Re-expression of cell cycle proteins induces neuronal cell death during Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 4, Issue 3, 2002, Pages 243-247

  Herrup, Karl ^a   Arendt, Thomas ^b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ALZHEIMER DISEASE; BRAIN DEVELOPMENT; BRAIN FUNCTION; HUMAN; LEARNING; MEMORY; MITOGENESIS; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; PATHOGENESIS; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036626830     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2002-4315     Document Type: Review

References (52)

1. M.R. Al-Ubaidi, J.G. Hollyfield, P.A. Overbeek and W. Baehr, Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice, Proc Natl Acad Sci USA 89 (1992), 1194-1198.
2. T. Arendt, Neuronal dedifferentiation and degeneration in Alzheimer's disease, Biol. Chem. Hoppe-Seyler 374 (1993), 911-912.
3. T. Arendt, Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain, Neurobiol. Aging 21 (2000), 783-796.
4. T. Arendt, Alzheimer's disease as a disorder of mechanisms underlaying structural brain self-organization, Commentary Neuroscience 102 (2001), 723-765.
5. T. Arendt, M. Brückner, V. Bigl and L. Marcova, Dendritic reorganization in the basal forebrain under degenerative conditions and its de-fects in Alzheimer's disease. II. Ageing, Korsa-koff's disease, Parkinson's disease, and Alzheimer's disease, J. Comp. Neurol. 351 (1995), 189-222.
6. T. Arendt, M. Brückner, V. Bigl and L. Marcova, Dendritic reorganization in the basal forebrain under degenerative conditions and its de-fects in Alzheimer's disease. III. The basal fore-brain compared to other subcortical areas, J. Comp. Neurol. 351 (1995), 223-246.
7. T. Arendt, M. Brückner, H.-J. Gertz and L. Marcova, Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain, Neuroscience 83 (1998), 991-1002.
8. T. Arendt, M. Holzer, A. Großmann, Zedlick and M. Brückner, Increased expres-sion and subcellular translocation of the mitogen- activated protein kinase kinase and mitogen-acti-vated protein kinase in Alzheimer's disease, Neuroscience 68 (1995), 5-18.
9. T. Arendt, L. Rödel, U. Gärtner and M. Holzer, Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease, Neuroreport 7 (1996), 3047-3049.
10. G. Borasio, A. Markus, R. Heumann, C. Ghezzi, A. Sampietro, Wittinghofer and S, V, Ras p21 protein promotes survival and differentiation of human embryonic neural crest-derived cells, Neurosci 73 (1996), 1121-1127.
11. R. Brambilla, N. Gnesutta, L. Minichiello, G. White, A. Roylance, C. Herron, M. Ramsey, D. Wolfer, V. Cestari, C. Rossi- Arnaud, S. Grant, P. Chapman, H. Lipp, E. Sturani and R. Klein, A role for the Ras signalling pathway in synaptic transmission and long-term memory, Nature 390 (1997), 281-286.
12. J. Busser, D.S. Geldmacher and K. Herrup, Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain, J Neurosci 18 (1998), 2801-2807.
13. A.R. Clarke, E.R. Maandag, M. van Roon, N.M. van der Vugt, M. van der Valk, M.L. Hooper, A. Berns and H. te Riele, Requirement for a functional Rb-1 gene in murine development [see comments], Nature 359 (1992), 328-330.
14. J. Cosgaya, M. Latasa and A. Pascual, Nerve growth factor and ras regulate b-amyloid precursor protein gene expression in PC12 cells, J. Neurochem. 67 (1996), 98-104.
15. J. Curtis and S. Finkbeiner, Sending signals from the synapse to the nucleus: possible roles for CaMK, Ras/ERK, and SAPK pathways in the regulation of synaptic plasticity and neuronal growth, J. Neurosci. Res 58 (1999), 88-95.
16. T. Dawson, M. Sasaki, M. Gonzales-Zulueta and D. VL, Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways, Prog. Brain Res. 118 (1998), 3-11.
17. J. Desdouits-Magnen, F. Desdouits, S. Takeda, L. Syu, A. Saltiel, J. Buxbaum, A. Czernik, A. Nairn and P. Greengard, Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade, J. Neurochem. 70 (1998), 524-530.
18. J. Diehl, M. Cheng, M. Roussel and C. Sherr, Glycogen synthase kinase-3b regulates cyclin D1 proteolysis and subcellular localization, Genes Dev. 12 (1998), 3499-3511.
19. G. Drewes, B. Lichtenberg-Kraag, F. Doring, E. Mandelkow, J. Biernat, J. Goris, M. Doree and E. Mandelkow, Mitogen Activated Protein (Map) Kinase Transforms Tau-Protein into an Alzheimer-Like State, EMBO J. 11 (1992), 2131-2138.
20. R.M. Feddersen, H.B. Clark, W.S. Yunis and H.T. Orr, In vivo viability of postmitotic Purkinje neurons requires pRb family member function, Mol Cell Neurosci 6 (1995), 153-167.
21. R.M. Feddersen, R. Ehlenfeldt, W.S. Yunis, H.B. Clark and H.T. Orr, Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice, Neuron 9 (1992), 955-966.
22. G. Ferrari and L. Greene, Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death, EMBO J. 13 (1994), 5922-5928.
23. U. Gärtner, M. Holzer and T. Arendt, Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration, Neuroscience 91 (1999), 1-5.
24. U. Gärtner, M. Holzer, R. Heumann and T. Arendt, Induction of p21ras in Alzheimer pathology, Neuroreport 6 (1995), 1313-1316.
25. U. Gärtner, M. Holzer and T. Arendt, Neurofibrillary lesions in Alzheimer's disease are associated with 14-3-3 protein, Biol. Chem. 377 Spec.Suppl (1996), S180.
26. M. Goedert, E. Cohen, R. Jakes and P, Cohen, p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1- implication for Alzheimer's disease, FEBS Lett. 312 (1992), 95-99.
27. S. Greenberg, E. Koo, J. Selkoe, W. Qiu and K. Kosik, Secreted beta amyloid precursor protein stimulates mitogen activated protein kinase and enhances tau phosphorylation, Proc. Natl. Acad. Sci. USA 91 (1994), 7104-7108.
28. K. Herrup and J.C. Busser, The induction of multiple cell cycle events precedes target-related neuronal death, Development 121 (1995), 2385-2395.
29. K. Herrup and K. Sunter, Numerical matching during cerebellar development: quantitative analysis of granule cell death in staggerer mouse chimeras, J Neu rosci 7 (1987), 829-836.
30. M. Holzer, U. Gärtner, F. Klinz, F. Narz, R. Heumann and T. Arendt, Activation of mitogen activated protein kinase cascade (MAPK)-cascade and phosphorylation of cytoskeletal proteins after neuron-specific activation of p21ras. I. MAPK-cascade, Neuroscience 105 (2001), 1031-1040.
31. M. Holzer, L. Rödel, G. Seeger, U. Gärtner, F. Narz, C. Janke, R. Heumann and T. Arendt, Activation of mitogen activated protein kinase (MAPK)-cascade and phosphorylation of cytoskeletal proteins after neuron-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology, Neuroscience 105 (2001), 1041-1054.
32. T. Jacks, A. Fazeli, E. Schmitt, R. Bronson, M. Goodell and R. Weinberg, Effects of an Rb mutation in the mouse, Nature 359 (1992), 295-300.
33. E.-H. Lee, N. Hu, S.S. Yuan, L.A. Cox, A. Bradley, W.H. Lee and K. Herrup, Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation, Genes Dev 8 (1994), 2008-2021.
34. E.Y.-H.P. Lee, C.-Y. Chang, N. Hu, Y.-C.J. Wang, C.-C. Lai, K. Herrup, W.-H. Lee and A. Bradley, Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis, Nature 359 (1992), 288-294.
35. H.-J. Lüth and T. Arendt, Nitric oxide and Alzheimer's disease, J. Brain Res. 39 (1998), 245-251.
36. H.-J. Lüth, M. Holzer, H.-J. Gertz and T. Arendt, Aberrant expression of nNOS in pyrami-dal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a, Brain Research 852 (2000), 45-55.
37. M. Malumbres, I. Perez De Castro, M. Hernandez, M. Jimenez, T. Corral and A. Pellicer, Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b), Mol Cell Biol. 20 (2000), 2915-2925.
38. A. McShea, P.L. Harris, K.R. Webster, A.F. Wahl and M.A. Smith, Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease, Am J Pathol 150 (1997), 1933-1939.
39. J. Mills, D. Charest, F. Lam, K. Beyreuther, N. Ida, S. Pelech and P. Reiner, Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway, J. Neurosci. 17 (1997), 9415-9422.
40. D. Morrison, 14-3-3: modulators of signaling proteins? Science 266 (1994), 56-57.
41. I. Palmero, C. Pantoja and M. Serrano, p19ARF links the tumour suppressor p53 to Ras, Nature 395 (1998), 125-126.
42. S. Pelech and J. Sanghera, Mitogen-activated protein kinases: versatile transducers for cell signaling, Trends. Biochem. Sci. 17 (1992), 233-238.
43. L. Phillips and E. Belardo, Increase of c-fos and ras oncoproteins in the denervated neuropil of the rat dentate gyrus, Neuroscience 58 (1994), 503-514.
44. K. Roovers and R. Assoian, Integrating the MAP kinase signal into the G1 phase cell cycle machinery, Bioessays 22 (2000), 818-826.
45. E. Sadot, H. Jaaro, R. Seger and I. Ginzburg, Ras-signaling pathways: Positive and negative regulation of tau expression in PC12 cells, J. Neurochem. 70 (1998), 428-431.
46. M. Serrano, A. Lin, M. McCurrach, D. Beach and S. Lowe, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell 88 (1997), 593-602.
47. T.W. Smith and C.F. Lippa, Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders, J Neuropathol Exp Neurol 54 (1995), 297-303.
48. D. Sweetser, R. Kapur, G. Froelick, K. Kafer and R. Palmiter, Oncogenesis and altered differentiation induced by activated Ras in neuroblasts of transgenic mice, Oncogene 15 (1997), 2783-2794.
49. I. Vincent, M. Rosado and P. Davies, Mitotic mechanisms in Alzheimer's disease? J Cell Biol 132 (1996), 413-425.
50. M.W. Vogel, K. Sunter and K. Herrup, Numerical matching between granule and Purkinje cells in lurcher chimeric mice: a hypothesis for the trophic rescue of granule cells from target- related cell death, J Neurosci 9 (1989), 3454-3462.
51. Y. Yang, D.S. Geldmacher and K. Herrup, DNA replication precedes neuronal cell death in Alzheimer's disease, J Neurosci 21 (2001), 2661-2668.
52. H. Yun, M. Gonzalez-Zulueta, V. Dawson and D. TM, Nitric oxide mediates N-methyl-D-aspartate receptor-induced activation of p21 ras, Proc. Natl. Acad. Sci. USA 95 (1998), 5773-5778.