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Volumn 32, Issue 11, 2011, Pages 2191-2207

Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes

Author keywords

Candidate gene studies; Genetic variability; Genome wide studies; Ghrelin; Ghrelin O acyl transferase (GOAT); Ghrelin receptor; GHSR; Growth hormone secretagogue receptor

Indexed keywords

GHRELIN; GHRELIN O ACYL TRANSFERASE; GHRELIN RECEPTOR; GROWTH HORMONE SECRETAGOGUE RECEPTOR; UNCLASSIFIED DRUG;

EID: 81755166340     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.09.006     Document Type: Review
Times cited : (39)

References (139)
  • 1
    • 84860289113 scopus 로고    scopus 로고
    • Model ID 331082dd3cfd07bb45fcb88e6e4cbd
    • Ghrelin o-acyltransferase. Model ID 331082dd3cfd07bb45fcb88e6e4cbd. http://modbase.compbio.ucsf.edu; 2010
    • (2010) Ghrelin o-acyltransferase
  • 2
    • 0037967201 scopus 로고    scopus 로고
    • Diagnostic reliability of a single IGF-I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency
    • G. Aimaretti, G. Corneli, R. Baldelli, C. Di Somma, V. Gasco, and C. Durante Diagnostic reliability of a single IGF-I measurement in 237 adults with total anterior hypopituitarism and severe GH deficiency Clin Endocrinol 59 2003 56 61
    • (2003) Clin Endocrinol , vol.59 , pp. 56-61
    • Aimaretti, G.1    Corneli, G.2    Baldelli, R.3    Di Somma, C.4    Gasco, V.5    Durante, C.6
  • 3
    • 34447263548 scopus 로고    scopus 로고
    • Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women
    • T. Ando, Y. Ichimaru, F. Konjiki, M. Shoji, and G. Komaki Variations in the preproghrelin gene correlate with higher body mass index, fat mass, and body dissatisfaction in young Japanese women Am J Clin Nutr 86 2007 25 32
    • (2007) Am J Clin Nutr , vol.86 , pp. 25-32
    • Ando, T.1    Ichimaru, Y.2    Konjiki, F.3    Shoji, M.4    Komaki, G.5
  • 5
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • A. Asakawa, A. Inui, T. Kaga, G. Katsuura, M. Fujimiya, and M.A. Fujino Antagonism of ghrelin receptor reduces food intake and body weight gain in mice Gut 52 2003 947 952
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6
  • 6
    • 34447298876 scopus 로고    scopus 로고
    • Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease
    • A. Baessler, M. Fischer, B. Mayer, M. Koehler, S. Wiedmann, and K. Stark Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease Hum Mol Genet 16 2007 887 899
    • (2007) Hum Mol Genet , vol.16 , pp. 887-899
    • Baessler, A.1    Fischer, M.2    Mayer, B.3    Koehler, M.4    Wiedmann, S.5    Stark, K.6
  • 7
    • 19944427023 scopus 로고    scopus 로고
    • Genetic linkage and association of the growth hormone secretagogue receptor (Ghrelin receptor) gene in human obesity
    • A. Baessler, M.J. Hasinoff, M. Fischer, W. Reinhard, G.E. Sonnenberg, and M. Olivier Genetic linkage and association of the growth hormone secretagogue receptor (Ghrelin receptor) gene in human obesity Diabetes 54 2005 259 267
    • (2005) Diabetes , vol.54 , pp. 259-267
    • Baessler, A.1    Hasinoff, M.J.2    Fischer, M.3    Reinhard, W.4    Sonnenberg, G.E.5    Olivier, M.6
  • 8
    • 33646141849 scopus 로고    scopus 로고
    • Association of the ghrelin receptor gene region with left ventricular hypertrophy in the general population - Results of the MONICA/KORA Augsburg Echocardiographic Substudy
    • A. Baessler, A.E. Kwitek, M. Fischer, M. Koehler, W. Reinhard, and J. Erdmann Association of the ghrelin receptor gene region with left ventricular hypertrophy in the general population - results of the MONICA/KORA Augsburg Echocardiographic Substudy Hypertension 47 2006 920 927
    • (2006) Hypertension , vol.47 , pp. 920-927
    • Baessler, A.1    Kwitek, A.E.2    Fischer, M.3    Koehler, M.4    Reinhard, W.5    Erdmann, J.6
  • 9
    • 30744470385 scopus 로고    scopus 로고
    • Conformational flexibility of the peptide hormone ghrelin in solution and lipid membrane bound: A molecular dynamics study
    • A.J. Beevers, and A. Kukol Conformational flexibility of the peptide hormone ghrelin in solution and lipid membrane bound: a molecular dynamics study J Biomol Struct Dyn 23 2006 357 363
    • (2006) J Biomol Struct Dyn , vol.23 , pp. 357-363
    • Beevers, A.J.1    Kukol, A.2
  • 10
    • 57049117340 scopus 로고    scopus 로고
    • The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes
    • H.K. Berthold, E. Giannakidou, W. Krone, C.S. Mantzoros, and I. Gouni-Berthold The Leu72Met polymorphism of the ghrelin gene is associated with a decreased risk for type 2 diabetes Clin Chim Acta 399 2009 112 116
    • (2009) Clin Chim Acta , vol.399 , pp. 112-116
    • Berthold, H.K.1    Giannakidou, E.2    Krone, W.3    Mantzoros, C.S.4    Gouni-Berthold, I.5
  • 12
    • 24044462104 scopus 로고    scopus 로고
    • Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits
    • C. Bing, L. Ambye, M. Fenger, T. Jorgensen, K. Borch-Johnsen, and S. Madsbad Large-scale studies of the Leu72Met polymorphism of the ghrelin gene in relation to the metabolic syndrome and associated quantitative traits Diabet Med 22 2005 1157 1160
    • (2005) Diabet Med , vol.22 , pp. 1157-1160
    • Bing, C.1    Ambye, L.2    Fenger, M.3    Jorgensen, T.4    Borch-Johnsen, K.5    Madsbad, S.6
  • 13
    • 70349738106 scopus 로고    scopus 로고
    • Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice
    • I.D. Blum, Z. Patterson, R. Khazall, E.W. Lamont, M.W. Sleeman, and T.L. Horvath Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice Neuroscience 164 2009 351 359
    • (2009) Neuroscience , vol.164 , pp. 351-359
    • Blum, I.D.1    Patterson, Z.2    Khazall, R.3    Lamont, E.W.4    Sleeman, M.W.5    Horvath, T.L.6
  • 15
    • 0034751526 scopus 로고    scopus 로고
    • Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    • F. Broglio, E. Arvat, A. Benso, C. Gottero, G. Muccioli, and M. Papotti Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans J Clin Endocrinol Metab 86 2001 5083 5086
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5083-5086
    • Broglio, F.1    Arvat, E.2    Benso, A.3    Gottero, C.4    Muccioli, G.5    Papotti, M.6
  • 17
    • 0037442092 scopus 로고    scopus 로고
    • Population stratification and spurious allelic association
    • L.R. Cardon, and L.J. Palmer Population stratification and spurious allelic association Lancet 361 2003 598 604
    • (2003) Lancet , vol.361 , pp. 598-604
    • Cardon, L.R.1    Palmer, L.J.2
  • 18
    • 33646834958 scopus 로고    scopus 로고
    • Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa
    • E. Cellini, B. Nacmias, D. Brecelj-Anderluh, A. Badia-Casanovas, L. Bellodi, and C. Boni Case-control and combined family trios analysis of three polymorphisms in the ghrelin gene in European patients with anorexia and bulimia nervosa Psychiatr Genet 16 2006 51 52
    • (2006) Psychiatr Genet , vol.16 , pp. 51-52
    • Cellini, E.1    Nacmias, B.2    Brecelj-Anderluh, D.3    Badia-Casanovas, A.4    Bellodi, L.5    Boni, C.6
  • 19
    • 0141919767 scopus 로고    scopus 로고
    • Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q
    • B.D. Chiodini, and C.M. Lewis Meta-analysis of 4 coronary heart disease genome-wide linkage studies confirms a susceptibility locus on chromosome 3q Arterioscler Thromb Vasc 23 2003 1863 1868
    • (2003) Arterioscler Thromb Vasc , vol.23 , pp. 1863-1868
    • Chiodini, B.D.1    Lewis, C.M.2
  • 20
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • Y.S. Cho, M.J. Go, Y.J. Kim, J.Y. Heo, J.H. Oh, and H.J. Ban A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits Nat Genet 41 2009 527 534
    • (2009) Nat Genet , vol.41 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3    Heo, J.Y.4    Oh, J.H.5    Ban, H.J.6
  • 21
    • 33751522297 scopus 로고    scopus 로고
    • Polymorphisms in the ghrelin gene are associated with serum high-density lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans
    • H.J. Choi, Y.M. Cho, M.K. Moon, H.H. Choi, H.D. Shin, and H.C. Jang Polymorphisms in the ghrelin gene are associated with serum high-density lipoprotein cholesterol level and not with type 2 diabetes mellitus in Koreans J Clin Endocrinol Metab 91 2006 4657 4663
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4657-4663
    • Choi, H.J.1    Cho, Y.M.2    Moon, M.K.3    Choi, H.H.4    Shin, H.D.5    Jang, H.C.6
  • 22
    • 2942558193 scopus 로고    scopus 로고
    • Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues
    • D.E. Cummings, R.S. Frayo, C. Marmonier, R. Aubert, and D. Chapelot Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues Am J Physiol-Endocr M 287 2004 E297 E304
    • (2004) Am J Physiol-Endocr M , vol.287
    • Cummings, D.E.1    Frayo, R.S.2    Marmonier, C.3    Aubert, R.4    Chapelot, D.5
  • 23
    • 33847207165 scopus 로고    scopus 로고
    • Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset
    • R.M. Dardennes, P. Zizzari, V. Tolle, C. Foulon, A. Kipman, and L. Romo Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset Psychoneuroendocrinology 32 2007 106 113
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 106-113
    • Dardennes, R.M.1    Zizzari, P.2    Tolle, V.3    Foulon, C.4    Kipman, A.5    Romo, L.6
  • 24
    • 0036097362 scopus 로고    scopus 로고
    • Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion
    • Y. Date, M. Nakazato, S. Hashiguchi, K. Dezaki, M.S. Mondal, and H. Hosoda Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion Diabetes 51 2002 124 129
    • (2002) Diabetes , vol.51 , pp. 124-129
    • Date, Y.1    Nakazato, M.2    Hashiguchi, S.3    Dezaki, K.4    Mondal, M.S.5    Hosoda, H.6
  • 25
    • 1542300099 scopus 로고    scopus 로고
    • Molecular screening of the ghrelin gene in Italian obese children: The Leu72Met variant is associated with an earlier onset of obesity
    • E.M. del Giudice, N. Santoro, G. Cirillo, P. Raimondo, A. Grandone, and A. D'Aniello Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity Int J Obes 28 2004 447 450
    • (2004) Int J Obes , vol.28 , pp. 447-450
    • Del Giudice, E.M.1    Santoro, N.2    Cirillo, G.3    Raimondo, P.4    Grandone, A.5    D'Aniello, A.6
  • 26
    • 57749201152 scopus 로고    scopus 로고
    • SNP analyses of postprandial responses in (an) orexigenic hormones and feelings of hunger reveal long-term physiological adaptations to facilitate homeostasis
    • M. den Hoed, A. Smeets, M.A.B. Veldhorst, A.G. Nieuwenhuizen, F.G. Bouwman, and A.G. Heidema SNP analyses of postprandial responses in (an) orexigenic hormones and feelings of hunger reveal long-term physiological adaptations to facilitate homeostasis Int J Obes 32 2008 1790 1798
    • (2008) Int J Obes , vol.32 , pp. 1790-1798
    • Den Hoed, M.1    Smeets, A.2    Veldhorst, M.A.B.3    Nieuwenhuizen, A.G.4    Bouwman, F.G.5    Heidema, A.G.6
  • 27
    • 49349111720 scopus 로고    scopus 로고
    • Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: A case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)
    • L. Dossus, J.D. McKay, F. Canzian, S. Wilkening, S. Rinaldi, and C. Biessy Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) Carcinogenesis 29 2008 1360 1366
    • (2008) Carcinogenesis , vol.29 , pp. 1360-1366
    • Dossus, L.1    McKay, J.D.2    Canzian, F.3    Wilkening, S.4    Rinaldi, S.5    Biessy, C.6
  • 28
    • 15444361604 scopus 로고    scopus 로고
    • Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues
    • S.D. Feighner, A.D. Howard, K. Prendergast, O.C. Palyha, D.L. Hreniuk, and R. Nargund Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues Mol Endocrinol 12 1998 137 145
    • (1998) Mol Endocrinol , vol.12 , pp. 137-145
    • Feighner, S.D.1    Howard, A.D.2    Prendergast, K.3    Palyha, O.C.4    Hreniuk, D.L.5    Nargund, R.6
  • 29
    • 77951884103 scopus 로고    scopus 로고
    • Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors
    • D.M. Ferens, L. Yin, R. Bron, B. Hunne, K. Ohashi-Doi, and P.D. Kitchener Functional and in situ hybridization evidence that preganglionic sympathetic vasoconstrictor neurons express ghrelin receptors Neuroscience 166 2010 671 679
    • (2010) Neuroscience , vol.166 , pp. 671-679
    • Ferens, D.M.1    Yin, L.2    Bron, R.3    Hunne, B.4    Ohashi-Doi, K.5    Kitchener, P.D.6
  • 32
    • 68349132093 scopus 로고    scopus 로고
    • The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes
    • E.A. Garcia, P. King, K. Sidhu, H. Ohgusu, A. Walley, and C. Lecoeur The role of ghrelin and ghrelin-receptor gene variants and promoter activity in type 2 diabetes Eur J Endocrinol 161 2009 307 315
    • (2009) Eur J Endocrinol , vol.161 , pp. 307-315
    • Garcia, E.A.1    King, P.2    Sidhu, K.3    Ohgusu, H.4    Walley, A.5    Lecoeur, C.6
  • 33
    • 77956316412 scopus 로고    scopus 로고
    • Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
    • A.P. Gjesing, L.H. Larsen, S.S. Torekov, I.A. Hainerova, R. Kapur, and A. Johansen Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity PLoS One 5 2010 8
    • (2010) PLoS One , vol.5 , pp. 8
    • Gjesing, A.P.1    Larsen, L.H.2    Torekov, S.S.3    Hainerova, I.A.4    Kapur, R.5    Johansen, A.6
  • 35
    • 66449131125 scopus 로고    scopus 로고
    • Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes
    • R. Gomez, F. Lago, J.J. Gomez-Reino, C. Dieguez, and O. Gualillo Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes Arthritis Rheum 60 2009 1704 1709
    • (2009) Arthritis Rheum , vol.60 , pp. 1704-1709
    • Gomez, R.1    Lago, F.2    Gomez-Reino, J.J.3    Dieguez, C.4    Gualillo, O.5
  • 36
    • 38049035630 scopus 로고    scopus 로고
    • Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents
    • G. Gourcerol, T. Coskun, L.S. Craft, J.P. Mayer, M.L. Heiman, and L. Wang Preproghrelin-derived peptide, obestatin, fails to influence food intake in lean or obese rodents Obesity 15 2007 2643 2652
    • (2007) Obesity , vol.15 , pp. 2643-2652
    • Gourcerol, G.1    Coskun, T.2    Craft, L.S.3    Mayer, J.P.4    Heiman, M.L.5    Wang, L.6
  • 37
    • 0030762351 scopus 로고    scopus 로고
    • Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues
    • X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J.S. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Mol Brain Res 48 1997 23 29
    • (1997) Mol Brain Res , vol.48 , pp. 23-29
    • Guan, X.M.1    Yu, H.2    Palyha, O.C.3    McKee, K.K.4    Feighner, S.D.5    Sirinathsinghji, D.J.S.6
  • 38
    • 58149291364 scopus 로고    scopus 로고
    • A genetic study of the ghrelin and growth hormone secretagogue receptor (GHSR) genes and stature
    • M. Gueorguiev, C. Lecoeur, M. Benzinou, C.A. Mein, D. Meyre, and V. Vatin A genetic study of the ghrelin and growth hormone secretagogue receptor (GHSR) genes and stature Ann Hum Genet 73 2009 1 9
    • (2009) Ann Hum Genet , vol.73 , pp. 1-9
    • Gueorguiev, M.1    Lecoeur, C.2    Benzinou, M.3    Mein, C.A.4    Meyre, D.5    Vatin, V.6
  • 39
    • 63049095890 scopus 로고    scopus 로고
    • Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity
    • M. Gueorguiev, C. Lecoeur, D. Meyre, M. Benzinou, C.A. Mein, and A. Hinney Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity Obesity 17 2009 745 754
    • (2009) Obesity , vol.17 , pp. 745-754
    • Gueorguiev, M.1    Lecoeur, C.2    Meyre, D.3    Benzinou, M.4    Mein, C.A.5    Hinney, A.6
  • 40
    • 34347269237 scopus 로고    scopus 로고
    • Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes
    • M. Gueorguiev, S. Wiltshire, E.A. Garcia, C. Mein, C. Lecoeur, and B. Kristen Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes J Clin Endocrinol Metab 92 2007 2201 2204
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2201-2204
    • Gueorguiev, M.1    Wiltshire, S.2    Garcia, E.A.3    Mein, C.4    Lecoeur, C.5    Kristen, B.6
  • 42
    • 34247098895 scopus 로고    scopus 로고
    • Ghrelin, the peripheral hunger hormone
    • S.C. Higgins, M. Gueorguiev, and M. Korbonits Ghrelin, the peripheral hunger hormone Ann Med 39 2007 116 136
    • (2007) Ann Med , vol.39 , pp. 116-136
    • Higgins, S.C.1    Gueorguiev, M.2    Korbonits, M.3
  • 43
    • 0036079504 scopus 로고    scopus 로고
    • Ghrelin gene: Identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students
    • A. Hinney, A. Hoch, F. Geller, H. Schafer, W. Siegfried, and H. Goldschmidt Ghrelin gene: Identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students J Clin Endocrinol Metab 87 2002 2716 2719
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2716-2719
    • Hinney, A.1    Hoch, A.2    Geller, F.3    Schafer, H.4    Siegfried, W.5    Goldschmidt, H.6
  • 44
    • 0242330291 scopus 로고    scopus 로고
    • High constitutive signaling of the ghrelin receptor - Identification of a potent inverse agonist
    • B. Holst, A. Cygankiewicz, T.H. Jensen, M. Ankersen, and T.W. Schwartz High constitutive signaling of the ghrelin receptor - identification of a potent inverse agonist Mol Endocrinol 17 2003 2201 2210
    • (2003) Mol Endocrinol , vol.17 , pp. 2201-2210
    • Holst, B.1    Cygankiewicz, A.2    Jensen, T.H.3    Ankersen, M.4    Schwartz, T.W.5
  • 47
    • 44949131889 scopus 로고    scopus 로고
    • No significant association between A-501C single nucleotide polymorphism in preproghrelin and body mass index or waist-to-hip ratio in central European population
    • J.A. Hubacek, V. Adamkova, R. Bohuslavova, P. Suchanek, R. Poledne, and V. Lanska No significant association between A-501C single nucleotide polymorphism in preproghrelin and body mass index or waist-to-hip ratio in central European population Metabolism 57 2008 1016 1017
    • (2008) Metabolism , vol.57 , pp. 1016-1017
    • Hubacek, J.A.1    Adamkova, V.2    Bohuslavova, R.3    Suchanek, P.4    Poledne, R.5    Lanska, V.6
  • 48
    • 0036224924 scopus 로고    scopus 로고
    • The role of IGF-I in the development of cardiovascular disease in type 2 diabetes mellitus: Is prevention possible?
    • J. Janssen, and S.W.J. Lamberts The role of IGF-I in the development of cardiovascular disease in type 2 diabetes mellitus: is prevention possible? Eur J Endocrinol 146 2002 467 477
    • (2002) Eur J Endocrinol , vol.146 , pp. 467-477
    • Janssen, J.1    Lamberts, S.W.J.2
  • 49
    • 33947139281 scopus 로고    scopus 로고
    • Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens
    • E. Jerlhag, E. Egecioglu, S.L. Dickson, A. Douhan, L. Svensson, and J.A. Engel Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens Addict Biol 12 2007 6 16
    • (2007) Addict Biol , vol.12 , pp. 6-16
    • Jerlhag, E.1    Egecioglu, E.2    Dickson, S.L.3    Douhan, A.4    Svensson, L.5    Engel, J.A.6
  • 53
    • 38749153653 scopus 로고    scopus 로고
    • Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study
    • T.O. Kilpelainen, T.A. Lakka, D.E. Laaksonen, U. Mager, T. Salopuro, and A. Kubaszek Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study Metabolism 57 2008 428 436
    • (2008) Metabolism , vol.57 , pp. 428-436
    • Kilpelainen, T.O.1    Lakka, T.A.2    Laaksonen, D.E.3    Mager, U.4    Salopuro, T.5    Kubaszek, A.6
  • 54
    • 0042200265 scopus 로고    scopus 로고
    • Changes in ghrelin and ghrelin receptor expression according to feeding status
    • M.S. Kim, C.Y. Yoon, K.H. Park, C.S. Shin, K.S. Park, and S.Y. Kim Changes in ghrelin and ghrelin receptor expression according to feeding status Neuroreport 14 2003 1317 1320
    • (2003) Neuroreport , vol.14 , pp. 1317-1320
    • Kim, M.S.1    Yoon, C.Y.2    Park, K.H.3    Shin, C.S.4    Park, K.S.5    Kim, S.Y.6
  • 55
    • 32544455462 scopus 로고    scopus 로고
    • Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus
    • S.Y. Kim, D.S. Jo, P.H. Hwang, J.H. Park, S.K. Park, and H.K. Yi Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus Metabolism 55 2006 366 370
    • (2006) Metabolism , vol.55 , pp. 366-370
    • Kim, S.Y.1    Jo, D.S.2    Hwang, P.H.3    Park, J.H.4    Park, S.K.5    Yi, H.K.6
  • 56
    • 81755167058 scopus 로고    scopus 로고
    • Ghrelin gene polymorphisms Arg51Gln and Leu72Met in eating disorders: An association study
    • J. Kindler, U. Bailer, M. De Zwaan, K. Fuchs, F. Leisch, and A. Strnad Ghrelin gene polymorphisms Arg51Gln and Leu72Met in eating disorders: an association study Am J Med Genet 141B 2006 771
    • (2006) Am J Med Genet , vol.141 B , pp. 771
    • Kindler, J.1    Bailer, U.2    De Zwaan, M.3    Fuchs, K.4    Leisch, F.5    Strnad, A.6
  • 59
    • 0035002124 scopus 로고    scopus 로고
    • Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample
    • K.L. Klump, K.B. Miller, P.K. Keel, M. McGue, and W.G. Iacono Genetic and environmental influences on anorexia nervosa syndromes in a population-based twin sample Psychol Med 31 2001 737 740
    • (2001) Psychol Med , vol.31 , pp. 737-740
    • Klump, K.L.1    Miller, K.B.2    Keel, P.K.3    McGue, M.4    Iacono, W.G.5
  • 60
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 61
    • 15544385058 scopus 로고    scopus 로고
    • Ghrelin: Structure and function
    • M. Kojima, and K. Kangawa Ghrelin: Structure and function Physiol Rev 85 2005 495 522
    • (2005) Physiol Rev , vol.85 , pp. 495-522
    • Kojima, M.1    Kangawa, K.2
  • 63
    • 0035097594 scopus 로고    scopus 로고
    • The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors
    • M. Korbonits, S.A. Bustin, M. Kojima, S. Jordan, E.F. Adams, and D.G. Lowe The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors J Clin Endocrinol Metab 86 2001 881 887
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 881-887
    • Korbonits, M.1    Bustin, S.A.2    Kojima, M.3    Jordan, S.4    Adams, E.F.5    Lowe, D.G.6
  • 64
    • 0036342530 scopus 로고    scopus 로고
    • A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children
    • M. Korbonits, M. Gueorguiev, E. O'Grady, C. Lecoeur, D.C. Swan, and C.A. Mein A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children J Clin Endocrinol Metab 87 2002 4005 4008
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4005-4008
    • Korbonits, M.1    Gueorguiev, M.2    O'Grady, E.3    Lecoeur, C.4    Swan, D.C.5    Mein, C.A.6
  • 65
    • 33750434312 scopus 로고    scopus 로고
    • Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort
    • M. Kuzuya, F. Ando, A. Iguchi, and H. Shimokata Preproghrelin Leu72Met variant contributes to overweight in middle-aged men of a Japanese large cohort Int J Obes 30 2006 1609 1614
    • (2006) Int J Obes , vol.30 , pp. 1609-1614
    • Kuzuya, M.1    Ando, F.2    Iguchi, A.3    Shimokata, H.4
  • 66
    • 34147120557 scopus 로고    scopus 로고
    • Obestatin reduces food intake and suppresses body weight gain in rodents
    • [Retracted article. See vol. 388, pg. 619, 2009]
    • G.J. Lagaud, A. Young, A. Acena, M.F. Morton, T.D. Barrett, and N.P. Shankley Obestatin reduces food intake and suppresses body weight gain in rodents Biochem Biophys Res Commun 357 2007 264 269 [Retracted article. See vol. 388, pg. 619, 2009]
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 264-269
    • Lagaud, G.J.1    Young, A.2    Acena, A.3    Morton, M.F.4    Barrett, T.D.5    Shankley, N.P.6
  • 67
    • 1642464956 scopus 로고    scopus 로고
    • Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons
    • S. Lall, N. Balthasar, D. Carmignac, C. Magoulas, A. Sesay, and P. Houston Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons Endocrinology 145 2004 1602 1611
    • (2004) Endocrinology , vol.145 , pp. 1602-1611
    • Lall, S.1    Balthasar, N.2    Carmignac, D.3    Magoulas, C.4    Sesay, A.5    Houston, P.6
  • 69
  • 70
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • H. Lango Allen, K. Estrada, G. Lettre, S.I. Berndt, M.N. Weedon, and F. Rivadeneira Hundreds of variants clustered in genomic loci and biological pathways affect human height Nature 467 2010 832 838
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1    Estrada, K.2    Lettre, G.3    Berndt, S.I.4    Weedon, M.N.5    Rivadeneira, F.6
  • 71
  • 72
    • 24044510845 scopus 로고    scopus 로고
    • Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat
    • A. Larsson, L. Edstrom, L. Svensson, B. Soderpalm, and J.A. Engel Voluntary ethanol intake increases extracellular acetylcholine levels in the ventral tegmental area in the rat Alcohol Alcohol 40 2005 349 358
    • (2005) Alcohol Alcohol , vol.40 , pp. 349-358
    • Larsson, A.1    Edstrom, L.2    Svensson, L.3    Soderpalm, B.4    Engel, J.A.5
  • 73
    • 2942648684 scopus 로고    scopus 로고
    • Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women
    • H.J. Leidy, J.K. Gardner, B.R. Frye, M.L. Snook, M.K. Schuchert, and E.L. Richard Circulating ghrelin is sensitive to changes in body weight during a diet and exercise program in normal-weight young women J Clin Endocrinol Metab 89 2004 2659 2664
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2659-2664
    • Leidy, H.J.1    Gardner, J.K.2    Frye, B.R.3    Snook, M.L.4    Schuchert, M.K.5    Richard, E.L.6
  • 74
    • 33947536063 scopus 로고    scopus 로고
    • Physiological, pathological and potential therapeutic roles of ghrelin
    • A.F. Leite-Moreira, and J.B. Soares Physiological, pathological and potential therapeutic roles of ghrelin Drug Discov Today 12 2007 276 288
    • (2007) Drug Discov Today , vol.12 , pp. 276-288
    • Leite-Moreira, A.F.1    Soares, J.B.2
  • 75
    • 42649092874 scopus 로고    scopus 로고
    • Identification of ten loci associated with height highlights new biological pathways in human growth
    • G. Lettre, A.U. Jackson, C. Gieger, F.R. Schumacher, S.I. Berndt, and S. Sanna Identification of ten loci associated with height highlights new biological pathways in human growth Nat Genet 40 2008 584 591
    • (2008) Nat Genet , vol.40 , pp. 584-591
    • Lettre, G.1    Jackson, A.U.2    Gieger, C.3    Schumacher, F.R.4    Berndt, S.I.5    Sanna, S.6
  • 76
    • 33947301456 scopus 로고    scopus 로고
    • The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor
    • P.K. Leung, K.B.S. Chow, P.N. Lau, K.M. Chu, C.B. Chan, and C.H.K. Cheng The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor Cell Signal 19 2007 1011 1022
    • (2007) Cell Signal , vol.19 , pp. 1011-1022
    • Leung, P.K.1    Chow, K.B.S.2    Lau, P.N.3    Chu, K.M.4    Chan, C.B.5    Cheng, C.H.K.6
  • 78
    • 67349167388 scopus 로고    scopus 로고
    • Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies
    • S. Lillioja, and A. Wilton Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies Diabetologia 52 2009 1061 1074
    • (2009) Diabetologia , vol.52 , pp. 1061-1074
    • Lillioja, S.1    Wilton, A.2
  • 79
    • 0037407315 scopus 로고    scopus 로고
    • Linkage for BMI at 3q27 region confirmed in an African-American population
    • A. Luke, X.D. Wu, X.F. Zhu, D.H. Kan, Y. Su, and R. Cooper Linkage for BMI at 3q27 region confirmed in an African-American population Diabetes 52 2003 1284 1287
    • (2003) Diabetes , vol.52 , pp. 1284-1287
    • Luke, A.1    Wu, X.D.2    Zhu, X.F.3    Kan, D.H.4    Su, Y.5    Cooper, R.6
  • 81
    • 51449100773 scopus 로고    scopus 로고
    • Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance
    • U. Mager, T. Degenhardt, L. Pulkkinen, M. Kolehmainen, A.M. Tolppanen, and J. Lindstrom Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance PLoS One 2008 3
    • (2008) PLoS One , pp. 3
    • Mager, U.1    Degenhardt, T.2    Pulkkinen, L.3    Kolehmainen, M.4    Tolppanen, A.M.5    Lindstrom, J.6
  • 82
    • 33846212805 scopus 로고    scopus 로고
    • Association between ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance
    • U. Mager, M. Kolehmainen, J. Lindstrom, J.G. Eriksson, T.T. Valle, and H. Hamalainen Association between ghrelin gene variations and blood pressure in subjects with impaired glucose tolerance Am J Hypertens 19 2006 920 926
    • (2006) Am J Hypertens , vol.19 , pp. 920-926
    • Mager, U.1    Kolehmainen, M.2    Lindstrom, J.3    Eriksson, J.G.4    Valle, T.T.5    Hamalainen, H.6
  • 83
    • 33747585364 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the Arc
    • A. Mano-Otagiri, T. Nemoto, A. Sekino, N. Yamauchi, Y. Shuto, and H. Sugihara Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the Arc Endocrinology 147 2006 4093 4103
    • (2006) Endocrinology , vol.147 , pp. 4093-4103
    • Mano-Otagiri, A.1    Nemoto, T.2    Sekino, A.3    Yamauchi, N.4    Shuto, Y.5    Sugihara, H.6
  • 84
    • 41549128569 scopus 로고    scopus 로고
    • Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles
    • G.R. Martin, J.C. Loredo, and G. Sun Lack of association of ghrelin precursor gene variants and percentage body fat or serum lipid profiles Obesity 16 2008 908 912
    • (2008) Obesity , vol.16 , pp. 908-912
    • Martin, G.R.1    Loredo, J.C.2    Sun, G.3
  • 86
    • 33747893128 scopus 로고    scopus 로고
    • Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population
    • K. Miyasaka, H. Hosoya, A. Sekime, M. Ohta, H. Amono, and S. Matsushita Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population J Neural Transm 113 2006 1279 1285
    • (2006) J Neural Transm , vol.113 , pp. 1279-1285
    • Miyasaka, K.1    Hosoya, H.2    Sekime, A.3    Ohta, M.4    Amono, H.5    Matsushita, S.6
  • 87
    • 0345570518 scopus 로고    scopus 로고
    • Ghrelin and leptin responses to food ingestion in bulimia nervosa: Implications for binge-eating and compensatory behaviours
    • P. Monteleone, V. Martiadis, M. Fabrazzo, C. Serritella, and M. Maj Ghrelin and leptin responses to food ingestion in bulimia nervosa: implications for binge-eating and compensatory behaviours Psychol Med 33 2003 1387 1394
    • (2003) Psychol Med , vol.33 , pp. 1387-1394
    • Monteleone, P.1    Martiadis, V.2    Fabrazzo, M.3    Serritella, C.4    Maj, M.5
  • 88
    • 33646352977 scopus 로고    scopus 로고
    • No association of the Arg51G1n and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa
    • P. Monteleone, A. Tortorella, E. Castaldo, C. Di Filippo, and M. Maj No association of the Arg51G1n and Leu72Met polymorphisms of the ghrelin gene with anorexia nervosa or bulimia nervosa Neurosci Lett 398 2006 325 327
    • (2006) Neurosci Lett , vol.398 , pp. 325-327
    • Monteleone, P.1    Tortorella, A.2    Castaldo, E.3    Di Filippo, C.4    Maj, M.5
  • 89
  • 90
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • C. Newton-Cheh, T. Johnson, V. Gateva, M.D. Tobin, M. Bochud, and L. Coin Genome-wide association study identifies eight loci associated with blood pressure Nat Genet 41 2009 666 676
    • (2009) Nat Genet , vol.41 , pp. 666-676
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3    Tobin, M.D.4    Bochud, M.5    Coin, L.6
  • 93
    • 45549105470 scopus 로고    scopus 로고
    • Ghrelin in the CNS: From hunger to a rewarding and memorable meal?
    • P.K. Olszewski, H.B. Schioth, and A.S. Levine Ghrelin in the CNS: from hunger to a rewarding and memorable meal? Brain Res Rev 58 2008 160 170
    • (2008) Brain Res Rev , vol.58 , pp. 160-170
    • Olszewski, P.K.1    Schioth, H.B.2    Levine, A.S.3
  • 95
    • 0142058099 scopus 로고    scopus 로고
    • Genetic approaches to stature, pubertal timing, and other complex traits
    • M.R. Palmert, and J.N. Hirschhorn Genetic approaches to stature, pubertal timing, and other complex traits Mol Genet Metab 80 2003 1 10
    • (2003) Mol Genet Metab , vol.80 , pp. 1-10
    • Palmert, M.R.1    Hirschhorn, J.N.2
  • 97
    • 33744814084 scopus 로고    scopus 로고
    • Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis
    • A. Pedretti, M. Villa, M. Pallavicini, E. Valoti, and G. Vistoli Construction of human ghrelin receptor (hGHS-R1a) model using a fragmental prediction approach and validation through docking analysis J Med Chem 49 2006 3077 3085
    • (2006) J Med Chem , vol.49 , pp. 3077-3085
    • Pedretti, A.1    Villa, M.2    Pallavicini, M.3    Valoti, E.4    Vistoli, G.5
  • 98
    • 0037955956 scopus 로고    scopus 로고
    • Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects
    • S. Poykko, O. Ukkola, H. Kauma, M.J. Savolainen, and Y.A. Kesaniemi Ghrelin Arg51Gln mutation is a risk factor for Type 2 diabetes and hypertension in a random sample of middle-aged subjects Diabetologia 46 2003 455 458
    • (2003) Diabetologia , vol.46 , pp. 455-458
    • Poykko, S.1    Ukkola, O.2    Kauma, H.3    Savolainen, M.J.4    Kesaniemi, Y.A.5
  • 99
    • 0141643291 scopus 로고    scopus 로고
    • Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes
    • S.M. Poykko, E. Kellokoski, S. Horkko, H. Kauma, Y.A. Kesaniemi, and O. Ukkola Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes Diabetes 52 2003 2546 2553
    • (2003) Diabetes , vol.52 , pp. 2546-2553
    • Poykko, S.M.1    Kellokoski, E.2    Horkko, S.3    Kauma, H.4    Kesaniemi, Y.A.5    Ukkola, O.6
  • 100
    • 81755180210 scopus 로고    scopus 로고
    • Three novel mutations in the growth hormone secretagogue receptor (GHSR) gene associated with constitutional delay in growth and puberty (CDGP) or isolated growth hormone deficiency (IGHD)
    • P.N. Pugliese-Pires, J.P. Fortin, Y.T. Zhu, B.B. Mendonca, I.J. Arnhold, and A.S. Kopin Three novel mutations in the growth hormone secretagogue receptor (GHSR) gene associated with constitutional delay in growth and puberty (CDGP) or isolated growth hormone deficiency (IGHD) Horm Res 72 2009 245
    • (2009) Horm Res , vol.72 , pp. 245
    • Pugliese-Pires, P.N.1    Fortin, J.P.2    Zhu, Y.T.3    Mendonca, B.B.4    Arnhold, I.J.5    Kopin, A.S.6
  • 101
    • 0346101851 scopus 로고    scopus 로고
    • Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans
    • J.Q. Purnell, D.S. Weigle, P. Breen, and D.E. Cummings Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans J Clin Endocrinol Metab 88 2003 5747 5752
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5747-5752
    • Purnell, J.Q.1    Weigle, D.S.2    Breen, P.3    Cummings, D.E.4
  • 103
    • 4444266408 scopus 로고    scopus 로고
    • Directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression
    • T. Riediger, C. Bothe, C. Becskei, T.A. Lutz, and Peptide YY directly inhibits ghrelin-activated neurons of the arcuate nucleus and reverses fasting-induced c-Fos expression Neuroendocrinology 79 2004 317 326
    • (2004) Neuroendocrinology , vol.79 , pp. 317-326
    • Riediger, T.1    Bothe, C.2    Becskei, C.3    Lutz, T.A.4    Yy, P.5
  • 104
    • 0032427048 scopus 로고    scopus 로고
    • The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases - I. DNA pooling
    • N. Risch, and J. Teng The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases - I. DNA pooling Genome Res 8 1998 1273 1288
    • (1998) Genome Res , vol.8 , pp. 1273-1288
    • Risch, N.1    Teng, J.2
  • 105
    • 0033580457 scopus 로고    scopus 로고
    • Organization of the gene for gelatin-binding protein (GBP28)
    • K. Saito, T. Tobe, S. Minoshima, S. Asakawa, J. Sumiya, and M. Yoda Organization of the gene for gelatin-binding protein (GBP28) Gene 229 1999 67 73
    • (1999) Gene , vol.229 , pp. 67-73
    • Saito, K.1    Tobe, T.2    Minoshima, S.3    Asakawa, S.4    Sumiya, J.5    Yoda, M.6
  • 106
    • 65549152532 scopus 로고    scopus 로고
    • Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats
    • N. Salome, D. Haage, D. Perrissoud, A. Moulin, L. Demange, and E. Egecioglu Anorexigenic and electrophysiological actions of novel ghrelin receptor (GHS-R1A) antagonists in rats Eur J Pharmacol 612 2009 167 173
    • (2009) Eur J Pharmacol , vol.612 , pp. 167-173
    • Salome, N.1    Haage, D.2    Perrissoud, D.3    Moulin, A.4    Demange, L.5    Egecioglu, E.6
  • 107
    • 79958016808 scopus 로고    scopus 로고
    • Effect of ghrelin on glucose-insulin homeostasis: Therapeutic implications
    • S. Sangiao-Alvarellos, and F. Cordido Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications Int J Pept 2010 2010
    • (2010) Int J Pept , pp. 2010
    • Sangiao-Alvarellos, S.1    Cordido, F.2
  • 108
  • 110
    • 35248827576 scopus 로고    scopus 로고
    • Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts
    • I. Seim, C. Collet, A.C. Herington, and L.K. Chopin Revised genomic structure of the human ghrelin gene and identification of novel exons, alternative splice variants and natural antisense transcripts BMC Genomics 8 2007 16
    • (2007) BMC Genomics , vol.8 , pp. 16
    • Seim, I.1    Collet, C.2    Herington, A.C.3    Chopin, L.K.4
  • 111
    • 33751062773 scopus 로고    scopus 로고
    • Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats
    • L.M. Seoane, O. Al-Massadi, Y. Pazos, U. Pagotto, and F.F. Casanueva Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats J Endocrinol Invest 29 2006 RC13 RC15
    • (2006) J Endocrinol Invest , vol.29
    • Seoane, L.M.1    Al-Massadi, O.2    Pazos, Y.3    Pagotto, U.4    Casanueva, F.F.5
  • 112
    • 33846996404 scopus 로고    scopus 로고
    • Intracerebroventricular acute and chronic administration of oblestatin minimally affect food intake but not weight gain in the rat
    • V. Sibilia, E. Bresciani, N. Lattuada, D. Rapetti, V. Locatelli, and V. De Luca Intracerebroventricular acute and chronic administration of oblestatin minimally affect food intake but not weight gain in the rat J Endocrinol Invest 29 2006 RC31 RC34
    • (2006) J Endocrinol Invest , vol.29
    • Sibilia, V.1    Bresciani, E.2    Lattuada, N.3    Rapetti, D.4    Locatelli, V.5    De Luca, V.6
  • 113
    • 0034047615 scopus 로고    scopus 로고
    • Case-control association studies for the genetics of complex respiratory diseases
    • E.K. Silverman, and L.J. Palmer Case-control association studies for the genetics of complex respiratory diseases Am J Respir Cell Mol Biol 22 2000 645 648
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 645-648
    • Silverman, E.K.1    Palmer, L.J.2
  • 115
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Y. Sun, M. Asnicar, P.K. Saha, L. Chan, and R.G. Smith Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice Cell Metab 3 2006 379 386
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 116
    • 71549131310 scopus 로고    scopus 로고
    • Preproghrelin gene polymorphisms in obese Japanese: Association with diabetes mellitus in men and with metabolic syndrome parameters in women
    • J. Takezawa, K. Yamada, A. Morita, N. Aiba, and S. Watanabe Preproghrelin gene polymorphisms in obese Japanese: Association with diabetes mellitus in men and with metabolic syndrome parameters in women Obes Res Clin Pract 3 2009 179 191
    • (2009) Obes Res Clin Pract , vol.3 , pp. 179-191
    • Takezawa, J.1    Yamada, K.2    Morita, A.3    Aiba, N.4    Watanabe, S.5
  • 117
    • 15744379010 scopus 로고    scopus 로고
    • Genetic and environmental influences on eating behavior: The Swedish young male twins study
    • S. Tholin, F. Rasmussen, P. Tynelius, and J. Karlsson Genetic and environmental influences on eating behavior: the Swedish young male twins study Am J Clin Nutr 81 2005 564 569
    • (2005) Am J Clin Nutr , vol.81 , pp. 564-569
    • Tholin, S.1    Rasmussen, F.2    Tynelius, P.3    Karlsson, J.4
  • 119
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • J. Tuomilehto, J. Lindstrom, J.G. Eriksson, T.T. Valle, H. Hamalainen, and P. Ilanne-Parikka Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance N Engl J Med 344 2001 1343 1350
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.G.3    Valle, T.T.4    Hamalainen, H.5    Ilanne-Parikka, P.6
  • 122
    • 65849133641 scopus 로고    scopus 로고
    • The endocrinopathies of anorexia nervosa
    • L.S. Usdan, L. Khaodhiar, and C.M. Apovian The endocrinopathies of anorexia nervosa Endocr Pract 14 2008 1055 1063
    • (2008) Endocr Pract , vol.14 , pp. 1055-1063
    • Usdan, L.S.1    Khaodhiar, L.2    Apovian, C.M.3
  • 123
    • 44949156587 scopus 로고    scopus 로고
    • No significant association between A-501C single nucleotide polymorphism in preproghrelin and body mass index or waist-to-hip ratio in central European population - Reply
    • J. Vartiainen, A. Kesaniemi, and O. Ukkola No significant association between A-501C single nucleotide polymorphism in preproghrelin and body mass index or waist-to-hip ratio in central European population - reply Metabolism 57 2008 1017 1018
    • (2008) Metabolism , vol.57 , pp. 1017-1018
    • Vartiainen, J.1    Kesaniemi, A.2    Ukkola, O.3
  • 124
    • 33748464912 scopus 로고    scopus 로고
    • Sequencing analysis of ghrelin gene 5′ flanking region: Relations between the sequence variants, fasting plasma total ghrelin concentrations, and body mass index
    • J. Vartiainen, Y.A. Kesaniemi, and O. Ukkola Sequencing analysis of ghrelin gene 5′ flanking region: relations between the sequence variants, fasting plasma total ghrelin concentrations, and body mass index Metabolism 55 2006 1420 1425
    • (2006) Metabolism , vol.55 , pp. 1420-1425
    • Vartiainen, J.1    Kesaniemi, Y.A.2    Ukkola, O.3
  • 125
    • 2342473272 scopus 로고    scopus 로고
    • Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene
    • J. Vartiainen, S.M. Poykko, T. Raisanen, Y.A. Kesaniemi, and O. Ukkola Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene Eur J Endocrinol 150 2004 457 463
    • (2004) Eur J Endocrinol , vol.150 , pp. 457-463
    • Vartiainen, J.1    Poykko, S.M.2    Raisanen, T.3    Kesaniemi, Y.A.4    Ukkola, O.5
  • 126
    • 0033652271 scopus 로고    scopus 로고
    • Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
    • N. Vionnet, E. Hani, S. Dupont, S. Gallina, S. Francke, and S. Dotte Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24 Am J Hum Genet 67 2000 1470 1480
    • (2000) Am J Hum Genet , vol.67 , pp. 1470-1480
    • Vionnet, N.1    Hani, E.2    Dupont, S.3    Gallina, S.4    Francke, S.5    Dotte, S.6
  • 127
    • 4344690017 scopus 로고    scopus 로고
    • Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents
    • D. Vivenza, A. Rapa, N. Castellino, S. Bellone, A. Petri, and G. Vacca Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents Eur J Endocrinol 151 2004 127 133
    • (2004) Eur J Endocrinol , vol.151 , pp. 127-133
    • Vivenza, D.1    Rapa, A.2    Castellino, N.3    Bellone, S.4    Petri, A.5    Vacca, G.6
  • 128
    • 10744222895 scopus 로고    scopus 로고
    • Ghrelin receptor gene: Identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature
    • H.J. Wang, F. Geller, A. Dempfle, N. Schauble, S. Friedel, and P. Lichtner Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature J Clin Endocrinol Metab 89 2004 157 162
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 157-162
    • Wang, H.J.1    Geller, F.2    Dempfle, A.3    Schauble, N.4    Friedel, S.5    Lichtner, P.6
  • 129
    • 42649139571 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 20 loci that influence adult height
    • M.N. Weedon, H. Lango, C.M. Lindgren, C. Wallace, D.M. Evans, and M. Mangino Genome-wide association analysis identifies 20 loci that influence adult height Nat Genet 40 2008 575 583
    • (2008) Nat Genet , vol.40 , pp. 575-583
    • Weedon, M.N.1    Lango, H.2    Lindgren, C.M.3    Wallace, C.4    Evans, D.M.5    Mangino, M.6
  • 130
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • C.J. Willer, E.K. Speliotes, R.J.F. Loos, S.X. Li, C.M. Lindgren, and I.M. Heid Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Nat Genet 41 2009 25 34
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.F.3    Li, S.X.4    Lindgren, C.M.5    Heid, I.M.6
  • 131
    • 18244398708 scopus 로고    scopus 로고
    • Evidence for linkage of stature to chromosome 3p26 in a large UK family data set ascertained for type 2 diabetes
    • S. Wiltshire, T.M. Frayling, A.T. Hattersley, G.A. Hitman, M. Walker, and J.C. Levy Evidence for linkage of stature to chromosome 3p26 in a large UK family data set ascertained for type 2 diabetes Am J Hum Genet 70 2002 543 546
    • (2002) Am J Hum Genet , vol.70 , pp. 543-546
    • Wiltshire, S.1    Frayling, T.M.2    Hattersley, A.T.3    Hitman, G.A.4    Walker, M.5    Levy, J.C.6
  • 134
    • 0036234398 scopus 로고    scopus 로고
    • A combined analysis of genomewide linkage scans for body mass index, from the National Heart, Lung, and Blood Institute Family Blood Pressure Program
    • X.D. Wu, R.S. Cooper, I. Borecki, C. Hanis, M. Bray, and C.E. Lewis A combined analysis of genomewide linkage scans for body mass index, from the National Heart, Lung, and Blood Institute Family Blood Pressure Program Am J Hum Genet 70 2002 1247 1256
    • (2002) Am J Hum Genet , vol.70 , pp. 1247-1256
    • Wu, X.D.1    Cooper, R.S.2    Borecki, I.3    Hanis, C.4    Bray, M.5    Lewis, C.E.6
  • 135
    • 42149126035 scopus 로고    scopus 로고
    • A new variation in the promoter region, the -604C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance
    • S. Zavarella, A. Petrone, S. Zampetti, M. Gueorguiev, M. Spoletini, and C.A. Mein A new variation in the promoter region, the -604C>T, and the Leu72Met polymorphism of the ghrelin gene are associated with protection to insulin resistance Int J Obes 32 2008 663 668
    • (2008) Int J Obes , vol.32 , pp. 663-668
    • Zavarella, S.1    Petrone, A.2    Zampetti, S.3    Gueorguiev, M.4    Spoletini, M.5    Mein, C.A.6
  • 136
    • 33846995594 scopus 로고    scopus 로고
    • Response to comment on "obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake"
    • J.V. Zhang, C. Klein, P.G. Ren, S. Kass, L.V. Donck, and D. Moechars Response to comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake" Science 315 2007 1
    • (2007) Science , vol.315 , pp. 1
    • Zhang, J.V.1    Klein, C.2    Ren, P.G.3    Kass, S.4    Donck, L.V.5    Moechars, D.6
  • 137
    • 27744600963 scopus 로고    scopus 로고
    • Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake
    • J.V. Zhang, P.G. Ren, O. Avsian-Kretchmer, C.W. Luo, R. Rauch, and C. Klein Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake Science 310 2005 996 999
    • (2005) Science , vol.310 , pp. 996-999
    • Zhang, J.V.1    Ren, P.G.2    Avsian-Kretchmer, O.3    Luo, C.W.4    Rauch, R.5    Klein, C.6
  • 138


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