1α,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543)

Diabetes

Volumn 49, Issue 8, 2000, Pages 1301-1307

  Overbergh, L ^a   Decallonne, B ^a   Waer, M ^a   Rutgeerts, O ^a   Valckx, D ^a   Casteels, K M ^a   Laureys, J ^a   Bouillon, R ^a   Mathieu, C ^a  

^a LEGENDO   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CALCITRIOL; GAD 65 PROTEIN; OVALBUMIN; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CHAPERONIN; CYTOKINE; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 65; HEAT SHOCK PROTEIN 65, MYCOBACTERIUM; HEAT-SHOCK PROTEIN 65, MYCOBACTERIUM; INSULIN; INTERLEUKIN 4; ISOENZYME; PEPTIDE FRAGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; LYMPH NODE; LYMPHOCYTE ACTIVATION; MOLECULAR GENETICS; NONOBESE DIABETIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; BACTERIAL PROTEINS; CALCITRIOL; CHAPERONINS; CYTOKINES; DIABETES MELLITUS, TYPE 1; GENE EXPRESSION REGULATION; GLUTAMATE DECARBOXYLASE; INSULIN; INTERFERON TYPE II; INTERLEUKIN-4; ISOENZYMES; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; TH1 CELLS; TH2 CELLS; TRANSCRIPTION, GENETIC;

EID: 0033624113     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.8.1301     Document Type: Article

References (45)

1. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes
2. Immune response to glutamic acid decarboxylase correlates with insulitis in nonobese diabetic mice
3. Immunization with the large isoform of mouse glutamic acid decarboxylase (GAD67) prevents autoimmune diabetes in NOD mice
4. Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice
5. Neonatal tolerization with glutamic acid decarboxylase but not with bovine serum albumin delays the onset of diabetes in nonobese diabetic mice
6. Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes
7. + Th1 cells induce diabetes in NOD/SCID mice
8. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in β cells
9. T-cell responses to autoantigens in IDDM: The search for the Holy Grail
10. Cellular immune response to diverse islet cell antigens in IDDM
11. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
12. Functional diversity of helper T lymphocytes
13. The expanding universe of T-cell subsets: Th1, Th2 and more
14. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus
15. T helper subsets in insulin-dependent diabetes
16. IL-4 induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
17. IL-4 prevents insulitis and insulin-dependent diabetes mellitus in nonobese diabetic mice by potentiation of regulatory T helper-2 cell function
18. 3
19. 3: Direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor
20. Nuclear factor of activated T cells (NFAT) as a molecular target for 1,25-dihydroxyvitamin D3-mediated effects
21. Vitamin D3: A transcriptional modulator of the interferon-γ gene
22. 3 receptor: Implications for allosteric influences on nuclear receptor structure and function by a DNA element
23. 1,25-Dihydroxyvitamin D3 and a variety of its natural metabolites transcriptionally repress nuclear-factor-κB-mediated interleukin-8 gene expression
24. 3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-β1 and IL-4
25. Antagonistic effects of transforming growth factor-beta on vitamin D-3, enhancement of osteocalcin and osteopontin transcription: Reduced interactions of vitamin D receptor retinoid X receptor complexes with vitamin D response elements
26. 3 prevents insulitis in NOD mice
27. 3
28. Vitamin D and diabetes
29. 3 in combination with a short induction course of cyclosporin A
30. 3 analog and cyclosporine
31. 3
32. 2D3
33. 3 in vitro and in vivo
34. NOD mouse colonies around the world: Recent facts and figures
35. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR
36. IL-4 reverses T-cell proliferative unresponsiveness and prevents the onset of diabetes in NOD mice
37. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM
38. 3 restores sensitivity to cyclophosphamide-induced apoptosis in non-obese diabetic (NOD) mice and protects against diabetes
39. + T-cells in syngeneic islet grafts in NOD mice produce interferon-γ during β-cell destruction
40. Prevention of type 1 diabetes in NOD mice by adjuvant immunotherapy
41. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes
42. 3 in human peripheral blood mononuclear cells: Presence in monocytes and induction in T lymphocytes following activation
43. 3 (calcitriol)
44. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: Analysis of a 'speed congenic' stock of NOD.Igμ(null) mice
45. B Lymphocytes are crucial antigen-presenting cells in the pathogenic autoimmune response to GAD65z antigen in nonobese diabetic mice