The vitamin D3 analog calcipotriol suppresses the number and antigen-presenting function of langerhans cells in normal human skin

Journal of Investigative Dermatology Symposium Proceedings

Volumn 1, Issue 1, 1996, Pages 72-77

  Dam, Tomas Norman ^a,b   Møller, Bjarne ^a   Hindkjær, Johnny ^a   Kragballe, Knud ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Vdriapcihla drll,25 dihv droxyvitatnin d3

Indexed keywords

CALCIPOTRIOL; CALCITRIOL; CALCITRIOL RECEPTOR; DRUG DERIVATIVE; HLA DR ANTIGEN; IMMUNOSUPPRESSIVE AGENT;

ADULT; ANTIGEN PRESENTATION; ARTICLE; CELL COUNT; CELL CULTURE; DRUG EFFECT; HUMAN; LANGERHANS CELL; LYMPHOCYTE ACTIVATION; PHYSIOLOGY;

ADULT; ANTIGEN PRESENTATION; CALCITRIOL; CELL COUNT; CELLS, CULTURED; HLA-DR ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; RECEPTORS, CALCITRIOL;

EID: 0030112307     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Fithan E, Kung P, Goldstcin G, Rubenfeld M, Fcnoglio C, Edelson R: Reactivity of Langerhans cells with hybridoma antibody. Proc Natl Acad Sei USA 78:2541-2545, 1981
2. Masutaka F, Nindl M, Kawabe K, Nakamura K, Ishibashi Y, Sagawa K: Epitope mapping of CDla, CDlb and CDlc antigens in human skin: differential localization on Langerhans cells, keratinocytes, and basement membrane zone. J Invest Dcnnatol 99:23S-26S, 1992
3. Caux C, Liu YJ, Banchereau J: Recent advances in the study of dendritic cells and follicular dendritic cells. Immnnol Today 16:2-4, 1995
4. Johnson JG, Jenkins MK: Co-stimulatory funcuons of antigen-presenting cells. J Invest Dermatol 99:625-65S, 1992
5. Teunissen MBM, WormmeesterJ, Kreig SR, Peters PJ, Vogels IMC, Kapsenberg ML, Dos JD: Human epidermal Langerhans cells undergo profound morphologic and phenotypical changes during in vitro culture. J Invest Dennatoï 94:166-173, 1990
6. 3 on cytokine-induced thymocyte proliferation. Cell Immnnol 96:455-461, 1985
7. Rigby WFC, Waugh M, Graziano RF: Regulation of human monocyte HLA-DR and CD4 antigen expression, and antigen presentation by 1,25dihydroxyvitamin Dj. Blood 76:189-197, 1990
8. 3-treated monocytes. Arthritis Rheum 35:110-119, 1992
9. 3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokhie 4:506-512, 1992
10. 3 by normal macrophages. Biochem Biophys Res Commun 127:596-603, 1985
11. Kragballe K: Treatment of psoriasis by the topical application of the novel cholecalciferol analogue calcipotriol (MC903). Arch Dcniiatol 125:1647-1652, 1989
12. Kragballe K, Gjertsen BT. De Hoope D, Karlsmark T, van de Kerkhof P, Larkö P: Double-blind, right-left comparison of caîcipotriol and betamcthasone valerate in treatment of psoriasis vulgaris. Lancet 337:193-196, 1991
13. Berth-Jones J, Chu AC, Dood WAH, Ganpule M, Griffiths WAD, Haydey RP; A multicentre parallel group comparison of calcipotriol ointment and shortcontact dithranol therapy in chronic plaque psoriasis. BrJ Dennatol 127:266271, 1992
14. 3 on the morphologic and biochemical differentiation of cultured human epidermal keratinocytes grown in serum-free conditions. J Invest Dennatol 86:709714, 1986
15. Emilson A, Lindberg M, Forslind B, Scheynius A: Quantitative and 3-dimensional analysis of Langerhans cells following occlusion with patch tests using confocal laser scanning microscopy. Ada Denn Veiiereol (Stockh) 73:323-329, 1993
16. Veiro JA, Cummins PG: Imaging of skin epidermis from various origins using confocal laser scanning microscopy. Dermatology 189:16-22, 1994
17. Yu RC, Abrams DC, Alaibac M, Chu AC: Morphological and quantitative analyses of normal epidermal Langerhans cells using confocal scanning laser microscopy. BrJ Dennatol 131:843-848, 1994
18. Scheynius A, Dalenberg M, Carlsson K, England R, Lindberg M: Quantitative analysis of Langerhans' cells in epidermis at irritant contact reactions using confocal laser scanning microscopy. Acta Denn Venereal (Stockh) 72:348-351, 1992
19. Scheynius A, Lundahl P: Three-dimensional visualization of human Langerhans cells using confocal scanning laser microscopy. Arch Dennatol Res 281:521-525, 1990
20. Teunissen MBM, Wormmeester J, Kapsenberg ML, Bos JD: Enrichment of unlabeled human Langerhans cells from epidermal cell suspensions by discontinuous density gradient centrifugation. J Infest Dennalol 91:358-362, 1988
21. Petersen CM, Ejlersen E, Hansen PW, Gliemann J: Binding of alpha-2macroglobulin trypsin complex to human monocytes in culture. ScatiJJ Clin Lab Invest 47:55-61, 1987
22. Madsen M, Johnsen HE: A methodological study of E-rosette formation using AET-treated sheep red blood cells. J Immwal Methods 27:61-74, 1979
23. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.J Immunol Methods 65:55-63, 1983
24. 3 receptor. Proc Natl Acad Sei USA 79:7719-7723, 1982
25. Kumar R, Schaefer J, Wieben E: The expression of milligram amounts of functional human 1,25-dihydroxyvitamin D_j receptor in a bacterial expression system. Biochem Biophys Res Commun 189:1417-1423, 1992
26. 3 on Langerhans cells and contact hypersensitivity in mice. Arch Denttatol Res 284:368-370, 1992
27. Mikulowska A, Falck B: Distributional changes of Langerhans cells in human skin during irritant contact dermatitis. Arch Dermatol Res 286:429-433, 1994
28. Willis CM, Stephens CJM, Wilkinson JD: Differential effects of structurally unrelated chemical irritants on the density and morphology of epidermal CD1 + cells. J Invest Dmnatol 95:711-716, 1990
29. Sterry W, Kunne N, Weber-Matthiesen K, BraschJ, Mielke V: Cell trafficking in positive and negative patch-test reactions: demonstration of a Stereotypie migration pathway. J Invest Dcrmatol 96:459-462, 1991
30. Moodyclifie AM, Kimber 1, Norval M: Role of tumour necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity. Immunology 81:79-84, 1994
31. Kimber 1, Cumberbatch-M: Stimulation of Langerhans cell migration by tumor necrosis factor alpha (TNF-alpha). J Invest Dermatol 99:48S-50S, 1992
32. 3 and its analogue calcipotriol on epidermal cells. Dr J Dcrmatol 130:424-431, 1994