A., Koeffler H.P., Thadhani R. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. Clin. Infect. Dis. 2009, 48:418-424.
46. Gombart A.F., Saito T., Koeffler H.P. Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates. BMC Genomics 2009, 10:321.
47. Gorman S., Kuritzky L.A., Judge M.A., Dixon K.M., McGlade J.P., Mason R.S., Finlay-Jones J.J., Hart P.H. Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes. J. Immunol. 2007, 179:6273-6283.
48. Gregori S., Casorati M., Amuchastegui S., Smiroldo S., Davalli A.M., Adorini L. Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance. J. Immunol. 2001, 167:1945-1953.
49. Gregori S., Giarratana N., Smiroldo S., Uskokovic M., Adorini L. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 2002, 51:1367-1374.
50. Griffin M.D., Lutz W.H., Phan V.A., Bachman L.A., McKean D.J., Kumar R. Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. Biochem. Biophys. Res. Commun. 2000, 270:701-708.
51. Griffin M.D., Xing N., Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu. Rev. Nutr. 2003, 23:117-145.
52. Gutierrez M.G., Master S.S., Singh S.B., Taylor G.A., Colombo M.I., Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004, 119:753-766.
53. Harrington L.E., Mangan P.R., Weaver C.T. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr. Opin. Immunol. 2006, 18:349-356.
54. Hertting O., Holm A., Luthje P., Brauner H., Dyrdak R., Jonasson A.F., Wiklund P., Chromek M., Brauner A. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS ONE 2010, 5:e15580.
55. Hewison M. Vitamin D and the immune system. J. Endocrinol. 1992, 132:173-175.
56. Hewison M. Vitamin D and the intracrinology of innate immunity. Mol. Cell. Endocrinol. 2010, 321:103-111.
57. Hewison M., Freeman L., Hughes S.V., Evans K.N., Bland R., Eliopoulos A.G., Kilby M.D., Moss P.A., Chakraverty R. Differential regulation of vitamin D receptor and its ligand in human monocyte-derived dendritic cells. J. Immunol. 2003, 170:5382-5390.
58. Hewison M., Zehnder D., Chakraverty R., Adams J.S. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol. Cell. Endocrinol. 2004, 215:31-38.
59. Hewison M., Burke F., Evans K.N., Lammas D.A., Sansom D.M., Liu P., Modlin R.L., Adams J.S. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J. Steroid Biochem. Mol. Biol. 2007, 103:316-321.
60. Holick M.F. Vitamin D deficiency. N. Engl. J. Med. 2007, 357:266-281.
61. Horne S.L., Cockcroft D.W., Dosman J.A. Possible protective effect against chronic obstructive airways disease by the GC2 allele. Hum. Hered. 1990, 40:173-176.
62. Ishii T., Keicho N., Teramoto S., Azuma A., Kudoh S., Fukuchi Y., Ouchi Y., Matsuse T. Association of Gc-globulin variation with susceptibility to COPD and diffuse panbronchiolitis. Eur. Respir. J. 2001, 18:753-757.
63. Janssens W., Bouillon R., Claes B., Carremans C., Lehouck A., Buysschaert I., Coolen J., Mathieu C., Decramer M., Lambrechts D. Vitamin D deficiency is highly prevalent in COPD and correlates with variants in the vitamin D binding gene. Thorax. 2009, 65:215-220.
64. Jeffery L.E., Burke F., Mura M., Zheng Y., Qureshi O.S., Hewison M., Walker L.S., Lammas D.A., Raza K., Sansom D.M. 1,25-Dihydroxyvitamin D(3) and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 2009, 183:5458-5467.
65. Jeng L., Yamshchikov A.V., Judd S.E., Blumberg H.M., Martin G.S., Ziegler T.R., Tangpricha V. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J. Translant. Med. 2009, 7:28.
66. Kallas M., Green F., Hewison M., White C., Kline G. Rare causes of calcitriol-mediated hypercalcemia: a case report and literature review. J. Clin. Endocrinol. Metab. 2010, 95:3111-3117.
67. Kamboh M.I., Ferrell R.E. Ethnic variation in vitamin D-binding protein (GC): a review of isoelectric focusing studies in human populations. Hum. Genet. 1986, 72:281-293.
68. Kao C.Y., Kim C., Huang F., Wu R. Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium. J. Biol. Chem. 2008, 283:15309-15318.
69. Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 2010, 11:373-384.
70. Klionsky D.J., Emr S.D. Autophagy as a regulated pathway of cellular degradation. Science 2000, 290:1717-1721.
71. Kohchi C., Inagawa H., Nishizawa T., Soma G. ROS and innate immunity. Anticancer Res. 2009, 29:817-821.
72. Koren R., Ravid A., Rotem C., Shohami E., Liberman U.A., Novogrodsky A. 1,25-Dihydroxyvitamin D3 enhances prostaglandin E2 production by monocytes. A mechanism which partially accounts for the antiproliferative effect of 1,25(OH)2D3 on lymphocytes. FEBS Lett. 1986, 205:113-116.
73. Korn T., Oukka M., Kuchroo V., Bettelli E. Th17 cells: effector T cells with inflammatory properties. Semin. Immunol. 2007, 19:362-371.
74. Krutzik S.R., Hewison M., Liu P.T., Robles J.A., Stenger S., Adams J.S., Modlin R.L. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J. Immunol. 2008, 181:7115-7120.
75. Lagishetty V., Chun R.F., Liu N.Q., Lisse T.S., Adams J.S., Hewison M. 1Alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines. J. Steroid Biochem. Mol. Biol. 2010, 121:228-233.
76. Lagishetty V., Misharin A.V., Liu N.Q., Lisse T.S., Chun R.F., Ouyang Y., McLachlan S.M., Adams J.S., Hewison M. Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis. Endocrinology 2010, 151:2423-2432.
77. Lemire J.M., Archer D.C., Beck L., Spiegelberg H.L. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J. Nutr. 1995, 125:1704S-1708S.
78. Levy M.M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., Cohen J., Opal S.M., Vincent J.L., Ramsay G. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit. Care Med. 2003, 31:1250-1256.
79. Litonjua A.A., Weiss S.T. Is vitamin D deficiency to blame for the asthma epidemic?. J. Allergy Clin. Immunol. 2007, 120:1031-1035.
80. Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 2005, 23:275-306.
81. Liu P.T., Stenger S., Li H., Wenzel L., Tan B.H., Krutzik S.R., Ochoa M.T., Schauber J., Wu K., Meinken C., Kamen D.L., Wagner M., Bals R., Steinmeyer A., Zugel U., Gallo R.L., Eisenberg D., Hewison M., Hollis B.W., Adams J.S., Bloom B.R., Modlin R.L. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 2006, 311:1770-1773.
82. Liu N., Nguyen L., Chun R.F., Lagishetty V., Ren S., Wu S., Hollis B., DeLuca H.F., Adams J.S., Hewison M. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology 2008, 149:4799-4808.
83. Liu N., Kaplan A.T., Low J., Nguyen L., Liu G.Y., Equils O., Hewison M. Vitamin D induces innate antibacterial responses in human trophoblasts via an intracrine pathway. Biol. Reprod. 2009, 80:398-406.
84. Liu P.T., Schenk M., Walker V.P., Dempsey P.W., Kanchanapoomi M., Wheelwright M., Vazirnia A., Zhang X., Steinmeyer A., Zugel U., Hollis B.W., Cheng G., Modlin R.L. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE 2009, 4:e5810.
85. Manolagas S.C., Haussler M.R., Deftos L.J. 1,25-Dihydroxyvitamin D3 receptors in cancer. Lancet 1980, 1:828.
86. Martineau A.R., Wilkinson R.J., Wilkinson K.A., Newton S.M., Kampmann B., Hall B.M., Packe G.E., Davidson R.N., Eldridge S.M., Maunsell Z.J., Rainbow S.J., Berry J.L., Griffiths C.J. A single dose of vitamin D enhances immunity to mycobacteria. Am. J. Respir. Crit. Care Med. 2007, 176:208-213.
87. Martineau A.R., Leandro A.C., Anderson S.T., Newton S.M., Wilkinson K.A., Nicol M.P., Pienaar S.M., Skolimowska K.H., Rocha M.A., Rolla V.C., Levin M., Davidson R.N., Bremner S.A., Griffiths C.J., Eley B.S., Bonecini-Almeida M.G., Wilkinson R.J. Association between Gc genotype and susceptibility to TB is dependent on vitamin D status. Eur. Respir. J. 2010, 35:1106-1112.
88. Martineau A.R., Timms P.M., Bothamley G.H., Hanifa Y., Islam K., Claxton A.P., Packe G.E., Moore-Gillon J.C., Darmalingam M., Davidson R.N., Milburn H.J., Baker L.V., Barker R.D., Woodward N.J., Venton T.R., Barnes K.E., Mullett C.J., Coussens A.K., Rutterford C.M., Mein C.A., Davies G.R., Wilkinson R.J., Nikolayevskyy V., Drobniewski F.A., Eldridge S.M., Griffiths C.J. High-dose vitamin D(3) during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial. Lancet 2011, 377:242-250.
89. Mathieu C., Badenhoop K. Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol. Metab. 2005, 16:261-266.
90. Mathieu C., Van Etten E., Gysemans C., Decallonne B., Kato S., Laureys J., Depovere J., Valckx D., Verstuyf A., Bouillon R. In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. J. Bone Miner. Res. 2001, 16:2057-2065.
91. Morcos M.M., Gabr A.A., Samuel S., Kamel M., el Baz M., el Beshry M., Michail R.R. Vitamin D administration to tuberculous children and its value. Boll. Chim. Farm. 1998, 137:157-164.
92. Nnoaham K.E., Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int. J. Epidemiol. 2008, 37:113-119.
93. Nursyam E.W., Amin Z., Rumende C.M. The effect of vitamin D as supplementary treatment in patients with moderately advanced pulmonary tuberculous lesion. Acta Med. Indones. 2006, 38:3-5.
94. O'Kelly J., Hisatake J., Hisatake Y., Bishop J., Norman A., Koeffler H.P. Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice. J. Clin. Invest. 2002, 109:1091-1099.
95. Overbergh L., Decallonne B., Waer M., Rutgeerts O., Valckx D., Casteels K.M., Laureys J., Bouillon R., Mathieu C. 1Alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543). Diabetes 2000, 49:1301-1307.
96. Packey C.D., Sartor R.B. Commensal bacteria, traditional and opportunistic pathogens, dysbiosis and bacterial killing in inflammatory bowel diseases. Curr. Opin. Infect. Dis. 2009, 22:292-301.
97. Papapoulos S.E., Clemens T.L., Fraher L.J., Lewin I.G., Sandler L.M., O'Riordan J.L. 1,25-Dihydroxycholecalciferol in the pathogenesis of the hypercalcaemia of sarcoidosis. Lancet 1979, 1:627-630.
98. Penna G., Adorini L. 1 Alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J. Immunol. 2000, 164:2405-2411.
99. Provvedini D.M., Tsoukas C.D., Deftos L.J., Manolagas S.C. 1,25-Dihydroxyvitamin D3 receptors in human leukocytes. Science 1983, 221:1181-1183.
100. Quarles L.D. Endocrine functions of bone in mineral metabolism regulation. J. Clin. Invest. 2008, 118:3820-3828.
101. Ren S., Nguyen L., Wu S., Encinas C., Adams J.S., Hewison M. Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J. Biol. Chem. 2005, 280:20604-20611.
102. Rockett K.A., Brookes R., Udalova I., Vidal V., Hill A.V., Kwiatkowski D. 1,25-Dihydroxyvitamin D3 induces nitric oxide synthase and suppresses growth of Mycobacterium tuberculosis in a human macrophage-like cell line. Infect. Immun. 1998, 66:5314-5321.
103. Rook G.A., Steele J., Fraher L., Barker S., Karmali R., O'Riordan J., Stanford J. Vitamin D3, gamma interferon, and control of proliferation of Mycobacterium tuberculosis by human monocytes. Immunology 1986, 57:159-163.
104. Sakaki T., Kagawa N., Yamamoto K., Inouye K. Metabolism of vitamin D3 by cytochromes P450. Front. Biosci. 2005, 10:119-134.
105. Sampsonas F., Karkoulias K., Kaparianos A., Spiropoulos K. Genetics of chronic obstructive pulmonary disease, beyond a1-antitrypsin deficiency. Curr. Med. Chem. 2006, 13:2857-2873.
106. Sasidharan P.K., Rajeev E., Vijayakumari V. Tuberculosis and vitamin D deficiency. J. Assoc. Physicians India 2002, 50:554-558.
107. Schauber J., Dorschner R.A., Yamasaki K., Brouha B., Gallo R.L. Control of the innate epithelial antimicrobial response is cell-type specific and dependent on relevant microenvironmental stimuli. Immunology 2006, 118:509-519.
108. Schauber J., Dorschner R.A., Coda A.B., Buchau A.S., Liu P.T., Kiken D., Helfrich Y.R., Kang S., Elalieh H.Z., Steinmeyer A., Zugel U., Bikle D.D., Modlin R.L., Gallo R.L. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J. Clin. Invest. 2007, 117:803-811.
109. Shin D.M., Yuk J.M., Lee H.M., Lee S.H., Son J.W., Harding C.V., Kim J.M., Modlin R.L., Jo E.K. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signaling. Cell. Microbiol. 2010, 12:1648-1665.
110. Shin J.S., Choi M.Y., Longtine M.S., Nelson D.M. Vitamin D effects on pregnancy and the placenta. Placenta 2010, 31:1027-1034.
111. Sly L.M., Lopez M., Nauseef W.M., Reiner N.E. 1Alpha,25-Dihydroxyvitamin D3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase. J. Biol. Chem. 2001, 276:35482-35493.
112. Sorensen O., Cowland J.B., Askaa J., Borregaard N. An ELISA for hCAP-18, the cathelicidin present in human neutrophils and plasma. J. Immunol. Methods 1997, 206:53-59.
113. Spach K.M., Nashold F.E., Dittel B.N., Hayes C.E. IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis. J. Immunol. 2006, 177:6030-6037.
114. Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 2003, 21:685-711.
115. Stoffels K., Overbergh L., Giulietti A., Verlinden L., Bouillon R., Mathieu C. Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J. Bone Miner. Res. 2006, 21:37-47.
116. Strober W., Murray P.J., Kitani A., Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 2006, 6:9-20.
117. Takeda K., Akira S. Toll-like receptors in innate immunity. Int. Immunol. 2005, 17:1-14.
118. Talat N., Perry S., Parsonnet J., Dawood G., Hussain R. Vitamin D deficiency and tuberculosis progression. Emerg. Infect. Dis. 2010, 16:853-855.
119. Timms P.M., Mannan N., Hitman G.A., Noonan K., Mills P.G., Syndercombe-Court D., Aganna E., Price C.P., Boucher B.J. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders?. QJM 2002, 95:787-796.
120. Urry Z., Xystrakis E., Richards D.F., McDonald J., Sattar Z., Cousins D.J., Corrigan C.J., Hickman E., Brown Z., Hawrylowicz C.M. Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J. Clin. Invest. 2009, 119:387-398.
121. Van Etten E., Decallonne B., Verlinden L., Verstuyf A., Bouillon R., Mathieu C. Analogs of 1alpha,25-dihydroxyvitamin D3 as pluripotent immunomodulators. J. Cell. Biochem. 2003, 88:223-226.
122. van Halteren A.G., Van Etten E., de Jong E.C., Bouillon R., Roep B.O., Mathieu C. Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3). Diabetes 2002, 51:2119-2125.
123. Wang T.T., Nestel F.P., Bourdeau V., Nagai Y., Wang Q., Liao J., Tavera-Mendoza L., Lin R., Hanrahan J.W., Mader S., White J.H. Cutting edge: 1,25-dihydroxyvitamin D3 is a direct inducer of antimicrobial peptide gene expression. J. Immunol. 2004, 173:2909-2912.
124. Wang T.T., Dabbas B., Laperriere D., Bitton A.J., Soualhine H., Tavera-Mendoza L.E., Dionne S., Servant M.J., Bitton A., Seidman E.G., Mader S., Behr M.A., White J.H. Direct and indirect induction by 1, 25-dihydroxyvitamin D3 of the NOD2/CARD15-beta defensin 2 innate immune pathway defective in Crohn's disease. J. Biol. Chem. 2010, 285:2227-2231.
125. Wang T.J., Zhang F., Richards J.B., Kestenbaum B., van Meurs J.B., Berry D., Kiel D.P., Streeten E.A., Ohlsson C., Koller D.L., Peltonen L., Cooper J.D., O'Reilly P.F., Houston D.K., Glazer N.L., Vandenput L., Peacock M., Shi J., Rivadeneira F., McCarthy M.I., Anneli P., de Boer I.H., Mangino M., Kato B., Smyth D.J., Booth S.L., Jacques P.F., Burke G.L., Goodarzi M., Cheung C.L., Wolf M., Rice K., Goltzman D., Hidiroglou N., Ladouceur M., Wareham N.J., Hocking L.J., Hart D., Arden N.K., Cooper C., Malik S., Fraser W.D., Hartikainen A.L., Zhai G., Macdonald H.M., Forouhi N.G., Loos R.J., Reid D.M., Hakim A., Dennison E., Liu Y., Power C., Stevens H.E., Jaana L., Vasan R.S., Soranzo N., Bojunga J., Psaty B.M., Lorentzon M., Foroud T., Harris T.B., Hofman A., Jansson J.O., Cauley J.A., Uitterlinden A.G., Gibson Q., Jarvelin M.R., Karasik D., Siscovick D.S., Econs M.J., Kritchevsky S.B., Florez J.C., Todd J.A., Dupuis J., Hypponen E., Spector T.D. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010, 376:180-188.
126. Weaver C.T., Hatton R.D., Mangan P.R., Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 2007, 25:821-852.
127. Wilkinson R.J., Llewelyn M., Toossi Z., Patel P., Pasvol G., Lalvani A., Wright D., Latif M., Davidson R.N. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 2000, 355:618-621.
128. Wood A.M., Bassford C., Webster D., Newby P., Rajesh P., Stockley R.A., Thickett D.R. Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages. Thorax 2011, 66:205-210.
129. Yang C.S., Shin D.M., Kim K.H., Lee Z.W., Lee C.H., Park S.G., Bae Y.S., Jo E.K. NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression. J. Immunol. 2009, 182:3696-3705.
130. Yim S., Dhawan P., Ragunath C., Christakos S., Diamond G. Induction of cathelicidin in normal and CF bronchial epithelial cells by 1, 25-dihydroxyvitamin D(3). J. Cyst. Fibros. 2007, 6:403-410.
131. Yuk J.M., Shin D.M., Lee H.M., Yang C.S., Jin H.S., Kim K.K., Lee Z.W., Lee S.H., Kim J.M., Jo E.K. Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe 2009, 6:231-243.
132. Zasloff M. Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J. Am. Soc. Nephrol. 2007, 18:2810-2816.
133. Zehnder D., Bland R., Williams M.C., McNinch R.W., Howie A.J., Stewart P.M., Hewison M. Extrarenal expression of 25-hydroxyvitamin D(3)-1 alpha-hydroxylase. J. Clin. Endocrinol. Metab. 2001, 86:888-894.