Nanoparticles for intracellular-targeted drug delivery

Nanotechnology

Volumn 22, Issue 49, 2011, Pages

  Paulo, Cristiana S O ^a,b   Pires Das Neves, Ricardo ^a,b   Ferreira, Lino S ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b Biocant Center of Innovation in Biotechnology   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ACTIVITY; CELLULAR ORGANELLES; DRUG EFFECTS; INTRACELLULAR DELIVERY; INTRACELLULAR DRUG DELIVERY; SIDE EFFECT; SMALL MOLECULES; SPATIAL CONTROL; STEM CELL DIFFERENTIATION;

DRUG DELIVERY; RNA; STEM CELLS;

NANOPARTICLES;

DRUG; NANOPARTICLE; PROTEIN; SMALL INTERFERING RNA;

AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; INTRACELLULAR SPACE; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; INTRACELLULAR SPACE; MOLECULAR SEQUENCE DATA; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; PROTEINS; RNA, SMALL INTERFERING;

EID: 81855212480     PISSN: 09574484     EISSN: 13616528     Source Type: Journal    
DOI: 10.1088/0957-4484/22/49/494002     Document Type: Review

References (137)

1. Luo D and Saltzman W M 2000 Synthetic DNA delivery systems Nature Biotechnol. 18 33-7 (Pubitemid 30041168)
2. Somia N and Verma I M 2000 Gene therapy: trials and tribulations Nature Rev. Genet. 1 91-9
3. Fay F, Quinn D J, Gilmore B F, Mccarron P A and Scott C J 2010 Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles Biomaterials 31 4214-22
4. Csaba N, Caamano P, Sanchez A, Dominguez F and Alonso M J 2005 PLGA:poloxamer and PLGA:poloxamine blend nanoparticles: new carriers for gene delivery Biomacromolecules 6 271-8 (Pubitemid 40277024)
5. Kim M H et al 2011 Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery ACS Nano 5 3568-76
6. Ruiz-Hernandez E, Baeza A and Vallet-Regi M 2011 Smart drug delivery through DNA/magnetic nanoparticle gates ACS Nano 5 1259-66
7. Fraley R, Subramani S, Berg P and Papahadjopoulos D 1980 Introduction of liposome-encapsulated SV40 DNA into cells J. Biol. Chem. 255 10431-5 (Pubitemid 11219975)
8. Wang C Y and Huang L 1987 pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse Proc. Natl Acad. Sci. USA 84 7851-5
9. van de Wetering P, Moret E E, Schuurmans-Nieuwenbroek N M, van Steenbergen M J and Hennink W E 1999 Structure-activity relationships of water-soluble cationic methacrylate/methacrylamide polymers for nonviral gene delivery Bioconjug. Chem. 10 589-97 (Pubitemid 29355237)
10. Choi Y H, Liu F, Choi J S, Kim S W and Park J S 1999 Characterization of a targeted gene carrier, lactose-polyethylene glycol-grafted poly-L-lysine and its complex with plasmid DNA Hum. Gene Ther. 10 2657-65
11. Pack D W, Putnam D and Langer R 2000 Design of imidazole-containing endosomolytic biopolymers for gene delivery Biotechnol. Bioeng. 67 217-23 (Pubitemid 30029783)
12. Ho Y P, Chen H H, Leong K W and Wang T H 2006 Evaluating the intracellular stability and unpacking of DNA nanocomplexes by quantum dots-FRET J. Control. Release 116 83-9 (Pubitemid 44792304)
13. Pantarotto D et al 2004 Functionalized carbon nanotubes for plasmid DNA gene delivery Angew. Chem. Int. Edn 43 5242-6 (Pubitemid 39382552)
14. Singh R et al 2005 Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors J. Am. Chem. Soc. 127 4388-96 (Pubitemid 40463064)
15. Cai D et al 2005 Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing Nature Methods 2 449-54 (Pubitemid 40916564)
16. Fire A et al 1998 Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 806-11 (Pubitemid 28099681)
17. Lewis D L, Hagstrom J E, Loomis A G, Wolff J A and Herweijer H 2002 Efficient delivery of siRNA for inhibition of gene expression in postnatal mice Nature Genet. 32 107-8 (Pubitemid 34977204)
18. McManus M T and Sharp P A 2002 Gene silencing in mammals by small interfering RNAs Nature Rev. Genet. 3 737-47
19. McCaffrey A P et al 2003 Inhibition of hepatitis B virus in mice by RNA interference Nature Biotechnol. 21 639-44 (Pubitemid 36638090)
20. Ferreira L, Karp J M, Nobre L and Langer R 2008 New opportunities: the use of nanotechnologies to manipulate and track stem cells Cell Stem Cell 3 136-46
21. Peer D et al 2007 Nanocarriers as an emerging platform for cancer therapy Nature Nanotechnol. 2 751-60 (Pubitemid 350223348)
22. Ferreira L 2009 Nanoparticles as tools to study and control stem cells J. Cell. Biochem. 108 746-52
23. Sahay G, Alakhova D Y and Kabanov A V 2010 Endocytosis of nanomedicines J.Control. Release 145 182-95
24. Duncan R 2011 Polymer therapeutics as nanomedicines: new perspectives Curr. Opin. Biotechnol. 22 492-501
25. Summers H D et al 2011 Statistical analysis of nanoparticle dosing in a dynamic cellular system Nature Nanotechnol. 6 170-4
26. Dacks J B and Field M C 2007 Evolution of the eukaryotic membrane-trafficking system: origin, tempo and mode J. Cell. Sci. 120 2977-85 (Pubitemid 47517081)
27. Martin W and Koonin E V 2006 Introns and the origin of nucleus-cytosol compartmentalization Nature 440 41-5 (Pubitemid 43336261)
28. Mayor S and Pagano R E 2007 Pathways of clathrin-independent endocytosis Nature Rev. Mol. Cell Biol. 8 603-12 (Pubitemid 47106613)
29. Traub L M 2009 Tickets to ride: selecting cargo for clathrin-regulated internalization Nature Rev. Mol. Cell Biol. 10 583-96
30. Grant B D and Donaldson J G 2009 Pathways and mechanisms of endocytic recycling Nature Rev. Mol. Cell Biol. 10 597-608
31. Doherty G J and Mcmahon H T 2009 Mechanisms of endocytosis Annu. Rev. Biochem. 78 857-902
32. De Matteis M A and Luini A 2008 Exiting the Golgi complex Nature Rev. Mol. Cell Biol. 9 273-84 (Pubitemid 351430855)
33. Miller S E, Collins B M, McCoy A J, Robinson M S and Owen D J 2007 A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles Nature 450 570-4 (Pubitemid 350190254)
34. Sandvig K and van Derus B 2002 Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin FEBS Lett. 529 49-53 (Pubitemid 35283911)
35. Zerial M and McBride H 2001 Rab proteins as membrane organizers Nature Rev. Mol. Cell Biol. 2 107-17 (Pubitemid 33674039)
36. Wittrup A et al 2010 Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery Proc. Natl Acad. Sci. USA 107 13342-7
37. Khalil I A, Kogure K, Akita H and Harashima H 2006 Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery Pharmacol. Rev. 58 32-45
38. Panyam J, Zhou W Z, Prabha S, Sahoo S K and Labhasetwar V 2002 Rapid endo-lysosomal escape of poly(DL-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery FASEB J. 16 1217-26 (Pubitemid 34815409)
39. Shen H et al 2006 Enhanced and prolonged cross-presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles Immunology 117 78-88
40. Breunig M et al 2008 Mechanistic investigation of poly(ethylene imine)-based siRNA delivery: disulfide bonds boost intracellular release of the cargo J. Control. Release 130 57-63
41. Lee Y et al 2007 Visualization of the degradation of a disulfide polymer, linear poly(ethylenimine sulfide), for gene delivery Bioconjug. Chem. 18 13-8 (Pubitemid 46145990)
42. Park K, Lee M Y, Kim K S and Hahn S K 2010 Target specific tumor treatment by VEGF siRNA complexed with reducible polyethyleneimine-hyaluronic acid conjugate Biomaterials 31 5258-65
43. Peng Q, Zhong Z and Zhuo R 2008 Disulfide cross-linked polyethylenimines (PEI) prepared via thiolation of low molecular weight PEI as highly efficient gene vectors Bioconjug. Chem. 19 499-506 (Pubitemid 351294922)
44. Son S, Singha K and Kim W J 2010 Bioreducible BPEI-SS-PEG-cNGR polymer as a tumor targeted nonviral gene carrier Biomaterials 31 6344-54
45. Lin C et al 2007 Novel bioreducible poly(amido amine)s for highly efficient gene delivery Bioconjug. Chem. 18 138-45 (Pubitemid 46146003)
46. Piest M et al 2008 Novel poly(amido amine)s with bioreducible disulfide linkages in their diamino-units: structure effects and in vitro gene transfer properties J. Control. Release 130 38-45
47. Kim S H et al 2008 Cardiomyocyte-targeted siRNA delivery by prostaglandin E(2)-Fas siRNA polyplexes formulated with reducible poly(amido amine) for preventing cardiomyocyte apoptosis Biomaterials 29 4439-46
48. Lin C et al 2008 Bioreducible poly(amido amine)s with oligoamine side chains: synthesis, characterization, and structural effects on gene delivery J. Control. Release 126 166-74
49. Christensen L V et al 2006 Reducible poly(amido ethylenimine)s designed for triggered intracellular gene delivery Bioconjug. Chem. 17 1233-40 (Pubitemid 44455332)
50. Hoon Jeong J et al 2007 Reducible poly(amido ethylenimine) directed to enhance RNA interference Biomaterials 28 1912-7 (Pubitemid 46123547)
51. Ou M, Xu R, Kim S H, Bull D A and Kim S W 2009 A family of bioreducible poly(disulfide amine)s for gene delivery Biomaterials 30 5804-14
52. Nel A E et al 2009 Understanding biophysicochemical interactions at the nano-bio interface Nature Mater. 8 543-57
53. Ogris M, Carlisle R C, Bettinger T and Seymour L W 2001 Melittin enables efficient vesicular escape and enhanced nuclear access of nonviral gene delivery vectors J. Biol. Chem. 276 47550-5
54. Di Guglielmo G M, Baass P C, Ou W J, Posner B I and Bergeron J J 1994 Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma EMBO J. 13 4269-77 (Pubitemid 24295199)
55. Kublaoui B, Lee J and Pilch P F 1995 Dynamics of signaling during insulin-stimulated endocytosis of its receptor in adipocytes J. Biol. Chem. 270 59-65
56. Kelly K L and Ruderman N B 1993 Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185 kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle J. Biol. Chem. 268 4391-8 (Pubitemid 23072984)
57. Murphy J E, Padilla B E, Hasdemir B, Cottrell G S and Bunnett N W 2009 Endosomes: a legitimate platform for the signaling train Proc. Natl Acad. Sci. USA 106 17615-22
58. Pelkmans L et al 2005 Genome-wide analysis of human kinases in clathrin-and caveolae/raft-mediated endocytosis Nature 436 78-86 (Pubitemid 40966188)
59. Polo S and Di Fiore P P 2006 Endocytosis conducts the cell signaling orchestra Cell 124 897-900 (Pubitemid 43344231)
60. Li H S, Stolz D B and Romero G 2005 Characterization of endocytic vesicles using magnetic microbeads coated with signalling ligands Traffic 6 324-34 (Pubitemid 40425984)
61. Cartiera M S, Johnson K M, Rajendran V, Caplan M J and Saltzman W M 2009 The uptake and intracellular fate of PLGA nanoparticles in epithelial cells Biomaterials 30 2790-8
62. Boddapati S V, D'souza G G, Erdogan S, Torchilin V P and Weissig V 2008 Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo Nano Lett. 8 2559-63
63. Hoshino A et al 2004 Quantum dots targeted to the assigned organelle in living cells Microbiol. Immunol. 48 985-94 (Pubitemid 40040708)
64. Yamada Y et al 2008 MITO-Porter: a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion Biochim. Biophys. Acta 1778 423-32
65. Hayashi A et al 2007 A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity J. Control. Release 117 11-9 (Pubitemid 46161870)
66. Matsuo K et al 2007 Efficient generation of antigen-specific cellular immunity by vaccination with poly(gamma-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides Biochem. Biophys. Res. Commun. 362 1069-72 (Pubitemid 47390683)
67. de la Fuente J M and Berry C C 2005 Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus Bioconjug. Chem. 16 1176-80 (Pubitemid 41368118)
68. Kang B, Mackey M A and El-Sayed M A 2010 Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis J. Am. Chem. Soc. 132 1517-9
69. Misra R and Sahoo S K 2010 Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy Eur. J. Pharm. Sci. 39 152-63
70. Won Y W, Lim K S and Kim Y H 2011 Intracellular organelle-targeted non-viral gene delivery systems J. Control. Release 152 99-109
71. Stepensky D 2010 Quantitative aspects of intracellularly-targeted drug delivery Pharm. Res. 27 2776-80
72. Ameres S L, Martinez J and Schroeder R 2007 Molecular basis for target RNA recognition and cleavage by human RISC Cell 130 101-12 (Pubitemid 47031315)
73. Frank-Kamenetsky M et al 2008 Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates Proc. Natl Acad. Sci. USA 105 11915-20
74. Sato Y et al 2008 Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone Nature Biotechnol. 26 431-42 (Pubitemid 351501817)
75. Song E et al 2003 RNA interference targeting Fas protects mice from fulminant hepatitis Nature Med. 9 347-51 (Pubitemid 36362792)
76. Niu X Y, Peng Z L, Duan W Q, Wang H and Wang P 2006 Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo Int. J. Gynecol. Cancer 16 743-51
77. Halder J et al 2006 Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy Clin. Cancer Res. 12 4916-24 (Pubitemid 44338579)
78. Takeshita F et al 2005 Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo Proc. Natl Acad. Sci. USA 102 12177-82 (Pubitemid 41291148)
79. Alshamsan A et al 2010 The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine Biomaterials 31 1420-8
80. Biswal B K, Debata N B and Verma R S 2010 Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate Mol. Biol. Rep. 37 2919-26
81. Kang J H et al 2010 Liver-targeted siRNA delivery by polyethylenimine (PEI)-pullulan carrier Bioorg. Med. Chem. 18 3946-50
82. Alshamsan A et al 2010 STAT3 silencing in dendritic cells by siRNA polyplexes encapsulated in PLGA nanoparticles for the modulation of anticancer immune response Mol. Pharm. 7 1643-54
83. Cun D, Foged C, Yang M, Frokjaer S and Nielsen H M 2010 Preparation and characterization of poly(DL-lactide-co-glycolide) nanoparticles for siRNA delivery Int. J. Pharm. 390 70-5
84. Ghosn B et al 2010 Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA Oligonucleotides 20 163-72
85. Han H D et al 2010 Targeted gene silencing using RGD-labeled chitosan nanoparticles Clin. Cancer Res. 16 3910-22
86. Boe S L, Longva A S and Hovig E 2010 Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing Oligonucleotides 20 175-82
87. Zhou J et al 2006 PAMAM dendrimers for efficient siRNA delivery and potent gene silencing Chem. Commun. 2362-4 (Pubitemid 43846378)
88. Liu X X et al 2009 PAMAM dendrimers mediate siRNA delivery to target Hsp27 and produce potent antiproliferative effects on prostate cancer cells ChemMedChem 4 1302-10
89. Johansson H J, Andaloussi S E and Langel U 2011 Mimicry of protein function with cell-penetrating peptides Methods Mol. Biol. 683 233-47
90. Elbakry A et al 2009 Layer-by-layer assembled gold nanoparticles for siRNA delivery Nano Lett. 9 2059-64
91. Giljohann D A, Seferos D S, Prigodich A E, Patel P C and Mirkin C A 2009 Gene regulation with polyvalent siRNA-nanoparticle conjugates J. Am. Chem. Soc. 131 2072-3
92. Pyhtila B et al 2008 Signal sequence-and translation-independent mRNA localization to the endoplasmic reticulum RNA 14 445-53 (Pubitemid 351397809)
93. Brengues M, Teixeira D and Parker R 2005 Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies Science 310 486-9 (Pubitemid 41507961)
94. Akagi T, Shima F and Akashi M 2011 Intracellular degradation and distribution of protein-encapsulated amphiphilic poly(amino acid) nanoparticles Biomaterials 32 4959-67
95. Slowing I I, Trewyn B G and Lin V S 2007 Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins J. Am. Chem. Soc. 129 8845-9 (Pubitemid 47492073)
96. Biswas A et al 2011 Endoprotease-mediated intracellular protein delivery using nanocapsules ACS Nano 5 1385-94
97. Shah D A et al 2011 Regulation of stem cell signaling by nanoparticle-mediated intracellular protein delivery Biomaterials 32 3210-9
98. Bale S S et al 2010 Nanoparticle-mediated cytoplasmic delivery of proteins to target cellular machinery ACS Nano 4 1493-500
99. Hu Y et al 2007 Cytosolic delivery of membrane-impermeable molecules in dendritic cells using pH-responsive core-shell nanoparticles Nano Lett. 7 3056-64
100. Ayame H, Morimoto N and Akiyoshi K 2008 Self-assembled cationic nanogels for intracellular protein delivery Bioconjug. Chem. 19 882-90 (Pubitemid 351614544)
101. Ghosh P et al 2010 Intracellular delivery of a membrane-impermeable enzyme in active form using functionalized gold nanoparticles J. Am. Chem. Soc. 132 2642-5
102. Hasadsri L, Kreuter J, Hattori H, Iwasaki T and George J M 2009 Functional protein delivery into neurons using polymeric nanoparticles J. Biol. Chem. 284 6972-81
103. Hamilton S K and Harth E 2009 Molecular dendritic transporter nanoparticle vectors provide efficient intracellular delivery of peptides ACS Nano 3 402-10
104. Koshman Y E et al 2008 Delivery and visualization of proteins conjugated to quantum dots in cardiac myocytes J. Mol. Cell. Cardiol. 45 853-6
105. Medintz I L et al 2008 Intracellular delivery of quantum dot-protein cargos mediated by cell penetrating peptides Bioconjug. Chem. 19 1785-95
106. Yan M et al 2010 A novel intracellular protein delivery platform based on single-protein nanocapsules Nature Nanotechnol. 5 48-53
107. Katoh M 2008 WNT signaling in stem cell biology and regenerative medicine Curr. Drug Targets 9 565-70
108. van Amerongen R and Nusse R 2009 Towards an integrated view of Wnt signaling in development Development 136 3205-14
109. Lai P S et al 2008 Enhanced cytotoxicity of saporin by polyamidoamine dendrimer conjugation and photochemical internalization J. Biomed. Mater. Res. A 87 147-55
110. Li Y, Chen X and Gu N 2008 Computational investigation of interaction between nanoparticles and membranes: hydrophobic/hydrophilic effect J. Phys. Chem. B 112 16647-53
111. Salaklang J et al 2008 Superparamagnetic nanoparticles as a powerful systems biology characterization tool in the physiological context Angew. Chem. Int. Edn 47 7857-60
112. Mo Y and Lim L Y 2005 Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin J. Control. Release 108 244-62 (Pubitemid 41608658)
113. Wang F et al 2011 Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells ACS Nano 5 3679-92
114. Xu P 2007 Targeted charge-reversal nanoparticles for nuclear drug delivery Angew. Chem. Int. Edn 46 4999-5002 (Pubitemid 47055979)
115. Destache C J et al 2009 Combination antiretroviral drugs in PLGA nanoparticle for HIV-1 BMC Infect. Dis. 9 198
116. Dutta T and Jain N K 2007 Targeting potential and anti-HIV activity of lamivudine loaded mannosylated poly (propyleneimine) dendrimer Biochim. Biophys. Acta 1770 681-6 (Pubitemid 46281473)
117. Das S, Haddadi A, Veniamin S and Samuel J 2008 Delivery of rapamycin-loaded nanoparticle down regulates ICAM-1 expression and maintains an immunosuppressive profile in human CD34 + progenitor-derived dendritic cells J. Biomed. Mater. Res. A 85 983-92 (Pubitemid 351717967)
118. Zou J et al 2011 Rapamycin-loaded nanoparticles for inhibition of neointimal hyperplasia in experimental vein grafts J. Cardiothorac. Surg. 6 69
119. Wilson K D 2009 Lipid-based delivery of CpG oligonucleotides enhances immunotherapeutic efficacy Adv. Drug Deliv. Rev. 61 233-42
120. Bandyopadhyay A, Fine R L, Demento S, Bockenstedt L K and Fahmy T M 2011 The impact of nanoparticle ligand density on dendritic-cell targeted vaccines Biomaterials 32 3094-105
121. Boes M, Stoppelenburg A J and Sille F C 2009 Endosomal processing for antigen presentation mediated by CD1 and Class I major histocompatibility complex: roads to display or destruction Immunology 127 163-70
122. Maia J et al 2011 Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles ACS Nano 5 97-106
123. Oliveira J M et al 2009 The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/ poly(amidoamine) dendrimer nanoparticles Biomaterials 30 804-13
124. Duvvuri M, Konkar S, Funk R S, Krise J M and Krise J P 2005 A chemical strategy to manipulate the intracellular localization of drugs in resistant cancer cells Biochemistry 44 15743-9 (Pubitemid 41746905)
125. Meng H et al 2010 Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line ACS Nano 4 4539-50
126. Suh J, Wirtz D and Hanes J 2003 Efficient active transport of gene nanocarriers to the cell nucleus Proc. Natl Acad. Sci. USA 100 3878-82 (Pubitemid 36418125)
127. Guan K, Chang H, Rolletschek A and Wobus A M 2001 Embryonic stem cell-derived neurogenesis. Retinoic acid induction and lineage selection of neuronal cells Cell Tissue Res. 305 171-6 (Pubitemid 32681894)
128. Maden M 2002 Retinoid signalling in the development of the central nervous system Nature Rev. Neurosci. 3 843-53 (Pubitemid 135706702)
129. Lynch I 2007 Are there generic mechanisms governing interactions between nanoparticles and cells? Epitope mapping the outer layer of the protein-material interface Physica A 373 511-20 (Pubitemid 44647725)
130. Rajagopal A and Simon S M 2003 Subcellular localization and activity of multidrug resistance proteins Mol. Biol. Cell 14 3389-99 (Pubitemid 37013135)
131. Larsen A K, Escargueil A E and Skladanowski A 2000 Resistance mechanisms associated with altered intracellular distribution of anticancer agents Pharmacol. Ther. 85 217-29 (Pubitemid 30160791)
132. Fuller J E et al 2008 Intracellular delivery of core-shell fluorescent silica nanoparticles Biomaterials 29 1526-32
133. Hu Y et al 2009 Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles Biomacromolecules 10 756-65
134. Ma K et al 2011 Development of a successive targeting liposome with multi-ligand for efficient targeting gene delivery J. Gen. Med. 13 290-301
135. Chen X, Shank S, Davis P B and Ziady A G 2011 Nucleolin-mediated cellular trafficking of DNA nanoparticle is lipid raft and microtubule dependent and can be modulated by glucocorticoid Mol. Ther. 19 93-102
136. Tachibana R et al 1998 Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: qualitative and quantitative evaluation of intracellular trafficking Biochem. Biophys. Res. Commun. 251 538-44 (Pubitemid 28505058)
137. Sahay G, Gautam V, Luxenhofer R and Kabanov A V 2010 The utilization of pathogen-like cellular trafficking by single chain block copolymer Biomaterials 31 1757-64