Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance

PLoS ONE

Volumn 3, Issue 8, 2008, Pages

  Mager, Ursula ^a   Degenhardt, Tatjana ^a   Pulkkinen, Leena ^a   Kolehmainen, Marjukka ^a   Tolppanen, Anna Maija ^a   Lindström, Jaana ^b   Eriksson, Johan G ^b,d   Carlberg, Carsten ^a,c   Tuomilehto, Jaakko ^b,d,e   Uusitupa, Matti ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^d UNIVERSITY OF HELSINKI   (Finland)

^e SOUTH OSTROBOTHNIA CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE SECRETAGOGUE RECEPTOR; GUANINE; INSULIN; NUCLEAR FACTOR I; TRANSCRIPTION FACTOR; GHRELIN RECEPTOR;

5' UNTRANSLATED REGION; ADULT; ALLELE; ARTICLE; BINDING SITE; BODY WEIGHT; CLINICAL ARTICLE; COMPUTER MODEL; DISEASE ASSOCIATION; FEMALE; FINLAND; FOLLOW UP; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; GLUCOSE METABOLISM; HUMAN; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN METABOLISM; LIFESTYLE MODIFICATION; LONG TERM CARE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PROMOTER REGION; PROTEIN BINDING; SCREENING TEST; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT REDUCTION; GENETICS; GLUCOSE INTOLERANCE; LIFESTYLE; METABOLISM;

BODY WEIGHT; GENETIC VARIATION; GLUCOSE; GLUCOSE INTOLERANCE; HUMANS; LIFE STYLE; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; PROTEIN BINDING; RECEPTORS, GHRELIN; WEIGHT LOSS;

EID: 51449100773     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002941     Document Type: Article

References (42)

1. Murphy KG, Bloom SR (2006) Gut hormones and the regulation of energy homeostasis. Nature 444: 854-859.
2. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
3. Kojima M, Kangawa K (2005) Ghrelin: structure and function. Physiol Rev 85: 495-522.
4. Inui A (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat Rev Neurosci 2: 551-560.
5. Tschöp M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913.
6. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, et al. (2001) A role for ghrelin in the central regulation of feeding. Nature 409: 194-198.
7. Holst B, Schwartz TW (2004) Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation. Trends Pharmacol Sci 25: 113-117.
8. Willesen MG, Kristensen P, Romer J (1999) Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70: 306-316.
9. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, et al. (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273: 974-977.
10. van der Lely AJ, Tschöp M, Heiman ML, Ghigo E (2004) Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 25: 426-457.
11. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, et al. (2002) The tissue distribution or the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87: 2988.
12. Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, et al. (2001) GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab 86: 4284-4291.
13. Dixit VD, Schaffer EM, Pyle RS, Collins GD, Sakthivel SK, et al. (2004) Ghrelin inhibits leptin- and activation-induced proinflammiatory cytokine expression by human monocytes and T cells. J Clin Invest 114: 57-66.
14. Zigman JM, Nakano Y, Coppari B, Balthasar N, Marcus JN, et al. (2005) Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest 115: 3564-3572.
15. Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, et al. (2005) Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes 54: 259-267.
16. Vartiainen J, Pöykkö SM, Räisänen T, Kesäniemi YA, Ukkola O (2004) Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene. Eur J Endocrinol 150: 457-463.
17. Dossus L, McKay JD, Canizian F, Wilkening S, Rinaldi S, et al. (2008) Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Carcinogenesis;doi:10.1093/carcin/bgn083.
18. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
19. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
20. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
21. Salonen JT, Uimari P, Aalto JM, Pirskanen M, Kaikkonen J, et al. (2007) Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium. Am J Hum Genet 81: 338-345.
22. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, et al. (2005) MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21: 2933-2942.
23. Wang HJ, Geller F, Dempfle A, Schauble N, Friedel S, et al. (2004) Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal statute. J Clin Endocrinol Metab 89: 157-162.
24. Gronostajski RM (2000) Roles or the NFI/CTF gene family in transcription and development Gene 249: 31-45.
25. Borgmeyer U, Nowock J, Sippel AE (1981) The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA. Nucleic Acids Res 12: 4295-4311.
26. Jones KA, Kadonaga JT, Rosenfeld PJ, Kelly TJ, Tjian R (1987) A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell 48: 79-89.
27. Santoro C, Mermod N, Andmvs PC, Tjian R (1988) A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature 334: 218-224.
28. Kim MS, Yoon CY, Park KH, Shin CS, Park KS, et al. (2003) Changes in ghrelin and ghrelin receptor expression according to reeding status. Neuroreport 14: 1317-1320.
29. Holst B, Cygankiewicz A, Jensen TH, Ankersen M, Schwartz TW (2003) High constitutive signaling of the ghrelin receptor-identification of a potent inverse agonist. Mol Endocrinol 17: 2201-2210.
30. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al. (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40: 638-645.
31. Hinney A, Nguyen TT, Scherug A, Friedel S, Bronner G, et al. (2007) Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS ONE 2: e 1361.
32. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115.
33. Liu YJ, Liu XG, Wang L, Dina C, Yan H, et al. (2008) Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet 17: 1803-1813.
34. Fox CS, Heard-Costa N, Cupples LA, Dupuis J, Vasan RS, et al. (2007) Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K. project. BMC Med Genet 8 Suppl 1: S18.
35. Eriksson J, Lindström J, Valle T, Aunola S, Hämäläinen H, et al. (1999) Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetologia 42: 793-801.
36. Tuomilehto J, Lindström, Eriksson JG, Valle TT, Hämäläinen H, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350.
37. WHO (1985) Diabetes mellitus. Report of a WHO Study Group. World Health Organ Tech Rep Set 727: i-xii, 1-113.
38. Altshuler D, Brooks LD, Chakravarti A, Collins FS, Daly MJ, et al. (2005) A haplotype map of the human genome. Nature 437: 1299-1320.
39. Wheeler DL, Barren T, Benson DA, Bryant SH, Canese K, et al. (2007) Database resources of the National Center for Biotechnology Information. Nucleic Acids Res 35: 135-12.
40. Hubbard TJ, Aken BL, Beal K, Ballester B, Caccamo M, et al. (2007) Ensembl 2007. Nucleic Acids Res 35: D610-617.
41. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
42. Barrett JC, Fry B, Mallet J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.