Conformational flexibility of the peptide hormone ghrelin in solution and lipid membrane bound: A molecular dynamics study

Journal of Biomolecular Structure and Dynamics

Volumn 23, Issue 4, 2006, Pages 357-363

  Beevers, Andrew J ^a   Kukol, Andreas ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

And Receptor binding; Ghrelin; Lipid bilayer; Molecular dynamics; Structure

Indexed keywords

AMINO ACID; ARGININE; GHRELIN; GLUTAMINE; GROWTH HORMONE; LYSINE; PEPTIDE HORMONE; PROLINE; SERINE;

ALPHA HELIX; ARTICLE; ENERGY METABOLISM; FOOD INTAKE; GROWTH HORMONE RELEASE; LIPID BILAYER; LIPID MEMBRANE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION;

EID: 30744470385     PISSN: 07391102     EISSN: 15380254     Source Type: Journal    
DOI: 10.1080/07391102.2006.10531231     Document Type: Article

References (27)

1. White, N., 1999. http://www.scripps.edu/mb/case/Biomer/.
2. Cornell, W. D., 1995. J. Am. Chem. Soc., 117:5179
3. Berendsen, H. J. C., van der Spoel, D., and van Drunen, R., 1995. Comp. Phys. Chem. Comm., 91:43
4. Lindahl, E., Hess, B., and Van der Spoel, D., 2001. J. Mol. Mod., 7:306
5. van Gunsteren, W. F., Daura, X., and Mark, A. E., 1999. Encyclopedia Comput. Chem., 2:1211
6. Hess, B., Bekker, H., Fraaije, J. G.E. M., and Berendsen, H. J. C., 1997. J. Comp. Chem., 18:1463
7. Berendsen, H. J. C., Grigera, J. R., and Straatsma, T. P., 1987. J. Phys. Chem, 91:6269
8. Weber, W., Hueneberger, P. H., and McCammon, J. A., 2000. J. Phys. Chem. B, 104:3668
9. Law, R. J., Tieleman, D. P., and Sansom, M. S., 2003. Biophys. J., 84:14
10. Shrivastava, I. H., Tieleman, D. P., Biggin, P. C., and Sansom, M. S., 2002. Biophys. J., 83:633
11. Gurtovenko, A. A., Patra, M., Karttunen, M., and Vattulainen, I., 2004. Biophys. J., 86:3461
12. Van Gunsteren, W. F., and Berendsen, H. J. C., 1987. Gromos-87 Manual
13. Tieleman, D. P., and Berendsen, H. J. C., 1996. Journal of Chemical Physics, 105:4871
14. Berger, O., Edholm, O., and Jahnig, F., 1997. Biophysical Journal, 72:2002
15. Humphrey, W., Dalke, A., and Schulten, K., 1996. J. Mol. Graphics, 14:33
16. Kojima, M., and Kangawa, K., 2005. Physiological Reviews, 85:495
17. Guillemin, R., 1982. Science, 218:585
18. Kojima, M., 1999. Nature, 402:656
19. Civelli, O., 1998. FEBS Lett., 430:55
20. Ariyasu, H., 2001. J. Clin. Endocrinol. Metab., 86:4753
21. Mori, K., 2000. FEBS Lett., 486:213
22. Silva Elipe, M. V., Bednarek, M. A., and Gao, Y. D., 2001. Biopolymers, 59:489
23. Sansom, M. S., Tieleman, D. P., Forrest, L. R., and Berendsen, H. J., 1998. Biochem. Soc. Trans., 26:438
24. Tieleman, D. P., Biggin, P. C., Smith, G. R., and Sansom, M. S., 2001. Q. Rev. Biophys., 34:473
25. Daura, X., Jaun, B., Seebach, D., F. Van Gunsteren, W., and Mark, A. E., 1998. Journal of Molecular Biology, 280:925
26. Duan, Y., and Kollman, P. A., 1998. Science, 282:740
27. Bednarek, M. A., 2000. J. Med. Chem., 43:4370