Efficient generation of antigen-specific cellular immunity by vaccination with poly(γ-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides

Biochemical and Biophysical Research Communications

Volumn 362, Issue 4, 2007, Pages 1069-1072

  Matsuo, Keisuke ^a,b   Yoshikawa, Tomoaki ^a,b   Oda, Atsushi ^a,b   Akagi, Takami ^a,b   Akashi, Mitsuru ^a,b   Mukai, Yohei ^a,b   Yoshioka, Yasuo ^a   Okada, Naoki ^a,b   Nakagawa, Shinsaku ^a,b  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

PGA nanoparticle; Antigen delivery carrier; ER insertion signal sequence; ER targeting; Peptide vaccine therapy

Indexed keywords

GAMMA INTERFERON; GLYCOPROTEIN GP 100; GLYCOPROTEIN GP 100[25-33]; HLA ANTIGEN CLASS 1; NANOPARTICLE; PEPTIDE DERIVATIVE; POLY(GAMMA GLUTAMIC ACID); POLYMER; SIGNAL PEPTIDE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; COMBINATORIAL LIBRARY; CONJUGATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM; FEMALE; GENE INSERTION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TUMOR IMMUNITY; VACCINATION;

ANIMALS; DRUG CARRIERS; ENDOPLASMIC RETICULUM; FEMALE; IMMUNITY, NATURAL; LYMPHOKINES; MICE; MICE, INBRED C3H; NANOPARTICLES; PEPTIDES; POLYGLUTAMIC ACID; VACCINES, SUBUNIT;

EID: 34548591713     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.08.112     Document Type: Article

References (14)

1. Morris E., Hart D., Gao L., Tsallios A., Xue S.A., and Stauss H. Generation of tumor-specific T-cell therapies. Blood Rev. 20 (2006) 61-69
2. Copier J., and Dalgleish A. Overview of tumor cell-based vaccines. Int. Rev. Immunol. 25 (2006) 297-319
3. Elamanchili P., Diwan M., Cao M., and Samuel J. Characterization of poly(d,l-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells. Vaccine 22 (2004) 2406-2412
4. Kawamura K., Kadowaki N., Suzuki R., Udagawa S., Kasaoka S., Utoguchi N., Kitawaki T., Sugimoto N., Okada N., Maruyama K., and Uchiyama T. Dendritic cells that endocytosed antigen-containing IgG-liposomes elicit effective antitumor immunity. J. Immunother. 29 (2006) 165-174
5. Regnault A., Lankar D., Lacabanne V., Rodriguez A., Théry C., Rescigno M., Saito T., Verbeek S., Bonnerot C., Ricciardi-Castagnoli P., and Amigorena S. Fcγ receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization. J. Exp. Med. 189 (1999) 371-380
6. Machy P., Serre K., and Leserman L. Class I-restricted presentation of exogenous antigen acquired by Fcγ receptor-mediated endocytosis is regulated in dendritic cells. Eur. J. Immunol. 30 (2000) 848-857
7. Bacik I., Cox J.H., Anderson R., Yewdell J.W., and Bennink J.R. TAP (transporter associated with antigen processing)-independent presentation of endogenously synthesized peptides is enhanced by endoplasmic reticulum insertion sequences located at the amino- but not carboxyl-terminus of the peptide. J. Immunol. 152 (1994) 381-387
8. + T-cell responses and prolongs survival of thymoma-bearing mice. Cancer Res. 54 (1994) 4155-4161
9. Minev B.R., Chavez F.L., Dudouet B.M., and Mitchell M.S. Synthetic insertion signal sequences enhance MHC class I presentation of a peptide from the melanoma antigen MART-1. Eur. J. Immunol. 30 (2000) 2115-2124
10. Hayashi A., Wakita H., Yoshikawa T., Nakanishi T., Tsutsumi Y., Mayumi T., Mukai Y., Yoshioka Y., Okada N., and Nakagawa S. A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity. J. Control. Release 117 (2007) 11-19
11. k-restricted epitope in the Tax protein of human T-lymphotropic virus type I is enhanced by the proteasome inhibitor lactacystin. J. Gen. Virol. 83 (2002) 641-650
12. Mendiratta S.K., Thai G., Eslahi N.K., Thull N.M., Matar M., Bronte V., and Pericle F. Therapeutic tumor immunity induced by polyimmunization with melanoma antigens gp100 and TRP-2. Cancer Res. 61 (2001) 859-863
13. Akagi T., Kaneko T., Kida T., and Akashi M. Preparation and characterization of biodegradable nanoparticles based on poly(γ-glutamic acid) with l-phenylalanine as a protein carrier. J. Control. Release 108 (2005) 226-236
14. Gajewski T.F., and Fitch F.W. Anti-proliferative effect of IFN-γ in immune regulation. I. IFN-γ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones. J. Immunol. 140 (1988) 4245-4252