Facile synthesis of monodispersed mesoporous silica nanoparticles with ultralarge pores and their application in gene delivery

ACS Nano

Volumn 5, Issue 5, 2011, Pages 3568-3576

  Kim, Mi Hee ^a   Na, Hee Kyung ^a   Kim, Young Kwan ^a   Ryoo, Soo Ryoon ^a   Cho, Hae Sung ^a   Lee, Kyung Eun ^a   Jeon, Hyesung ^a   Ryoo, Ryong ^a,b   Min, Dal Hee ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Biocompatibility; Gene delivery; Large pores; Plasmid; Porous silica nanoparticle

Indexed keywords

BIOMACROMOLECULES; FACILE SYNTHESIS; GENE DELIVERY; GREEN FLUORESCENT PROTEIN; HUMAN CELLS; LARGE PORES; LARGE SURFACE AREA; LOADING CAPACITIES; LOW COSTS; MESOPOROUS SILICA NANOPARTICLES; MONO-DISPERSED; PLASMID; PLASMID DNA; POROUS SILICA; SILICA NANOPARTICLES; STORAGE STABILITY; TRANSFECTION EFFICIENCY; ULTRALARGE PORES;

BIOCOMPATIBILITY; BIOMOLECULES; DENDRIMERS; DNA; DRUG THERAPY; GENE THERAPY; GENE TRANSFER; SILICA;

NANOPARTICLES;

NANOCAPSULE; SILICON DIOXIDE;

ARTICLE; CHEMISTRY; DIFFUSION; GENETIC TRANSFECTION; GENETICS; HELA CELL; HUMAN; MATERIALS TESTING; METHODOLOGY; PLASMID; POROSITY;

DIFFUSION; HELA CELLS; HUMANS; MATERIALS TESTING; NANOCAPSULES; PLASMIDS; POROSITY; SILICON DIOXIDE; TRANSFECTION;

EID: 80051489934     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn103130q     Document Type: Article

References (35)

1. McCormick, F. Cancer Gene Therapy: Fringe or Cutting Edge? Nat. Rev. Cancer 2001, 1, 130-141. (Pubitemid 33741888)
2. Cross, D.; Burmester, J. K. Gene Therapy for Cancer Treatment: Past, Present and Future. Clin. Med. Res. 2006, 4, 218-227. (Pubitemid 44496015)
3. Brannon-Peppas, L.; Ghosn, B.; Roy, K.; Cornetta, K. Encapsulation of Nucleic Acids and Opportunities for Cancer Treatment. Pharm. Res. 2007, 24, 618-627. (Pubitemid 46411970)
4. Kim, S. I.; Shin, D.; Lee, H.; Ahn, B. Y.; Yoon, Y.; Kim, M. Targeted Delivery of siRNA against Hepatitis C Virus by Apolipoprotein A-I-Bound Cationic Liposomes. J. Hepatol. 2009, 50, 479-488.
5. Yang, X.; Haurigot, V.; Zhou, S.; Luo, G.; Couto, L. B. Inhibition of Hepatitis C Virus Replication Using Adeno-Associated Virus Vector Delivery of an Exogenous Anti-Hepatitis C Virus Microrna Cluster. Hepatology 2010, 52, 1877-1887.
6. Blouin, M. J.; Beauchemin, H.; Wright, A.; De Paepe, M.; Sorette, M.; Bleau, A. M.; Nakamoto, B.; Ou, C. N.; Stamatoyannopoulos, G.; Trudel, M. Genetic Correction of Sickle Cell Disease: Insights Using Transgenic Mouse Models. Nat. Med. 2000, 6, 177-182. (Pubitemid 30082362)
7. Pawliuk, R.; Westerman, K. A.; Fabry, M. E.; Payen, E.; Tighe, R.; Bouhassira, E. E.; Acharya, S. A.; Ellis, J.; London, I. M.; Eaves, C. J.; et al. Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy. Science 2001, 294, 2368-2371. (Pubitemid 33140563)
8. Thomas, C. E.; Ehrhardt, A.; Kay, M. A. Progress and Problems with the Use of Viral Vectors for Gene Therapy. Nat. Rev. Genet. 2003, 4, 346-358. (Pubitemid 36538359)
9. De Smedt, S. C.; Demeester, J.; Hennink, W. E. Cationic Polymer Based Gene Delivery Systems. Pharm. Res. 2000, 17, 113-126. (Pubitemid 30158358)
10. Aris, A.; Villaverde, A. Modular Protein Engineering for Non-viral Gene Therapy. Trends Biotechnol. 2004, 22, 371-377. (Pubitemid 38887546)
11. Panyam, J.; Labhasetwar, V. Biodegradable Nanoparticles for Drug and Gene Delivery to Cells and Tissue. Adv. Drug Delivery Rev. 2003, 55, 329-347. (Pubitemid 36297053)
12. Zhang, X. Q.; Chen, M.; Lam, R.; Xu, X.; Osawa, E.; Ho, D. Polymer-Functionalized Nanodiamond Platforms as Vehicles for Gene Delivery. ACS Nano 2009, 3, 2609-2616.
13. Lv, H.; Zhang, S.; Wang, B.; Cui, S.; Yan, J. Toxicity of Cationic Lipids and Cationic Polymers in Gene Delivery. J. Controlled Release 2006, 114, 100-109. (Pubitemid 44128621)
14. Xu, Z. P.; Hua Zeng, Q.; Lu, G. Q.; Bing, Yu, A. Inorganic Nanoparticles as Carriers for Efficient Cellular Delivery. Chem. Eng. Sci. 2006, 61, 1027-1040. (Pubitemid 41650188)
15. Rhim, W. K.; Kim, J. S.; Nam, J. M. Lipid-Gold-Nanoparticle Hybrid-Based Gene Delivery. Small 2008, 4, 1651-1655.
16. Ghosh, P. S.; Kim, C. K.; Han, G.; Forbes, N. S.; Rotello, V. M. Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles. ACS Nano 2008, 2, 2213-2218.
17. Derfus, A. M.; Chen, A. A.; Min, D.-H.; Ruoslahti, E.; Bhatia, S. N. Targeted Quantum Dot Conjugates for siRNA Delivery. Bioconjugate Chem. 2007, 18, 1391-1396. (Pubitemid 47464045)
18. Li, D.; Li, G.; Guo, W.; Li, P.; Wang, E.; Wang, J. Glutathione-Mediated Release of Functional Plasmid DNA from Positively Charged Quantum Dots. Biomaterials 2008, 29, 2776-2782.
19. Fu, H.; Hu, Y.; McNelis, T.; Hollinger, J. O. A Calcium Phosphate-Based Gene Delivery System. J. Biomed. Mater. Res. A 2005, 74, 40-48. (Pubitemid 41099249)
20. Pantarotto, D.; Singh, R.; McCarthy, D.; Erhardt, M.; Briand, J. P.; Prato, M.; Kostarelos, K.; Bianco, A. Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery. Angew. Chem., Int. Ed. 2004, 43, 5242-5246. (Pubitemid 39382552)
21. Gao, L.; Nie, L.; Wang, T.; Qin, Y.; Guo, Z.; Yang, D.; Yan, X. Carbon Nanotube Delivery of the GFP Gene into Mammalian Cells. ChemBioChem 2006, 7, 239-242. (Pubitemid 43220934)
22. Hom, C.; Lu, J.; Tamanoi, F. Silica Nanoparticles as a Delivery System for Nucleic Acid-Based Reagents. J. Mater. Chem. 2009, 19, 6308-6316.
23. Xia, T.; Kovochich, M.; Liong, M.; Meng, H.; Kabehie, S.; George, S.; Zink, J. I.; Nel, A. E. Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs. ACS Nano 2009, 3, 3273-3286.
24. Radu, D. R.; Lai, C. Y.; Jeftinija, K.; Rowe, E. W.; Jeftinija, S.; Lin, V. S. A Polyamidoamine Dendrimer-Capped Mesoporous Silica Nanosphere-Based Gene Transfection Reagent. J. Am. Chem. Soc. 2004, 126, 13216-13217. (Pubitemid 39382736)
25. Liu, J.; Stace-Naughton, A.; Brinker, C. J. Silica Nanoparticle Supported Lipid Bilayers for Gene Delivery. Chem. Commun. 2009, 14, 5100-5102.
26. Lewis, R. J.; Huang, J. H.; Pecora, R. Rotational and Translational Motion of Supercoiled Plasmids in Solution. Macromolecules 1985, 18, 944-948.
27. Tam, P.; Monck, M.; Lee, D.; Ludkovski, O.; Leng, E. C.; Clow, K.; Stark, H.; Scherrer, P.; Graham, R. W.; Cullis, P. R. Stabilized Plasmid-Lipid Particles for Systemic Gene Therapy. Gene Ther. 2000, 7, 1867-1874.
28. Kienberger, F.; Costa, L. T.; Zhu, R.; Kada, G.; Reithmayer, M.; Chtcheglova, L.; Rankl, C.; Pacheco, A. B.; Thalhammer, S.; Pastushenko, V.; et al. Dynamic Force Microscopy Imaging of Plasmid DNA and Viral RNA. Biomaterials 2007, 28, 2403-2411. (Pubitemid 46389402)
29. Mizutani, M.; Yamada, Y.; Nakamura, T.; Yano, K. Anomalous Pore Expansion of Highly Monodispersed Mesoporous Silica Spheres and Its Application to the Synthesis of Porous Ferromagnetic Composite. Chem. Mater. 2008, 20, 4777-4782.
30. Yano, K.; Fukushima, Y. Synthesis of Mono-dispersed Mesoporous Silica Spheres with Highly Ordered Hexagonal Regularity Using Conventional Alkyltrimethylammonium Halide as a Surfactant. J. Mater. Chem. 2004, 14, 1579-1584.
31. For a previous report on adsorption of linear DNA to mesoporous silica nanoparticles, see: Solberg, S. M.; Landry, C. C. Adsorption of DNA into Mesoporous Silica. J. Phys. Chem. B 2006, 110, 15261-15268. (Pubitemid 44318494)
32. Escriou, V.; Ciolina, C.; Lacroix, F.; Byk, G.; Scherman, D.; Wils, P. Cationic Lipid-Mediated Gene Transfer: Effect of Serum on Cellular Uptake and Intracellular Fate of Lipopolyamine/DNA Complexes. Biochim. Biophys. Acta 1998, 1368, 276-288. (Pubitemid 28031881)
33. Hom, C.; Lu, J.; Liong, M.; Luo, H.; Li, Z.; Zink, J. I.; Tamanoi, F. Mesoporous Silica Nanoparticles Facilitate Delivery of siRNA to Shutdown Signaling Pathways in Mammalian Cells. Small 2010, 6, 1185-1190.
34. Liu, H.-S.; Jan, M.-S.; Chou, C.-K.; Chen, P.-H.; Ke, N.-J. Is Green Fluorescent Protein Toxic to the Living Cells? Biochem. Biophys. Res. Commun. 1999, 260, 712-717. (Pubitemid 29371116)
35. Gene expression of the cells treated with pDNA-MMSN23 complex in the presence of serum was negligible even though the MMSN-23 is expected to protect pDNA from serum induced degradation. The reason is not clear at this point.