메뉴 건너뛰기




Volumn 25, Issue 6, 2011, Pages 1135-1161

Diagnostic and Prognostic Value of Cytogenetics in Acute Myeloid Leukemia

Author keywords

Acute myeloid leukemia; Cytogenetics; Diagnosis; Prognosis

Indexed keywords

ARSENIC TRIOXIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; CORE BINDING FACTOR; DNA TOPOISOMERASE (ATP HYDROLYSING); EPIPODOPHYLLOTOXIN; FLT3 LIGAND; ISOCITRATE DEHYDROGENASE; MIXED LINEAGE LEUKEMIA PROTEIN; MYOSIN HEAVY CHAIN; NUCLEOPHOSMIN; NUCLEOPORIN 98; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ERG; TRANSCRIPTION FACTOR RUNX1;

EID: 81255170298     PISSN: 08898588     EISSN: 15581977     Source Type: Journal    
DOI: 10.1016/j.hoc.2011.09.018     Document Type: Review
Times cited : (97)

References (172)
  • 1
    • 0015694741 scopus 로고
    • Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia
    • Rowley J.D. Identification of a translocation with quinacrine fluorescence in a patient with acute leukemia. Ann Genet 1973, 16(2):109-112.
    • (1973) Ann Genet , vol.16 , Issue.2 , pp. 109-112
    • Rowley, J.D.1
  • 2
    • 0017362792 scopus 로고
    • 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia
    • Rowley J.D., Golomb H.M., Dougherty C. 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia. Lancet 1977, 1(8010):549-550.
    • (1977) Lancet , vol.1 , Issue.8010 , pp. 549-550
    • Rowley, J.D.1    Golomb, H.M.2    Dougherty, C.3
  • 3
    • 0014802484 scopus 로고
    • Differential binding of alkylating fluorochromes in human chromosomes
    • Caspersson T., Zech L., Johansson C. Differential binding of alkylating fluorochromes in human chromosomes. Exp Cell Res 1970, 60(3):315-319.
    • (1970) Exp Cell Res , vol.60 , Issue.3 , pp. 315-319
    • Caspersson, T.1    Zech, L.2    Johansson, C.3
  • 4
    • 0015246254 scopus 로고
    • A rapid banding technique for human chromosomes
    • Seabright M. A rapid banding technique for human chromosomes. Lancet 1971, 2(7731):971-972.
    • (1971) Lancet , vol.2 , Issue.7731 , pp. 971-972
    • Seabright, M.1
  • 5
    • 84859886582 scopus 로고    scopus 로고
    • editors, Mitelman database of chromosome aberrations and gene fusions in cancer. 2011. Available: Accessed August 2,
    • Mitelman F, Johansson B, Mertens F, editors, Mitelman database of chromosome aberrations and gene fusions in cancer. 2011. Available: Accessed August 2, 2011. http://cgap.nci.nih.gov/Chromosomes/Mitelman.
    • (2011)
    • Mitelman, F.1    Johansson, B.2    Mertens, F.3
  • 7
    • 0034758836 scopus 로고    scopus 로고
    • The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia
    • Grimwade D. The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia. Best Pract Res Clin Haematol 2001, 14(3):497-529.
    • (2001) Best Pract Res Clin Haematol , vol.14 , Issue.3 , pp. 497-529
    • Grimwade, D.1
  • 9
    • 78649905124 scopus 로고    scopus 로고
    • Independent prognostic variables in acute myeloid leukaemia
    • Smith M.L., Hills R.K., Grimwade D. Independent prognostic variables in acute myeloid leukaemia. Blood Rev 2011, 25(1):39-51.
    • (2011) Blood Rev , vol.25 , Issue.1 , pp. 39-51
    • Smith, M.L.1    Hills, R.K.2    Grimwade, D.3
  • 11
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
    • Vardiman J.W., Thiele J., Arber D.A., et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009, 114(5):937-951.
    • (2009) Blood , vol.114 , Issue.5 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3
  • 12
    • 0025043959 scopus 로고
    • The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus
    • de Thé H., Chomienne C., Lanotte M., et al. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 1990, 347(6293):558-561.
    • (1990) Nature , vol.347 , Issue.6293 , pp. 558-561
    • de Thé, H.1    Chomienne, C.2    Lanotte, M.3
  • 13
    • 0025089467 scopus 로고
    • Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17
    • Borrow J., Goddard A.D., Sheer D., et al. Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 1990, 249(4976):1577-1580.
    • (1990) Science , vol.249 , Issue.4976 , pp. 1577-1580
    • Borrow, J.1    Goddard, A.D.2    Sheer, D.3
  • 14
    • 0026326963 scopus 로고
    • Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia
    • Goddard A.D., Borrow J., Freemont P.S., et al. Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 1991, 254(5036):1371-1374.
    • (1991) Science , vol.254 , Issue.5036 , pp. 1371-1374
    • Goddard, A.D.1    Borrow, J.2    Freemont, P.S.3
  • 15
    • 63849220435 scopus 로고    scopus 로고
    • PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders?
    • Brown N.J., Ramalho M., Pedersen E.W., et al. PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders?. Front Biosci 2009, 14:1684-1707.
    • (2009) Front Biosci , vol.14 , pp. 1684-1707
    • Brown, N.J.1    Ramalho, M.2    Pedersen, E.W.3
  • 16
    • 0034663029 scopus 로고    scopus 로고
    • Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party
    • Grimwade D., Biondi A., Mozziconacci M.-J., et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Blood 2000, 96(4):1297-1308.
    • (2000) Blood , vol.96 , Issue.4 , pp. 1297-1308
    • Grimwade, D.1    Biondi, A.2    Mozziconacci, M.-J.3
  • 17
    • 0027411688 scopus 로고
    • Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia
    • Chen Z., Brand N.J., Chen A., et al. Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-α locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J 1993, 12(3):1161-1167.
    • (1993) EMBO J , vol.12 , Issue.3 , pp. 1161-1167
    • Chen, Z.1    Brand, N.J.2    Chen, A.3
  • 18
    • 0030022316 scopus 로고    scopus 로고
    • The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion
    • Redner R.L., Rush E.A., Faas S., et al. The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion. Blood 1996, 87(3):882-886.
    • (1996) Blood , vol.87 , Issue.3 , pp. 882-886
    • Redner, R.L.1    Rush, E.A.2    Faas, S.3
  • 19
    • 0030771192 scopus 로고    scopus 로고
    • Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia
    • Wells R.A., Catzavelos C., Kamel-Reid S. Fusion of retinoic acid receptor α to NuMA, the nuclear mitotic apparatus protein, by a variant translocation in acute promyelocytic leukaemia. Nat Genet 1997, 17(1):109-113.
    • (1997) Nat Genet , vol.17 , Issue.1 , pp. 109-113
    • Wells, R.A.1    Catzavelos, C.2    Kamel-Reid, S.3
  • 20
    • 50849123755 scopus 로고    scopus 로고
    • The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia
    • Kondo T., Mori A., Darmanin S., et al. The seventh pathogenic fusion gene FIP1L1-RARA was isolated from a t(4;17)-positive acute promyelocytic leukemia. Haematologica 2008, 93(9):1414-1416.
    • (2008) Haematologica , vol.93 , Issue.9 , pp. 1414-1416
    • Kondo, T.1    Mori, A.2    Darmanin, S.3
  • 21
    • 78549267880 scopus 로고    scopus 로고
    • BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia
    • Yamamoto Y., Tsuzuki S., Tsuzuki M., et al. BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia. Blood 2010, 116(20):4274-4283.
    • (2010) Blood , vol.116 , Issue.20 , pp. 4274-4283
    • Yamamoto, Y.1    Tsuzuki, S.2    Tsuzuki, M.3
  • 22
    • 37049011235 scopus 로고    scopus 로고
    • The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia
    • Catalano A., Dawson M.A., Somana K., et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007, 110(12):4073-4076.
    • (2007) Blood , vol.110 , Issue.12 , pp. 4073-4076
    • Catalano, A.1    Dawson, M.A.2    Somana, K.3
  • 23
    • 0032867588 scopus 로고    scopus 로고
    • The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia
    • Arnould C., Philippe C., Bourdon V., et al. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia. Hum Mol Genet 1999, 8(9):1741-1749.
    • (1999) Hum Mol Genet , vol.8 , Issue.9 , pp. 1741-1749
    • Arnould, C.1    Philippe, C.2    Bourdon, V.3
  • 24
    • 77953048986 scopus 로고    scopus 로고
    • Acute promyelocytic leukemia: a paradigm for differentiation therapy
    • Grimwade D., Mistry A.R., Solomon E., et al. Acute promyelocytic leukemia: a paradigm for differentiation therapy. Cancer Treat Res 2010, 145:219-235.
    • (2010) Cancer Treat Res , vol.145 , pp. 219-235
    • Grimwade, D.1    Mistry, A.R.2    Solomon, E.3
  • 25
    • 0028899552 scopus 로고
    • Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)
    • Licht J.D., Chomienne C., Goy A., et al. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17). Blood 1995, 85(4):1083-1094.
    • (1995) Blood , vol.85 , Issue.4 , pp. 1083-1094
    • Licht, J.D.1    Chomienne, C.2    Goy, A.3
  • 26
    • 0037088996 scopus 로고    scopus 로고
    • Interactions of STAT5b-RARα, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways
    • Dong S., Tweardy D.J. Interactions of STAT5b-RARα, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways. Blood 2002, 99(8):2637-2646.
    • (2002) Blood , vol.99 , Issue.8 , pp. 2637-2646
    • Dong, S.1    Tweardy, D.J.2
  • 27
    • 36749092865 scopus 로고    scopus 로고
    • RARα-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia
    • Guidez F., Parks S., Wong H., et al. RARα-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia. Proc Natl Acad Sci U S A 2007, 104(47):18694-18699.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.47 , pp. 18694-18699
    • Guidez, F.1    Parks, S.2    Wong, H.3
  • 28
    • 77950826446 scopus 로고    scopus 로고
    • Arsenic trioxide controls the fate of the PML-RARα oncoprotein by directly binding PML
    • Zhang X.W., Yan X.J., Zhou Z.R., et al. Arsenic trioxide controls the fate of the PML-RARα oncoprotein by directly binding PML. Science 2010, 328(5975):240-243.
    • (2010) Science , vol.328 , Issue.5975 , pp. 240-243
    • Zhang, X.W.1    Yan, X.J.2    Zhou, Z.R.3
  • 29
    • 78650979126 scopus 로고    scopus 로고
    • A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia
    • Such E., Cervera J., Valencia A., et al. A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia. Blood 2011, 117(1):242-245.
    • (2011) Blood , vol.117 , Issue.1 , pp. 242-245
    • Such, E.1    Cervera, J.2    Valencia, A.3
  • 30
    • 80052366564 scopus 로고    scopus 로고
    • Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects
    • Goyama S., Mulloy J.C. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol 2011, 94(2):126-133.
    • (2011) Int J Hematol , vol.94 , Issue.2 , pp. 126-133
    • Goyama, S.1    Mulloy, J.C.2
  • 31
    • 77953135667 scopus 로고    scopus 로고
    • The molecular signature of oncofusion proteins in acute myeloid leukemia
    • Martens J.H.A., Stunnenberg H.G. The molecular signature of oncofusion proteins in acute myeloid leukemia. FEBS Lett 2010, 584(12):2662-2669.
    • (2010) FEBS Lett , vol.584 , Issue.12 , pp. 2662-2669
    • Martens, J.H.A.1    Stunnenberg, H.G.2
  • 32
  • 33
    • 77955713862 scopus 로고    scopus 로고
    • CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia
    • Guastadisegni M.C., Lonoce A., Impera L., et al. CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia. Leukemia 2010, 24(8):1516-1519.
    • (2010) Leukemia , vol.24 , Issue.8 , pp. 1516-1519
    • Guastadisegni, M.C.1    Lonoce, A.2    Impera, L.3
  • 34
    • 0036197484 scopus 로고    scopus 로고
    • 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop
    • Slovak M.L., Bedell V., Popplewell L., et al. 21q22 balanced chromosome aberrations in therapy-related hematopoietic disorders: report from an international workshop. Genes Chromosomes Cancer 2002, 33(4):379-394.
    • (2002) Genes Chromosomes Cancer , vol.33 , Issue.4 , pp. 379-394
    • Slovak, M.L.1    Bedell, V.2    Popplewell, L.3
  • 35
    • 62449145322 scopus 로고    scopus 로고
    • Identification of a potential " hotspot" DNA region in the RUNX1 gene targeted by mitoxantrone in therapy-related acute myeloid leukemia with t(16;21) translocation
    • Ottone T., Hasan S.K., Montefusco E., et al. Identification of a potential " hotspot" DNA region in the RUNX1 gene targeted by mitoxantrone in therapy-related acute myeloid leukemia with t(16;21) translocation. Genes Chromosomes Cancer 2009, 48(3):213-221.
    • (2009) Genes Chromosomes Cancer , vol.48 , Issue.3 , pp. 213-221
    • Ottone, T.1    Hasan, S.K.2    Montefusco, E.3
  • 36
    • 68749120703 scopus 로고    scopus 로고
    • New insights to the MLL recombinome of acute leukemias
    • Meyer C., Kowarz E., Hofmann J., et al. New insights to the MLL recombinome of acute leukemias. Leukemia 2009, 23(8):1490-1499.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1490-1499
    • Meyer, C.1    Kowarz, E.2    Hofmann, J.3
  • 37
    • 79954552505 scopus 로고    scopus 로고
    • The super elongation complex (SEC) and MLL in development and disease
    • Smith E., Lin C., Shilatifard A. The super elongation complex (SEC) and MLL in development and disease. Genes Dev 2011, 25(7):661-672.
    • (2011) Genes Dev , vol.25 , Issue.7 , pp. 661-672
    • Smith, E.1    Lin, C.2    Shilatifard, A.3
  • 38
    • 20244389694 scopus 로고    scopus 로고
    • Favorable impact of the t(9;11) in childhood acute myeloid leukemia
    • Rubnitz J.E., Raimondi S.C., Tong X., et al. Favorable impact of the t(9;11) in childhood acute myeloid leukemia. J Clin Oncol 2002, 20(9):2302-2309.
    • (2002) J Clin Oncol , vol.20 , Issue.9 , pp. 2302-2309
    • Rubnitz, J.E.1    Raimondi, S.C.2    Tong, X.3
  • 39
    • 1842289846 scopus 로고    scopus 로고
    • Adult patients with de novo acute myeloid leukemia and t(9;11)(p22;q23) have a superior outcome to patients with other translocations involving band 11q23: a Cancer and Leukemia Group B study
    • Mrózek K., Heinonen K., Lawrence D., et al. Adult patients with de novo acute myeloid leukemia and t(9;11)(p22;q23) have a superior outcome to patients with other translocations involving band 11q23: a Cancer and Leukemia Group B study. Blood 1997, 90(11):4532-4538.
    • (1997) Blood , vol.90 , Issue.11 , pp. 4532-4538
    • Mrózek, K.1    Heinonen, K.2    Lawrence, D.3
  • 40
    • 0029068727 scopus 로고
    • Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis
    • Beverloo H.B., Le Coniat M., Wijsman J., et al. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis. Cancer Res 1995, 55(19):4220-4224.
    • (1995) Cancer Res , vol.55 , Issue.19 , pp. 4220-4224
    • Beverloo, H.B.1    Le Coniat, M.2    Wijsman, J.3
  • 41
    • 0038794729 scopus 로고    scopus 로고
    • Cytogenetics, fluorescence in situ hybridization, and reverse transcriptase polymerase chain reaction are necessary to clarify the various mechanisms leading to an MLL-AF10 fusion in acute myelocytic leukemia with 10;11 rearrangement
    • Klaus M., Schnittger S., Haferlach T., et al. Cytogenetics, fluorescence in situ hybridization, and reverse transcriptase polymerase chain reaction are necessary to clarify the various mechanisms leading to an MLL-AF10 fusion in acute myelocytic leukemia with 10;11 rearrangement. Cancer Genet Cytogenet 2003, 144(1):36-43.
    • (2003) Cancer Genet Cytogenet , vol.144 , Issue.1 , pp. 36-43
    • Klaus, M.1    Schnittger, S.2    Haferlach, T.3
  • 42
    • 0036197783 scopus 로고    scopus 로고
    • 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop
    • Bloomfield C.D., Archer K.J., Mrózek K., et al. 11q23 balanced chromosome aberrations in treatment-related myelodysplastic syndromes and acute leukemia: report from an international workshop. Genes Chromosomes Cancer 2002, 33(4):362-378.
    • (2002) Genes Chromosomes Cancer , vol.33 , Issue.4 , pp. 362-378
    • Bloomfield, C.D.1    Archer, K.J.2    Mrózek, K.3
  • 43
    • 33747892853 scopus 로고    scopus 로고
    • Topoisomerase II and the etiology of chromosomal translocations
    • Felix C.A., Kolaris C.P., Osheroff N. Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) 2006, 5(9-10):1093-1108.
    • (2006) DNA Repair (Amst) , vol.5 , Issue.9-10 , pp. 1093-1108
    • Felix, C.A.1    Kolaris, C.P.2    Osheroff, N.3
  • 44
    • 0026780698 scopus 로고
    • The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features
    • Soekarman D., von Lindern M., Daenen S., et al. The translocation (6;9)(p23;q34) shows consistent rearrangement of two genes and defines a myeloproliferative disorder with specific clinical features. Blood 1992, 79(11):2990-2997.
    • (1992) Blood , vol.79 , Issue.11 , pp. 2990-2997
    • Soekarman, D.1    von Lindern, M.2    Daenen, S.3
  • 45
    • 67649435612 scopus 로고    scopus 로고
    • Nuclear pore proteins and cancer
    • Xu S., Powers M.A. Nuclear pore proteins and cancer. Semin Cell Dev Biol 2009, 20(5):620-630.
    • (2009) Semin Cell Dev Biol , vol.20 , Issue.5 , pp. 620-630
    • Xu, S.1    Powers, M.A.2
  • 46
    • 0028846256 scopus 로고
    • Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study
    • Secker-Walker L.M., Mehta A., Bain B. Abnormalities of 3q21 and 3q26 in myeloid malignancy: a United Kingdom Cancer Cytogenetic Group study. Br J Haematol 1995, 91(2):490-501.
    • (1995) Br J Haematol , vol.91 , Issue.2 , pp. 490-501
    • Secker-Walker, L.M.1    Mehta, A.2    Bain, B.3
  • 47
    • 0023678897 scopus 로고
    • Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines
    • Morishita K., Parker D.S., Mucenski M.L., et al. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 1988, 54(6):831-840.
    • (1988) Cell , vol.54 , Issue.6 , pp. 831-840
    • Morishita, K.1    Parker, D.S.2    Mucenski, M.L.3
  • 48
    • 27944449787 scopus 로고    scopus 로고
    • Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells
    • Du Y., Jenkins N.A., Copeland N.G. Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood 2005, 106(12):3932-3939.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3932-3939
    • Du, Y.1    Jenkins, N.A.2    Copeland, N.G.3
  • 49
    • 76249131912 scopus 로고    scopus 로고
    • Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
    • Stein S., Ott M.G., Schultze-Strasser S., et al. Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med 2010, 16(2):198-204.
    • (2010) Nat Med , vol.16 , Issue.2 , pp. 198-204
    • Stein, S.1    Ott, M.G.2    Schultze-Strasser, S.3
  • 50
    • 14344280044 scopus 로고    scopus 로고
    • Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia
    • Mercher T., Le Coniat M.B., Monni R., et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A 2001, 98(10):5776-5779.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.10 , pp. 5776-5779
    • Mercher, T.1    Le Coniat, M.B.2    Monni, R.3
  • 51
    • 0034941166 scopus 로고    scopus 로고
    • Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia
    • Ma Z., Morris S.W., Valentine V., et al. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 2001, 28(3):220-221.
    • (2001) Nat Genet , vol.28 , Issue.3 , pp. 220-221
    • Ma, Z.1    Morris, S.W.2    Valentine, V.3
  • 52
    • 63849253049 scopus 로고    scopus 로고
    • Role for MKL1 in megakaryocytic maturation
    • Cheng E.-C., Luo Q., Bruscia E.M., et al. Role for MKL1 in megakaryocytic maturation. Blood 2009, 113(12):2826-2834.
    • (2009) Blood , vol.113 , Issue.12 , pp. 2826-2834
    • Cheng, E.-C.1    Luo, Q.2    Bruscia, E.M.3
  • 53
    • 77955914238 scopus 로고    scopus 로고
    • Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities amongst 5,876 younger adult patients treated in the UK Medical Research Council trials
    • Grimwade D., Hills R.K., Moorman A.V., et al. Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities amongst 5,876 younger adult patients treated in the UK Medical Research Council trials. Blood 2010, 116(3):354-365.
    • (2010) Blood , vol.116 , Issue.3 , pp. 354-365
    • Grimwade, D.1    Hills, R.K.2    Moorman, A.V.3
  • 54
    • 0036262776 scopus 로고    scopus 로고
    • Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q
    • Mrózek K., Heinonen K., Theil K.S., et al. Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q. Genes Chromosomes Cancer 2002, 34(2):137-153.
    • (2002) Genes Chromosomes Cancer , vol.34 , Issue.2 , pp. 137-153
    • Mrózek, K.1    Heinonen, K.2    Theil, K.S.3
  • 55
    • 77955255893 scopus 로고    scopus 로고
    • Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?
    • Galván A.B., Mallo M., Arenillas L., et al. Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?. Leuk Res 2010, 34(9):1242-1245.
    • (2010) Leuk Res , vol.34 , Issue.9 , pp. 1242-1245
    • Galván, A.B.1    Mallo, M.2    Arenillas, L.3
  • 56
    • 0030071926 scopus 로고    scopus 로고
    • The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1
    • Yoneda-Kato N., Look A.T., Kirstein M.N., et al. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1. Oncogene 1996, 12(2):265-275.
    • (1996) Oncogene , vol.12 , Issue.2 , pp. 265-275
    • Yoneda-Kato, N.1    Look, A.T.2    Kirstein, M.N.3
  • 57
    • 67650859652 scopus 로고    scopus 로고
    • Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer
    • Ebert B.L. Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer. Leukemia 2009, 23(7):1252-1256.
    • (2009) Leukemia , vol.23 , Issue.7 , pp. 1252-1256
    • Ebert, B.L.1
  • 58
    • 78649920418 scopus 로고    scopus 로고
    • Genetic deletions in AML and MDS
    • Ebert B.L. Genetic deletions in AML and MDS. Best Pract Res Clin Haematol 2010, 23(4):457-461.
    • (2010) Best Pract Res Clin Haematol , vol.23 , Issue.4 , pp. 457-461
    • Ebert, B.L.1
  • 59
    • 85016768577 scopus 로고    scopus 로고
    • Prognostic significance of unbalanced chromosome abnormalities used by 2008 World Health Organization (WHO) classification to define " acute myeloid leukemia (AML) with myelodysplasia-related changes" in adults: a Cancer and Leukemia Group B (CALGB) study
    • [abstract 2602]
    • Mrózek K., Holland K.B., Pettenati M.J., et al. Prognostic significance of unbalanced chromosome abnormalities used by 2008 World Health Organization (WHO) classification to define " acute myeloid leukemia (AML) with myelodysplasia-related changes" in adults: a Cancer and Leukemia Group B (CALGB) study. Blood 2009, 114(22):1021. [abstract 2602].
    • (2009) Blood , vol.114 , Issue.22 , pp. 1021
    • Mrózek, K.1    Holland, K.B.2    Pettenati, M.J.3
  • 60
    • 84859925060 scopus 로고    scopus 로고
    • Haematological Malignancy Research Network, University of York, United Kingdom. Available at: Accessed July 25,
    • Haematological Malignancy Research Network, University of York, United Kingdom. Available at: Accessed July 25, 2011. http://www.hmrn.org/Statistics/Incidence_Wizard.aspx.
    • (2011)
  • 61
    • 0036099561 scopus 로고    scopus 로고
    • Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia Working Party
    • Chessells J.M., Harrison C.J., Kempski H., et al. Clinical features, cytogenetics and outcome in acute lymphoblastic and myeloid leukaemia of infancy: report from the MRC Childhood Leukaemia Working Party. Leukemia 2002, 16(5):776-784.
    • (2002) Leukemia , vol.16 , Issue.5 , pp. 776-784
    • Chessells, J.M.1    Harrison, C.J.2    Kempski, H.3
  • 62
    • 77449159028 scopus 로고    scopus 로고
    • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
    • Döhner H., Estey E.H., Amadori S., et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood 2010, 115(3):453-474.
    • (2010) Blood , vol.115 , Issue.3 , pp. 453-474
    • Döhner, H.1    Estey, E.H.2    Amadori, S.3
  • 63
    • 9344237642 scopus 로고    scopus 로고
    • Fifty-one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor
    • Schoch C., Haase D., Haferlach T., et al. Fifty-one patients with acute myeloid leukemia and translocation t(8;21)(q22;q22): an additional deletion in 9q is an adverse prognostic factor. Leukemia 1996, 10(8):1288-1295.
    • (1996) Leukemia , vol.10 , Issue.8 , pp. 1288-1295
    • Schoch, C.1    Haase, D.2    Haferlach, T.3
  • 64
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd J.C., Mrózek K., Dodge R.K., et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002, 100(13):4325-4336.
    • (2002) Blood , vol.100 , Issue.13 , pp. 4325-4336
    • Byrd, J.C.1    Mrózek, K.2    Dodge, R.K.3
  • 65
    • 4644288302 scopus 로고    scopus 로고
    • Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup
    • Schlenk R.F., Benner A., Krauter J., et al. Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup. J Clin Oncol 2004, 22(18):3741-3750.
    • (2004) J Clin Oncol , vol.22 , Issue.18 , pp. 3741-3750
    • Schlenk, R.F.1    Benner, A.2    Krauter, J.3
  • 66
    • 24944464648 scopus 로고    scopus 로고
    • Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study
    • Marcucci G., Mrózek K., Ruppert A.S., et al. Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study. J Clin Oncol 2005, 23(24):5705-5717.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5705-5717
    • Marcucci, G.1    Mrózek, K.2    Ruppert, A.S.3
  • 67
    • 0035339877 scopus 로고    scopus 로고
    • Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Mrózek K., Prior T.W., Edwards C., et al. Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2001, 19(9):2482-2492.
    • (2001) J Clin Oncol , vol.19 , Issue.9 , pp. 2482-2492
    • Mrózek, K.1    Prior, T.W.2    Edwards, C.3
  • 68
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
    • Mrózek K., Marcucci G., Paschka P., et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?. Blood 2007, 109(2):431-448.
    • (2007) Blood , vol.109 , Issue.2 , pp. 431-448
    • Mrózek, K.1    Marcucci, G.2    Paschka, P.3
  • 69
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications
    • Marcucci G., Haferlach T., Döhner H. Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications. J Clin Oncol 2011, 29(5):475-486.
    • (2011) J Clin Oncol , vol.29 , Issue.5 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Döhner, H.3
  • 70
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D., Walker H., Oliver F., et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 1998, 92(7):2322-2333.
    • (1998) Blood , vol.92 , Issue.7 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 71
    • 34247325560 scopus 로고    scopus 로고
    • Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
    • Cornelissen J.J., van Putten W.L.J., Verdonck L.F., et al. Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?. Blood 2007, 109(9):3658-3666.
    • (2007) Blood , vol.109 , Issue.9 , pp. 3658-3666
    • Cornelissen, J.J.1    van Putten, W.L.J.2    Verdonck, L.F.3
  • 72
    • 67049164836 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials
    • Koreth J., Schlenk R., Kopecky K.J., et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA 2009, 301(22):2349-2361.
    • (2009) JAMA , vol.301 , Issue.22 , pp. 2349-2361
    • Koreth, J.1    Schlenk, R.2    Kopecky, K.J.3
  • 73
    • 0038170400 scopus 로고    scopus 로고
    • Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
    • Care R.S., Valk P.J.M., Goodeve A.C., et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br J Haematol 2003, 121(5):775-777.
    • (2003) Br J Haematol , vol.121 , Issue.5 , pp. 775-777
    • Care, R.S.1    Valk, P.J.M.2    Goodeve, A.C.3
  • 74
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B study
    • Paschka P., Marcucci G., Ruppert A.S., et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B study. J Clin Oncol 2006, 24(24):3904-3911.
    • (2006) J Clin Oncol , vol.24 , Issue.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 75
    • 0030324507 scopus 로고    scopus 로고
    • Philadelphia chromosome-positive acute myeloid leukemia: cytoimmunologic and cytogenetic features
    • Cuneo A., Ferrant A., Michaux J.L., et al. Philadelphia chromosome-positive acute myeloid leukemia: cytoimmunologic and cytogenetic features. Haematologica 1996, 81(5):423-427.
    • (1996) Haematologica , vol.81 , Issue.5 , pp. 423-427
    • Cuneo, A.1    Ferrant, A.2    Michaux, J.L.3
  • 76
    • 33745184051 scopus 로고    scopus 로고
    • A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies
    • Slovak M.L., Gundacker H., Bloomfield C.D., et al. A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies. Leukemia 2006, 20(7):1295-1297.
    • (2006) Leukemia , vol.20 , Issue.7 , pp. 1295-1297
    • Slovak, M.L.1    Gundacker, H.2    Bloomfield, C.D.3
  • 77
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C., Steudel C., Mohr B., et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 2002, 99(12):4326-4335.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 78
    • 54349092877 scopus 로고    scopus 로고
    • Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype
    • Breems D.A., Van Putten W.L.J., De Greef G.E., et al. Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype. J Clin Oncol 2008, 26(29):4791-4797.
    • (2008) J Clin Oncol , vol.26 , Issue.29 , pp. 4791-4797
    • Breems, D.A.1    Van Putten, W.L.J.2    De Greef, G.E.3
  • 79
    • 48749098918 scopus 로고    scopus 로고
    • Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype
    • Mrózek K. Cytogenetic, molecular genetic, and clinical characteristics of acute myeloid leukemia with a complex karyotype. Semin Oncol 2008, 35(4):365-377.
    • (2008) Semin Oncol , vol.35 , Issue.4 , pp. 365-377
    • Mrózek, K.1
  • 80
    • 77957715843 scopus 로고    scopus 로고
    • Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience
    • Medeiros B.C., Othus M., Fang M., et al. Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group (SWOG) experience. Blood 2010, 116(13):2224-2228.
    • (2010) Blood , vol.116 , Issue.13 , pp. 2224-2228
    • Medeiros, B.C.1    Othus, M.2    Fang, M.3
  • 81
    • 80051609304 scopus 로고    scopus 로고
    • Outcome of patients with acute myeloid leukemia with monosomal karyotype who undergo hematopoietic cell transplantation
    • Fang M., Storer B., Estey E., et al. Outcome of patients with acute myeloid leukemia with monosomal karyotype who undergo hematopoietic cell transplantation. Blood 2011, 118(6):1490-1494.
    • (2011) Blood , vol.118 , Issue.6 , pp. 1490-1494
    • Fang, M.1    Storer, B.2    Estey, E.3
  • 82
    • 0033485565 scopus 로고    scopus 로고
    • Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative Pediatric Oncology Group study-POG 8821
    • Raimondi S.C., Chang M.N., Ravindranath Y., et al. Chromosomal abnormalities in 478 children with acute myeloid leukemia: clinical characteristics and treatment outcome in a cooperative Pediatric Oncology Group study-POG 8821. Blood 1999, 94(11):3707-3716.
    • (1999) Blood , vol.94 , Issue.11 , pp. 3707-3716
    • Raimondi, S.C.1    Chang, M.N.2    Ravindranath, Y.3
  • 83
    • 77954949832 scopus 로고    scopus 로고
    • Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98
    • von Neuhoff C., Reinhardt D., Sander A., et al. Prognostic impact of specific chromosomal aberrations in a large group of pediatric patients with acute myeloid leukemia treated uniformly according to trial AML-BFM 98. J Clin Oncol 2010, 28(16):2682-2689.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2682-2689
    • von Neuhoff, C.1    Reinhardt, D.2    Sander, A.3
  • 84
    • 77954933160 scopus 로고    scopus 로고
    • Cytogenetics of childhood acute myeloid leukemia: 753 patients in UK Medical Research Council treatment trials, AML 10 and 12
    • Harrison C.J., Moorman A.V., Hills R.K., et al. Cytogenetics of childhood acute myeloid leukemia: 753 patients in UK Medical Research Council treatment trials, AML 10 and 12. J Clin Oncol 2010, 28(16):2674-2681.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2674-2681
    • Harrison, C.J.1    Moorman, A.V.2    Hills, R.K.3
  • 85
    • 79959822135 scopus 로고    scopus 로고
    • Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study
    • Coenen E.A., Raimondi S.C., Harbott J., et al. Prognostic significance of additional cytogenetic aberrations in 733 de novo pediatric 11q23/MLL-rearranged AML patients: results of an international study. Blood 2011, 117(26):7102-7111.
    • (2011) Blood , vol.117 , Issue.26 , pp. 7102-7111
    • Coenen, E.A.1    Raimondi, S.C.2    Harbott, J.3
  • 86
    • 0035469883 scopus 로고    scopus 로고
    • The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade D., Walker H., Harrison G., et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 2001, 98(5):1312-1320.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3
  • 87
    • 33745191374 scopus 로고    scopus 로고
    • Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461
    • Farag S.S., Archer K.J., Mrózek K., et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461. Blood 2006, 108(1):63-73.
    • (2006) Blood , vol.108 , Issue.1 , pp. 63-73
    • Farag, S.S.1    Archer, K.J.2    Mrózek, K.3
  • 88
    • 33751172127 scopus 로고    scopus 로고
    • Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B
    • Fröhling S., Schlenk R.F., Kayser S., et al. Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B. Blood 2006, 108(10):3280-3288.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3280-3288
    • Fröhling, S.1    Schlenk, R.F.2    Kayser, S.3
  • 89
    • 0035135876 scopus 로고    scopus 로고
    • Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients
    • Schoch C., Haferlach T., Haase D., et al. Patients with de novo acute myeloid leukaemia and complex karyotype aberrations show a poor prognosis despite intensive treatment: a study of 90 patients. Br J Haematol 2001, 112(1):118-126.
    • (2001) Br J Haematol , vol.112 , Issue.1 , pp. 118-126
    • Schoch, C.1    Haferlach, T.2    Haase, D.3
  • 90
    • 80054717791 scopus 로고    scopus 로고
    • Comparison of reduced-intensity hematopoietic cell transplantation with chemotherapy in patients aged 60-70 years with acute myeloid leukemia in first remission
    • Farag S.S., Maharry K., Zhang M-J., et al. Comparison of reduced-intensity hematopoietic cell transplantation with chemotherapy in patients aged 60-70 years with acute myeloid leukemia in first remission. Biol Blood Marrow Transplant 2011, 10.1016/j.bbmt.2011.06.005.
    • (2011) Biol Blood Marrow Transplant
    • Farag, S.S.1    Maharry, K.2    Zhang, M.-J.3
  • 91
    • 77952140672 scopus 로고    scopus 로고
    • Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
    • Blum W., Garzon R., Klisovic R.B., et al. Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine. Proc Natl Acad Sci U S A 2010, 107(16):7473-7478.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.16 , pp. 7473-7478
    • Blum, W.1    Garzon, R.2    Klisovic, R.B.3
  • 92
    • 79960661181 scopus 로고    scopus 로고
    • Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities
    • Perrot A., Luquet I., Pigneux A., et al. Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities. Blood 2011, 118(3):679-685.
    • (2011) Blood , vol.118 , Issue.3 , pp. 679-685
    • Perrot, A.1    Luquet, I.2    Pigneux, A.3
  • 93
    • 0036107915 scopus 로고    scopus 로고
    • Screening for core binding factor gene rearrangements in acute myeloid leukemia
    • Grimwade D. Screening for core binding factor gene rearrangements in acute myeloid leukemia. Leukemia 2002, 16(5):964-969.
    • (2002) Leukemia , vol.16 , Issue.5 , pp. 964-969
    • Grimwade, D.1
  • 94
    • 0033564337 scopus 로고    scopus 로고
    • Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the randomized MRC trial
    • Burnett A.K., Grimwade D., Solomon E., et al. Presenting white blood cell count and kinetics of molecular remission predict prognosis in acute promyelocytic leukemia treated with all-trans retinoic acid: result of the randomized MRC trial. Blood 1999, 93(12):4131-4143.
    • (1999) Blood , vol.93 , Issue.12 , pp. 4131-4143
    • Burnett, A.K.1    Grimwade, D.2    Solomon, E.3
  • 95
    • 17744385958 scopus 로고    scopus 로고
    • Comparison of outcome in acute myelogenous leukemia patients with translocation (8;21) found by standard cytogenetic analysis and patients with AML1/ETO fusion transcript found only by PCR testing
    • Sarriera J.E., Albitar M., Estrov Z., et al. Comparison of outcome in acute myelogenous leukemia patients with translocation (8;21) found by standard cytogenetic analysis and patients with AML1/ETO fusion transcript found only by PCR testing. Leukemia 2001, 15(1):57-61.
    • (2001) Leukemia , vol.15 , Issue.1 , pp. 57-61
    • Sarriera, J.E.1    Albitar, M.2    Estrov, Z.3
  • 96
    • 78249263824 scopus 로고    scopus 로고
    • Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML
    • Rücker F.G., Bullinger L., Gribov A., et al. Molecular characterization of AML with ins(21;8)(q22;q22q22) reveals similarity to t(8;21) AML. Genes Chromosomes Cancer 2011, 50(1):51-58.
    • (2011) Genes Chromosomes Cancer , vol.50 , Issue.1 , pp. 51-58
    • Rücker, F.G.1    Bullinger, L.2    Gribov, A.3
  • 97
    • 48749119622 scopus 로고    scopus 로고
    • Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the Cancer and Leukemia Group B experience
    • Mrózek K., Carroll A.J., Maharry K., et al. Central review of cytogenetics is necessary for cooperative group correlative and clinical studies of adult acute leukemia: the Cancer and Leukemia Group B experience. Int J Oncol 2008, 33(2):239-244.
    • (2008) Int J Oncol , vol.33 , Issue.2 , pp. 239-244
    • Mrózek, K.1    Carroll, A.J.2    Maharry, K.3
  • 98
    • 42949122111 scopus 로고    scopus 로고
    • High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated
    • Lugthart S., van Drunen E., van Norden Y., et al. High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated. Blood 2008, 111(8):4329-4337.
    • (2008) Blood , vol.111 , Issue.8 , pp. 4329-4337
    • Lugthart, S.1    van Drunen, E.2    van Norden, Y.3
  • 99
    • 80053354797 scopus 로고    scopus 로고
    • NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern
    • Hollink I.H.I.M., van den Heuvel-Eibrink M.M., Arentsen-Peters S.T.C.J.M., et al. NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. Blood 2011, 118(13):3645-3656.
    • (2011) Blood , vol.118 , Issue.13 , pp. 3645-3656
    • Hollink, I.H.I.M.1    van den Heuvel-Eibrink, M.M.2    Arentsen-Peters, S.T.C.J.M.3
  • 100
    • 69149100639 scopus 로고    scopus 로고
    • Acquired copy number alterations in adult acute myeloid leukemia genomes
    • Walter M.J., Payton J.E., Ries R.E., et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A 2009, 106(31):12950-12955.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.31 , pp. 12950-12955
    • Walter, M.J.1    Payton, J.E.2    Ries, R.E.3
  • 101
    • 70449715477 scopus 로고    scopus 로고
    • New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia
    • Tiu R.V., Gondek L.P., O'Keefe C.L., et al. New lesions detected by single nucleotide polymorphism array-based chromosomal analysis have important clinical impact in acute myeloid leukemia. J Clin Oncol 2009, 27(31):5219-5226.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5219-5226
    • Tiu, R.V.1    Gondek, L.P.2    O'Keefe, C.L.3
  • 102
    • 76749153827 scopus 로고    scopus 로고
    • Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis
    • Bullinger L., Krönke J., Schön C., et al. Identification of acquired copy number alterations and uniparental disomies in cytogenetically normal acute myeloid leukemia using high-resolution single-nucleotide polymorphism analysis. Leukemia 2010, 24(2):438-449.
    • (2010) Leukemia , vol.24 , Issue.2 , pp. 438-449
    • Bullinger, L.1    Krönke, J.2    Schön, C.3
  • 103
    • 78649753896 scopus 로고    scopus 로고
    • Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia
    • Parkin B., Erba H., Ouillette P., et al. Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia. Blood 2010, 116(23):4958-4967.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4958-4967
    • Parkin, B.1    Erba, H.2    Ouillette, P.3
  • 105
    • 84859894619 scopus 로고    scopus 로고
    • Genetic markers in relation to the therapeutic management of acute myeloid leukemia
    • Löwenberg B. Genetic markers in relation to the therapeutic management of acute myeloid leukemia. Hematology Education 2011, 5:36-41.
    • (2011) Hematology Education , vol.5 , pp. 36-41
    • Löwenberg, B.1
  • 106
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M., Yokota S., Iwai T., et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia 1996, 10(12):1911-1918.
    • (1996) Leukemia , vol.10 , Issue.12 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 107
    • 16944362760 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
    • Kiyoi H., Naoe T., Yokota S., et al. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia 1997, 11(9):1447-1452.
    • (1997) Leukemia , vol.11 , Issue.9 , pp. 1447-1452
    • Kiyoi, H.1    Naoe, T.2    Yokota, S.3
  • 109
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a Cancer and Leukemia Group B study
    • Whitman S.P., Archer K.J., Feng L., et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a Cancer and Leukemia Group B study. Cancer Res 2001, 61(19):7233-7239.
    • (2001) Cancer Res , vol.61 , Issue.19 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 110
    • 27144478643 scopus 로고    scopus 로고
    • Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias
    • Fitzgibbon J., Smith L.L., Raghavan M., et al. Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias. Cancer Res 2005, 65(20):9152-9154.
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9152-9154
    • Fitzgibbon, J.1    Smith, L.L.2    Raghavan, M.3
  • 111
    • 53749101166 scopus 로고    scopus 로고
    • Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Paschka P., Marcucci G., Ruppert A.S., et al. Wilms' tumor 1 gene mutations independently predict poor outcome in adults with cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2008, 26(28):4595-4602.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4595-4602
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 112
    • 56749098118 scopus 로고    scopus 로고
    • Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party
    • Virappane P., Gale R., Hills R., et al. Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008, 26(33):5429-5435.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5429-5435
    • Virappane, P.1    Gale, R.2    Hills, R.3
  • 113
    • 68549132617 scopus 로고    scopus 로고
    • Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association
    • Renneville A., Boissel N., Zurawski V., et al. Wilms tumor 1 gene mutations are associated with a higher risk of recurrence in young adults with acute myeloid leukemia: a study from the Acute Leukemia French Association. Cancer 2009, 115(16):3719-3727.
    • (2009) Cancer , vol.115 , Issue.16 , pp. 3719-3727
    • Renneville, A.1    Boissel, N.2    Zurawski, V.3
  • 114
    • 66549116716 scopus 로고    scopus 로고
    • Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group
    • Gaidzik V.I., Schlenk R.F., Moschny S., et al. Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group. Blood 2009, 113(19):4505-4511.
    • (2009) Blood , vol.113 , Issue.19 , pp. 4505-4511
    • Gaidzik, V.I.1    Schlenk, R.F.2    Moschny, S.3
  • 115
    • 73949090504 scopus 로고    scopus 로고
    • AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations
    • Tang J-L., Hou H-A., Chen C-Y., et al. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood 2009, 114(26):5352-5361.
    • (2009) Blood , vol.114 , Issue.26 , pp. 5352-5361
    • Tang, J.-L.1    Hou, H.-A.2    Chen, C.-Y.3
  • 116
    • 79952134550 scopus 로고    scopus 로고
    • RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis
    • Schnittger S., Dicker F., Kern W., et al. RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis. Blood 2011, 117(8):2348-2357.
    • (2011) Blood , vol.117 , Issue.8 , pp. 2348-2357
    • Schnittger, S.1    Dicker, F.2    Kern, W.3
  • 117
    • 79954448043 scopus 로고    scopus 로고
    • RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group
    • Gaidzik V.I., Bullinger L., Schlenk R.F., et al. RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group. J Clin Oncol 2011, 29(10):1364-1372.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1364-1372
    • Gaidzik, V.I.1    Bullinger, L.2    Schlenk, R.F.3
  • 118
    • 0031984414 scopus 로고    scopus 로고
    • Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics
    • Caligiuri M.A., Strout M.P., Lawrence D., et al. Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics. Cancer Res 1998, 58(1):55-59.
    • (1998) Cancer Res , vol.58 , Issue.1 , pp. 55-59
    • Caligiuri, M.A.1    Strout, M.P.2    Lawrence, D.3
  • 119
    • 0034097609 scopus 로고    scopus 로고
    • Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML
    • Schnittger S., Kinkelin U., Schoch C., et al. Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML. Leukemia 2000, 14(5):796-804.
    • (2000) Leukemia , vol.14 , Issue.5 , pp. 796-804
    • Schnittger, S.1    Kinkelin, U.2    Schoch, C.3
  • 120
    • 0036682174 scopus 로고    scopus 로고
    • Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm
    • Döhner K., Tobis K., Ulrich R., et al. Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm. J Clin Oncol 2002, 20(15):3254-3261.
    • (2002) J Clin Oncol , vol.20 , Issue.15 , pp. 3254-3261
    • Döhner, K.1    Tobis, K.2    Ulrich, R.3
  • 121
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk R.F., Döhner K., Krauter J., et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008, 358(18):1909-1918.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1909-1918
    • Schlenk, R.F.1    Döhner, K.2    Krauter, J.3
  • 122
    • 34250011216 scopus 로고    scopus 로고
    • Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study
    • Whitman S.P., Ruppert A.S., Marcucci G., et al. Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study. Blood 2007, 109(12):5164-5167.
    • (2007) Blood , vol.109 , Issue.12 , pp. 5164-5167
    • Whitman, S.P.1    Ruppert, A.S.2    Marcucci, G.3
  • 123
    • 0035093813 scopus 로고    scopus 로고
    • Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
    • Pabst T., Mueller B.U., Zhang P., et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia. Nat Genet 2001, 27(3):263-270.
    • (2001) Nat Genet , vol.27 , Issue.3 , pp. 263-270
    • Pabst, T.1    Mueller, B.U.2    Zhang, P.3
  • 124
    • 19944427850 scopus 로고    scopus 로고
    • Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype
    • Falini B., Mecucci C., Tiacci E., et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005, 352(3):254-266.
    • (2005) N Engl J Med , vol.352 , Issue.3 , pp. 254-266
    • Falini, B.1    Mecucci, C.2    Tiacci, E.3
  • 125
    • 2342544921 scopus 로고    scopus 로고
    • C/EBPα mutations in acute myeloid leukaemias
    • Nerlov C. C/EBPα mutations in acute myeloid leukaemias. Nat Rev Cancer 2004, 4(5):394-400.
    • (2004) Nat Rev Cancer , vol.4 , Issue.5 , pp. 394-400
    • Nerlov, C.1
  • 126
    • 69949085958 scopus 로고    scopus 로고
    • Complexity of CEBPA dysregulation in human acute myeloid leukemia
    • Pabst T., Mueller B.U. Complexity of CEBPA dysregulation in human acute myeloid leukemia. Clin Cancer Res 2009, 15(17):5303-5307.
    • (2009) Clin Cancer Res , vol.15 , Issue.17 , pp. 5303-5307
    • Pabst, T.1    Mueller, B.U.2
  • 127
    • 16544391755 scopus 로고    scopus 로고
    • Mutation of CEBPA in familial acute myeloid leukemia
    • Smith M.L., Cavenagh J.D., Lister T.A., et al. Mutation of CEBPA in familial acute myeloid leukemia. N Engl J Med 2004, 351(23):2403-2407.
    • (2004) N Engl J Med , vol.351 , Issue.23 , pp. 2403-2407
    • Smith, M.L.1    Cavenagh, J.D.2    Lister, T.A.3
  • 128
    • 55549133272 scopus 로고    scopus 로고
    • Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia
    • Pabst T., Eyholzer M., Haefliger S., et al. Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. J Clin Oncol 2008, 26(31):5088-5093.
    • (2008) J Clin Oncol , vol.26 , Issue.31 , pp. 5088-5093
    • Pabst, T.1    Eyholzer, M.2    Haefliger, S.3
  • 129
    • 41249103144 scopus 로고    scopus 로고
    • Modeling of C/EBPα mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
    • Kirstetter P., Schuster M.B., Bereshchenko O., et al. Modeling of C/EBPα mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells. Cancer Cell 2008, 13(4):299-310.
    • (2008) Cancer Cell , vol.13 , Issue.4 , pp. 299-310
    • Kirstetter, P.1    Schuster, M.B.2    Bereshchenko, O.3
  • 130
    • 70350497395 scopus 로고    scopus 로고
    • Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPα mutant AML
    • Bereshchenko O., Mancini E., Moore S., et al. Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPα mutant AML. Cancer Cell 2009, 16(5):390-400.
    • (2009) Cancer Cell , vol.16 , Issue.5 , pp. 390-400
    • Bereshchenko, O.1    Mancini, E.2    Moore, S.3
  • 131
    • 0037108111 scopus 로고    scopus 로고
    • Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)
    • Preudhomme C., Sagot C., Boissel N., et al. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). Blood 2002, 100(8):2717-2723.
    • (2002) Blood , vol.100 , Issue.8 , pp. 2717-2723
    • Preudhomme, C.1    Sagot, C.2    Boissel, N.3
  • 132
    • 1442356729 scopus 로고    scopus 로고
    • CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations
    • Fröhling S., Schlenk R.F., Stolze I., et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. J Clin Oncol 2004, 22(4):624-633.
    • (2004) J Clin Oncol , vol.22 , Issue.4 , pp. 624-633
    • Fröhling, S.1    Schlenk, R.F.2    Stolze, I.3
  • 133
    • 55549103713 scopus 로고    scopus 로고
    • Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B study
    • Marcucci G., Maharry K., Radmacher M.D., et al. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B study. J Clin Oncol 2008, 26(31):5078-5087.
    • (2008) J Clin Oncol , vol.26 , Issue.31 , pp. 5078-5087
    • Marcucci, G.1    Maharry, K.2    Radmacher, M.D.3
  • 134
    • 63849241865 scopus 로고    scopus 로고
    • Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome
    • Wouters B.J., Löwenberg B., Erpelinck-Verschueren C.A.J., et al. Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome. Blood 2009, 113(13):3088-3091.
    • (2009) Blood , vol.113 , Issue.13 , pp. 3088-3091
    • Wouters, B.J.1    Löwenberg, B.2    Erpelinck-Verschueren, C.A.J.3
  • 135
    • 64949122396 scopus 로고    scopus 로고
    • Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis
    • Pabst T., Eyholzer M., Fos J., et al. Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favourable prognosis. Br J Cancer 2009, 100(8):1343-1346.
    • (2009) Br J Cancer , vol.100 , Issue.8 , pp. 1343-1346
    • Pabst, T.1    Eyholzer, M.2    Fos, J.3
  • 136
    • 67149119558 scopus 로고    scopus 로고
    • The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 internal duplication
    • Renneville A., Boissel N., Gachard N., et al. The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 internal duplication. Blood 2009, 113(21):5090-5093.
    • (2009) Blood , vol.113 , Issue.21 , pp. 5090-5093
    • Renneville, A.1    Boissel, N.2    Gachard, N.3
  • 137
    • 77954921625 scopus 로고    scopus 로고
    • Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    • Green C.L., Koo K.K., Hills R.K., et al. Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. J Clin Oncol 2010, 28(16):2739-2747.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2739-2747
    • Green, C.L.1    Koo, K.K.2    Hills, R.K.3
  • 138
    • 79952122978 scopus 로고    scopus 로고
    • Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity
    • Taskesen E., Bullinger L., Corbacioglu A., et al. Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity. Blood 2011, 117(8):2469-2475.
    • (2011) Blood , vol.117 , Issue.8 , pp. 2469-2475
    • Taskesen, E.1    Bullinger, L.2    Corbacioglu, A.3
  • 139
    • 77956159563 scopus 로고    scopus 로고
    • Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features
    • Falini B. Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features. Cancer Treat Res 2010, 145:149-168.
    • (2010) Cancer Treat Res , vol.145 , pp. 149-168
    • Falini, B.1
  • 140
    • 70349579540 scopus 로고    scopus 로고
    • Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML
    • Schnittger S., Kern W., Tschulik C., et al. Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML. Blood 2009, 114(11):2220-2231.
    • (2009) Blood , vol.114 , Issue.11 , pp. 2220-2231
    • Schnittger, S.1    Kern, W.2    Tschulik, C.3
  • 141
    • 79960127726 scopus 로고    scopus 로고
    • Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian Acute Myeloid Leukemia Study Group
    • Krönke J., Schlenk R.F., Jensen K-O., et al. Monitoring of minimal residual disease in NPM1-mutated acute myeloid leukemia: a study from the German-Austrian Acute Myeloid Leukemia Study Group. J Clin Oncol 2011, 29(19):2709-2716.
    • (2011) J Clin Oncol , vol.29 , Issue.19 , pp. 2709-2716
    • Krönke, J.1    Schlenk, R.F.2    Jensen, K.-O.3
  • 142
    • 79955469651 scopus 로고    scopus 로고
    • Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
    • Vassiliou G.S., Cooper J.L., Rad R., et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet 2011, 43(5):470-475.
    • (2011) Nat Genet , vol.43 , Issue.5 , pp. 470-475
    • Vassiliou, G.S.1    Cooper, J.L.2    Rad, R.3
  • 143
    • 28444449081 scopus 로고    scopus 로고
    • Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
    • Schnittger S., Schoch C., Kern W., et al. Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. Blood 2005, 106(12):3733-3739.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3733-3739
    • Schnittger, S.1    Schoch, C.2    Kern, W.3
  • 144
    • 28444473100 scopus 로고    scopus 로고
    • Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations
    • Döhner K., Schlenk R.F., Habdank M., et al. Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations. Blood 2005, 106(12):3740-3746.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3740-3746
    • Döhner, K.1    Schlenk, R.F.2    Habdank, M.3
  • 145
    • 28444446313 scopus 로고    scopus 로고
    • Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
    • Verhaak R.G.W., Goudswaard C.S., van Putten W., et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 2005, 106(12):3747-3754.
    • (2005) Blood , vol.106 , Issue.12 , pp. 3747-3754
    • Verhaak, R.G.W.1    Goudswaard, C.S.2    van Putten, W.3
  • 146
    • 41949090673 scopus 로고    scopus 로고
    • The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    • Gale R.E., Green C., Allen C., et al. The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia. Blood 2008, 111(5):2776-2784.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2776-2784
    • Gale, R.E.1    Green, C.2    Allen, C.3
  • 147
    • 77449140390 scopus 로고    scopus 로고
    • Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study
    • Becker H., Marcucci G., Maharry K., et al. Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28(4):596-604.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 596-604
    • Becker, H.1    Marcucci, G.2    Maharry, K.3
  • 148
    • 70350637903 scopus 로고    scopus 로고
    • AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
    • Haferlach C., Mecucci C., Schnittger S., et al. AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features. Blood 2009, 114(14):3024-3032.
    • (2009) Blood , vol.114 , Issue.14 , pp. 3024-3032
    • Haferlach, C.1    Mecucci, C.2    Schnittger, S.3
  • 149
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis E.R., Ding L., Dooling D.J., et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 2009, 361(11):1058-1066.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 150
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley T.J., Ding L., Walter M.J., et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med 2010, 363(25):2424-2433.
    • (2010) N Engl J Med , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 151
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Marcucci G., Maharry K., Wu Y-Z., et al. IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28(14):2348-2355.
    • (2010) J Clin Oncol , vol.28 , Issue.14 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.-Z.3
  • 152
    • 79960534917 scopus 로고    scopus 로고
    • The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
    • Green C.L., Evans C.M., Zhao L., et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood 2011, 118(2):409-412.
    • (2011) Blood , vol.118 , Issue.2 , pp. 409-412
    • Green, C.L.1    Evans, C.M.2    Zhao, L.3
  • 153
    • 79953700548 scopus 로고    scopus 로고
    • Differential prognosis impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia
    • Boissel N., Nibourel O., Renneville A., et al. Differential prognosis impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. Blood 2011, 117(13):3696-3697.
    • (2011) Blood , vol.117 , Issue.13 , pp. 3696-3697
    • Boissel, N.1    Nibourel, O.2    Renneville, A.3
  • 154
    • 79961155567 scopus 로고    scopus 로고
    • Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma
    • Best T., Li D., Skol A.D., et al. Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Nat Med 2011, 17(8):941-943.
    • (2011) Nat Med , vol.17 , Issue.8 , pp. 941-943
    • Best, T.1    Li, D.2    Skol, A.D.3
  • 155
    • 79955016374 scopus 로고    scopus 로고
    • Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML
    • Link D.C., Schuettpelz L.G., Shen D., et al. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA 2011, 305(15):1568-1576.
    • (2011) JAMA , vol.305 , Issue.15 , pp. 1568-1576
    • Link, D.C.1    Schuettpelz, L.G.2    Shen, D.3
  • 156
    • 79251585937 scopus 로고    scopus 로고
    • The prognostic and functional role of microRNAs in acute myeloid leukemia
    • Marcucci G., Mrózek K., Radmacher M.D., et al. The prognostic and functional role of microRNAs in acute myeloid leukemia. Blood 2011, 117(4):1121-1129.
    • (2011) Blood , vol.117 , Issue.4 , pp. 1121-1129
    • Marcucci, G.1    Mrózek, K.2    Radmacher, M.D.3
  • 157
    • 42949083345 scopus 로고    scopus 로고
    • MicroRNA expression in cytogenetically normal acute myeloid leukemia
    • Marcucci G., Radmacher M.D., Maharry K., et al. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008, 358(18):1919-1928.
    • (2008) N Engl J Med , vol.358 , Issue.18 , pp. 1919-1928
    • Marcucci, G.1    Radmacher, M.D.2    Maharry, K.3
  • 158
    • 79251585678 scopus 로고    scopus 로고
    • Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study
    • Schwind S., Maharry K., Radmacher M.D., et al. Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. J Clin Oncol 2010, 28(36):5257-5264.
    • (2010) J Clin Oncol , vol.28 , Issue.36 , pp. 5257-5264
    • Schwind, S.1    Maharry, K.2    Radmacher, M.D.3
  • 159
    • 77956251480 scopus 로고    scopus 로고
    • Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
    • Mohrin M., Bourke E., Alexander D., et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell 2010, 7(2):174-185.
    • (2010) Cell Stem Cell , vol.7 , Issue.2 , pp. 174-185
    • Mohrin, M.1    Bourke, E.2    Alexander, D.3
  • 160
    • 77956233247 scopus 로고    scopus 로고
    • A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
    • Milyavsky M., Gan O.I., Trottier M., et al. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 2010, 7(2):186-197.
    • (2010) Cell Stem Cell , vol.7 , Issue.2 , pp. 186-197
    • Milyavsky, M.1    Gan, O.I.2    Trottier, M.3
  • 161
    • 0035814808 scopus 로고    scopus 로고
    • Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints
    • Lovett B.D., Strumberg D., Blair I.A., et al. Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints. Biochemistry 2001, 40(5):1159-1170.
    • (2001) Biochemistry , vol.40 , Issue.5 , pp. 1159-1170
    • Lovett, B.D.1    Strumberg, D.2    Blair, I.A.3
  • 162
    • 20144388623 scopus 로고    scopus 로고
    • DNA topoisomerase II in therapy-related acute promyelocytic leukemia
    • Mistry A.R., Felix C.A., Whitmarsh R.J., et al. DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med 2005, 352(15):1529-1538.
    • (2005) N Engl J Med , vol.352 , Issue.15 , pp. 1529-1538
    • Mistry, A.R.1    Felix, C.A.2    Whitmarsh, R.J.3
  • 163
    • 54049153246 scopus 로고    scopus 로고
    • Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis
    • Hasan S.K., Mays A.N., Ottone T., et al. Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood 2008, 112(8):3383-3390.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3383-3390
    • Hasan, S.K.1    Mays, A.N.2    Ottone, T.3
  • 164
    • 75649084232 scopus 로고    scopus 로고
    • Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia
    • Mays A.N., Osheroff N., Xiao Y., et al. Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood 2010, 115(2):326-330.
    • (2010) Blood , vol.115 , Issue.2 , pp. 326-330
    • Mays, A.N.1    Osheroff, N.2    Xiao, Y.3
  • 165
    • 0035866811 scopus 로고    scopus 로고
    • Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion
    • Alexander F.E., Patheal S.L., Biondi A., et al. Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion. Cancer Res 2001, 61(6):2542-2546.
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2542-2546
    • Alexander, F.E.1    Patheal, S.L.2    Biondi, A.3
  • 166
    • 0034760207 scopus 로고    scopus 로고
    • Childhood myeloid leukaemias
    • Hall G.W. Childhood myeloid leukaemias. Best Pract Res Clin Haematol 2001, 14(3):573-591.
    • (2001) Best Pract Res Clin Haematol , vol.14 , Issue.3 , pp. 573-591
    • Hall, G.W.1
  • 167
    • 77955069195 scopus 로고    scopus 로고
    • Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements
    • Haffner M.C., Aryee M.J., Toubaji A., et al. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nat Genet 2010, 42(8):668-675.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 668-675
    • Haffner, M.C.1    Aryee, M.J.2    Toubaji, A.3
  • 168
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J., Shi J., Wang E., et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 2011, 478(7370):524-528.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 524-528
    • Zuber, J.1    Shi, J.2    Wang, E.3
  • 169
    • 80054984945 scopus 로고    scopus 로고
    • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
    • Dawson M.A., Prinjha R.K., Dittmann A., et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature 2011, 478(7370):529-533.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 529-533
    • Dawson, M.A.1    Prinjha, R.K.2    Dittmann, A.3
  • 170
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study
    • Slovak M.L., Kopecky K.J., Cassileth P.A., et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study. Blood 2000, 96(13):4075-4083.
    • (2000) Blood , vol.96 , Issue.13 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 171
    • 0041737626 scopus 로고    scopus 로고
    • Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMA AML-10 trial
    • Suciu S., Mandelli F., de Witte T., et al. Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC/GIMEMA AML-10 trial. Blood 2003, 102(4):1232-1240.
    • (2003) Blood , vol.102 , Issue.4 , pp. 1232-1240
    • Suciu, S.1    Mandelli, F.2    de Witte, T.3
  • 172
    • 0141816710 scopus 로고    scopus 로고
    • AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases
    • Schoch C., Schnittger S., Klaus M., et al. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood 2003, 102(7):2395-2402.
    • (2003) Blood , vol.102 , Issue.7 , pp. 2395-2402
    • Schoch, C.1    Schnittger, S.2    Klaus, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.