1α,25-Dihydroxyvitamin D3 has a direct effect on naive CD4+ T cells to enhance the development of Th2 cells

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 4974-4980

  Boonstra, A ^a   Barrat, F J ^a   Crain, C ^a   Heath, V L ^a   Savelkoul, H F J ^a   O'Garra, A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CALCITRIOL; CD28 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 5; L SELECTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3; DNA BINDING PROTEIN; GATA3 PROTEIN, MOUSE; MAF PROTEIN, MOUSE; ONCOPROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR C MAF;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; CELL MATURATION; CELL POLARITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; IMMUNOREGULATION; MACROPHAGE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; DRUG EFFECT; PHYSIOLOGY;

ANIMALS; ANTIGEN-PRESENTING CELLS; CALCITRIOL; CD4-POSITIVE T-LYMPHOCYTES; CELL POLARITY; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; INTERFERON TYPE II; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MAF; TH2 CELLS; TRANS-ACTIVATORS;

EID: 0035497752     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.4974     Document Type: Article

References (52)

1. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
2. Role of T-cell derived cytokines in the down-regulation of immune responses in parasitic and retroviral infection
3. Functional diversity of helper T lymphocytes
4. + T cells
5. Signaling and transcription in T helper development
6. Interleukin-12: A proinflammatory cytokine with immuno-regulatory functions that bridge innate resistance and antigen-specific adaptive immunity
7. Cytokines induce the development of functionally heterogeneous T helper cell subsets
8. The proto-oncogene c-mafis responsible for tissue-specific expression of interleukin-4
9. Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3
10. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
11. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
12. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
13. GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels
14. A novel transcription factor, T-bet, directs Th1 lineage commitment
15. + lymphocytes
16. Glucocorticoids inhibit bioactive IL-12p70 production by in vitro-generated human dendritic cells without affecting their T cell stimulatory potential
17. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes
18. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: Preferential inhibition of Th1 functions
19. Retinoid treatment of experimental allergic encephalomyelitis: IL-4 production correlates with improved disease course
20. Immunomodulatory actions of 1,25-dihydroxyvitamin D3
21. Transcriptional repression of the interleukin-2 gene by vitamin D3: Direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor
22. Down-regulation of NF-KB protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3
23. Convergence of transforming growth factor-β and vitamin D signaling pathways on SMAD transcriptional coactivators
24. 25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages
25. 1,25-Dihydroxyvitamin D3 attenuates the expression of experimental murine lupus of MRL/I mice
26. 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis
27. Prevention of autoimmune diabetes in NOD mice by 1,25-dihydroxyvitamin D3
28. 1,25-dihydroxyvitamin D3: A novel immunoregulatory hormone
29. Newly identified actions of the vitamin D endocrine system
30. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells
31. Inhibition of IL-12 production by I,25-dihydroxyvitamin D3: Involvement of NF-κB downregulation in transcriptional repression of the p40 gene
32. 1α,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation
33. Inhibition of Th1 development and treatment of chronic-relapsing experimental allergic encephalomyelitis by a non-hypercalcemic analogue of 1,25-dihydroxyvitamin D(3)
34. 1.25-Dihydroxyvitamin D3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitro
35. 1,25-Dihydroxyvitamin D3 is a positive regulator for the two and-encephalitogenic cytokines TGF-β1 and IL-4
36. 1α.25-Dihydroxyvitamin D3 induces an autoantigen-specific T-helper I/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543)
37. The effects of 1,25-dihydroxyvitamin D3 on human T lymphocyte activation and proliferation: A cell cycle analysis
38. lo thymocytes in vivo
39. Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1
40. Interleukin 12, interferon 7, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction
41. + effector T cells in vivo: Immunization results in a transient population of MEL-14-, CD45RB-helper cells that secretes interleukin 2 (IL-2), IL-3, IL-4, and interferon γ
42. + T cells
43. Heterogeneity of intracellular cytokine synthesis at the singlecell level in polarized T helper I and T helper 2 populations
44. Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA
45. Anti-proliferative effect of IFN-T in immune regulation. I. IFN-ηinhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones
46. 1,25-Dihydroxyvitamin D3 as a natural regulator of human immune functions
47. Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells
48. LFA-I interaction with 1CAM-1 and 1CAM-2 regulates Th2 cytokine production
49. + T cell responses: The alternative approaches
50. Vitamin D3: A transcriptional modulator of the interferon-γ gene
51. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
52. Vitamin D and the immune system