The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. I. DNA pooling

Genome Research

Volumn 8, Issue 12, 1998, Pages 1273-1288

  Risch, Neu ^a,b   Teng, Jun ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; FAMILY; GENE LINKAGE DISEQUILIBRIUM; GENETIC DISORDER; GENETIC MARKER; GENOTYPE; HUMAN; PARENT; PRIORITY JOURNAL; SIBLING; STATISTICS;

EID: 0032427048     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.8.12.1273     Document Type: Article

References (21)

1. Arnheim, N., C. Strange, and H. Erlich. 1985. Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: Studies of the HLA class II loci. Proc. Natl. Acad. Sci. 82: 6970-6974.
2. Barcellos, L.F., W. Klitz, L.L. Field et al. 1997. Association mapping of disease loci by use of a pooled DNA genomic screen. Am. J. Hum. Genet. 61: 734-747.
3. Bengtsson, B.O. and G. Thomson. 1981. Measuring the strength of associations between HLA antigens and diseases. Tissue Antigens 18: 356-363.
4. Camp, N.J. 1997. Genomewide transmission/disequilibrium testing: Consideration of the genotype relative risks at disease loci. Am. J. Hum. Genet. 61: 1424-1430.
5. Carmi, R., T. Rokhlina, A.E. Kwitek-Black, K. Eibedour, D. Nishimura, E.M. Stone, and V.C. Sheffield. 1995. Use of DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15. Hum. Mol. Genet. 3: 1331-1335.
6. Clarke, C.A., J. Wyn Edwards, D.R.W. Haddock, A.W. Howel-Evans, R.B. McConnell, and P.M. Sheppard. 1956. ABO blood groups and secretor character in duodenal ulcer. Br. Med. J. 2: 725-731.
7. Curtis, D. 1997. Use of siblings as controls in case-control association studies. Ann. Hum. Genet. 61: 319-333.
8. Eaves, L. and J. Meyer. 1994. Locating human quantitative trait loci: Guidelines for the selection of sibling pairs for genotyping. Behav. Genet. 24: 443-455.
9. Ewens, W.J. and R.S. Spielman. 1995. The transmission disequilibrium test: History, subdivision and admixture. Am. J. Hum. Genet. 57: 455-464.
10. Falk, C.T. and P. Rubinstein. 1987. Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations. Ann. Hum. Genet. 51: 227-233.
11. Muller-Myhsok, B. and L. Abel. 1997. Genetic analysis of complex diseases. Science 275: 1328-1329.
12. Nelson, S.T., J.H. McCusker, M.A. Sander, Y. Kee, P. Modrich, and P.O. Brown. 1993. Genome mismatch scanning: A new approach to genetic linkage mapping. Nat. Genet. 4: 11-18.
13. Risch, N. 1984. Segregation analysis incorporating linkage markers. I. Single locus models with an application to type 1 diabetes. Am. J. Hum. Genet. 36: 363-386.
14. Risch, N. and K. Merikangas. 1996. The future of genetic studies of complex human diseases. Science 273: 1516-1517.
15. _. 1997. Genetic analysis of complex diseases. Science 275: 1329-1330.
16. Risch, N. and H. Zhang. 1995. Extreme discordant sib pairs for mapping quantitative trait loci in humans. Science 268: 1584-1589.
17. Schaid, D.J. and S.S. Sommer. 1993. Genotype relative risks: Methods for design and analysis of candidate-gene association studies. Am. J. Hum. Genet. 53: 1114-1126.
18. _. 1994. Comparison of statistics for candidate gene association studies. Am. J. Hum. Genet. 55: 402-409.
19. Spielman, R.S., R.E. McGinnis, and W.J. Ewens. 1993. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52: 506-516.
20. Terwilliger, J.D. and J. Ott. 1992. A haplotype-based "haplotype relative risk" approach to detecting allelic associations. Hum. Hered. 42: 337-346.
21. Thomson, G. 1995. Mapping disease genes: Family-based association studies. Am. J. Hum. Genet. 57: 487-498.